Synthetic Datasets for Autonomous Driving: A Survey

Autonomous driving techniques have been flourishing in recent years while thirsting for huge amounts of high-quality data. However, it is difficult for real-world datasets to keep up with the pace of changing requirements due to their expensive and time-consuming experimental and labeling costs. Therefore, more and more researchers are turning to synthetic datasets to easily generate rich and changeable data as an effective complement to the real world and to improve the performance of algorithms. In this paper, we summarize the evolution of synthetic dataset generation methods and review the work to date in synthetic datasets related to single and multi-task categories for to autonomous driving study. We also discuss the role that synthetic dataset plays the evaluation, gap test, and positive effect in autonomous driving related algorithm testing, especially on trustworthiness and safety aspects. Finally, we discuss general trends and possible development directions. To the best of our knowledge, this is the first survey focusing on the application of synthetic datasets in autonomous driving. This survey also raises awareness of the problems of real-world deployment of autonomous driving technology and provides researchers with a possible solution.Comment: 19 pages, 5 figure

Manipulation of ionized impurity scattering for achieving high thermoelectric performance in n-type Mg

Achieving higher carrier mobility plays a pivotal role for obtaining potentially high thermoelectric performance. In principle, the carrier mobility is governed by the band structure as well as by the carrier scattering mechanism. Here, we demonstrate that by manipulating the carrier scattering mechanism in n-type Mg[subscript 3]Sb[subscript 2 ]-based materials, a substantial improvement in carrier mobility, and hence the power factor, can be achieved. In this work, Fe, Co, Hf, and Ta are doped on the Mg site of Mg[subscript 3.2]Sb[subscript 1.5]Bi[subscript 0.49]Te [subscript 0.01], where the ionized impurity scattering crosses over to mixed ionized impurity and acoustic phonon scattering. A significant improvement in Hall mobility from ∼16 to ∼81 cm 2 ·V[superscript −1]·s[superscript − 1] is obtained, thus leading to a notably enhanced power factor of ∼13 μW·cm [superscript −1]·K [superscript −2] from ∼5 μW·cm[superscript −1]·K[superscript −2]. A simultaneous reduction in thermal conductivity is also achieved. Collectively, a figure of merit (ZT) of ∼1.7 is obtained at 773 K in Mg[subscript 3.1]Co[subscript 0.1]Sb[subscript 1.5]Bi[subscript 0.49]Te [subscript 0.01]. The concept of manipulating the carrier scattering mechanism to improve the mobility should also be applicable to other material systems. Keywords: thermoelectric; carrier scattering mechanism; ionized impurity scattering; n-type; Mg[subscript 3]Sb[subscript 2]; defect

Unraveling the immunological landscape in acute pancreatitis progression to sepsis: insights from a Mendelian randomization study on immune cell traits

BackgroundAcute pancreatitis (AP) is a severe digestive system disorder with a significant risk of progressing to sepsis, a major cause of mortality. Unraveling the immunological pathways in AP is essential for developing effective treatments, particularly understanding the role of specific immune cell traits in this progression.MethodsEmploying a bidirectional two-sample Mendelian Randomization (MR) approach, this study first examined the causal relationship between AP and 731 immune cell traits to identify those significantly associated with AP. Subsequently, we explored the causal associations between 731 immune cell traits and sepsis. The analysis utilized extensive genome-wide association studies (GWAS) summary datasets, with a focus on identifying common immune cell traits with statistically significant causal associations between AP and sepsis.ResultsOur investigation identified 44 immune cell traits unidirectionally associated with AP and 36 traits unidirectionally associated with sepsis. Among these, CD127 on CD28+ CD45RA- CD8+ T cells emerged as a common mediator, accounting for 5.296% of the increased risk of sepsis in AP patients. This finding highlights the significant role of specific memory CD8+ T cells in the pathophysiology of AP and its progression to sepsis.ConclusionThis study elucidates the critical role of specific immune cell traits, particularly CD127hi memory CD8+ T cells, in the progression of AP to sepsis. Our findings provide a foundation for future research into targeted immune-modulatory therapies, potentially improving patient outcomes in AP-related sepsis and offering new insights into the complex immunological dynamics of this condition

PSR J1926-0652: A Pulsar with Interesting Emission Properties Discovered at FAST

We describe PSR J1926-0652, a pulsar recently discovered with the Five-hundred-meter Aperture Spherical radio Telescope (FAST). Using sensitive single-pulse detections from FAST and long-term timing observations from the Parkes 64-m radio telescope, we probed phenomena on both long and short time scales. The FAST observations covered a wide frequency range from 270 to 800 MHz, enabling individual pulses to be studied in detail. The pulsar exhibits at least four profile components, short-term nulling lasting from 4 to 450 pulses, complex subpulse drifting behaviours and intermittency on scales of tens of minutes. While the average band spacing P3 is relatively constant across different bursts and components, significant variations in the separation of adjacent bands are seen, especially near the beginning and end of a burst. Band shapes and slopes are quite variable, especially for the trailing components and for the shorter bursts. We show that for each burst the last detectable pulse prior to emission ceasing has different properties compared to other pulses. These complexities pose challenges for the classic carousel-type models.Comment: 13pages with 12 figure

Global analysis of alternative splicing events based on long- and short-read RNA sequencing during grape berry development

This study was supported by Natural Science Foundation of China (NSFC: U1904113), National Key Research and Development Program of China (2018YFD1000105) and Program for Innovative Research Team (in Science and Technology) in University of Henan Province (21IRTSTHN021).Peer reviewe

SIRT1 deacetylates SATB1 to facilitate MARHS2-MARε interaction and promote ε-globin expression

The higher order chromatin structure has recently been revealed as a critical new layer of gene transcriptional control. Changes in higher order chromatin structures were shown to correlate with the availability of transcriptional factors and/or MAR (matrix attachment region) binding proteins, which tether genomic DNA to the nuclear matrix. How posttranslational modification to these protein organizers may affect higher order chromatin structure still pending experimental investigation. The type III histone deacetylase silent mating type information regulator 2, S. cerevisiae, homolog 1 (SIRT1) participates in many physiological processes through targeting both histone and transcriptional factors. We show that MAR binding protein SATB1, which mediates chromatin looping in cytokine, MHC-I and β-globin gene loci, as a new type of SIRT1 substrate. SIRT1 expression increased accompanying erythroid differentiation and the strengthening of β-globin cluster higher order chromatin structure, while knockdown of SIRT1 in erythroid k562 cells weakened the long-range interaction between two SATB1 binding sites in the β-globin locus, MARHS2 and MARε. We also show that SIRT1 activity significantly affects ε-globin gene expression in a SATB1-dependent manner and that knockdown of SIRT1 largely blocks ε-globin gene activation during erythroid differentiation. Our work proposes that SIRT1 orchestrates changes in higher order chromatin structure during erythropoiesis, and reveals the dynamic higher order chromatin structure regulation at posttranslational modification level

Ground calibration of Gamma-Ray Detectors of GECAM-C

As a new member of GECAM mission, GECAM-C (also named High Energy Burst Searcher, HEBS) was launched onboard the SATech-01 satellite on July 27th, 2022, which is capable to monitor gamma-ray transients from $\sim$ 6 keV to 6 MeV. As the main detector, there are 12 gamma-ray detectors (GRDs) equipped for GECAM-C. In order to verify the GECAM-C GRD detector performance and to validate the Monte Carlo simulations of detector response, comprehensive on-ground calibration experiments have been performed using X-ray beam and radioactive sources, including Energy-Channel relation, energy resolution, detection efficiency, SiPM voltage-gain relation and the non-uniformity of positional response. In this paper, the detailed calibration campaigns and data analysis results for GECAM-C GRDs are presented, demonstrating the excellent performance of GECAM-C GRD detectors.Comment: third versio

Moxibustion for cancer care: a systematic review and meta-analysis

<p>Abstract</p> <p>Background</p> <p>Moxibustion is a traditional Chinese method that uses the heat generated by burning herbal preparations containing <it>Artemisia vulgaris </it>to stimulate acupuncture points. Considering moxibustion is closely related to acupuncture, it seems pertinent to evaluate the effectiveness of moxibustion as a treatment of symptoms of cancer. The objective of this review was to systematically assess the effectiveness of moxibustion for supportive cancer care.</p> <p>Methods</p> <p>We searched the literature using 11 databases from their inceptions to February 2010, without language restrictions. We included randomised clinical trials (RCTs) in which moxibustion was employed as an adjuvant treatment for conventional medicine in patients with any type of cancer. The selection of studies, data extraction, and validations were performed independently by two reviewers.</p> <p>Results</p> <p>Five RCTs compared the effects of moxibustion with conventional therapy. Four RCTs failed to show favourable effects of moxibustion for response rate compared with chemotherapy (n = 229, RR, 1.04, 95% CI 0.94 to 1.15, P = 0.43). Two RCTs assessed the occurrence of side effects of chemotherapy and showed favourable effects of moxibustion. A meta-analysis showed significant less frequency of nausea and vomiting from chemotherapy for moxibustion group (n = 80, RR, 0.38, 95% CIs 0.22 to 0.65, P = 0.0005, heterogeneity: χ²= 0.18, P = 0.67, I²= 0%).</p> <p>Conclusion</p> <p>The evidence is limited to suggest moxibustion is an effective supportive cancer care in nausea and vomiting. However, all studies have a high risk of bias so effectively there is not enough evidence to draw any conclusion. Further research is required to investigate whether there are specific benefits of moxibustion for supportive cancer care.</p

Recent progress in magnesium-based thermoelectric materials

Magnesium-based thermoelectric materials (Mg2X, X = Si, Ge, Sn) are considered one of the most attractive groups for large-scale application, due to their materials’ high availability, low cost, low mass density and reasonably high efficiency. In this work, we present an overview of the recent developments relating to magnesium-based thermoelectric materials and review the current approaches towards high thermoelectric efficiency

Synthetic strategies to nanostructured photocatalysts for CO2 reduction to solar fuels and chemicals

Artificial photosynthesis represents one of the great scientific challenges of the 21st century, offering the possibility of clean energy through water photolysis and renewable chemicals through CO2 utilisation as a sustainable feedstock. Catalysis will undoubtedly play a key role in delivering technologies able to meet these goals, mediating solar energy via excited generate charge carriers to selectively activate molecular bonds under ambient conditions. This review describes recent synthetic approaches adopted to engineer nanostructured photocatalytic materials for efficient light harnessing, charge separation and the photoreduction of CO2 to higher hydrocarbons such as methane, methanol and even olefins