A Computerized System to Solve Difficulties in Finding Medicines under the Medicine Shortages in Sri Lanka

Due to ongoing financial crisis in Sri Lanka, patients are starting to suffer from medicine shortages at an increasing rate. Patients are having to go to multiple pharmacies to find certain medicines which could result in health complications. Although e-pharmacy platforms provide the functionality to order medicines by uploading the prescription sheet, they do not provide alternatives on where to find the medicines that are not available in the pharmacy. This research introduces a new functionality to provide patients suggestion on where exactly to find missing medicines. This is found through checking the stock availability of the medicine in other pharmacies in sorted order with respect to the delivery location of the patient taken via Google map API to make the process much more efficient and practical. This is achieved by implementing a global identifier for each medicine where all pharmacies keep the records of the medicines in reference to the defined global identifier of that medicine. In addition to that, the system allows patients to view all the pharmacies nearest to their delivery location and give the freedom to place orders to whichever pharmacy they prefer. If a medicine is not available in the pharmacy which the order was placed for, the system will give suggestions to the patient on where exactly to buy the medicine

Bacterial modes of action for enhancing of plant growth

The greatest issue affecting the sustainability of broad acre cropping both environmentally and economically is the requirement of fertilizers. These are based on mined phosphorous or other mineral ores, ammonia produced through the Harbour-Bosch process and industrially manufactured potash. As global demand for fertilizers increases, the costs associated with the production for each of these major nutrients increases. Biofertilizers such as plant growth promoting bacteria (PGPB) are a possible biotechnology that could alleviate the need for addition of increasing amounts of fertilizers. These bacteria naturally occur in soils and aggressively colonize around plant roots and have been shown to have plant growth promoting effects. PGPB are known to influence plant growth by various direct and indirect mechanisms; while some can affect plant physiology directly by mimicking synthesis of plant hormones,others increase mineral availability and nitrogen content in soil. Here we review the previously characterized modes of action for enhancement of plant growth by PGPB such as nitrogen fixation, nutrient solubilization and production of auxins and enzymes, as well as discussing more recent proposed modes of action such as secondary metabolites

Gravitational waves from Sco X-1: A comparison of search methods and prospects for detection with advanced detectors

The low-mass X-ray binary Scorpius X-1 (Sco X-1) is potentially the most luminous source of continuous gravitational-wave radiation for interferometers such as LIGO and Virgo. For low-mass X-ray binaries this radiation would be sustained by active accretion of matter from its binary companion. With the Advanced Detector Era fast approaching, work is underway to develop an array of robust tools for maximizing the science and detection potential of Sco X-1. We describe the plans and progress of a project designed to compare the numerous independent search algorithms currently available. We employ a mock-data challenge in which the search pipelines are tested for their relative proficiencies in parameter estimation, computational efficiency, robust- ness, and most importantly, search sensitivity. The mock-data challenge data contains an ensemble of 50 Scorpius X-1 (Sco X-1) type signals, simulated within a frequency band of 50-1500 Hz. Simulated detector noise was generated assuming the expected best strain sensitivity of Advanced LIGO and Advanced VIRGO ($4 \times 10^{-24}$ Hz$^{-1/2}$). A distribution of signal amplitudes was then chosen so as to allow a useful comparison of search methodologies. A factor of 2 in strain separates the quietest detected signal, at $6.8 \times 10^{-26}$ strain, from the torque-balance limit at a spin frequency of 300 Hz, although this limit could range from $1.2 \times 10^{-25}$ (25 Hz) to $2.2 \times 10^{-26}$ (750 Hz) depending on the unknown frequency of Sco X-1. With future improvements to the search algorithms and using advanced detector data, our expectations for probing below the theoretical torque-balance strain limit are optimistic.Comment: 33 pages, 11 figure

Novel member of Ras family proteins from Disk Abalone (Haliotis discus discus): Structural profiling and its transcriptional modulation under host pathologic conditions

Among small GTPases, the Ras family proteins capture a remarkable place in dictating cellular proliferation, differentiation and survival in development of an organism. Major members of the Ras family include Ras (H-Ras, K-Ras, N-Ras), Rap1, and Rap2, all of which can act as oncogenes upon mutation. In the present study, a novel Ras family protein (AbRFP) was characterized from Disk Abalone (Haliotis discus discus), an economically important, edible marine gastropod; further analyzing its transcriptional profile in healthy and immune-challenged animals. The full-length cDNA of AbRFP is 2704 bp and it consists of an open reading frame of 552 bp, encoding a 184 amino acid peptide with a calculated molecular mass of ~21 kDa and isoelectric point of 8.63. The amino acid sequence resembles the characteristic features of typical Ras family proteins, including GTP/Mg2+ binding sites and guanine nucleotide exchange factor (GEF) interaction sites, as predicted by the NCBI-conserved domain database server. Phylogenetic study of AbRFP showed the generally accepted relationships, with AbRFP exhibiting highest proximity to a Ras protein from Portuguese oyster. Quantitative real-time PCR detected ubiquitous AbRFP mRNA expression, with strongest levels in muscle along with mantle and the lowest level in hepatopancreas. The AbRFP transcriptional profile in gills of Abalone challenged with Vibrio parahaemolyticus or viral hemorrhagic septicemia virus (VHSV) demonstrated significant up-regulations (p < 0.05) at 12 h and 24 h post-injection (p.i.), respectively. Moreover, significant elevation (p < 0.05) of mRNA expression was detected in hemocytes at 72 h p.i. with V. parahaemolyticus. These findings suggest that AbRFP may play a role under pathological conditions in Disk Abalon

Search for post-merger gravitational waves from the remnant of the binary neutron star merger GW170817

In Advanced LIGO, detection and astrophysical source parameter estimation of the binary black hole merger GW150914 requires a calibrated estimate of the gravitational-wave strain sensed by the detectors. Producing an estimate from each detector's differential arm length control loop readout signals requires applying time domain filters, which are designed from a frequency domain model of the detector's gravitational-wave response. The gravitational-wave response model is determined by the detector's opto-mechanical response and the properties of its feedback control system. The measurements used to validate the model and characterize its uncertainty are derived primarily from a dedicated photon radiation pressure actuator, with cross-checks provided by optical and radio frequency references. We describe how the gravitational-wave readout signal is calibrated into equivalent gravitational-wave-induced strain and how the statistical uncertainties and systematic errors are assessed. Detector data collected over 38 calendar days, from September 12 to October 20, 2015, contain the event GW150914 and approximately 16 of coincident data used to estimate the event false alarm probability. The calibration uncertainty is less than 10% in magnitude and 10 degrees in phase across the relevant frequency band 20 Hz to 1 kHz

Supplement: "Localization and broadband follow-up of the gravitational-wave transient GW150914" (2016, ApJL, 826, L13)

This Supplement provides supporting material for Abbott et al. (2016a). We briefly summarize past electromagnetic (EM) follow-up efforts as well as the organization and policy of the current EM follow-up program. We compare the four probability sky maps produced for the gravitational-wave transient GW150914, and provide additional details of the EM follow-up observations that were performed in the different bands