10 research outputs found
Reproducible, Interactive, Scalable and Extensible Microbiome Data Science Using QIIME 2
- Author
- Abnet Christian
- Al-Ghalith Gabriel
- Alexander Harriet
- Alm Eric
- Arumugam Manimozhiyan
- Asnicar Francesco
- Bai Yang
- Bisanz Jordan
- Bittinger Kyle
- Bokulich Nicholas
- Bolyen Evan
- Brejnrod Asker
- Brislawn Colin J.
- Brown C. Titus
- Callahan Benjamin
- Caporaso James Gregory
- Caraballo Mauricio
- Chase John
- Da Silva Ricardo
- Diener Christian
- Dillon Matthew
- Dorrenstein Pieter
- Douglas Gavin M.
- Durall Daniel M.
- Duvallet Claire
- Edwardson Christian
- Ernst Madeleine
- Estaki Mehrbod
- Fouquier Jennifer
- Gauglitz Julia M.
- Gibbons Sean
- Gibson Deanna L.
- Gonzalez Antonio
- Gorlick Kestrel
- Guo Jiarong
- Hillmann Benjamin
- Holmes Susan
- Holste Hannes
- Huttenhower Curtis
- Huttley Gavin A.
- Jarmusch Alan K.
- Jessen Stefan
- Jiang Lingjing
- K. Emily, Cope
- Kaehler Benjamin D.
- Kang Kyo Bin
- Keefe Christopher
- Keim Paul
- Kelley Scott T.
- Knight Rob
- Knights Dan
- Koester Irina
- Kreps Jorden
- Langille Morgan G.I.
- Lee Joslynn
- Ley Ruth
- Liu Yong-Xin
- Loftfield Erikka
- Lozupone Catherine
- Maher Massoud
- Marotz Clarisse
- Martin Bryan
- McDonald Daniel
- McIver Lauren J.
- Melnik Alexey
- Metcalf Jessica L.
- Morgan Sydney C.
- Morton Jamie T.
- Naimey Ahmad Turan
- Navas-Molina Jose Antonio
- Nothias Louis Felix
- Orchanian Stephanie
- Pearson Talima
- Peoples Samuel L.
- Petras Daniel
- Preuss Mary Lai
- Pruesse Elmar
- Rasmussen Lasse Buur
- Rideout Jai Ram
- Rivers Adam
- Robeson Michael
- Rosenthal Patrick
- Segata Nicola
- Shaffer Michael
- Shiffer Arron
- Sinha Rashmi
- Song Se Jin
- Spear John R.
- Swafford Austin D.
- Thompson Luke R.
- Torres Pedro J.
- Trinh Pauline
- Tripathi Anupriya
- Turnbaugh Peter
- Ul-Hasan Sabah
- Van der Hooft Justin
- Vargas Fernando
- Vogtmann Emily
- Von Hippel Max
- Vázquez-Baeza Yoshiki
- Walters William
- Wan Yunhu
- Wang Mingxun
- Warren Jonathan
- Weber Kyle C.
- Williamson Charles H.D.
- Willis Amy
- Xu Zhenjiang Zech
- Zhang Yilong
- Zhu Qiyun
- Publication venue
- The Aquila Digital Community
- Publication date
- 01/08/2019
- Field of study
QIIME 2: Reproducible, interactive, scalable, and extensible microbiome data science
- Author
- Abnet Christian
- Al-Ghalith Gabriel A
- Alexander Harriet
- Alm Eric J
- Arumugam Manimozhiyan
- Asnicar Francesco
- Bai Yang
- Bisanz Jordan E
- Bittinger Kyle
- Bokulich Nicholas A
- Bolyen Evan
- Brejnrod Asker
- Brislawn Colin J
- Brown C Titus
- Callahan Benjamin J
- Caporaso J Gregory
- Caraballo-Rodríguez Andrés Mauricio
- Chase John
- Cope Emily
- Da Silva Ricardo
- Dillon Matthew R
- Dorrestein Pieter C
- Douglas Gavin M
- Durall Daniel M
- Duvallet Claire
- Edwardson Christian F
- Ernst Madeleine
- Estaki Mehrbod
- Fouquier Jennifer
- Gauglitz Julia M
- Gibson Deanna L
- Gonzalez Antonio
- Gorlick Kestrel
- Guo Jiarong
- Hillmann Benjamin
- Holmes Susan
- Holste Hannes
- Huttenhower Curtis
- Huttley Gavin
- Janssen Stefan
- Jarmusch Alan K
- Jiang Lingjing
- Kaehler Benjamin
- Kang Kyo Bin
- Keefe Christopher R
- Keim Paul
- Kelley Scott T
- Knight Rob
- Knights Dan
- Koester Irina
- Kosciolek Tomasz
- Kreps Jorden
- Langille Morgan GI
- Lee Joslynn
- Ley Ruth
- Liu Yong-Xin
- Loftfield Erikka
- Lozupone Catherine
- Maher Massoud
- Marotz Clarisse
- Martin Bryan
- McDonald Daniel
- McIver Lauren J
- Melnik Alexey V
- Metcalf Jessica L
- Morgan Sydney C
- Morton Jamie
- Naimey Ahmad Turan
- Navas-Molina Jose A
- Nothias Louis Felix
- Orchanian Stephanie B
- Pearson Talima
- Peoples Samuel L
- Petras Daniel
- Preuss Mary Lai
- Pruesse Elmar
- Rasmussen Lasse Buur
- Rideout Jai Ram
- Rivers Adam
- Robeson II, Michael S
- Rosenthal Patrick
- Segata Nicola
- Shaffer Michael
- Shiffer Arron
- Sinha Rashmi
- Song Se Jin
- Spear John R
- Swafford Austin D
- Thompson Luke R
- Torres Pedro J
- Trinh Pauline
- Tripathi Anupriya
- Turnbaugh Peter J
- Ul-Hasan Sabah
- van der Hooft Justin JJ
- Vargas Fernando
- Vogtmann Emily
- von Hippel Max
- Vázquez-Baeza Yoshiki
- Walters William
- Wan Yunhu
- Wang Mingxun
- Warren Jonathan
- Weber Kyle C
- Williamson Chase HD
- Willis Amy D
- Xu Zhenjiang Zech
- Zaneveld Jesse R
- Zhang Yilong
- Publication venue
- 'PeerJ'
- Publication date
- 01/01/2018
- Field of study
Bolyen E, Rideout JR, Dillon MR, et al. QIIME 2: Reproducible, interactive, scalable, and extensible microbiome data science. PeerJ. 2018
Author Correction: Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
- Author
- Abnet Christian C.
- Al-Ghalith Gabriel A.
- Alexander Harriet
- Alm Eric J.
- Arumugam Manimozhiyan
- Asnicar Francesco
- Bai Yang
- Bisanz Jordan E.
- Bittinger Kyle
- Bokulich Nicholas A.
- Bolyen Evan
- Brejnrod Asker
- Brislawn Colin J.
- Brown C.T.
- Callahan Benjamin J.
- Caporaso J.G.
- Caraballo-Rodríguez Andrés Mauricio
- Chase John
- Cope Emily K.
- Diener Christian
- Dillon Matthew R.
- Dorrestein Pieter C.
- Douglas Gavin M.
- Durall Daniel M.
- Duvallet Claire
- Edwardson Christian F.
- Ernst Madeleine
- Estaki Mehrbod
- Fouquier Jennifer
- Gauglitz Julia M.
- Gibbons Sean M.
- Gibson Deanna L.
- Gonzalez Antonio
- Gorlick Kestrel
- Guo Jiarong
- Hillmann Benjamin
- Hippel von, Max
- Holmes Susan
- Holste Hannes
- Hooft van der, Justin J.J.
- Huttenhower Curtis
- Huttley Gavin A.
- Janssen Stefan
- Jarmusch Alan K.
- Jiang Lingjing
- Kaehler Benjamin D.
- Kang Kyo Bin
- Keefe Christopher R.
- Keim Paul
- Kelley Scott T.
- Knight Rob
- Knights Dan
- Koester Irina
- Kosciolek Tomasz
- Kreps Jorden
- Langille Morgan G.I.
- Lee Joslynn
- Ley Ruth
- Liu Yong Xin
- Loftfield Erikka
- Lozupone Catherine
- Maher Massoud
- Marotz Clarisse
- Martin Bryan D.
- McDonald Daniel
- McIver Lauren J.
- Melnik Alexey V.
- Metcalf Jessica L.
- Morgan Sydney C.
- Morton Jamie T.
- Naimey Ahmad Turan
- Navas-Molina Jose A.
- Nothias Louis Felix
- Orchanian Stephanie B.
- Pearson Talima
- Peoples Samuel L.
- Petras Daniel
- Preuss Mary Lai
- Pruesse Elmar
- Rasmussen Lasse Buur
- Rideout Jai Ram
- Rivers Adam
- Robeson Michael S.
- Rosenthal Patrick
- Segata Nicola
- Shaffer Michael
- Shiffer Arron
- Silva Da, Ricardo
- Sinha Rashmi
- Song Se Jin
- Spear John R.
- Swafford Austin D.
- Thompson Luke R.
- Torres Pedro J.
- Trinh Pauline
- Tripathi Anupriya
- Turnbaugh Peter J.
- Ul-Hasan Sabah
- Vargas Fernando
- Vogtmann Emily
- Vázquez-Baeza Yoshiki
- Walters William
- Wan Yunhu
- Wang Mingxun
- Warren Jonathan
- Weber Kyle C.
- Williamson Charles H.D.
- Willis Amy D.
- Xu Zhenjiang Zech
- Zaneveld Jesse R.
- Zhang Yilong
- Zhu Qiyun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
In the version of this article initially published, some reference citations were incorrect. The three references to Jupyter Notebooks should have cited Kluyver et al. instead of Gonzalez et al. The reference to Qiita should have cited Gonzalez et al. instead of Schloss et al. The reference to mothur should have cited Schloss et al. instead of McMurdie & Holmes. The reference to phyloseq should have cited McMurdie & Holmes instead of Huber et al. The reference to Bioconductor should have cited Huber et al. instead of Franzosa et al. And the reference to the biobakery suite should have cited Franzosa et al. instead of Kluyver et al. The errors have been corrected in the HTML and PDF versions of the article.</p
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
- Author
- Abnet Christian C.
- Al-Ghalith Gabriel A.
- Alexander Harriet
- Alm Eric J.
- Arumugam Manimozhiyan
- Asnicar Francesco
- Bai Yang
- Bisanz Jordan E.
- Bittinger Kyle
- Bokulich Nicholas A.
- Bolyen Evan
- Brejnrod Asker
- Brislawn Colin J.
- Brown Titus C.
- Callahan Benjamin J.
- Caporaso J.G.
- Caraballo-Rodríguez Andrés Mauricio
- Chase John
- Cope Emily K.
- Diener Christian
- Dillon Matthew R.
- Dorrestein Pieter C.
- Douglas Gavin M.
- Durall Daniel M.
- Duvallet Claire
- Edwardson Christian F.
- Ernst Madeleine
- Estaki Mehrbod
- Fouquier Jennifer
- Gauglitz Julia M.
- Gibbons Sean M.
- Gibson Deanna L.
- Gonzalez Antonio
- Gorlick Kestrel
- Guo Jiarong
- Hillmann Benjamin
- Hippel Max, von
- Holmes Susan
- Holste Hannes
- Hooft Justin J.J., van der
- Huttenhower Curtis
- Huttley Gavin A.
- Janssen Stefan
- Jarmusch Alan K.
- Jiang Lingjing
- Kaehler Benjamin D.
- Kang Kyo Bin
- Keefe Christopher R.
- Keim Paul
- Kelley Scott T.
- Knight Rob
- Knights Dan
- Koester Irina
- Kosciolek Tomasz
- Kreps Jorden
- Langille Morgan G.I.
- Lee Joslynn
- Ley Ruth
- Liu Yong Xin
- Loftfield Erikka
- Lozupone Catherine
- Maher Massoud
- Marotz Clarisse
- Martin Bryan D.
- McDonald Daniel
- McIver Lauren J.
- Melnik Alexey V.
- Metcalf Jessica L.
- Morgan Sydney C.
- Morton Jamie T.
- Naimey Ahmad Turan
- Navas-Molina Jose A.
- Nothias Louis Felix
- Orchanian Stephanie B.
- Pearson Talima
- Peoples Samuel L.
- Petras Daniel
- Preuss Mary Lai
- Pruesse Elmar
- Rasmussen Lasse Buur
- Rideout Jai Ram
- Rivers Adam
- Robeson Michael S.
- Rosenthal Patrick
- Segata Nicola
- Shaffer Michael
- Shiffer Arron
- Silva Ricardo, da
- Sinha Rashmi
- Song Se Jin
- Spear John R.
- Swafford Austin D.
- Thompson Luke R.
- Torres Pedro J.
- Trinh Pauline
- Tripathi Anupriya
- Turnbaugh Peter J.
- Ul-Hasan Sabah
- Vargas Fernando
- Vogtmann Emily
- Vázquez-Baeza Yoshiki
- Walters William
- Wan Yunhu
- Wang Mingxun
- Warren Jonathan
- Weber Kyle C.
- Williamson Charles H.D.
- Willis Amy D.
- Xu Zhenjiang Zech
- Zaneveld Jesse R.
- Zhang Yilong
- Zhu Qiyun
- Publication venue
- Publication date
- 01/01/2019
- Field of study
An amendment to this paper has been published and can be accessed via a link at the top of the paper
Author Correction: Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
- Author
- Adam Rivers
- Ahmad Turan Naimey
- Alan K. Jarmusch
- Alexey V. Melnik
- Amy D. Willis
- Andrés Mauricio Caraballo-Rodríguez
- Antonio Gonzalez
- Anupriya Tripathi
- Arron Shiffer
- Asker Brejnrod
- Austin D. Swafford
- Benjamin D. Kaehler
- Benjamin Hillmann
- Benjamin J. Callahan
- Bryan D. Martin
- C. Titus Brown
- Catherine Lozupone
- Charles H. D. Williamson
- Christian C. Abnet
- Christian Diener
- Christian F. Edwardson
- Christopher R. Keefe
- Claire Duvallet
- Clarisse Marotz
- Colin J. Brislawn
- Curtis Huttenhower
- Dan Knights
- Daniel M. Durall
- Daniel McDonald
- Daniel Petras
- Deanna L. Gibson
- Elmar Pruesse
- Emily K. Cope
- Emily Vogtmann
- Eric J. Alm
- Erikka Loftfield
- Evan Bolyen
- Fernando Vargas
- Francesco Asnicar
- Gabriel A. Al-Ghalith
- Gavin A. Huttley
- Gavin M. Douglas
- Hannes Holste
- Harriet Alexander
- Irina Koester
- J. Gregory Caporaso
- Jai Ram Rideout
- Jamie T. Morton
- Jennifer Fouquier
- Jesse R. Zaneveld
- Jessica L. Metcalf
- Jiarong Guo
- John Chase
- John R. Spear
- Jonathan Warren
- Jordan E. Bisanz
- Jorden Kreps
- Jose A. Navas-Molina
- Joslynn Lee
- Julia M. Gauglitz
- Justin J. J. van der Hooft
- Kestrel Gorlick
- Kyle Bittinger
- Kyle C. Weber
- Kyo Bin Kang
- Lasse Buur Rasmussen
- Lauren J. McIver
- Lingjing Jiang
- Louis Felix Nothias
- Luke R. Thompson
- Madeleine Ernst
- Manimozhiyan Arumugam
- Mary Lai Preuss
- Massoud Maher
- Matthew R. Dillon
- Max von Hippel
- Mehrbod Estaki
- Michael S. Robeson
- Michael Shaffer
- Mingxun Wang
- Morgan G. I. Langille
- Nicholas A. Bokulich
- Nicola Segata
- Patrick Rosenthal
- Paul Keim
- Pauline Trinh
- Pedro J. Torres
- Peter J. Turnbaugh
- Pieter C. Dorrestein
- Qiyun Zhu
- Rashmi Sinha
- Ricardo Da Silva
- Rob Knight
- Ruth Ley
- Sabah Ul-Hasan
- Samuel L. Peoples
- Scott T. Kelley
- Se Jin Song
- Sean M. Gibbons
- Stefan Janssen
- Stephanie B. Orchanian
- Susan Holmes
- Sydney C. Morgan
- Talima Pearson
- Tomasz Kosciolek
- William Walters
- Yang Bai
- Yilong Zhang
- Yong-Xin Liu
- Yoshiki Vázquez-Baeza
- Yunhu Wan
- Zhenjiang Zech Xu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
- Author
- Abecasis Goncalo R.
- Aben K K
- Absher D
- Adair L S
- Adair Linda S
- Adeyemo Adebowale
- Ahmadi Kourosh R.
- Ala-Korpela Mika
- Alavere H
- Albrecht E
- Alexander Myriam
- Alizadeh Behrooz Z.
- Almgren P
- Altmaier E L
- Altshuler D
- Amin N
- An P
- Ardlie K
- Ardlie K G
- Ariyurek Y
- Arking Dan E
- Arnold A M
- Arora Pankaj
- Artigas Maria Soler
- Aspelund T
- Aspelund Thor
- Assimes T L
- Atwood Larry D.
- Aulchenko Y S
- Aulchenko Yurii
- Bakker Stephan J L
- Balkau B
- Ballantyne C M
- Ballantyne T L
- Balmforth A J
- Bandinelli S
- Bandinelli Stefania
- Barbalic M
- Barroso Ines
- Barroso Inês
- Barter P
- Baumeister Sebastian E.
- Beckmann J S
- Beckmann Jacques S
- Beilby J P
- Beilby John P
- Ben-Shlomo Y
- Benediktsson R
- Bengtsson Boström Kristina
- Bennett A J
- Bennett Amanda J
- Bergman R N
- Bergman Richard N
- Bergmann S
- Bergmann Sven
- Berndt S I
- Bhangale T
- Bis J C
- Bis Joshua C
- Blagieva Roza
- Bochud M
- Boehm Bernhard O
- Boehnke M
- Boekholdt S M
- Boerwinkle E
- Bolton Judith A Hoffman
- Bonnefond A
- Bonnycastle L L
- Bonnycastle Lori L
- Boomsma Dorret I.
- Borch-Johnsen K
- Borecki Ingrid B.
- Bornstein S R
- Bornstein Stefan R
- Bots Michiel L
- Bouatia-Naji N
- Boucher G
- Bragg-Gresham Jennifer L
- Brand Eva
- Brand Stefan-Martin
- Braund Peter S
- Bravenboer Bert
- Brown Morris J.
- Brunner E
- Buchanan T A
- Bumpstead S J
- Bumpstead Suzannah
- Burton Paul R
- Burtt N P
- Burtt Noël P
- Butler Johannah L
- Böttcher Y
- Campbell H
- Cao A
- Carr J Jeffrey
- Casas Juan P
- Cauchi Stephane
- Caulfield Mark
- Cavalcanti-Proença C
- Chakravarti Aravinda
- Chambers John C.
- Chandak Giriraj R
- Chang Yen-Pei C
- Chanock S J
- Charchar Fadi J
- Charoen Pimphen
- Charpentier G
- Chasman D I
- Chasman Daniel I
- Chatterjee N
- Chaturvedi Nish R
- Chen C
- Chen Ming-Huei
- Chen Y D
- Chines P
- Cho Y Shin
- Cho Yoon Shin
- Citterio L
- Clark Jeanne M
- Clarke R
- Coin Lachlan J.
- Collins F S
- Collins Francis S
- Collins Rory
- Connell John M
- Cookson William O.
- Cooper C
- Cooper Jackie A
- Cooper M N
- Cooper Matthew N
- Cooper Richard S
- Coresh Josef
- Cornelis M
- Corsi Anna Maria
- Couper David J
- Crawford G
- Crisponi L
- Croteau-Chonka D C
- Cucca Francesco
- Cupples L A
- Cusi D
- Dahgam Santosh
- Daly Mark J
- Danesh John
- Das Debashish
- Day I N
- Day Ian N M
- de Faire U
- De Geus Eco J C
- De Grandi A
- Dedoussis G V
- Dehghan A
- Deloukas P
- Deloukas Panos
- Delplanque J
- Demirkan Ayse
- Demissie S
- den Heijer M
- Deng Guohong
- Denniff Matthew
- Dina C
- Dixon Anna L.
- Dominiczak A
- Dominiczak A F
- Dominiczak Anna F
- Doney A
- Dong Yanbin
- Dorr Marcus
- Doumatey Ayo
- Dreisbach Albert W
- Duan J
- Dupuis J
- Döring Angela
- Ebrahim S
- Edmondson A C
- Egan J M
- Ehret Georg
- Eiriksdottir G
- Eiriksdottir Gudny
- Ejebe K G
- Elliott A
- Elliott Katherine S
- Elliott Paul
- Elosua R
- Elosua Roberto
- Emilsson Valur
- Erdmann J
- Erdmann Jeanette
- Erdos M R
- Erdos Michael R
- Eriksson J G
- Ernst F
- Esko T
- Estrada K
- Eyheramendy Susana
- Eyjolfsson Gudmundur I.
- Farrall Martin
- Fava Cristiano
- Fedson A C
- Feitosa M F
- Feitosa Mary F
- Feranil A B
- Ferreira T
- Ferrucci L
- Ferrucci Luigi
- Fischer-Rosinsky A
- Florez J C
- Florez Jose C
- Forouhi Nita G.
- Forrester Terrence
- Fouchier S W
- Fowkes F Gerald R
- Fox Caroline S.
- Fox Ervin R
- Franklin C S
- Franklin Christopher S
- Franks P W
- Frants R
- Franzosi M G
- Frayling T M
- Frayling Timothy M
- Freimer N B
- Friedrich Nele
- Froguel Philippe
- Gabriel S B
- Galan P
- Ganesh Santhi K
- Ganser Martha
- Garcia Melissa
- Gaunt Tom R
- Gejman P V
- Gibson Q
- Gieger Christian
- Gieger N B
- Glazer N L
- Glazer Nicole L
- Glorioso N
- Gloyn A L
- Gloyn Anna L
- Go M Jin
- Go Min Jin
- Goddard M E
- Goel A
- Goessling Wolfram
- Gonzalez E
- Goodarzi M O
- Graessler J
- Grallert H
- Grarup N
- Grassler Jurgen
- Green Todd
- Griffin Simon
- Grobbee Diederick E
- Groop L
- Groop L C
- Groves C J
- Groves Christopher J
- Grundberg E
- Grundy S
- Grönberg H
- Guarrera Simonetta
- Gudbjartsson Daniel F.
- Gudnason V
- Gudnason Vilmundur
- Guiducci C
- Guo X
- Guo Xiuqing
- Gwilliam R
- Gyllensten U
- Gyllensten Ulf B
- Hadjadj S
- Hadley David
- Haiqing S
- Hall A S
- Hall P
- Hallmans G
- Hammond N
- Hamsten A
- Hamsten Anders
- Han Bok-Ghee
- Han X
- Hansen T
- Hao K
- Hardy Rebecca
- Haritunians T
- Harris Tamara B.
- Hartikainen Anna Liisa
- Hassanali N
- Hastie N D
- Hattersley A T
- Hattersley Andrew T
- Havulinna A S
- Hayes R B
- Hayward C
- Hayward Caroline
- Heard-Costa Nancy L.
- Heath A C
- Heath Simon
- Heckbert Susan R
- Hedblad Bo
- Hegele R A
- Heid I M
- Hengstenberg C
- Henneman P
- Hercberg S
- Herder C
- Hernaez Ruben
- Hernandez Dena
- Hicks A A
- Hicks Andrew A
- Hide Winston A
- Hillman D R
- Hilton Gina
- Hingorani A D
- Hingorani Aroon D
- Hirschfield Gideon M.
- Hirschhorn J N
- Hirschhorn Joel N
- Hitman Graham A
- Hoffman W
- Hoffmann Udo
- Hofman Albert
- Hofmann Oliver M
- Holm Hilma
- Homuth Georg
- Hopewell Jemma C
- Hottenga Jouke Jan
- Hovingh G Kees
- Howard Philip
- Hu F B
- Hu Frank B
- Hui J
- Huikuri H V
- Humphries Steve E
- Hung J
- Hunt Steven C
- Hunter D J
- Hunter David J
- Huth Cornelia
- Hveem Kristian
- Hwang Shih-Jen
- Hyppönen Elina
- Igl W
- Igl Wilmar
- Ikram M Arfan
- Illig T
- Ingelsson E
- Iribarren C
- Isaacs A
- Isaacs Aaron
- Islam Muhammad
- Isomaa B
- Iwai Naoharu
- Jackson A U
- Jackson Anne U
- Jacobs K B
- Jafar Tazeen H
- Janipalli Charles S
- Janssen Harry L A
- Janssens A C
- Johansen C T
- Johansson A
- Johnson Andrew D
- Johnson P R
- Johnson Paul R V
- Johnson Toby
- Juhani Junttila M
- Jula A
- Járvelin Marjo Riitta
- Järvelin Marjo-Riitta
- Jørgensen T
- Kaakinen M
- Kahonen Mika
- Kajantie E
- Kangas Antti J.
- Kanoni S
- Kao W H
- Kao Wen H L
- Kao Wen Hong Linda
- Kaplan L M
- Kaplan R C
- Kaprio J
- Kardia Sharon L
- Karpe F
- Kastelein J J
- Kathiresan S
- Kathiresan Sekar
- Kavousi Maryam
- Kayser M
- Kema Ido P.
- Kesaniemi Y A
- Ketkar S
- Kettunen J
- Kettunen Johannes
- Khaw K T
- Khaw Kay-Tee
- Kiemeney L
- Kilpeläinen T O
- Kim Hyung-Lae
- Kim K
- Kim Lauren J
- Kim Y Jin
- Kinra Sanjay
- Kita Yoshikuni
- Kivimaki M
- Klopp Norman
- Knight B
- Knowles J W
- Kocher T
- Koiranen M
- Kolcic I
- Kong A
- Kooner Jaspal S.
- Koseki M
- Koskinen S
- Kottgen Anna
- Kovacs P
- Kraft P
- Krauss R M
- Kroemer Heyo K
- Kronenberg F
- Kuh Diana
- Kulkarni Smita R
- Kumar M J Kranthi
- Kumar Vinod
- Kumari M
- Kutalik Z
- Kuusisto J
- Kuzawa C W
- Kuznetsova Tatiana
- Kwan T
- Kyvik K O
- Kähönen M
- König I R
- Kühn Jens P.
- Kühnel Brigitte
- Laakso M
- Laaksonen R
- Laan Maris
- Lagou Vasiliki
- Lai Sandra
- Laitinen J
- Laitinen Jaana
- Lajunen T
- Lakatta E G
- Lakatta Edward G
- Lamina C
- Lange L A
- Langefeld Carl D
- Langenberg C
- Lango Allen H
- Larson Martin G
- Lathrop Mark
- Launer L J
- Launer Lenore
- Lauritzen Torsten
- Lawlor D A
- Lawlor Debbie A
- Lawrence R W
- Lawrence Robert W
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- Workalemahu T
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- Wu Ying
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- Xu Chun
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- Yarnell J W
- Yerges-Armstrong Laura M.
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- Yuan Xin
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- Zeggini E
- Zelenika D
- Zethelius B
- Zgaga L
- Zhai G
- Zhang Feng
- Zhang Weihua
- Zhao J H
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- Zhu Haidong
- Zhu Xiaofeng
- Ziegler A
- Zillikens M C
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- Zitting Paavo
- Zukowska-Szczechowska Ewa
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2011
- Field of study
Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10(-8) to P = 10(-190)). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- Agüero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich Alexandra
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha Afshar Etemadi
- Alexander Peter.
- Alfonso J.
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- Ali Altaf
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- Ali Syamlan
- Aliannejad Rasoul
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Genetic studies of body mass index yield new insights for obesity biology
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- Wojczynski Mary K.
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- Workalemahu Tsegaselassie
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- Zhang Weihua
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- Zhao Jing Hua
- Zhao Wei
- Zheng W
- Zheng Wei
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- Ziegler A
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- Ärnlöv J
- Ärnlöv Johan
- Österholm AM
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Note: A full list of authors and affiliations appears at the end of the article.
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.</p