Neutrino Emission from Goldstone Modes in Dense Quark Matter

We calculate neutrino emissivities from the decay and scattering of Goldstone bosons in the color-flavor-locked (CFL) phase of quarks at high baryon density. Interactions in the CFL phase are described by an effective low-energy theory. For temperatures in the tens of keV range, relevant to the long-term cooling of neutron stars, the emissivities involving Goldstone bosons dominate over those involving quarks, because gaps in the CFL phase are $\sim 100$ MeV while the masses of Goldstone modes are on the order of 10 MeV. For the same reason, the specific heat of the CFL phase is also dominated by the Goldstone modes. Notwithstanding this, both the emissivity and the specific heat from the massive modes remain rather small, because of their extremely small number densities. The values of the emissivity and the specific heat imply that the timescale for the cooling of the CFL core in isolation is $\sim 10^{26}$ y, which makes the CFL phase invisible as the exterior layers of normal matter surrounding the core will continue to cool through significantly more rapid processes. If the CFL phase appears during the evolution of a proto-neutron star, neutrino interactions with Goldstone bosons are expected to be significantly more important since temperatures are high enough ($\sim 20-40$ MeV) to admit large number densities of Goldstone modes.Comment: 29 pages, no figures. slightly modified text, one new eqn. and new refs. adde

Neutrino processes in the K0K^0 condensed phase of color flavor locked quark matter

We study weak interactions involving Goldstone bosons in the neutral kaon condensed phase of color flavor locked quark matter. We calculate the rates for the dominant processes that contribute to the neutrino mean free p ath and to neutrino production. A light $K^+$ state, with a mass $\tilde{m}_{K^+} \propto (\Delta/\mu) (\Delta/m_s)(m_d-m_u)$, where $\mu$ and $\Delta$ are the quark chemical potential and superconducting gap respectively, is shown to play an important role. We identify unique characteristics of weak interaction rates in this novel phase and discuss how they might influence neutrino emission in core collapse supernova and neutron stars.Comment: 21 pages, 4 figure

Effects of color superconductivity on the structure and formation of compact stars

We show that if color superconducting quark matter forms in hybrid or quark stars it is possible to satisfy most of recent observational boundaries on masses and radii of compact stellar objects. An energy of the order of $10^{53}$ erg is released in the conversion from a (metastable) hadronic star into a (stable) hybrid or quark star in presence of a color superconducting phase. If the conversion occurs immediately after the deleptonization of the proto-neutron star, the released energy can help Supernovae to explode. If the conversion is delayed the energy released can power a Gamma Ray Burst. A delay between the Supernova and the subsequent Gamma Ray Burst is possible, in agreement with the delay proposed in recent analysis of astrophysical data.Comment: 4 pages, 2 figures. To be published in Phys.Rev.

Color-Neutral Superconducting Quark Matter

We investigate the consequences of enforcing local color neutrality on the color superconducting phases of quark matter by utilizing the Nambu-Jona-Lasinio model supplemented by diquark and the t'Hooft six-fermion interactions. In neutrino free matter at zero temperature, color neutrality guarantees that the number densities of u, d, and s quarks in the Color-Flavor-Locked (CFL) phase will be equal even with physical current quark masses. Electric charge neutrality follows as a consequence and without the presence of electrons. In contrast, electric charge neutrality in the less symmetric 2-flavor superconducting (2SC) phase with ud pairing requires more electrons than the normal quark phase. The free energy density cost of enforcing color and electric charge neutrality in the CFL phase is lower than that in the 2SC phase, which favors the formation of the CFL phase. With increasing temperature and neutrino content, an unlocking transition occurs from the CFL phase to the 2SC phase with the order of the transition depending on the temperature, the quark and lepton number chemical potentials. The astrophysical implications of this rich structure in the phase diagram, including estimates of the effects from Goldstone bosons in the CFL phase, are discussed.Comment: 20 pages, 4 figures; version to appear in Phys. Rev.

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Targeted therapies and the consequent adoption of "personalized" oncology have achieved notablesuccesses in some cancers; however, significant problems remain with this approach. Many targetedtherapies are highly toxic, costs are extremely high, and most patients experience relapse after a fewdisease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistantimmortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are notreliant upon the same mechanisms as those which have been targeted). To address these limitations, aninternational task force of 180 scientists was assembled to explore the concept of a low-toxicity "broad-spectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspectsof relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a widerange of high-priority targets (74 in total) that could be modified to improve patient outcomes. For thesetargets, corresponding low-toxicity therapeutic approaches were then suggested, many of which werephytochemicals. Proposed actions on each target and all of the approaches were further reviewed forknown effects on other hallmark areas and the tumor microenvironment. Potential contrary or procar-cinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixedevidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of therelationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. Thisnovel approach has potential to be relatively inexpensive, it should help us address stages and types ofcancer that lack conventional treatment, and it may reduce relapse risks. A proposed agenda for futureresearch is offered

Mapping child growth failure across low- and middle-income countries

Childhood malnutrition is associated with high morbidity and mortality globally1. Undernourished children are more likely to experience cognitive, physical, and metabolic developmental impairments that can lead to later cardiovascular disease, reduced intellectual ability and school attainment, and reduced economic productivity in adulthood2. Child growth failure (CGF), expressed as stunting, wasting, and underweight in children under five years of age (0�59 months), is a specific subset of undernutrition characterized by insufficient height or weight against age-specific growth reference standards3�5. The prevalence of stunting, wasting, or underweight in children under five is the proportion of children with a height-for-age, weight-for-height, or weight-for-age z-score, respectively, that is more than two standard deviations below the World Health Organization�s median growth reference standards for a healthy population6. Subnational estimates of CGF report substantial heterogeneity within countries, but are available primarily at the first administrative level (for example, states or provinces)7; the uneven geographical distribution of CGF has motivated further calls for assessments that can match the local scale of many public health programmes8. Building from our previous work mapping CGF in Africa9, here we provide the first, to our knowledge, mapped high-spatial-resolution estimates of CGF indicators from 2000 to 2017 across 105 low- and middle-income countries (LMICs), where 99 of affected children live1, aggregated to policy-relevant first and second (for example, districts or counties) administrative-level units and national levels. Despite remarkable declines over the study period, many LMICs remain far from the ambitious World Health Organization Global Nutrition Targets to reduce stunting by 40 and wasting to less than 5 by 2025. Large disparities in prevalence and progress exist across and within countries; our maps identify high-prevalence areas even within nations otherwise succeeding in reducing overall CGF prevalence. By highlighting where the highest-need populations reside, these geospatial estimates can support policy-makers in planning interventions that are adapted locally and in efficiently directing resources towards reducing CGF and its health implications. © 2020, The Author(s)

On the mechanisms governing gas penetration into a tokamak plasma during a massive gas injection

A new 1D radial fluid code, IMAGINE, is used to simulate the penetration of gas into a tokamak plasma during a massive gas injection (MGI). The main result is that the gas is in general strongly braked as it reaches the plasma, due to mechanisms related to charge exchange and (to a smaller extent) recombination. As a result, only a fraction of the gas penetrates into the plasma. Also, a shock wave is created in the gas which propagates away from the plasma, braking and compressing the incoming gas. Simulation results are quantitatively consistent, at least in terms of orders of magnitude, with experimental data for a D 2 MGI into a JET Ohmic plasma. Simulations of MGI into the background plasma surrounding a runaway electron beam show that if the background electron density is too high, the gas may not penetrate, suggesting a possible explanation for the recent results of Reux et al in JET (2015 Nucl. Fusion 55 093013)

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

We show the distribution of SARS-CoV-2 genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three available genomic nomenclature systems for SARS-CoV-2 to all sequence data from the WHO European Region available during the COVID-19 pandemic until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation. We provide a comparison of the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2.Peer reviewe