Ventilation Targets for Patients Undergoing Mechanical Thrombectomy for Acute Ischemic Stroke: A Systematic Review

Mechanical thrombectomy (MT) has become a standard treatment for acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). Recent evidence suggests that general anesthesia (GA) and mechanical ventilation do not lead to inferior neurologic outcomes if compared to non-GA. However, the guidelines lack specific recommendations for ventilation targets during MT under GA. This systematic review aims to identify ventilation strategies correlating with better neurological outcomes in AIS patients undergoing MT, particularly focusing on oxygenation and carbon dioxide (CO2) targets. A systematic search of multiple databases was conducted to identify human studies reporting the correlation between ventilation strategies and neurological outcomes in MT for AIS. Eligible studies included clinical trials, observational studies, and case–control studies. Out of 157 studies assessed, 11 met the inclusion criteria. Five studies investigated oxygenation targets, while six studies explored CO2 targets. The published studies highlighted the controversial role of supplemental normobaric oxygen therapy and its potential association with worse outcomes. Regarding CO2 targets, the studies identified a potential association between end tidal CO2 levels and functional outcomes, with hypocapnia being unfavorable. This systematic review demonstrates that the current available evidence still lacks strength to suggest specific ventilation targets, but it highlights the potential risks of hyperoxia and hypocapnia in this specific cohort of patients

On mechanism of formation of SBA-15/furfuryl alcohol-derived mesoporous carbon replicas and its relationship with catalytic activity in oxidative dehydrogenation of ethylbenzene

A series of CMK-3-like carbon replicas was synthesized by precipitation polycondensation of furfuryl alcohol in an aqueous slurry of SBA-15 at a polymer/SiO2 mass ratio of 0.50–2.00. Changes in textural and structural parameters of SBA-15 after polymer deposition were studied by N2 adsorption and X-ray diffraction. Morphology of the replicas was investigated by transmission electron microscopy, while their surface composition was determined by temperature-programmed desorption and X-ray photoelectron spectroscopy. The mechanism of deposition of poly(furfuryl alcohol) (PFA) onto silica surface was elucidated. It was found that PFA accumulates in SBA-15 pores randomly; certain channels are completely filled, while others remain partially empty. The incomplete filling of mesopores results in “pseudo-CMK-3” structures featuring the bimodal porosity (the typical mesopores of CMK-3 are accompanied by broader ones formed by the coalescence of adjacent partially hollow pores). The total filling of pores with PFA leads to the formation of good-quality CMK-3. The carbon replicas exhibited the presence of abundant amounts of superficial oxygen-containing moieties. These entities are responsible for high activity of the materials in the oxidative dehydrogenation (ODH) of ethylbenzene, bringing evidence supporting the mechanism of active coke, considered as governing the catalytic performance of carbon materials in ODH of alkanes.This work was supported by the Polish National Science Centre under the grant no. DEC-2011/01/N/ST5/05595. The research was carried out with the equipment purchased thanks to the financial support of the European Regional Development Fund in the framework of the Polish Innovation Economy Operational Program (contract No. POIG.02.01.00-12-023/08). The research was carried out using the infrastructure of the AGH Centre of Energy, AGH University of Science and Technology

Effect of classic back massage on spinal pain in a woman with large breasts - case report

Introduction. The most common ailment of the motion system is spinal pain. For one of the main reasons, it consider a sedentary lifestyle that weakens the musculo-skeletal system, obesity that increases spine load, sleep disorders resulting from unsettled positions during rest or sleep, and chronic stress. The use of massage can reduce the painful pain of the spine, by loosening the excessively tight spine muscles, the articular joints of the joints and the relaxation of the body.Objective. An assessment of the effect of classical spine massage on spinal pain in a woman with large breasts.Material and methods. 10 massage treatments of the classical ridge using olive oil were performed. Sessions took place 2-3 times a week after 30-50 minutes. Before and after intervention were measured: linear measurements of upper and lower limbs; Measurement of the first and short long and short for the upper and lower limbs for the upper and lower extremities; Measurement of the range of mobility of individual segments of the spine; Measurement of muscle strength of the cervical, thoracic and lumbar musculature of the upper limbs; Assessment of deviation from the symmetry of body posture. Also tested was the Cross Stroke Challenge, finger-to-floor test, lumbar vertebrae overtaxis test, Laseque test, Scherer test and Gilett test.Results. The difference in the range of motion, ie the flexion of the thorax and lumbar spine and the finger-to-floor examination, was statistically significantly different. After intervention the silhouette of the body was positioned closer to the vertical axis. The Laseque test for both lower limbs turned out to be negative. The difference in linear and limb length measurements and the Schober test was not statistically significant. The test of cross-provocation, the overtaking test for the lumbar spine movement and the Gillet test did not show deviations before or after intervention.Conclusions. Therapeutic massage of the classic back reduced the pain of the spine. Improved body posture and increased range of motion in individual spinal segments. In addition, no effect of classical massage on muscle strength and limb circumference was found

Zarządzanie przepływem i ochroną informacji

Publikacja recenzowana / Peer-reviewed publicationPrzedstawione wydawnictwo stanowi zasadniczy plon obrad konferencji naukowej zorganizowanej przez Katedrę Zarządzania Informacją na Wydziale Ekonomii i Zarządzania w dniach 25—26 marca 2007 roku. Ambicją organizatorów konferencji było włączenie w tok dyskusji licznych przedstawicieli praktyki gospodarczej, mediów oraz studentów. W odpowiedzi na zaproszenie do udziału w konferencji napłynęło ponad dwadzieścia referatów problemowych, z których kilka, ze względu na problematykę ściśle wiążącą się z zagadnieniami bezpieczeństwa, zostanie opublikowanych w nowym czasopiśmie naukowym Krakowskiej Szkoły Wyższej im. Andrzeja Frycza Modrzewskiego pt. „Problemy Bezpieczeństwa”. Autorami wszystkich przygotowanych tekstów są uznani eksperci w dziedzinie przepływu i ochrony informacji, a także młodzi pracownicy szkół wyższych i przedstawiciele praktyki gospodarczej. Patronat medialny objęły pisma o ogólnopolskim zasięgu i uznanej renomie: „Przegląd Organizacji”, „CSO Magazyn Zarządzających Bezpieczeństwem” i „Czasopismo Zabezpieczenia”. Całość rozważań Autorów podzielona została na trzy części, ściśle ze sobą powiązane. Część pierwsza grupuje teksty pod wspólnym tytułem „Przepływ, przetwarzanie i ochrona informacji we współczesnych systemach zarządzania”, część druga nosi tytuł: „Informacja jako determinanta tworzenia wartości dodanej oraz przewagi konkurencyjnej”, część trzecia zaś omawia „Zarządzanie wiedzą w wybranych dziedzinach aktywności gospodarczej i publicznej”

Self-Reported Time in Bed and Sleep Quality in Association with Internalizing and Externalizing Symptoms in School-Age Youth

This study investigated the relationship between self-reported time in bed and sleep quality in association with self-reported internalizing and externalizing symptoms in a sample of 285 elementary school students (52% female) recruited from a rural Midwestern elementary school. Path models were used to estimate proposed associations, controlling for grade level and gender. Curvilinear associations were found between time in bed and anxiety, depressive symptoms, and irritability. Marginal curvilinear trends were found between time in bed and emotion dysregulation, reactive aggression, and proactive aggression. Sleep quality was negatively associated with anxiety, depressive symptoms, irritability, reactive aggression, and delinquency engagement. Gender and grade differences were found across models. Findings suggest that examining self-reported time in bed (both linear and quadratic) and sleep quality is important for understanding internalizing and externalizing symptoms associated with sleep in school-age youth. Incorporating self-reported sleep assessments into clinical practice and school-based evaluations may have implications for a child’s adjustment

Light-front holographic QCD and emerging confinement

In this report we explore the remarkable connections between light-front dynamics, its holographic mapping to gravity in a higher-dimensional anti-de Sitter (AdS) space, and conformal quantum mechanics. This approach provides new insights into the origin of a fundamental mass scale and the physics underlying confinement dynamics in QCD in the limit of massless quarks. The result is a relativistic light-front wave equation for arbitrary spin with an effective confinement potential derived from a conformal action and its embedding in AdS space. This equation allows for the computation of essential features of hadron spectra in terms of a single scale. The light-front holographic methods described here give a precise interpretation of holographic variables and quantities in AdS space in terms of light-front variables and quantum numbers. This leads to a relation between the AdS wave functions and the boost-invariant light-front wave functions describing the internal structure of hadronic bound-states in physical space-time. The pion is massless in the chiral limit and the excitation spectra of relativistic light-quark meson and baryon bound states lie on linear Regge trajectories with identical slopes in the radial and orbital quantum numbers. In the light-front holographic approach described here currents are expressed as an infinite sum of poles, and form factors as a product of poles. At large q(2) the form factor incorporates the correct power-law fall-off for hard scattering independent of the specific dynamics and is dictated by the twist. At low q2 the form factor leads to vector dominance. The approach is also extended to include small quark masses. We briefly review in this report other holographic approaches to QCD, in particular top-down and bottom-up models based on chiral symmetry breaking. We also include a discussion of open problems and future applications. (C)) 2015 Elsevier B.V. All rights reserved

Multidifferential study of identified charged hadron distributions in ZZ-tagged jets in proton-proton collisions at s=\sqrt{s}=13 TeV

Jet fragmentation functions are measured for the first time in proton-proton collisions for charged pions, kaons, and protons within jets recoiling against a $Z$ boson. The charged-hadron distributions are studied longitudinally and transversely to the jet direction for jets with transverse momentum 20 $< p_{\textrm{T}} < 100$ GeV and in the pseudorapidity range $2.5 < \eta < 4$. The data sample was collected with the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1.64 fb$^{-1}$. Triple differential distributions as a function of the hadron longitudinal momentum fraction, hadron transverse momentum, and jet transverse momentum are also measured for the first time. This helps constrain transverse-momentum-dependent fragmentation functions. Differences in the shapes and magnitudes of the measured distributions for the different hadron species provide insights into the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb public pages

Study of the B−→Λc+Λˉc−K−B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-} decay

The decay $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ is studied in proton-proton collisions at a center-of-mass energy of $\sqrt{s}=13$ TeV using data corresponding to an integrated luminosity of 5 $\mathrm{fb}^{-1}$ collected by the LHCb experiment. In the $\Lambda_{c}^+ K^{-}$ system, the $\Xi_{c}(2930)^{0}$ state observed at the BaBar and Belle experiments is resolved into two narrower states, $\Xi_{c}(2923)^{0}$ and $\Xi_{c}(2939)^{0}$, whose masses and widths are measured to be $$m(\Xi_{c}(2923)^{0}) = 2924.5 \pm 0.4 \pm 1.1 \,\mathrm{MeV}, \\ m(\Xi_{c}(2939)^{0}) = 2938.5 \pm 0.9 \pm 2.3 \,\mathrm{MeV}, \\ \Gamma(\Xi_{c}(2923)^{0}) = \phantom{000}4.8 \pm 0.9 \pm 1.5 \,\mathrm{MeV},\\ \Gamma(\Xi_{c}(2939)^{0}) = \phantom{00}11.0 \pm 1.9 \pm 7.5 \,\mathrm{MeV},$$ where the first uncertainties are statistical and the second systematic. The results are consistent with a previous LHCb measurement using a prompt $\Lambda_{c}^{+} K^{-}$ sample. Evidence of a new $\Xi_{c}(2880)^{0}$ state is found with a local significance of $3.8\,\sigma$, whose mass and width are measured to be $2881.8 \pm 3.1 \pm 8.5\,\mathrm{MeV}$ and $12.4 \pm 5.3 \pm 5.8 \,\mathrm{MeV}$, respectively. In addition, evidence of a new decay mode $\Xi_{c}(2790)^{0} \to \Lambda_{c}^{+} K^{-}$ is found with a significance of $3.7\,\sigma$. The relative branching fraction of $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ with respect to the $B^{-} \to D^{+} D^{-} K^{-}$ decay is measured to be $2.36 \pm 0.11 \pm 0.22 \pm 0.25$, where the first uncertainty is statistical, the second systematic and the third originates from the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb public pages

Measurement of the ratios of branching fractions R(D∗)\mathcal{R}(D^{*}) and R(D0)\mathcal{R}(D^{0})

The ratios of branching fractions $\mathcal{R}(D^{*})\equiv\mathcal{B}(\bar{B}\to D^{*}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(\bar{B}\to D^{*}\mu^{-}\bar{\nu}_{\mu})$ and $\mathcal{R}(D^{0})\equiv\mathcal{B}(B^{-}\to D^{0}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(B^{-}\to D^{0}\mu^{-}\bar{\nu}_{\mu})$ are measured, assuming isospin symmetry, using a sample of proton-proton collision data corresponding to 3.0 fb${ }^{-1}$ of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode $\tau^{-}\to\mu^{-}\nu_{\tau}\bar{\nu}_{\mu}$. The measured values are $\mathcal{R}(D^{*})=0.281\pm0.018\pm0.024$ and $\mathcal{R}(D^{0})=0.441\pm0.060\pm0.066$, where the first uncertainty is statistical and the second is systematic. The correlation between these measurements is $\rho=-0.43$. Results are consistent with the current average of these quantities and are at a combined 1.9 standard deviations from the predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb public pages