Zoolexis in Semantic Aspect (by Example of Nouns Derived from Zoonyms)

The article is devoted to semantic analysis zoonymic vocabulary of the Russian language. The paper presents definitions of terms zoonym and zoolexis . The characteristic of Russian nouns derived from zoonyms is given from the point of view of grammatical semantics. In accordance with the nature of grammatical semantics of nouns derived from zoonyms their semantic classes are distinguished. The focus is on the description of the whole semantic groups of nouns derived from zoonyms with a particular meaning. The relevance of the study is determined by the fact that nouns derived from zoonyms with the meaning of a particular item represent a considerable variety among all nouns derived from zoonyms (383 of 489 recorded in derivational dictionary) and are an important part of zoonymic vocabulary in nominative and communicative aspect. On the basis of definition and contextual analysis of lexical units the authors divided them into groups. It is shown that the semantic grouping of nouns derived from zoonyms with the specific meaning depend on belonging to a lexico-grammatical category of animate or inanimate nouns, as lexical representatives of each category form different semantic groups that have certain characteristics. The novelty of the research is seen in the fact that for the first time the Russian nouns derived from zoonyms and naming animals fully analysed from the point of view of semantics

Теория и практика современной допечатной подготовки вузовских изданий

The organisation of the university educational process requires a high availability of educational and scientific literature, which implies the high quality of the preparation of educational and teaching aids, reference materials and scientific publications. However, one can note a change in the technologies of premedia and printing processes, optimisation of the activity of publishing offices and, as a result, a drop in the quality of published printed matter. In 2019 a quantitative analysis of preparation of conference materials for publication was conducted on the basis of the Ural University Publishing House. According to this analysis, one can argue that the quality of the publishing product depends on the ratio of prepress volumes and timelines, the quality of materials provided to the publishing house, the responsibility of the authors and members of the editorial board, their readiness to work within a short time period, etc. According to the documents, the editorial board ensures the quality of scientific publications, which in this case consists of four Grand PhDs and two PhDs; in fact, the quality of the content left much to be desired. Separately, the quality of preparation of the bibliographic apparatus should be noted. In this case, the editorial preparation of the bibliography was carried out by a library employee in an extremely limited time (two days). It was done in order to bring the bibliographic description to some uniformity-there was no discussion on compliance with All-Union State Standards 7.1.-2003 and 7.05-2008. There was also a shift of areas of responsibility when the preparation of separate elements of a scientific article (for example, the bibliographic description) is not planned in advance, but becomes spontaneous and, as a result, entails a partial reimposition of the manuscript. The priorities of the practical model of preparing a university publication have changed significantly. The publication of conference proceedings prioritises releasing the publication at a certain time (by the beginning of a scientific event), which jeopardises the quality of its prepress. When preparing a university publication in tight deadlines, functions are redistributed, and professional communication has its features: both the authors and the publishers do not have the necessary conditions for an effective interaction in order to prepare a high-quality scientific publication. Most definitions of a scientific and educational book emphasise its task, properties, functions, role as a means of communication of the professional community and a method of transmitting relevant information. It seems that a university publication, like no other, should prioritise the quality of prepress and, therefore, should be planned ahead. © 2020 Tomsk State University - Faculty of Philology. All rights reserved

Development and support of small innovative entrepreneurship in Europe and the USA

Modern business practice shows that small innovative entrepreneurship needs special support in the context of rapid development of science and technology. To implement the outlined, various business support programs are being developed at a rapid pace, which are being actively implemented in practice. The aim of the article is to present the conceptual features of the development and support of small innovative entrepreneurship in Europe and the United States. The purpose of the academic paper is to present the conceptual features of supporting small innovative entrepreneurship in Europe and the United States of America

Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer\u27s disease

The intramembrane proteolytic activities of presenilins (PSEN1/PS1 and PSEN2/PS2) underlie production of beta-amyloid, the key process in Alzheimer\u27s disease (AD). Dysregulation of presenilin-mediated signaling is linked to cancers. Inhibition of the gamma-cleavage activities of PSENs that produce Abeta, but not the epsilon-like cleavage activity that release physiologically essential transcription activators, is a potential approach for the development of rational therapies for AD. In order to identify whether different activities of PSEN1 can be dissociated, we designed multiple mutations in the evolutionary conserved sites of PSEN1. We tested them in vitro and in vivo assays and compared their activities with mutant isoforms of presenilin-related intramembrane di-aspartyl protease (IMPAS1 (IMP1)/signal peptide peptidase (SPP)). PSEN1 auto-cleavage was more resistant to the mutation remodeling than the epsilon-like proteolysis. PSEN1 with a G382A or a P433A mutation in evolutionary invariant sites retains functionally important APP epsilon- and Notch S3- cleavage activities, but G382A inhibits APP gamma-cleavage and Abeta production and a P433A elevates Abeta. The G382A variant cannot restore the normal cellular ER Ca(2+) leak in PSEN1/PSEN2 double knockout cells, but efficiently rescues the loss-of-function (Egl) phenotype of presenilin in C. elegans. We found that, unlike in PSEN1 knockout cells, endoplasmic reticulum (ER) Ca(2+) leak is not changed in the absence of IMP1/SPP. IMP1/SPP with the analogous mutations retained efficiency in cleavage of transmembrane substrates and rescued the lethality of Ce-imp-2 knockouts. In summary, our data show that mutations near the active catalytic sites of intramembrane di-aspartyl proteases have different consequences on proteolytic and signaling functions

Deficiency in origin licensing proteins impairs cilia formation: implications for the aetiology of meier-gorlin syndrome

Mutations in ORC1, ORC4, ORC6, CDT1, and CDC6, which encode proteins required for DNA replication origin licensing, cause Meier-Gorlin syndrome (MGS), a disorder conferring microcephaly, primordial dwarfism, underdeveloped ears, and skeletal abnormalities. Mutations in ATR, which also functions during replication, can cause Seckel syndrome, a clinically related disorder. These findings suggest that impaired DNA replication could underlie the developmental defects characteristic of these disorders. Here, we show that although origin licensing capacity is impaired in all patient cells with mutations in origin licensing component proteins, this does not correlate with the rate of progression through S phase. Thus, the replicative capacity in MGS patient cells does not correlate with clinical manifestation. However, ORC1-deficient cells from MGS patients and siRNA-mediated depletion of origin licensing proteins also have impaired centrosome and centriole copy number. As a novel and unexpected finding, we show that they also display a striking defect in the rate of formation of primary cilia. We demonstrate that this impacts sonic hedgehog signalling in ORC1-deficient primary fibroblasts. Additionally, reduced growth factor-dependent signaling via primary cilia affects the kinetics of cell cycle progression following cell cycle exit and re-entry, highlighting an unexpected mechanism whereby origin licensing components can influence cell cycle progression. Finally, using a cell-based model, we show that defects in cilia function impair chondroinduction. Our findings raise the possibility that a reduced efficiency in forming cilia could contribute to the clinical features of MGS, particularly the bone development abnormalities, and could provide a new dimension for considering developmental impacts of licensing deficiency

Environmental factors affecting posture disorders in children

The purpose of the study is to identify environmental factors in the organization of the educational process and lifestyle factors that adversely affect the formation of posture in children.Цель исследования - выявить факторы окружающей среды при организации учебного процесса и факторы образа жизни, неблагоприятно влияющие на формирование осанки у детей

Interrelations of innate and humoral immune indicators with the character of allergic pathology in children from ecologically unfavorable territories

The purpose of the study. Evaluation of the clinical course of allergic pathology depending on the concentration of IgA and lysozyme in the blood of children and in relation to the level of toxic load on the body of children living in Nizhny Tagil.Цель исследования. Оценка клинического течения аллергической патологии в зависимости от концентрации IgA и лизоцима в крови детей и во взаимосвязи с уровнем токсической нагрузки на организм детей, проживающих в Нижнем Тагиле

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13