High-Precision Photothermal Ablation using Biocompatible Palladium Nanoparticles and Laser Scanning Microscopy

Herein, we report a straightforward method for the scalable preparation of Pd nanoparticles (Pd-NPs) with reduced inherent cytotoxicity and high photothermal conversion capacity. These Pd-NPs are rapidly taken up by cells and able to kill labeled cancer cells upon short exposure to near-infrared (NIR) light. Following cell treatment with Pd-NPs, ablated areas were patterned with high precision by laser scanning microscopy, allowing one to perform cell migration assays with unprecedented accuracy. Using coherent Raman microscopy, cells containing Pd-NPs were simultaneously ablated and imaged. This novel methodology was combined with intravital imaging to mediate microablation of cancerous tissue in tumor xenografts in mice

Morphological evolution of pulsed laser deposited ZrO2 thin films

Morphological evolution of ZrO2 thin films deposited during pulsed laser deposition of Zr in O2 atmosphere has been experimentally studied at two different film deposition temperatures, 300 and 873 K. The roughness exponent, , the growth exponent, , the coarsening exponent, 1/z, and the exponent defining the evolution of the characteristic wavelength of the surface, p, for depositions at 300 K amounted to = 1.00.1, = 0.40.1, 1/z= 0.340.03, and p= 0.490.03, whereas for depositions carried out at 873 K amounted to = 0.30.3, = 0.40.2, and 1/z= 0.00.2. Experimental error becomes important due to the flat morphology of the films inherent to the deposition technique. The change in the surface topography with the film temperature has been studied with the help of a simple Monte Carlo model which indicates the existence of two different growth regimes: a shadowing dominated growth, occurring at low temperatures, characterized by calculated values = 1.000.04, = 0.500.04, p= 0.460.01, and 1/z= 0.350.02 and a diffusion dominated growth that takes place at high temperatures as well as at low deposition rates, characterized by calculated values = 0.150.08, = 0.330.04, and 1/z= 0.330.07. The good agreement obtained between the experimental and simulated parameters is discussed within the frame of the general characteristics of the deposition method.Universidad Nacional Autónoma de México-PAPIIT-IN107808Consejo Nacional de Ciencia y Tecnología de México-CONACyT-50203-FMinisterio de Ciencia, Innovación y Universidades de España-MAT 2007-65764, PIE 200960I132 y CONSOLIDER INGENIO 2010-CSD2008-00023Junta de Andalucía-TEP2275 y P07-FQM-0329

Weak gauge principle and electric charge quantization

Starting from a weak gauge principle we give a new and critical revision of the argument leading to charge quantization on arbitrary spacetimes. The main differences of our approach with respect to previous works appear on spacetimes with non trivial torsion elements on its second integral cohomology group. We show that in these spacetimes there can be topologically non-trivial configurations of charged fields which do not imply charge quantization. However, the existence of a non-exact electromagnetic field always implies the quantization of charges. Another consequence of the theory for spacetimes with torsion is the fact that it gives rise to two natural quantization units that could be identified with the electric quantization unit (realized inside the quarks) and with the electron charge. In this framework the color charge can have a topological origin, with the number of colors being related to the order of the torsion subgroup. Finally, we discuss the possibility that the quantization of charge may be due to a weak non-exact component of the electromagnetic field extended over cosmological scales.Comment: Latex2e, 24 pages, no figure

MASSIV: Mass Assembly Survey with SINFONI in VVDS. V. The major merger rate of star-forming galaxies at 0.9 < z < 1.8 from IFS-based close pairs

We aim to measure the major merger rate of star-forming galaxies at 0.9 < z <1.8, using close pairs identified from integral field spectroscopy (IFS). We use the velocity field maps obtained with SINFONI/VLT on the MASSIV sample, selected from the star-forming population in the VVDS. We identify physical pairs of galaxies from the measurement of the relative velocity and the projected separation (r_p) of the galaxies in the pair. Using the well constrained selection function of the MASSIV sample we derive the gas-rich major merger fraction (luminosity ratio mu = L_2/L_1 >= 1/4), and, using merger time scales from cosmological simulations, the gas-rich major merger rate at a mean redshift up to z = 1.54. We find a high gas-rich major merger fraction of 20.8+15.2-6.8 %, 20.1+8.0-5.1 % and 22.0+13.7-7.3 % for close pairs with r_p <= 20h^-1 kpc in redshift ranges z = [0.94, 1.06], [1.2, 1.5) and [1.5, 1.8), respectively. This translates into a gas-rich major merger rate of 0.116+0.084-0.038 Gyr^-1, 0.147+0.058-0.037 Gyr^-1 and 0.127+0.079-0.042 Gyr^-1 at z = 1.03, 1.32 and 1.54, respectively. Combining our results with previous studies at z < 1, the gas-rich major merger rate evolves as (1+z)^n, with n = 3.95 +- 0.12, up to z = 1.5. From these results we infer that ~35% of the star-forming galaxies with stellar masses M = 10^10 - 10^10.5 M_Sun have undergone a major merger since z ~ 1.5. We develop a simple model which shows that, assuming that all gas-rich major mergers lead to early-type galaxies, the combined effect of gas-rich and dry mergers is able to explain most of the evolution in the number density of massive early-type galaxies since z ~ 1.5, with our measured gas-rich merger rate accounting for about two-thirds of this evolution.Comment: Published in Astronomy and Astrophysics, 24 pages, 30 figures, 2 tables. Appendix with the residual images from GALFIT added. Minor changes with respect to the initial versio

New polymorphisms associated with response to anti-TNF drugs in patients with moderate-to-severe plaque psoriasis

Anti-tumor necrosis factor (anti-TNF) drugs are effective against psoriasis, although 20–30% of patients are nonresponders. Few pharmacogenomic studies have been performed to predict the response to anti-TNF drugs in psoriasis. We studied 173 polymorphisms to establish an association with the response to anti-TNF drugs in patients with moderate-to-severe plaque psoriasis (N=144). We evaluated the response using PASI75 at 3, 6 and 12 months. The results of the multivariate analysis showed an association between polymorphisms in PGLYR4, ZNF816A, CTNNA2, IL12B, MAP3K1 and HLA-C genes and the response at 3 months. Besides, the results for polymorphisms in IL12B and MAP3K1 were replicated at 6 months. We also obtained significant results for IL12B polymorphism at 1 year. Moreover, polymorphisms in FCGR2A, HTR2A and CDKAL1 were significant at 6 months. This is the first study to show an association with these polymorphisms. However, these biomarkers should be validated in large-scale studies before implementation in clinical practiceThis study was supported by Instituto de Salud Carlos III (FIS PI10/01740), Fundación Teófilo Hernando, and AbbVie. RPP has a grant from Universidad Autónoma de Madrid (FPI program 2013

Analyzing derived metallicities and ionization parameters from model-based determinations in ionized gaseous nebulae

We analyze the reliability of oxygen abundances and ionization parameters obtained from different diagnostic diagrams. For this, we compiled from the literature observational emission line intensities and oxygen abundance of 446 star-forming regions whose O/H abundance was determined by direct estimation of electron temperature. The abundances compiled were compared with the values calculated in this work using different diagnostic diagrams in combination with results from a grid of photoionization models. We found that the [\ion{O}{iii}]/[\ion{O}{ii}] vs. [\ion{N}{ii}]/[\ion{O}{ii}], [\ion{O}{iii}]/H$\beta$ vs. [\ion{N}{ii}]/[\ion{O}{ii}], and ([\ion{O}{iii}]/H$\beta$)/([\ion{N}{ii}]/H$\alpha$) vs. [\ion{S}{ii}]/[\ion{S}{iii}] diagnostic diagrams give O/H values close to the $T_{\rm e}$-method, with differences of about 0.04 dex and dispersion of about 0.3 dex. Similar results were obtained by detailed models but with a dispersion of 0.08 dex. The origin of the dispersion found in the use of diagnostic diagrams is probably due to differences between the real N/O-O/H relation of the sample and the one assumed in the models. This is confirmed by the use of detailed models that do not have a fixed N/O-O/H relation. We found no correlation between ionization parameter and the metallicity for the objects of our sample. We conclude that the combination of two line ratio predicted by photoionization models, one sensitive to the metallicity and another sensitive to the ionization parameter, which takes into account the physical conditions of star-forming regions, gives O/H estimates close to the values derived using direct detections of electron temperatures.Comment: 12 pages, 9 figures, accepted by MNRA

A peculiar class of debris disks from Herschel/DUNES - A steep fall off in the far infrared

Aims. We present photometric data of debris disks around HIP 103389 (HD 199260), HIP 107350 (HN Peg, HD206860), and HIP 114948 (HD 219482), obtained in the context of our Herschel Open Time Key Program DUNES (DUst around NEarby Stars). Methods. We used Herschel/PACS to detect the thermal emission of the three debris disks with a 3 sigma sensitivity of a few mJy at 100 um and 160 um. In addition, we obtained Herschel/PACS photometric data at 70 um for HIP 103389. Two different approaches are applied to reduce the Herschel data to investigate the impact of data reduction on the photometry. We fit analytical models to the available spectral energy distribution (SED) data. Results. The SEDs of the three disks potentially exhibit an unusually steep decrease at wavelengths > 70 um. We investigate the significance of the peculiar shape of these SEDs and the impact on models of the disks provided it is real. Our modeling reveals that such a steep decrease of the SEDs in the long wavelength regime is inconsistent with a power-law exponent of the grain size distribution -3.5 expected from a standard equilibrium collisional cascade. In contrast, a very distinct range of grain sizes is implied to dominate the thermal emission of such disks. However, we demonstrate that the understanding of the data of faint sources obtained with Herschel is still incomplete and that the significance of our results depends on the version of the data reduction pipeline used. Conclusions. A new mechanism to produce the dust in the presented debris disks, deviations from the conditions required for a standard equilibrium collisional cascade (grain size exponent of -3.5), and/or significantly different dust properties would be necessary to explain the potentially steep SED shape of the three debris disks presented. (abridged)Comment: 14 pages, 4 figures, accepted by A&

The intrinsic shape of galaxy bulges

The knowledge of the intrinsic three-dimensional (3D) structure of galaxy components provides crucial information about the physical processes driving their formation and evolution. In this paper I discuss the main developments and results in the quest to better understand the 3D shape of galaxy bulges. I start by establishing the basic geometrical description of the problem. Our understanding of the intrinsic shape of elliptical galaxies and galaxy discs is then presented in a historical context, in order to place the role that the 3D structure of bulges play in the broader picture of galaxy evolution. Our current view on the 3D shape of the Milky Way bulge and future prospects in the field are also depicted.Comment: Invited Review to appear in "Galactic Bulges" Editors: Laurikainen E., Peletier R., Gadotti D. Springer Publishing. 24 pages, 7 figure

The Spanish Infrared Camera onboard the EUSO-BALLOON (CNES) flight on August 24, 2014

The EUSO-Balloon (CNES) campaign was held during Summer 2014 with a launch on August 24. In the gondola, next to the Photo Detector Module (PDM), a completely isolated Infrared camera was allocated. Also, a helicopter which shooted flashers flew below the balloon. We have retrieved the Cloud Top Height (CTH) with the IR camera, and also the optical depth of the nonclear atmosphere have been inferred with two approaches: The first one is with the comparison of the brightness temperature of the cloud and the real temperature obtained after the pertinent corrections. The second one is by measuring the detected signal from the helicopter flashers by the IR Camera, considering the energy of the flashers and the location of the helicopter

Comparing inequalities in the labour market from a segmentation perspective

Production of INCASI Project H2020-MSCA-RISE-2015 GA 691004The purpose of this chapter is to carry out a comparative analysis of labour markets in Europe and Latin America from the perspective of segmentation in order to explain the processes of social inequality that arise in the workplace, in light of recent trends in global socio-economic changes. The chapter proposes two main objectives. The first is to perform a comparative descriptive analysis of the main features of labour markets among 60 European and Latin American countries. The second objective is to propose a model of comparative analysis of labour inequality from the theoretical perspective of the segmentation of the labour market and structural heterogeneity. We will focus our analysis by selecting two countries, Spain and Argentina, which both underwent a late development of capitalism. The following general hypothesis is formulated: Spain and Argentina, having clearly differentiated features in economic structure, level of development, institutional frameworks and socio-historical processes, show common dynamics in the structuring of the capitalist labour market between a primary and secondary segment. Using equivalent databases on the workforce a typology of segmentation of employment is constructed that show, in addition to the specificities of each country, the similarities in the structuring of the labour market