15 research outputs found
Room Temperature Dehalogenation of Chloroarenes by Polymethylhydrosiloxane (PMHS) under Palladium Catalysis.
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Textile-supported silver nanoparticles as a highly efficient and recyclable heterogeneous catalyst for nitroaromatic reduction at room temperature
No full textFunction through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors
No full textThe human kinome comprises over 500 protein kinases. When mutated or over-expressed, many play critical roles in abnormal cellular functions associated with cancer, cardiovascular disease and neurological disorders. Here we report a step-economical approach to designed kinase inhibitors inspired by the potent, but non-selective, natural product staurosporine, and synthetically enabled by a novel, complexity-increasing, serialized [5 + 2]/[4 + 2] cycloaddition strategy. This function-oriented synthesis approach rapidly affords tunable scaffolds, and produced a low nanomolar inhibitor of protein kinase C.clos
A Pd-Catalyzed in situ domino process for mild and quantitative production of 2,5-dimethylfuran directly from carbohydrates
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Systematic Variation of Cyanobuta-1,3-dienes and Expanded Tetracyanoquinodimethane Analogues as Electron Acceptors in Photoactive, Rigid Porphyrin Conjugates
No full textSynthesis of coumarins via PIDA/I2-mediated oxidative cyclization of substituted phenylacrylic acids
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