Синтез диарилиодониевых солей в соответствии с принципами «зеленой» химии

Объектами исследования являются диарилиодониевые тозилаты и бромиды. Цель работы – разработка нового метода получения соединений поливалентного иода – диарилиодониевых солей, в частности замещенных диарилиодониевых тозилатов и бромидов с применением окислительной системы на основе Oxone®, серной кислоты и силикагеля. В ходе проведенного исследования были получены субстраты: 4-метилфенилфенилиодониевые тозилаты и бромиды, 2,6-диметилфенилфенилиодониевые тозилаты и бромиды, 2,4,6-триметилфенилфенилиодониевые тозилаты и бромиды, 2,3,5,6-тетрафенилфенилиодониевые тозилаты и бромиды. Область применения: синтезированные продукты могут применяться в качестве фотоинициаторов катионной полимеризации ряда мономеров. Экономическая эффективность/значимость работы определяется следующими факторами: 1) разработанные методики обладают меньшей токсичностью по сравнению с методиками для получения аналогичных соединений; 2) отсутствие данных реагентов на отечественном рынке.Objects of research are diaryliodonium tosylates and bromides. Purpose of work is development of a new method of receiving polyvalent iodine compounds – diaryliodonium salts in particular diaryliodonium tosylates with using of oxidizing system based on Oxone® sulfuric acid and silica gel for the further carrying out of anion exchange reaction. In the course of research 4-methylphenylphenyliodonium tosylates and bromides, 2,6-dimethylphenylphenyliodonium tosylates and bromides, 2,4,6-trimethylphenylphenyliodonium tosylates and bromides, 2,3,5,6-tetramethylphenylphenyliodonium tosylates and bromides have been received. The synthesized products can be applied as photoinitiators of cationic polymerization of a number of monomers. Economic efficiency / importance of work is defined by the following factors: 1) the developed techniques possess smaller toxicity in comparison with techniques for obtaining similar substances; 2) lack of these reagents in the local market

Future paradigms for precision oncology

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Inflammatory Gene Regulatory Networks in Amnion Cells Following Cytokine Stimulation: Translational Systems Approach to Modeling Human Parturition

A majority of the studies examining the molecular regulation of human labor have been conducted using single gene approaches. While the technology to produce multi-dimensional datasets is readily available, the means for facile analysis of such data are limited. The objective of this study was to develop a systems approach to infer regulatory mechanisms governing global gene expression in cytokine-challenged cells in vitro, and to apply these methods to predict gene regulatory networks (GRNs) in intrauterine tissues during term parturition. To this end, microarray analysis was applied to human amnion mesenchymal cells (AMCs) stimulated with interleukin-1β, and differentially expressed transcripts were subjected to hierarchical clustering, temporal expression profiling, and motif enrichment analysis, from which a GRN was constructed. These methods were then applied to fetal membrane specimens collected in the absence or presence of spontaneous term labor. Analysis of cytokine-responsive genes in AMCs revealed a sterile immune response signature, with promoters enriched in response elements for several inflammation-associated transcription factors. In comparison to the fetal membrane dataset, there were 34 genes commonly upregulated, many of which were part of an acute inflammation gene expression signature. Binding motifs for nuclear factor-κB were prominent in the gene interaction and regulatory networks for both datasets; however, we found little evidence to support the utilization of pathogen-associated molecular pattern (PAMP) signaling. The tissue specimens were also enriched for transcripts governed by hypoxia-inducible factor. The approach presented here provides an uncomplicated means to infer global relationships among gene clusters involved in cellular responses to labor-associated signals

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe

Forward-central two-particle correlations in p-Pb collisions at root s(NN)=5.02 TeV

Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 2GeV/c. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B. V.Peer reviewe

Event-shape engineering for inclusive spectra and elliptic flow in Pb-Pb collisions at root(NN)-N-S=2.76 TeV

Peer reviewe

Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe