506 research outputs found
Macrophage Subset Sensitivity to Endotoxin Tolerisation by Porphyromonas gingivalis
- Author
- AD Foey
- Andrew D. Foey
- B Pulendran
- C Porta
- CW Cutler
- E Gemmell
- FO Martinez
- FR Greten
- GD Tribble
- GP Garlet
- H Okada
- HE Barksby
- HJ Robertshaw
- HM Wilson
- J Fletcher
- L Duncan
- LA Ximenez-Fyvie
- LAJ O'Neill
- LE Smythies
- M Daigneault
- M Hirschfeld
- M Muthukuru
- MA Dobrovolskaia
- O Yilmaz
- O Yilmaz
- P Ezzo
- PC Heinrich
- PD Smith
- R Jotwani
- R Merry
- RP Darveau
- S Sato
- SK Biswas
- SL Foster
- SS Socransky
- StJohn Crean
- T Hagemann
- T Tervonen
- Y Liu
- YG Kim
- Z Xing
- Özlem Yilmaz
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2013
- Field of study
Macrophages (MΦs) determine oral mucosal responses; mediating tolerance to commensal microbes and food whilst maintaining the capacity to activate immune defences to pathogens. MΦ responses are determined by both differentiation and activation stimuli, giving rise to two distinct subsets; pro-inflammatory M1- and anti-inflammatory/regulatory M2- MΦs. M2-like subsets predominate tolerance induction whereas M1 MΦs predominate in inflammatory pathologies, mediating destructive inflammatory mechanisms, such as those in chronic P.gingivalis (PG) periodontal infection. MΦ responses can be suppressed to benefit either the host or the pathogen. Chronic stimulation by bacterial pathogen associated molecular patterns (PAMPs), such as LPS, is well established to induce tolerance. The aim of this study was to investigate the susceptibility of MΦ subsets to suppression by P. gingivalis. CD14hi and CD14lo M1- and M2-like MΦs were generated in vitro from the THP-1 monocyte cell line by differentiation with PMA and vitamin D3, respectively. MΦ subsets were pre-treated with heat-killed PG (HKPG) and PG-LPS prior to stimulation by bacterial PAMPs. Modulation of inflammation was measured by TNFα, IL-1β, IL-6, IL-10 ELISA and NFκB activation by reporter gene assay. HKPG and PG-LPS differentially suppress PAMP-induced TNFα, IL-6 and IL-10 but fail to suppress IL-1β expression in M1 and M2 MΦs. In addition, P.gingivalis suppressed NFκB activation in CD14lo and CD14hi M2 regulatory MΦs and CD14lo M1 MΦs whereas CD14hi M1 pro-inflammatory MΦs were refractory to suppression. In conclusion, P.gingivalis selectively tolerises regulatory M2 MΦs with little effect on pro-inflammatory CD14hi M1 MΦs; differential suppression facilitating immunopathology at the expense of immunity
Suppression of the c-erbB-2 gene product decreases transformation abilities but not the proliferation and secretion of proteases of SK-OV-3 ovarian cancer cells
- Author
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
The overexpression of the c-erbB-2 oncogene product has been reported in approximately 20–30% of human ovarian cancers and has been correlated with a poor prognosis in ovarian cancer patients. To investigate the function of p185c-erbB-2 in human ovarian cancer cells, a c-erbB-2-specific single-chain antibody (scFv-5R) was expressed in the c-erbB-2-overexpressing SK-OV-3 cell line using a retroviral expression vector. Eight individual clones expressing the single-chain antibody were isolated. These clones have a prominent retention of the cell surface p185c-erbB-2. In this study we compared the proliferation rate, the anchorage-independent growth, the secretion of matrix metalloproteases and of the urokinase-type plasminogen activator. The clones expressing the c-erbB-2 single-chain antibody, the control cells harbouring the empty vector and the parental SK-OV-3 cells they all had similar proliferation rates in the presence of 10% serum and secreted similar amounts of matrix metalloproteases and of the urokinase-type plasminogen activator. However, the expression of the c-erbB-2 oncogene product offers a strong growth advantage under serum-reduced conditions with 1% serum. In contrast to the parental SK-OV-3 and empty vector control cells, the scFv-5R-expressing clones were not able to grow anchorage-independently. These findings suggest that c-erbB-2 enhances transformation abilities of SK-OV-3 ovarian cancer cells without affecting the secretion of proteases and the proliferation of SK-OV-3 ovarian cancer cells in the presence of high concentrations of serum. © 1999 Cancer Research Campaig
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Angel investor's selection criteria: a comparative institutional perspective
- Author
- AL Maxwell
- AL Riding
- AL Riding
- AL Zacharakis
- AS Bryk
- C Herrmann-Pillath
- CM Mason
- CM Mason
- CM Mason
- D Ahlstrom
- D Ahlstrom
- D Ahlstrom
- D Ahlstrom
- D Ahlstrom
- D Ahlstrom
- D Ahlstrom
- D Cumming
- D Guthrie
- D Lovallo
- DA Shepherd
- DC North
- DC North
- DJ Cumming
- DL Wank
- DL Wank
- DM Short
- EU Weber
- F Allen
- F Fukuyama
- G Cassar
- G Hofstede
- GA Shinkle
- GB Northcraft
- GD Bruton
- GD Bruton
- GD Bruton
- GD Bruton
- GD Bruton
- GD Bruton
- GH Haines Jr
- H Landström
- H Landström
- I Guler
- J Boatsman
- J Cohen
- J McMillan
- JC Hayton
- JG March
- JJ Reuer
- JM Hagen
- JW Webb
- K Au
- Kevin Au
- KG Hindle
- KG Hindle
- KM York
- KR Xin
- KZ Zhou
- L Duxbury
- L Feeney
- L Poppo
- L Szerb
- M Carney
- M Kenney
- M Maula
- M Osnabrugge Van
- MA Hitt
- MA Hitt
- MA Hitt
- MN Young
- MS Granovetter
- MS Granovetter
- MW Peng
- MW Peng
- MW Peng
- MW Peng
- NE Haar
- OE Williamson
- OE Williamson
- P Davidsson
- P Slovic
- Q Gu
- R Ma
- R Porta La
- R Porta La
- R Sudek
- R Wiltbank
- RJ Karren
- RLM Dunbar
- RT Harrison
- S Djankov
- S Prowse
- S Shane
- SH Lee
- SL Sun
- SP Shapiro
- Sunny Li Sun
- T Baker
- T Hamamura
- WD Bygrave
- WEJ Wetzel
- WEJ Wetzel
- WJ Baumol
- WJ Baumol
- WR Scott
- WS Shi
- Y Bian
- Y Liu
- Y Tashiro
- Zhujun Ding
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/09/2014
- Field of study
Despite the important role of angel investors as critical financial providers for new ventures, little is known regarding how institutions make their investment decisions. While angels make decisions based on selection criteria during the first stage, they are also embedded within and affected by different institutional settings and as a result weight these criteria differently than other investors. We compare angel investors' selection criteria in China and Denmark using the comparative institutional perspective. We use a policy capturing approach and hierarchy linear modeling, revealing that since Chinese angels are embedded within relationship-based institutional settings they tend to reply more on strong ties such as family and friends in management team, as well as weighting risks less compared to Danish angels operating within more rule-based institutional contexts
Tyrosine kinase signalling in breast cancer
- Author
- Publication venue
- BioMed Central
- Publication date
- 17/04/2000
- Field of study
Cells are continuously exposed to diverse stimuli ranging from soluble endocrine and paracrine factors to signalling molecules on neighbouring cells. Receptors of the tyrosine kinase family play an important role in the integration and interpretation of these external stimuli, allowing a cell to respond appropriately to its environment. The activation of receptor tyrosine kinases (RTKs) is tightly controlled, allowing a normal cell to correctly integrate its external environment with internal signal transduction pathways. In contrast, due to numerous molecular alterations arising during the course of malignancy, a tumour is characterized by an abnormal response to its environment, which allows cancer cells to evade the normal mechanisms controlling cellular proliferation. Alterations in the expression of various RTKs, in their activation, and in the signalling molecules lying downstream of the receptors play important roles in the development of cancer. This topic is the major focus of the thematic review section of this issue of Breast Cancer Research
Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells
- Author
- A deFazio
- AD Thor
- AD Thor
- Aeree Kim
- Ann D Thor
- B Li
- B Liu
- B Liu
- Bolin Liu
- C Knuefermann
- C Wallasch
- Christine McKimmey
- CI Bargmann
- CR King
- CT Guy
- D Graus-Porta
- D Harari
- Dalia Ordonez-Ercan
- DB Agus
- DJ Riese 2nd
- DJ Riese 2nd
- DJ Slamon
- DJ Slamon
- E Penuel
- E Tzahar
- ER Andrechek
- F Cardoso
- G Pearson
- GD Plowman
- GD Plowman
- HW Chang
- I Bieche
- IL Andrulis
- J Baselga
- JS Jeruss
- Kathy M Alvarez
- L Bouchard
- L Coussens
- Lynn D Jones
- M Alimandi
- MA Cobleigh
- MA Olayioye
- MC Paterson
- MG Sacco
- MH Kraus
- MJ Campbell
- MP DiGiovanna
- MP DiGiovanna
- NH Chow
- P Siegel
- PM Siegel
- R Lupu
- R Pinkas-Kramarski
- S Kosanke
- SL Anzick
- SS Bacus
- Susan M Edgerton
- T Holbro
- U Hermanto
- WJ Gullick
- WJ Muller
- X Yang
- XiaoHe Yang
- Y Yarden
- Publication venue
- BioMed Central
- Publication date
- 01/01/2005
- Field of study
INTRODUCTION: Co-expression of several receptor tyrosine kinases (RTKs), including erbB2 and erbB3, is frequently identified in breast cancers. A member of the RTK family, the kinase-deficient erbB3 can activate downstream signaling via heterodimer formation with erbB2. We studied the expression of RTK receptors in mammary tumors from the wild-type (wt) rat c-neu transgenic model. We hypothesized that physical and functional interactions between the wt rat neu/ErbB2 transgene and mouse ErbB3-encoded proteins could occur, activating downstream signaling and promoting mammary oncogenesis. METHODS: Immunohistochemical and Western blot analyses were performed to study the expression of rat c-neu/ErbB2 and mouse erbB3 in mammary tumors and tumor-derived cell lines from the wt rat c-neu transgenic mice. Co-immunoprecipitation methods were employed to quantitate heterodimerization between the transgene-encoded protein erbB2 and the endogenous mouse erbB3. Tumor cell growth in response to growth factors, such as Heregulin (HRG), epidermal growth factor (EGF), or insulin-like growth factor-1 (IGF-1), was also studied. Post-HRG stimulation, activation of the RTK downstream signaling was determined by Western blot analyses using antibodies against phosphorylated Akt and mitogen-activated protein kinase (MAPK), respectively. Specific inhibitors were then used with cell proliferation assays to study the phosphoinositide-3 kinase (PI-3K)/Akt and MAPK kinase (MEK)/MAPK pathways as possible mechanisms of HRG-induced tumor cell proliferation. RESULTS: Mammary tumors and tumor-derived cell lines frequently exhibited elevated co-expression of erbB2 and erbB3. The transgene-encoded protein erbB2 formed a stable heterodimer complex with endogenous mouse erbB3. HRG stimulation promoted physical and functional erbB2/erbB3 interactions and tumor cell growth, whereas no response to EGF or IGF-1 was observed. HRG treatment activated both the Akt and MAPK pathways in a dose- and time-dependent manner. Both the PI-3K inhibitor LY 294002 and MEK inhibitor PD 98059 significantly decreased the stimulatory effect of HRG on tumor cell proliferation. CONCLUSION: The co-expression of wt rat neu/ErbB2 transgene and mouse ErbB3, with physical and functional interactions between these two species of RTK receptors, was demonstrated. These data strongly suggest a role for erbB3 in c-neu (ErbB2)-associated mammary tumorigenesis, as has been reported in human breast cancers
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogana T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Aktas A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoun S
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Aranda CP
- Arce ATH
- Archambault JP
- Arfaoui S
- Arguin J-F
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnault C
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Asfandiyarov R
- Ask S
- Asman B
- Asner D
- Asquith L
- Assamagan K
- Astbury A
- Astvatsatourov A
- Atoian G
- Aubert B
- Auge E
- Augsten K
- Aurousseau M
- Austin N
- Avolio G
- Avramidou R
- Axen D
- Ay C
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Bachy G
- Backes M
- Backhaus M
- Badescu E
- Bagnaia P
- Bahinipati S
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker MD
- Baker OK
- Baker S
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barajas CAC
- Barak L
- Baranov SP
- Barashkou A
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro F
- Barrera CO
- Barrillon P
- Bartoldus R
- Barton AE
- Bartsch D
- Bartsch V
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Battistoni G
- Bauer F
- Bawa HS
- Beare B
- Beau T
- Beauchemin PH
- Beccherle R
- Bechtle P
- Beck GA
- Beck HP
- Beckingham M
- Becks KH
- Beddall A
- Beddall AJ
- Bedikian S
- Bednyakov VA
- Bee CP
- Begel M
- Behera PK
- Beimforde M
- Belanger-Champagne C
- Belenguer MJ
- Bell PJ
- Bell WH
- Bella G
- Bella LA
- Bellagamba L
- Bellina F
- Bellomo M
- Belloni A
- Beloborodova O
- Belotskiy K
- Beltramello O
- Ben Ami S
- Benary O
- Benchekroun D
- Benchouk C
- Bendel M
- Benekos N
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Benslama K
- Bentvelsen S
- Beretta M
- Berge D
- Berger N
- Berghaus F
- Berglund E
- Beringer J
- Bernardet K
- Bernat P
- Bernhard R
- Bernius C
- Berry T
- Bertin A
- Bertinelli F
- Bertolucci F
- Besana MI
- Besson N
- Bethke S
- Bhimji W
- Bianchi RM
- Bianco M
- Biebel O
- Bieniek SP
- Bierwagen K
- Biesiada J
- Biglietti M
- Bilokon H
- Bindi M
- Binet S
- Bingul A
- Bini C
- Biscarat C
- Bitenc U
- Black KM
- Blair RE
- Blanchard J-B
- Blanchot G
- Blazek T
- Blocker C
- Blocki J
- Blondel A
- Blum W
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VB
- Bocchetta SS
- Bocci A
- Boddy CR
- Boehler M
- Boek J
- Boelaert N
- Boeriu OEV
- Boeser S
- Bogaerts JA
- Bogdanchikov A
- Bogouch A
- Bohm C
- Boisvert V
- Bold T
- Boldea V
- Bolnet NM
- Bona M
- Bondarenko VG
- Bondioli M
- Boonekamp M
- Boorman G
- Booth CN
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- Borer C
- Borisov A
- Borissov G
- Borjanovic I
- Borroni S
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- Boscherini D
- Bosman M
- Boterenbrood H
- Botterill D
- Bouchami J
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- Bouhova-Thacker EV
- Bourdarios C
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- Boyko IR
- Bozhko NI
- Bozovic-Jelisavcic I
- Bracinik J
- Braem A
- Branchini P
- Brandenburg GW
- Brandt A
- Brandt G
- Brandt O
- Bratzler U
- Brau B
- Brau JE
- Braun HM
- Brelier B
- Bremer J
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- Breton D
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- Brock I
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- Brodbeck TJ
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- Broggi F
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- Brooijmans G
- Brooks WK
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- Bruncko D
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- Bruni A
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- Bucci F
- Buchanan J
- Buchanan NJ
- Buchholz P
- Buckingham RM
- Buckley AG
- Buda SI
- Budagov IA
- Budick B
- Bueso XP
- Bugge L
- Buira-Clark D
- Bulekov O
- Bunse M
- Buran T
- Burckhart H
- Burdin S
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- Burke S
- Busato E
- Bussey P
- Buszello CP
- Butin F
- Butler B
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Caballero J
- Caforio D
- Cakir IT
- Cakir O
- Calafiura P
- Calderini G
- Calfayan P
- Calkins R
- Caloba LP
- Caloi R
- Calvet D
- Calvet S
- Camarri P
- Cambiaghi M
- Cameron D
- Camilocci ES
- Campana S
- Campanelli M
- Canale V
- Canelli F
- Canepaa A
- Cantero J
- Capasso L
- Caprini I
- Caprini M
- Capriotti D
- Capua M
- Caputo R
- Caramarcu C
- Cardarelli R
- Carli T
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- Carter AA
- Carter JR
- Carvalho J
- Casadei D
- Casado MP
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- Caso C
- Castaneda-Miranda E
- Castanheira MTD
- Castillo LRF
- Castro NF
- Cataldi G
- Cataneo F
- Catinaccio A
- Catmore JR
- Cattai A
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- Caughron S
- Cauz D
- Cavalcanti TP
- Cavalleri P
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- Cavasinni V
- Ceradini F
- Cerqueira AS
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- Cerutti F
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- Chapman JD
- Chapman JW
- Chareyre E
- Charlton DG
- Chavda V
- Cheatham S
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chelstowska MA
- Chen C
- Chen H
- Chen S
- Chen T
- Chen X
- Cheng S
- Cheong ALF
- Cheplakov A
- Chepurnov VF
- Chernyatin V
- Cheu E
- Cheung SL
- Chevalier L
- Chiefari G
- Chikovani L
- Childers JT
- Chilingarov A
- Chiodini G
- Chizhov MV
- Choudalakis G
- Chouridou S
- Christidi IA
- Christov A
- Chromek-Burckhart D
- Chu ML
- Chudoba J
- Ciapetti G
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- Ciftci AK
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- Cinca D
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- Ciobotaru MD
- Cioccaa C
- Ciocio A
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- Clemens JC
- Clement B
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- Coccaro A
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- Codina EP
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- Cogan JG
- Coggeshall J
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- Cojocaru CD
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- Collaboration ATLAS
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- Cortes-Gonzalez A
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- Costin T
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- Courneyea L
- Cowan G
- Cowden C
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- Cranmer K
- Cranshaw J
- Crepe-Renaudin S
- Crescioli F
- Cristinziani M
- Crosetti G
- Crupi R
- Cuciuc C-M
- Curatolo M
- Curtis CJ
- Curull XE
- Cwetanski P
- Czirr H
- Czyczula Z
- D'Auria S
- D'Onofrio M
- D'Orazio A
- Da Costa JBG
- Da Costa JGPF
- Da Silva PVM
- Da Via C
- Dabrowski W
- Dai T
- Dallapiccola C
- Daly CH
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- Damazio DO
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- Danielsson HO
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- Darbo G
- Darlea GL
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- Dauvergne JP
- Davey W
- Davidek T
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- Davison AR
- Davygora Y
- Dawe E
- Dawson I
- Dawson JW
- Daya-Ishmukhametova RK
- de Asmundis R
- De Castro S
- De Cecco S
- De Graat J
- De Groot N
- De Jong P
- De la Hoz SG
- De la Taille C
- De la Torre H
- De Lima JGR
- De Lotto B
- De Mora L
- De Nooij L
- De Pedis D
- De Regie JBDV
- De Renstrom PAB
- De Salvo A
- De Sanctis U
- De Santo A
- De K
- Dean S
- Debbe R
- Dedovich DV
- Degenhardt J
- Dehchar M
- Del Papa C
- Del Peso J
- Del Prete T
- Deliyergiyev M
- Dell'Acqua A
- Dell'Asta L
- Della Pietra M
- Della Porta GZ
- della Volpe D
- Delmastro M
- Delpierre P
- Delruelle N
- Delsart PA
- Deluca C
- Demers S
- Demichev M
- Demirkoz B
- Deng J
- Deng W
- Denis RDS
- Denisov SP
- Derendarz D
- Derkaoui JE
- Derue F
- Dervan P
- Desch K
- Devetak E
- Deviveiros PO
- Dewhurst A
- DeWilde B
- Dhaliwal S
- Dhullipudi R
- Di Ciaccio A
- Di Ciaccio L
- Di Girolamo A
- Di Girolamo B
- Di Luise S
- Di Mattia A
- Di Micco B
- Di Nardo R
- Di Simone A
- Di Sipio R
- Diaz MA
- Diblen F
- Diehl EB
- Dietrich J
- Dietzscha TA
- Diglio S
- Dingfelder J
- Dionisi C
- Dita P
- Dita S
- Dittus F
- Djama F
- Djobava T
- do Vale MAB
- Do ValleWemans A
- Doan TKO
- Dobbs M
- Dobinson R
- Dobos D
- Dobson E
- Dobson M
- Dodd J
- Doglioni C
- Doherty T
- Dohmae T
- Doi Y
- Dolejsi J
- Dolenc I
- Dolezal Z
- Dolgoshein BA
- Donadelli M
- Donega M
- Donini J
- Donszelmann TC
- Dopke J
- Doria A
- Dos Anjos A
- Dos Santos DR
- Dosil M
- Dotti A
- Dova MT
- Dowell JD
- Doxiadis AD
- Doyle AT
- Drasal Z
- Drees J
- Dressnandt N
- Drevermann H
- Driouichi C
- Dris M
- Dubbert J
- Dubbs T
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- Yilmaz M
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- Zhemchugov A
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- Zitoun R
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- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Ackers M
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adam ER
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- Ahlen SP
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- Ahsan M
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- Akesson TPA
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- Aleksandrov IN
- Alessandria F
- Alexa C
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- Alexandre G
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- Alimonti G
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
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- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or τ lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, φ, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan β in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdel Khalek S
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- Abouzeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Alam MA
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
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- Zhemchugov A
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- Zibell A
- Zieminska D
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- Zimmermann S
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- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivković L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- American Physical Society
- Publication date
- 01/01/2012
- Field of study
Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02 TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos2Δϕ modulation for all ΣETPb ranges and particle pT
Presence of HER4 associates with increased sensitivity to Herceptin™ in patients with metastatic breast cancer
- Author
- A Alkarain
- A Naresh
- A Sassen
- Andrea Sassen
- C Lottner
- C Rio
- CC Williams
- CD Britten
- CH Lu
- CI Sartor
- CJ Witton
- CW Elston
- D Graus-Porta
- D Slamon
- DF Stern
- DJ Slamon
- DL Nielsen
- FE Jones
- Ferdinand Hofstaedter
- G Brockhoff
- G Carpenter
- GA Vidal
- GD Plowman
- GD Plowman
- Gero Brockhoff
- GL Plosker
- HA Lane
- HS Cho
- J Baselga
- JA Maatta
- JS Ross
- K Elenius
- K Elenius
- KI Pritchard
- M Hollmen
- M Pickl
- M Scaltriti
- M Sundvall
- Manuela Sieben
- MP DiGiovanna
- MP DiGiovanna
- MP DiGiovanna
- NL Barnes
- Olaf Ortmann
- P Casalini
- PL Bedard
- R Chiarle
- R Nahta
- R Nahta
- RS Muraoka-Cook
- S Diermeier
- S Diermeier-Daucher
- Simone Diermeier-Daucher
- SM Tovey
- SM Tovey
- ST Lee-Hoeflich
- Stephan Schwarz
- T Holbro
- T Kute
- TT Junttila
- TT Junttila
- W Remmele
- XF Le
- Y Nagata
- Y Yarden
- Y Zhu
- Z Suo
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
- …