50 research outputs found
Virtual Touch (TM) Quantification to Diagnose and Monitor Liver Fibrosis in Hepatitis B and Hepatitis C: A NICE Medical Technology Guidance
- Author
- Abdel Douiri
- Anastasia Chalkidou
- Anita Patel
- C Cassinotto
- Cornelius Lewis
- Elizabeth Morris
- G Crespo
- H Kuroda
- H Takahashi
- I Sporea
- I Sporea
- I Sporea
- I Sporea
- I Sporea
- I Sporea
- J Nierhoff
- Janet Peacock
- Jennifer A. Summers
- Joanne Higgins
- L Rizzo
- LT Le
- M Friedrich-Rust
- M Friedrich-Rust
- M Friedrich-Rust
- M Friedrich-Rust
- M Lupsor
- M Lupsor
- M Noruegas
- Muralikrishnan Radhakrishnan
- National Institute for Health and Care Excellence
- R Badea
- R Dhillon
- R Steadman
- R Yamada
- S Atzori
- S Bota
- S Bota
- S Hanquinet
- Salma Ayis
- SH Chen
- Stephen Keevil
- T Aoki
- T Karlas
- T Nishikawa
- T Toshima
- Tiago Rua
- V Calvaruso
- V Calvaruso
- Viktoria McMillan
- XP Ye
- Y Liu
- Yanzhong Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
King’s Technology Evaluation Centre is funded by NICE to
act as an External Assessment Centre for the Medical Technologies
Evaluation Programme. The NHS has a financial interest in the
guidance issued by NICE as a result of this work and two authors are
NHS employees (Prof. Keevil and Dr. Lewis
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
- Author
- Abantanga F
- Abbas M
- Abbo O
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elrasoul Y
- Abdallah E
- Abdel-Wahab NYE
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelkader M
- Abdelkareem A
- Abdelraheim M
- Abdelshafy M
- Abdulgawad M
- Abdullah AAN
- Abdullah NAN
- Abebe NS
- Abebe NS
- Aber A
- Abington E
- Aboarab A
- Aboraya M
- Aboraya M
- Abouelnasr A
- Abouzahra A
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- Abozeid K
- Abozyed MAF
- Abudeeb H
- Abuseif M
- Acharya P
- Adams R
- Adebanjo A
- Adekoya A
- Adel A
- Adel A
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- Ademuyiwa AO
- Adeniran J
- Adeniyi A
- Adesanya O
- Adesina A
- Adesuyi A
- Adeyeye A
- Adham W
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- Aguilar-Jimenez J
- Aguilera M
- Aguilera O
- Ahlqvist S
- Ahmed A
- Ahmed EA
- Ahmed H
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- Al-Faifi JJ
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- Al-Hasani RKMJ
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- Al-Mousa M
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- Al-Obaedi O
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- Alahmady O
- Alakaloko F
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- Albeladi B
- Aldalaq A
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
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- Abaliksta T
- Abantanga F
- Abantanga F
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- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
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- Macchitella Y
- Macchitella Y
- Macdermid E
- Macdonald A
- Macdonald E
- Macdonald KL
- Maceviciute K
- Macfarlane A
- Machaca M
- Machain Vega GM
- Machain Vega GM
- Maciejec L
- Madiba T
- Madkor MH
- Madrid Barrientos LA
- Maffioli A
- Maffioli A
- Magdy A
- Magdy B
- Magdy E
- Magdy H
- Magdy M
- Magdy S
- Magee C
- Maghrabi A
- Maghrabi AA
- Magri D
- Mahanty S
- Maharaj G
- Mahdi A
- Mahdi S
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- Maher ME
- Mahmoud B
- Mahmoud H
- Mahmoud M
- Mahmoud MA
- Mahmoud MI
- Mahmoud S
- Mahmoud SME
- Mahmud K
- Maillot B
- Maimbo M
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- Mairs NG
- Maison K
- Maistry N
- Majauskyte D
- Majbar A
- Majid AHHA
- Majid K
- Major CP
- Major P
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- Mak T
- Mak TWC
- Makama J
- Makinde M
- Makupe A
- Malaga B
- Malavenda M
- Malik K
- Malik P
- Malik TAM
- Mamdouh E
- Mamdouh R
- Manatakis DK
- Manchego Bautista AC
- Manchego Bautista AC
- Manfreda S
- Mangan C
- Mangan C
- Mangiapane M
- Manipal CE
- Maniscalco A
- Mann T
- Mannu GS
- Mano MJB
- Manrique Sila G
- Manrique Sila GC
- Manriquez-Reyes M
- Manrrique Sila G
- Mansor EY
- Mansour B
- Mansour S
- Mansuri A
- Mao P
- Mapasse D
- Maple N
- Maraie N
- Marcelo Delgado J
- Marey A
- Marey AS
- Margaritis M
- Maria Garcia-Perez J
- Mariani A
- Marinkovic B
- Marinos C
- Marks E
- Marples L
- Marret J-B
- Marroquin Rodriguez DE
- Marshall DC
- Martian B-V
- Martin A
- Mas R
- Mason C
- Mat TNT
- Mata LPS
- Matheu A
- Mathew SW
- Matos-Puig R
- Mattar O
- Matter SM
- Mauro L
- Mayasari M
- Mazelyte R
- Mazrimas P
- Mazzella A
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- Mcaleer S
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- McGarvie S
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- Mcnish D
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- Mehdi A
- Mehrez S
- Melo Cardozo RA
- Melo R
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- Mendoza I
- Menegussi J
- Mensah E
- Menshawy A
- Mentula P
- Meqbil J
- Mercado Rodriguez L-A
- Mericliler M
- Merlini D
- Merlini D
- Merlo MS
- Mesbah N
- Meshref A
- Messa Aguilar WL
- Messa Aguilar WL
- Metwally MM
- Migliore M
- Mihaljevic AL
- Mihaljevic AL
- Mihanovic J
- Mihanovic J
- Mijuskovic B
- Mikalauskas S
- Mikalauskas S
- Mikuckyte D
- Mikwar Z
- Milligan W
- Milligan W
- Mingrone P
- Minguez Garcia J
- Minguez G
- Minocha A
- Minocha A
- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
- Mironescu A
- Mironescu AS
- Mironescu AS
- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
- Mitroudis N
- Mittal A
- Mitul AR
- Mitul AR
- Miyarde Leon A
- Mizzi C
- Mizzi S
- Mlotshwa M
- Moaty M
- Mochet S
- Modolo MM
- Modolo MM
- Modolo MM
- Moe TT
- Mogan YP
- Moghazy ME
- Mohamed A
- Mohamed A
- Mohamed AM
- Mohamed AR
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
- Mohammed A
- Mohammed AR
- Mohammed H
- Mohammed MM
- Mohammed MMH
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok YT
- Mokhtar A
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- Monaghan E
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- Monrad-Hansen PW
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montoya Botero JA
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
- Moore R
- Mora JJV
- Morales C
- Morandi E
- Moreira G
- Moreno SC
- Morgan C
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- Morshedy EM
- Morsi A
- Morsi M
- Morton D
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- Morton R
- Mosad A
- Mosalum O
- Mostafa HA
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe AM
- Mshelbwala P
- Msiska N
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- Mukin ADF
- Muktar U
- Mukuzunga C
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- Munhoz MM
- Munipalle PC
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- Murutoglu B
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- Musowoya J
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- Musyoka CK
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- Mutabazi AZ
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- Mutlu V
- Muzio E
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- Mykoniatis I
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- Nadkarni S
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- Nagy GS
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- Najjar M
- Nanthakumaran S
- Napolitano L
- Napolitano L
- Naqvi SA
- Naqvi T
- Naranjo Aristizaibal FA
- Narayanan R
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- Narvestad JK
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- Nashat M
- Nasher O
- Nashidengo P
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- Nassif D
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- Nataraja R
- Natili A
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- Nazir M
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- Ndegwa W
- Ndlovu SR
- Ndwambi P
- Negida A
- Negoi I
- Nel D
- Nemeth K
- Neo YN
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- Neophytou C
- Nepogodiev D
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- Nesaratnam A
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- Nestorovic M
- Nevieraite V
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- Ngwa TE
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- Njokanma I
- Nnajiuba H
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- Nofal E
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- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana VJP
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- Nurqistan HD
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
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- Palomino Castillo VD
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- Papaskarlatos I-A
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- Pena L
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- Perez Velasquez CI
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- Pertersen Servin GR
- Pesenti G
- Petrikenas S
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- Pezas T
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- Pezelj N
- Phillips N
- Picardo A
- Picciariello A
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- Pinkney T
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- Powell A
- Prabhudesai A
- Pranevicius R
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- Preckailaite E
- Primavesi F
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- Punja V
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- Qureshi AU
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- Rakita I
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- Ramarez Cabrera CC
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- Razi SAU
- Razmdjou S
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- Sahel S
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- Salah OM
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- Samaraweera DI
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- Sandoval Barrantes AM
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- Schivo D
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- Schultz JK
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- Scott M
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- Semeda N
- Semiz A
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- Senanayake KJ
- Senanayake WSMKJ
- Setiawan J
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- Sfougaris D
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- Shahbaz AR
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- Snyder E
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- Sobnach S
- Sodde P
- Soeselo DA
- Sokratous A
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- Solar Garcia L
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- Soldevila-Verdeguer C
- Soley R
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- Soltani N
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- Staerkle RF
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- Stefanopoulos A
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- Sundstrom SM
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- Tackie E
- Taddei A
- Tade A
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- Tahboub H
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- Taieb C
- Taiwo A
- Taiwo O
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- Tanase A
- Tang A
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- Tani SI
- Tansoker I
- Tarek A
- Tarek A
- Tarek D
- Targa S
- Tariq S
- Tata MD
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- Tawfik BA
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- Teasdale E
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- Tedeschi U
- Tedjaatmadja C
- Telfah MM
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- Tennakoon A
- Teo SY
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- Th'ng F
- Thabet W
- Thalgaspitiya SPB
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- Thanusan V
- Tharmalingam S
- Theodosopoulos T
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- Tolonen M
- Tolotra TEC
- Tomas K
- Tori SA
- Toribio Orbegozo PA
- Torrance HD
- Torrance HD
- Torres Cardozo J
- Toto OF
- Tou S
- Townsend D
- Tracy J
- Trompetto M
- Tselos A
- Tshisola SK
- Tugnoli G
- Tugnoli G
- Tun AK
- Tun M
- Tun M
- Turati L
- Turati L
- Turkustani S
- Turner M
- Turpo Espinoza K
- Turpo Espinoza K
- Tutino R
- Tverskis Z
- Tyler R
- Tyler R
- Tze RGE
- Tze RGE
- Tzikos G
- Ubhi HK
- Ubiali P
- Ugalde P
- Ukwenya Y
- Ulusahin M
- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbina Rojas NM
- Urbonas T
- Urbonas T
- Urniezius Z
- Urniezius Z
- Usaityte A
- Uscinas L
- Utter M
- Uzabumwana N
- Vaicius A
- Valcarcel-Saldana M
- Valente Laufer LA
- Valioulis I
- Van Der Naald N
- Van Duren B
- Van Niekerk M
- Van Straten S
- Varcada M
- Vargas M
- Varkalys K
- Vartanoglu T
- Vartic M
- Vartic M
- Vasquez G
- Vasquez I
- Veen T
- Velasquez R
- Vella-Baldacchino M
- Venclauskas L
- Vendramin E
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venugopal C
- Verbeek A
- Vergara Celis JM
- Vergara Mejia AG
- Verjee A
- Vermaas M
- Veronese E
- Vianna JGP
- Vicario E
- Vicenta Collado M
- Vida LC
- Vida LC
- Vilcinskas M
- Villa R
- Villalobos S
- Vimalachandran D
- Vincent J
- Violi P
- Visinskas P
- Vivekanantham S
- Vlachogiorgos A
- Voulgaris E
- Wael N
- Wagener M
- Wakefield R
- Waledziak M
- Waleed H
- Walker M
- Walker N
- Walls L
- Walsh M
- Walsh U
- Waqar M
- Ward AE
- Ward S
- Warda M
- Warren O
- Warren O
- Warwick AM
- Waterman A
- Watson NF
- Watson NF
- Watts A
- Weber B
- Weber P
- Weber P
- Weinstein MS
- Weiser TG
- Werder G
- Wheeler J
- Whewell H
- Whitaker J
- White R
- White T
- Whitehurst K
- Wiborg J
- Widiastini TA
- Widmer LW
- Wijayarathna LS
- Wild JRL
- Williams E
- Williams G
- Williams O
- Williams O
- Williamson A
- Wilson A
- Wilson L
- Wilson M
- Wilson M
- Wilson MSJ
- Wilson MSJ
- Wimalge PMSN
- Winstanley J
- Witherspoon P
- Wogensen F
- Wogensen F
- Wogensen F
- Woin E
- Wold TB
- Wolf B
- Wolf B
- Wondimu S
- Wondoh P
- Wondoh P
- Wong CS
- Wong CY
- Wong F
- Wong HY
- Wood G
- Woodward H
- Worku M
- Worku M
- Worku T
- Wredberg C
- Wright N
- Wright NJ
- Xerri T
- Xerri T
- Yahaya MT
- Yakubu M
- Yallop L
- Yam SY
- Yang J
- Yap S
- Yaseen T
- Yaseen TM
- Yau JD
- Yavuz MA
- Ye J
- Yeang LJ
- Yee J
- Yeo LS
- Yeung ENW
- Yeung MHA
- Yifieyeh A
- Yildirim R
- Yip C
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong CO
- Yong GL
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif JH
- Yuksek MA
- Yusufali T
- Zaa'treh R
- Zachariades D-C
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia MF
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
- Zanini N
- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
- Zidan M
- Zielinski M
- Ziff O
- Zikry M
- Zil-E-Ali A
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zilinskiene R
- Zimmermann EF
- Ziubryte G
- Zohair A
- Zorrilla CD
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study
- Author
- Abdullah Nassreen
- Accurso Antonello
- Accurso Antonello
- Achuthan Raj
- Adam Rahma
- Adelekan Matthew
- Adwani Asha
- Aertssen Anna
- Agrawal Amit
- Agrawal Avi
- Ain Quratul
- Ainsworth Rachel
- Akerlund Malin
- Akolekar Deepika
- Alder Louise
- Alexander Susanna
- Ali Deedar
- Ali Rozina
- Allan Anna
- Allum William
- Aloraifi Fatima
- Amin Khalid
- Amorosi Vittoria
- Arif Tahera
- Armstrong Alexander
- Asaad Oubida
- Asgeirsson Kristjan
- Athanasiou Irene
- Audisio Riccardo
- Azmy Iman
- Bache Sarah
- Bains Salena
- Bajrusevic Sladana
- Balasubramanian Balapathiran
- Balata Safa Ahmed
- Bali Radhika
- Barnes Nicola
- Barnes Nicola LP
- Barrows Sara
- Barry Peter
- Barua Ellora
- Basu Naren
- Bathla Sonia
- Benyon Sarah L
- Bernaudo Lorenzo
- Bhaskar Pud
- Bibi Saira
- Biddle M
- Bignell Kym
- Biswas Bashishta
- Blazeby Jane
- Bourne Roger
- Brock Lisa
- Brown Victoria
- Bucata Claudiu
- Bucknor Alexandra
- Byrne Miriam
- Cain Henry
- Callaghan Maria
- Canny Rebecca
- Catanuto Giuseppe
- Cawthorn Simon
- Ceccarino Raffaele
- Chagla Leena
- Challoner Tom
- Chana Jagdeep
- Chand Natalie
- Chandrashekar Mysore
- Charalambous Michalis
- Charalampou-Dis Petros
- Chew Ben
- Chicken Dennis Wayne
- Chin Kian
- Chong Kelvin
- Choy Christina
- Christopoulos Petros
- Chrysafi Ada
- Clark Sarah
- Clarke Natalie
- Coco Guido
- Colizzi Livio
- Collab Breast Reconstruction Res
- Collis Nick
- Conroy Elizabeth
- Constantinou Chloe
- Critchley Adam
- Cullinane Carolyn
- Curnier Alain
- Curran Terry-Ann
- Dauria Marta
- Dave Rajiv
- Dave Rajiv V
- Dave Rajiv V
- Davey Simon
- de Sousa Emma
- Debanth Debasish
- Depasquale Ivan
- Devane Liam
- Dhooma Naseem
- Di Micco Rosa
- Dixon JM
- Dordea Matei
- Douek Michael
- Down Sue
- Downey Sarah
- Dragoumis Dimitris
- Dumitru Dorin
- Dunn Julie
- Durbar Michael
- El-Sharief Deena
- Elahi Bilal
- Elfadl Dalia
- Epurescu Daniel
- Evoy Denis
- Exarchos Georgios
- Fabio Santanelli di Pompeo
- Fafemi Oladapo
- Fage Elena
- Farrell Eric
- Ferguson Douglas
- Fiddes Roanne
- Figus Andrea
- Fopp Laura
- Foster Rachel
- Fuller Mairi
- Fustaino Loredana
- Gahir Jasdeep
- Gandamihardja Tasha
- Gandhi Ashu
- Gardiner Matthew
- Gardiner Matthew
- Garg Neeraj
- Garnsey Clare
- Geraghty James
- Geropantas Konstantinos
- Ghali Shadi
- Ghilli Matteo
- Gill Emma
- Goh Steven
- Govindarajulu Sasirekha
- Graja Tomasz
- Granger Emily
- Grassi Veronica
- Grover Kartikae
- Grp iBRA-2 Steering
- Guest Francesca
- Gui Gerald
- Gutteridge Eleanor
- Gvaramadze Anzors
- Hallam Kelly
- Hamad Ahmed
- Hamed Hisham
- Hamilton Stephen
- Hamnett Kathryn
- Hamo Ishrak
- Haq Anwar
- Harcourt Ruth
- Harding-MacKean Claudia
- Harnett Adrian
- Harnett Adrian
- Harnett Adrian
- Harris Chad
- Harris Kevin
- Harris Paul
- Harvey James
- Harvey Kate L
- Haywood Richard M
- Healy Samuel
- Henderson Julia
- Henry Francis P
- Hernan Izaro
- Heys Steven
- Hignett Susan
- Hill Arnold DK
- Hogan Brian
- Holcombe Chris
- Holcombe Chris
- Holcombe Chris
- Hollywood Ciaran
- Holt Simon
- Horgan Kieran
- Howes Rachel
- Hu Jennifer
- Humphreys Laura
- Hunter Judith
- Hussien Maged I
- Ihsan Naila
- Iqbal Azhar
- Irakleidis Foivos
- Irwin Gareth
- Irwin Michael S
- Isherwood Jennifer
- Ives Charlotte
- Jafferbhoy Sadaf
- Jafferbhoy Sadaf
- Jain Yogesh
- Jallali Navid
- James Karen
- James Ruth
- James Stuart
- Jibril Jibril A
- Jiwa Natasha
- Johns Neil
- Johnson Laura
- Johnson Richard
- Jones Ben Mancey
- Jones Robin
- Kalles Vasileios
- Kalra Loraine
- Kaushik Monika
- Kearns Marie
- Kelsall Jennett
- Kennedy Katy
- Kenny Frances
- Khalil Haitham
- Khan Mansoor
- Khan Shazia M
- Khattak Ilyas
- Khawaja Saira
- Khout Hazem
- Kirby Robert
- Kirchhoff Chris
- Kirkpatrick Katharine
- Kiruparan Pasupathy
- Kirwan Cliona C
- Kleidi Eleftheria
- Kneeshaw Peter
- Kokan Jalal
- Koris Jacob
- Kothari Ashutosh
- Kovacs Tibor
- Krupa Jaroslaw
- Krupa Katerine
- Kryjak Zbigniew
- Kulkarni Dhananjay
- Lai Lee Min
- Lambert Kelly
- Lampropoulos Pavlos
- Lane Risha
- Langlands Fiona
- Lansdown Mark
- Laurence Nicola
- Lawlor Catriona
- Laws Siobhan
- Ledwidge Serena
- Lee Jason
- Lewis Rebecca
- Li Alessandro Quattrini
- Liccardo Raffaele
- Limite Gennaro
- Lo Michelle
- Lund Jonathan
- Lymperopoulos N
- Maalo Joseph
- Mackay Iain
- MacLean Gael
- MacLennan Louise
- Macmillan Douglas
- MacNeill Fiona
- Mahapatra Tapan
- Majeed Yousef
- Malata Charles M
- Mallon Peter
- Malyon Andy
- Mansfield Lucy
- Mariniello Maria Donatella
- Marsh Daniel
- Marzia Lo Russo
- Masannat Yazan A
- Masood Mohammad
- Massey Julia
- Matey Pilar
- Mathen Vinod
- Mathew Tom
- Mazari Fayyaz
- McCartan Damian
- McCulley Stephen
- McDermott Enda
- McEvoy Kat
- McGill David
- McGuiness Caroline
- McIntosh Jamie
- McIntosh Stuart A
- Mckenzie Shireen
- McManus Penelope
- Mehmood Iftikhar
- Mehta Disha
- Michalakis Ioannis
- Michieletto Silvia
- Milligan Robert
- Misky Adam
- Mitchell Geraldine
- Monib Sherif
- Morgan Mary
- Morrison Colin
- Mortimer Caroline
- Mosahebi Afshin
- Moss Sarah
- Muhibullah Nazli
- Mullan Michelle
- Munot Kailas
- Murali Kothandaraman
- Murphy Claire
- Murphy Declan C
- Murphy John
- Mustafa Mohammed
- Mylvaganam Senthurun
- Nagachandra Geerthan
- Narayanan Sankaran
- Naseem Salma
- Nasr Rana
- Navin Channegowda
- Nguyen Dai
- Nizamoglu Metin
- O'Brien Ciara
- O'Brien Ciara
- O'Brien James
- O'Connell Rachel
- O'Connell Rachel L
- O'Donoghue Joe
- O'Leary Peter
- Okwemba Sylvia
- Oliver James
- Olsen Sisse
- Oluwajana Michael
- Otieno Charlene
- Pain Simon J
- Park Alan
- Parvanta Laila
- Patel Ashraf
- Patel Krupali
- Peel Anthony
- Pereira Bernadette
- Pereira Jerome
- Pikoulas Panagiotis
- Pilgrim Simon
- Piper Jenny
- Poonawala Shabbir
- Popa Elena
- Pope Vanessa
- Potter Shelley
- Potter Shelley
- Potter Shelley
- Power Kieran
- Prichard Ruth
- Prousskaia Elena
- Pujji Ojas
- Rainsbury Dick
- Ramakrishnan Venkat
- Ramsey Kelvin
- Rasheed Tuabin
- Rattay Tim
- Rattay Tim
- Ravichandran Duraisamy
- Ray Biswajit
- Rayter Zenon
- Refsum Sigi
- Reissis Dimitris
- Remoundos Dionysios Dennis
- Ribas Maria Dalmau
- Rizkalla Maged
- Rizki Hirah
- Rocco Nicola
- Roche Nicola
- Roncella Manuela
- Roshanlall Chandeena
- Rossetti Elena
- Rothwell Jane
- Roy Pankaj
- Rusby Jennifer
- Sahu Ajay
- Saibene Tania
- Saleem Talha
- Sami AS
- Sassoon EM
- Scott John
- Seetharam Seema
- Sethu Claire
- Seward Joanna
- Shanks Lindsay
- Shariaha Yousef
- Sherwin Liz
- Shetty Geeta
- Shokuhi Sheila
- Shrestha Deepak
- Sircar Tapan
- Sirianni Chiara
- Sirianni Chiara
- Sjokvist Olivia
- Skillman Joanna
- Skillman Joanna
- Slade-Sharman Diana
- Sloan Samantha
- Smyth Elizabeth
- Sojitra Nilesh
- Soulsby Rachel
- Soumian Soni
- Sowdi Ravi
- Stebbing Anne
- Sundaramoorthy Souganthy
- Sutton Richard
- Svenning Matilda
- Syed Farah
- Tadros Amir
- Taghizadeh Rieka
- Tansley Anne
- Tasoulis Marios
- Tayeh Salim
- Taylor Amanda
- Taylor Jevan
- Taylor Lauren
- Tebbal Sally
- Tevlin Ruth
- Thekkinkattil Dinesh
- Thomas Rachel Bright
- Thomson Simon
- Thorne Amanda
- Thrush Steven
- Tillett Rachel
- To Natalie
- Tomlins Abigail
- Trapszo Pawel
- Trickey Adam
- Turton Philip
- Udayasankar S
- Valassiadou Kalliope
- Verjee Liaquat S
- Vidya Raghavan
- Vigneswaran Natali
- Vinayagam Raman
- Vollermere Angela J
- Walker Philip
- Weiler-Mithoff Eva
- Weston-Petrides Gina
- Whisker Lisa
- Wilkins Alex
- Williamson Paula
- Wilson Rebecca
- Wilson Sherif
- Windle Rebecca
- Wintrip Dorothy
- Wood Simon
- Wooler Brendan
- Woollard Alex
- Woollard Alexander
- Yoshimura Ryo
- Young Oliver
- Younis Ibby
- Youssef Mina
- Zechmeister Katalin
- Zeidan Bashar
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Background:
Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy.
Methods:
Consecutive women undergoing mastectomy ± IBR for breast cancer July–December, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomy ± IBR were compared and risk factors associated with delays explored.
Results:
A total of 2540 patients were recruited from 76 centres; 1008 (39.7%) underwent IBR (implant-only [n = 675, 26.6%]; pedicled flaps [n = 105,4.1%] and free-flaps [n = 228, 8.9%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays.
Conclusions:
IBR does not result in clinically significant delays to adjuvant therapy, but post-operative complications are associated with treatment delays. Strategies to minimise complications, including careful patient selection, are required to improve outcomes for patients
Mortality of emergency abdominal surgery in high-, middle- and low-income countries
- Author
- A A Ahmed Ata
- A A Ibrahem
- A A Maghrabi
- A A Nasir
- A A Ne'ma Abdullah
- A Abd El Galeel
- A Abdel-Rahman Al-Aarag
- A AbdelFattah
- A Abdelgelil
- A Abdelkareem
- A Abdelmotaleb Ghazy
- A Aber
- A Abo El Magd
- A Abo Elazayem
- A Aboarab
- A Abouelnasr
- A Abouzahra
- A Adebanjo
- A Adekoya
- A Adel
- A Adel
- A Ademuyiwa
- A Adeniyi
- A Adesina
- A Adesuyi
- A Adeyeye
- A Afandy
- A Agarwal
- A Ahmed
- A Al-Mallah
- A Al-Shammari
- A Aldalaq
- A Ali
- A Ali
- A Alkammash
- A Allegri
- A Almallah
- A Almoflihi
- A Alrifaie
- A Altaf
- A Altamimi
- A Althwainy
- A Arenas
- A Ashton
- A Atef Omar
- A Austraite
- A B Zerihun
- A Badr
- A Badwy
- A Baird
- A Bamicha
- A Benevento
- A Bhangu
- A Bhargava
- A Birring
- A Boddy
- A Bondurri
- A Bonnard
- A C Manchego Bautista
- A C Manchego Bautista
- A C Roslani
- A C Snaith
- A Cacurri
- A Chambers
- A Chambers
- A Chapman
- A Chowdhury
- A Chun
- A Daltri Lazzarini Cury
- A Daqeeq
- A Das
- A Diab
- A Driscoll
- A Dubois
- A Dwydar
- A E Ajao
- A E K Musa
- A E Ward
- A Echevarria Rosas Moran
- A El Gendy
- A El Kholy
- A Elbatahgy
- A Elgebaly
- A Elkelany
- A Elkelany
- A Elkelany
- A Elkelany
- A Elkholy
- A Elshafay
- A Elwaey
- A Elwan
- A Essam Elnemr
- A Eysa
- A F Palma
- A Fadel
- A Fahiem
- A Farah
- A Faraz
- A Farquharson
- A Faure
- A Fawzy
- A Fouad
- A G N Robertson
- A Gamal Toeema
- A Garland
- A Gerosa
- A Gharib
- A Gharib
- A Gheith
- A Gomaa
- A Gouda
- A Grant
- A Gudal
- A Habeebullah
- A Hafez El-Badri Kotb
- A Hagar
- A Hammad
- A Hanks
- A Haroun
- A Hasan
- A Hasheminia
- A Hashish
- A Hassan
- A Hassan
- A Hassan
- A Hegazy Khedr
- A Horobjowsky
- A Hussein
- A Huwait
- A J Fowler
- A Jabbar
- A Karim
- A Kenibar
- A Khairy Aly
- A Khalique
- A Khan
- A Khoja
- A Khyrallh
- A Kiasat
- A Kirishnan
- A Kirupagaran
- A Kjellin
- A Kolosov
- A Kyaw Tun
- A L Contreras Vergara
- A L Mclean
- A Lasheen
- A Leal
- A Leppäniemi
- A Livesey
- A M Afifi
- A M Altwigry
- A M Attia
- A M Elkorashy
- A M Hammad
- A M Mphatsoe
- A M Saeed
- A M Shariffuddin
- A M Warwick
- A Macdonald
- A Macfarlane
- A Maffioli
- A Mahdi
- A Maniscalco
- A Marey
- A Martin
- A Mcguigan
- A Mcphee
- A Menshawy
- A Minocha
- A Mirza
- A Mistry
- A Mittal
- A Mohameden
- A Mohammad
- A Mohammed
- A Mohammed
- A Mokhtar
- A Morsi
- A Mosad
- A Munera
- A Nabawi
- A Nashaat
- A Nasr
- A Nawawi
- A Negida
- A Nesaratnam
- A Niragire
- A Nocito
- A Novak
- A Ogunyemi
- A Oluwagbemiga Lawal
- A Oosterkamp
- A Osama Elsebaaye
- A Osinowo
- A Osman Abdelaziz Elhendawy
- A P Arnaud
- A Popoola
- A Powell
- A Prabhudesai
- A R Mitul
- A Ragab Nayel
- A Ragab Soliman
- A Ramadan
- A Ramos-De La Medina
- A Rasendran
- A Rasendran
- A Rasendran
- A Rashid
- A Raslan
- A Riaz
- A Rotundo
- A Rslan
- A Rudzenskaite
- A S Mironescu
- A S North
- A Sabry
- A Sabry El-Hamouly
- A Sadek
- A Safwan Marey
- A Sakr
- A Salah Elsherbiny
- A Salleh
- A Samir
- A Sanad
- A Sayed
- A Scalabre
- A Shabkah
- A Shah
- A Shalaby
- A Sheshe
- A Skardžiukaitė
- A Solaiman El-Ma'doul
- A Spina
- A Sreedharan
- A Sriram
- A Stephen
- A Strazdas
- A Szczap
- A Tade
- A Tammam
- A Tanase
- A Tanase
- A Tang
- A Tarek
- A Tarek Hafez
- A Thorell
- A Usaityte
- A Vega Carreiro De Freitas
- A Venâncio De Sousa
- A Vlachogiorgos
- A W Anwar
- A Watts
- A Williamson
- A Wilson
- A Zani
- A Zardab
- A Zeynel A Balkan
- A Zil-E-Ali
- Abid Bin Mahamood
- B Albeladi
- B Alghamdi
- B B Ozkan
- B B Ozkan
- B Cameron
- B F Hon Khi Chong
- B Frisk
- B Magdy
- B Mansour
- B Mijuskovic
- B Nighat
- B Odeyemi
- B Pereira
- B Pereira Silvestre
- B S Kumar
- B Sieda
- B Skelly
- B Thompson
- B Van Duren
- B Weber
- B Wolf
- B-V Martian
- C A Arroyo Basto
- C A Azmitia Mendizabal
- C Agalianos
- C Anthoulakis
- C Beaton
- C Bode
- C Boereboom
- C Bowman
- C C Goh
- C C L Szeto
- C C Ramã Rez Cabrera
- C Ceriani
- C Chandrakumar
- C Clifford
- C Currow
- C Dervenis
- C Diaz-Zorrilla
- C E Lopez
- C Fahy
- C Fairfield
- C Fairfield
- C Fermani
- C Gouldthorpe
- C Grossart
- C Hand
- C Hinojosa
- C Houlden
- C I Pérez Velásquez
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- Y N Neo
- Y P Mogan
- Y Rajjoub
- Y Reddy
- Y Salama
- Y Sinha
- Z Chan
- Z Dambrauskas
- Z Hassan
- Z Iftikhar
- Z Jaffry
- Z Mikwar
- Z Oof
- Z Urniezius
- Z Zhang
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2016
- Field of study
Background: Surgical mortality data are collected routinely in high-income countries, yet virtually no low- or middle-income countries have outcome surveillance in place. The aim was prospectively to collect worldwide mortality data following emergency abdominal surgery, comparing findings across countries with a low, middle or high Human Development Index (HDI).
Methods: This was a prospective, multicentre, cohort study. Self-selected hospitals performing emergency surgery submitted prespecified data for consecutive patients from at least one 2-week interval during July to December 2014. Postoperative mortality was analysed by hierarchical multivariable logistic regression.
Results: Data were obtained for 10 745 patients from 357 centres in 58 countries; 6538 were from high-, 2889 from middle- and 1318 from low-HDI settings. The overall mortality rate was 1⋅6 per cent at 24 h (high 1⋅1 per cent, middle 1⋅9 per cent, low 3⋅4 per cent; P < 0⋅001), increasing to 5⋅4 per cent by 30 days (high 4⋅5 per cent, middle 6⋅0 per cent, low 8⋅6 per cent; P < 0⋅001). Of the 578 patients who died, 404 (69⋅9 per cent) did so between 24 h and 30 days following surgery (high 74⋅2 per cent, middle 68⋅8 per cent, low 60⋅5 per cent). After adjustment, 30-day mortality remained higher in middle-income (odds ratio (OR) 2⋅78, 95 per cent c.i. 1⋅84 to 4⋅20) and low-income (OR 2⋅97, 1⋅84 to 4⋅81) countries. Surgical safety checklist use was less frequent in low- and middle-income countries, but when used was associated with reduced mortality at 30 days.
Conclusion: Mortality is three times higher in low- compared with high-HDI countries even when adjusted for prognostic factors. Patient safety factors may have an important role. Registration number: NCT02179112 (http://www.clinicaltrials.gov)
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
- Author
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- &apos
- Aahlin Ek
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader Sm
- Abdel-Wahab Nye
- Abdelaal A
- Abdelaty M
- Abdelazeam Ar
- Abdelazim G
- Abdelaziz Ma
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf Am
- Abdelrouf Dm
- Abdelshafy M
- Abdelshakour M
- Abdrabou Ak
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdulgawad M
- Abdulhakeem Em
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- Abdullah Nan
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- Abdurrazzaaq A
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- Abington E
- Abiola O
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- Aboelmagd O
- Aboelsoud Mr
- Aboraya M
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- Ademuyiwa A
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- Adeniran J
- Adeniran J
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- Adeniyi A
- Adesanya O
- Adesanya O
- Adesina A
- Adesina A
- Adesuyi A
- Adeyeye A
- Adeyeye A
- Adeyeye A
- Adham W
- Adhitama N
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- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
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- Al-Faqawi M
- Al-Farram H
- Al-Hameedi Hii
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- Aljiffry M
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- Alkaaki A
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- Alkhabbaz D
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- Allam M
- Allam Y
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- Allott R
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- Alomar In
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- AlRowais M
- Alsaggaf M
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- Altinel Y
- Altinel Y
- Altoe F
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- Alvi Ar
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- Aly Ak
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- Alyami R
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- Alzahrani Mna
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- Aman Nf
- Amandito R
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- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer Ma
- Amin Haa
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- Amin J
- Amjad M
- Ammar M
- Ammar Ms
- Amoah M
- Amoako J
- Amoako Pt
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
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- Andika Ffa
- Andreotti D
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- Andriola V
- Ang Yl
- Angelieri D
- Anis E
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- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
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- Antoniozzi A
- Anwar Aw
- Anwar N
- Anwer W
- Anyanwu Lj
- Anyanwu Lj
- Aonzo P
- Appeadu-Mensah W
- Appiah Ek
- Aql S
- Aquilino F
- Arachchi Pp
- Arachchige Lajj
- Arafa O
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- Arango Mcm
- Arango Mcm
- Arango Mcm
- Arango Mcm
- Araujo Jslr
- Arcudi C
- Ardley R
- Arenas A
- Arman S
- Arman S
- Armellini A
- Arnaud A
- Arnaud Ap
- Arnaud Ap
- Arnaud Ap
- Arshad Mm
- Arslan E
- Arsyad Hm
- Arthur T
- Arulampalam T
- Aruldas N
- Asaat Ul Razi S
- Asal M
- Asar Yh
- Asare-Bediako K
- Asele Fa
- Ashour A
- Ashour A
- Ashour K
- Ashraf Sf
- Ashtari M
- Ashton A
- Asi F
- Asilah Smd
- Assal A
- Assouto Pa
- Asturias S
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- Atiyeh A
- Atkins Et
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- Attallah Na
- Attard M
- Attia A
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- Augestad Km
- Aung Kp
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad Sa
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo Oo
- Aydin Mc
- Ayyar S
- Aziz Dna
- Aziz Mra
- Aziz Na
- Azizeldine Mg
- Azmitia Jra
- Azodo Ia
- Azzie G
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- Bachri H
- Badawy M
- Badenjki Ma
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- Baheeg M
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- Baillie K
- Baillie K
- Baird A
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- Baki Be
- Bakr A
- Bakry Hm
- Baky Fahmy MA
- Bala M
- Balalis D
- Baldacchino M
- Balducci G
- Balila Rmh
- Balkan Aza
- Ballouhey Q
- Balmaceda R
- Balmaceda R
- Balmaceda R
- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis Vj
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal Gs
- Baraka H
- Barakat Sae
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas Gn
- Barnacle J
- Barneo L
- Barrantes Ams
- Barreda Lma
- Barrientos Lam
- Barrios E
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- Batt J
- Bautista Acm
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- Bayram S
- Beamon M
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- Beaton C
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- Bediako-Bowan A
- Behar N
- Beisa V
- Beisa V
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- Bhopal Kf
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- Blacker S
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- Bluelle R
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- Burmistrovas A
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- Castro Mr
- Catani M
- Cautiero R
- Caydiid H
- Cecilia T
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- Clifford C
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- Danys D
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- de Lima CVB
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- El Sayed GS
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- El-Latif Nka
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- El-Rabaa S
- El-Sagheer N
- El-Salam Fa
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- El-Taher E
- Elabdin Hz
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- Elfouly Y
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- Elhadad A
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- Elhendawy A
- Elhendawy Aoa
- Elhoseny G
- Elhusseiny Aae
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek Ea
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- Elkholy Ss
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- Elkorashy Am
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- Elmashala A
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- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar Ma
- Elnemr Ae
- Elrasoul Ya
- Elrazek Aa
- Elsabbagh N
- Elsameea Aa
- Elsawahly Dme
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed Nar
- Elsayed Zm
- Elsebaaye Ao
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay Ae
- Elshami M
- Elshanwany S
- Elsharkawy Aa
- Elsheikh S
- Elsherbiney S
- Elsherbiny As
- Elsherif Fa
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy Deaa
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escobar Eg.
- Espin-Basany E
- Espinoza F
- Espinoza Kt
- Espinoza Kt
- Essam A
- Essam Aa
- Essam M
- Essoun S
- Esteban E
- Estee Mm
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista Cv
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
- Fakher R
- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat Mm
- Faraz A
- Fares M
- Farfan Esf
- Farhad M
- Farhan-Alanie Mmh
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
- Fergusson Sj
- Fergusson Sj
- Fermani C
- Fermani Cg
- Ferná
- Fernandes C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferreira Sak
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald Je
- Florez Ljg
- Foco M
- Fok Cyj
- Fontana T
- Foo Cc
- Forlin L
- Forno W
- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler Aj
- Fozard T
- Fozard T
- Frade F
- Fraga Gp
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas Av
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan Mm
- Gü
- Gü
- Gaafar S
- Gaarder T
- Gad A
- Gad Mo
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaiž
- Gaignard E
- Gaignard E
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez Cp
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan Yy
- Gani Ma
- Garaycochea O
- Garcí
- Garcí
- Garcí
- Garcia-Florez L
- Garcia-Marin Ja
- Garcia-Perez Jm
- Garland A
- Gash K
- Gash K
- Gash K
- Gastaldi P
- Gasteratos K
- Gaujoux S
- Gavagna L
- Gbessi Dg
- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
- Germanos S
- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
- Ghandora N
- Ghanem A
- Ghanem E
- Ghanem S
- Ghanem S
- Ghannam M
- Gharib A
- Gharib A
- Ghazy Aa
- Gheith A
- Ghetia M
- Ghetia M
- Ghonaim Ma
- Ghoneem M
- Ghoneim O
- Giacci L
- Giardino Fr
- Giavarini L
- Giglio Mc
- Gilbert R
- Gilbert Rw
- Giles J
- Gillespie M
- Gimzewska M
- Giraldo Rsr
- Giuliani S
- Giuliani S
- Giuriato Tf
- Gkiokas G
- Glasbey J
- Glasbey J
- Glasbey Jc
- Glasbey Jc
- Glover Te
- Glover-Addy H
- Glynn M
- Gobin N
- Gobin N
- Goh Cc
- Goh Cc
- Goh W
- Gohar Meam
- Gokani S
- Goldin E
- Golding D
- Gomaa A
- Gomah M
- Gonzalez M
- Gonzalez Sc
- Goodstein M
- Gosling S
- Gosling Sg
- Gouda A
- Gould L
- Gouldthorpe C
- Gouvas N
- Gouws J
- Graffeille V
- Graffieille V
- Gran M
- Grandinetti Pp
- Grant A
- Grasset E
- Grasset E
- Grassi V
- Gratton R
- Gravante G
- Gravante G
- Gray D
- Grech N
- Green N
- Grella Mg
- Gribauskaite J
- Griffiths E
- Griffiths E
- Griffiths M
- Grima T
- Grisin E
- Grizhja B
- Grobler Dc
- Grosos C
- Grossart C
- Guasti Bpsj
- Gudal A
- Gudal A
- Gudal A
- Gudlaugsdottir K
- Guevara R
- Guglielmo V
- Gui D
- Gulbinas A
- Gulcicek Ob
- Gulielmi A
- Gultom Pa
- Gumar M
- Gunaseelan K
- Gunawan R
- Guner A
- Gunnarsson U
- Guo W
- Gupta A
- Gustafsson U
- Gyamfi Fe
- Gyanchandani N
- Gyedu A
- Habeeb Ma
- Habeeb O
- Habeebullah A
- Hache-Marliere M
- Haddad N
- Hafez At
- Hafez M
- Hafez M
- Hafez S
- Haffreingue A
- Hafiz S
- Hagan R
- Hagar A
- Haines M
- Haines S
- Hajeh H
- Hakim H
- Halhouli O
- Halhouli O
- Halicioglu I
- Hall E
- Hall N
- Hall Nj
- Hall Tf
- Hallam S
- Haloho A
- Hamad Mgm
- Hamaguchi Jlh
- Hamarshi A
- Hamasaki J
- Hamdan A
- Hamdan M
- Hamed Mf
- Hamill D
- Hammad A
- Hammad A
- Hammad Am
- Hampton M
- Hampton Mi
- Hamsho W
- Hanafy M
- Hand C
- Hanks A
- Hanley I
- Hanoun S
- Hanrahan M
- Hanrahan M
- Hanrahan M
- Hanrahan M
- Hantour U
- Hantour U
- Hany E
- Haque M
- Har Pa
- Haraux E
- Harbord P
- Haroun A
- Harper E
- Harrison Em
- Harrison Em
- Harrison N
- Harrison P
- Harrison R
- Hartford L
- Harvey N
- Hasan A
- Hasan A
- Hasan D
- Hasanah A
- Hasanain D
- Hascoet J
- Hashad E
- Hasheminia A
- Hashim A
- Hashish A
- Hashish M
- Haslegrave A
- Hasnan Mb
- Hassaan A
- Hassaan A
- Hassan A
- Hassan A
- Hassan A
- Hassan Ata
- Hassan I
- Hassan M
- Hassan Omm
- Hassan S
- Hassan Z
- Hassanain M
- Hassanain M
- Hassanein Ab
- Havemann I
- Hawkins W
- Heard R
- Heath J
- Heffernan D
- Hegazy Em
- Hegazy Y
- Helene Fc
- Helguero-Santin Lm
- Hemeda D
- Hemingway D
- Hemmila M
- Hemmila M
- Henderson L
- Henderson L
- Heng He
- Henric N
- Henry F
- Henshall De
- Herebat A
- Herikstad R
- Herrera N
- Herrera-Matta J
- Herrod P
- Hervieux E
- Hervieux E
- Hesham O
- Hettiarachchi Ts
- Hewage K
- Heywood Eg
- Highcock S
- Hilal K
- Hinojosa C
- Hjertberg M
- Hjertberg M
- Hmila S
- Ho A
- Ho Cw
- Ho W
- Ho Wc
- Hodonou F
- Hogea M
- Holte S
- Holton P
- Homeida A
- Hoogakker E
- Horobjowsky A
- Hosein Sp
- Hosh M
- Hossaini S
- Hossameldin A
- Houlden C
- Howells L
- Howie Ee
- Hrora A
- Huaman E
- Huaraya Rc
- Humm G
- Hunter K
- Hussain M
- Hussein A
- Hussein S
- Husseini M
- Husseiny R
- Hutch W
- Huwait A
- Iş
- Iacono C
- Iannone I
- Ibraheem Aa
- Ibraheem Hi
- Ibrahem Aa
- Ibrahem Aa
- Ibrahim A
- Ibrahim A
- Ibrahim A
- Ibrahim Am
- Ibrahim E
- Ibrahim Em
- Ibrahim I
- Ibrahim K
- Ibrahim M
- Ibrahim Mh
- Ibrahim Y
- Idress T
- Idris F
- Idris Sai
- Iftekhar F
- Iftikhar Z
- Iftikhar Z
- Ignatavicius P
- Ihediwa G
- Imoro O
- Ingabire Jca
- Ingabire Jca
- Ingabire Jca
- Ioannidis O
- Iordache Fm
- Iqbal Fm
- Iqbal Mr
- Ireland P
- Irtan S
- Irtan S
- Irwin G
- Irwin G
- Irwin G
- Irwin G
- Ishak N
- Iskandar F
- Ismaï
- Ismaï
- Ismaï
- Ismaï
- Ismail A
- Ismail M
- Ismail M
- Ismail Mjb
- Ismail Mk
- Ismail Sa
- Israelsson L
- Ivros N
- Iyer D
- Iyer D
- Iyer D
- Jabal Ms
- Jabbar A
- Jaber S
- Jackson P
- Jacobe M
- Jaffry Z
- Jaffry Z
- Jaich R
- Jain P
- Jama Gm
- Jamal L
- Janardha Kc
- Janik M
- Jankus T
- Jaradat D
- Jaramillo Ra
- Jarmin M
- Jasaitis K
- Javaid M
- Javed O
- Javed O
- Jawaid M
- Jayathilake Ab
- Jck Ng
- Jean-Francois C
- Jeffery A
- Jeffery A
- Jenner E
- Jennings L
- Jennings V
- Jennings V
- Jensen E
- Jenvey C
- Jeo Ws
- Jeon H
- Jeremic L
- Jethwani Dl
- Jeyakumar J
- Jeyakumar J
- Jha M
- Jimenez J
- Jimenez-Morillas P
- Joel Lwl
- Johanna N
- Johnson K
- Johnston R
- Jokubauskas M
- Jokubauskas M
- Jokubonis K
- Jones C
- Jones C
- Jones E
- Jones Tf
- Jonnalagadda R
- Joosten J
- Jordan H
- Jotautas V
- Jotautas V
- Jovine E
- Jovine E
- Jubran Af
- Juciute S
- Julaihi R
- Jurdell E
- Kaafarani H
- Kabariti R
- Kabariti R
- Kabba J
- Kabongo K
- Kache S
- Kaci Aa
- Kadiwar S
- Kalakouti E
- Kalles V
- Kalles V
- Kalles V
- Kamarajah Sk
- Kamarulzamil Sna
- Kamil R
- Kamya S
- Kanani A
- Kandil Am
- Kandil H
- Kang Mk
- Kanta Th
- Karabacak U
- Karabelias G
- Karabulut K
- Karahan Sr
- Karakahya M
- Karandikar S
- Karandikar S
- Kariem N
- Karim A
- Karim R
- Karim S
- Karismaningtyas H
- Karjiker P
- Karkeet M
- Karkeet M
- Karlo R
- Karlo R
- Karousos D
- Karumnas P
- Kaselis N
- Kaselis N
- Kasem E
- Kasem Ea
- Kasputyte S
- Kaul A
- Kazanavicius D
- Kedar A
- Kefalidi E
- Keke Kr
- Kelany M
- Kenibar A
- Kennedy Ed
- Kennedy M
- Kennedy R
- Keogh K
- Kerley R
- Kershaw S
- Kesinger M
- Khafagy T
- Khairy H
- Khairy H
- Khajanchi M
- Khaled H
- Khalifah E
- Khalili M
- Khalique A
- Khallaf S
- Khamajeet A
- Khan A
- Khan K
- Khan Ma
- Khan R
- Khan S
- Khan T
- Khan Za
- Kharsa S
- Khatri C
- Khatri C
- Khattab K
- Khedr Aeh
- Khg Li
- Khoja A
- Khoja A
- Khokha D
- Khokha V
- Khosla S
- Khreishi R
- Khreishi R
- Khulu Lb
- Khyrallh A
- Kiasat A
- Kidd T
- Kielty P
- Kim My
- Kim Sb
- Kim Sh
- Kimaro M
- Kinandu K
- King R
- King S
- King S
- Kinnera Sv
- Kiran Rp
- Kirby A
- Kirishnan A
- Kirupagaran A
- Kiudelis M
- Kjellin A
- Kkk Li
- Klappenbach R
- Knight S
- Koay Kl
- Kobal Bb
- Koh C
- Koh H
- Koh Py
- Koh S
- Koh S
- Kojo Att
- Kojo Att
- Kojo Att
- Kolosov A
- Komolafe O
- Kondrotas P
- Kong C
- Kong Sn
- Kong V
- Kong V
- Konstantina K
- Kontos M
- Kordorwu Hek
- Korkolis D
- Kosai Nr
- Kosai Nr
- Kose E
- Koskenvuo L
- Kostov E
- Kotb Ahe
- Kotecha D
- Koto Mz
- Kotobi H
- Koumpa F
- Kouraklis G
- Kourdouli A
- Kourdouli A
- Kretzmann H
- Krishna K
- Kruspi S
- Kufeji D
- Kulasabanathan K
- Kuliavas J
- Kumar B
- Kumar B
- Kumar B
- Kumar Bs
- Kumar Mn
- Kumar S
- Kumar S
- Kumar S
- Kumar S
- Kumar T
- Kumwenda D
- Kushwaha S
- Kushwaha S
- Kusi K
- Kutkevicius J
- Kwakyeafriyie P
- Kwatiwani C
- Kwizera S
- Kwok Sh
- Kyereh M
- Kyriazanos I
- Kyrou G
- Kyziridis D
- Ló
- L&apos
- La Brocca A
- la Medina AR
- la Medina AR
- la Medina AR
- Labib P
- Ladukas A
- Lafferty K
- Lagunavicius K
- Lai Ac
- Lakhani Sm
- Lakshmi Hn
- Lam Fy
- Lam Jcy
- Lam Wh
- Lamanna Gl
- Lanau Miv
- Lando J
- Landolfo G
- Landolfo G
- Lap G
- Lapitan Mc
- Lapitan Mc
- Larsen Jw
- Lasek A
- Lasheen A
- Lasheen Kt
- Latif A
- Laufer Lav
- Laugzemys E
- Laugzemys E
- Laurie K
- Lauzikas G
- Law Jh
- Lawal A
- Lawal Ao
- Lawal T
- Lawal Ta
- Lawani I
- Lawther R
- Lazzari G
- Lazzari V
- Leal A
- Leal M
- Lecompte Jf
- Lee C
- Lee Ex
- Lee F
- Lee K
- Lee Kc
- Lee Ky
- Lee Tsb
- Lemaire Sb
- Leone N
- Leong Fqh
- Leppä
- Leppä
- Leroux J
- Leung Kw
- Leung Mf
- Leusink A
- Lewis J
- Li Ws
- Licari L
- Lieske B
- Lieske B
- Liew I
- Liew I
- Lilford R
- Lilford R
- Lilford Rj
- Lim G
- Lim H
- Lim J
- Lim Pj
- Lim Sj
- Lim Sj
- Lim Sy
- Limache S
- Limaye N
- Limoges B
- Lintin L
- Lipnickas V
- Litvin A
- Liu Q
- Liu Q
- Livesey A
- Livingston M
- Ljuhar D
- Lo Conte A
- Loaloa Mr
- Lockey J
- Lohse Has
- Lohse Has
- Loizides S
- Lokman Maa
- Longstaff L
- Lopez Ce
- Lopez Lip
- Lopez M
- Lopez M
- Lopez-Arevalo C
- Lorenzon L
- Lossius Wj
- Loughran D
- Low X
- Luc Ar
- Luck J
- Luck J
- Luck J
- Luglio G
- Lund J
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- Lundgren Po
- Luque Gb
- Luque L
- Luque L
- Lytras D
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- Má
- Mé
- Mü
- Mañ
- Ma J
- Mabitsela Me
- Mabrouk M
- Macchiavello R
- Macchitella Y
- Macchitella Y
- Macdermid E
- Macdonald A
- Macdonald E
- Macdonald L
- Maceviciute K
- Macfarlane A
- Machaca M
- Maciejec L
- Madiba T
- Madkor Mh
- Maffioli A
- Maffioli A
- Magdy A
- Magdy B
- Magdy E
- Magdy H
- Magdy M
- Magdy S
- Magee C
- Maghrabi A
- Maghrabi Aa
- Magri D
- Mahamood Ab
- Mahanty S
- Maharaj G
- Mahdi A
- Mahdi S
- Mahdi S
- Maher Me
- Mahmoud B
- Mahmoud H
- Mahmoud M
- Mahmoud Ma
- Mahmoud Mi
- Mahmoud S
- Mahmoud Sme
- Mahmud K
- Maillot B
- Maimbo M
- Maimbo M
- Mairs Ng
- Maison K
- Maistry N
- Majauskyté
- Majbar A
- Majid Ahha
- Majid K
- Major Cp
- Major P
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- Mak T
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- Makama J
- Makinde M
- Makupe A
- Malavenda M
- Malik K
- Malik P
- Malik Ta
- Mamdouh E
- Mamdouh R
- Manatakis Dk
- Manfreda S
- Mangan C
- Mangan C
- Mangiapane M
- Manipal Ce
- Maniscalco A
- Mann T
- Mannu Gs
- Manriquez-Reyes M
- Mansor Ey
- Mansour B
- Mansour S
- Mansuri A
- Mao P
- Mapasse D
- Maple N
- Maraie N
- Marey A
- Marey As
- Margaritis M
- Mariani A
- Marinkovic B
- Marinos C
- Marks E
- Marples L
- Marret Jb
- Marshall Dc
- Martian Bv
- Martin A
- Mas R
- Mason C
- Mata Lps
- Matheu A
- Mathew Sw
- Matos-Puig R
- Matta Jjh
- Mattar O
- Matter Sm
- Mauro L
- Mayasari M
- Mazelyte R
- Mazrimas P
- Mazzella A
- Mcaleer E
- Mcaleer S
- Mccarthy K
- Mccarthy M
- Mccarthy M
- McCullagh D
- Mcdonald R
- McGarvie S
- Mcguigan A
- McIntosh K
- Mcintosh R
- Mcintyre Cj
- Mcintyre N
- Mcintyre R
- Mckechnie D
- Mclachlan G
- Mclean Al
- Mclean K
- McMorran D
- Mcnish D
- Mcphee A
- Mealy K
- Mehdi A
- Mehrez S
- Mejia Agv
- Melo R
- Melo R
- Mendel H
- Mendez M
- Mendez N
- Mendizabal Caa
- Mendoza I
- Menegussi J
- Mensah E
- Menshawy A
- Mentula P
- Meqbil J
- Mericliler M
- Merlini D
- Merlini D
- Merlo Ms
- Mesbah N
- Meshref A
- Metwally Mm
- Migliore M
- Miguel Gps
- Mihaljevic Al
- Mihanovic J
- Mihanovic J
- Mijuskovic B
- Mikalauskas S
- Mikalauskas S
- Mikuckyte D
- Mikwar Z
- Milligan W
- Milligan W
- Mingrone P
- Minguez G
- Minocha A
- Minocha A
- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
- Mironescu A
- Mironescu As
- Mironescu As
- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
- Mitroudis N
- Mittal A
- Mitul Ar
- Mitul Ar
- Miyasato Hs
- Mizzi C
- Mizzi S
- Mlotshwa M
- Moaty M
- Mochet S
- Modolo Mm
- Modolo Mm
- Modolo Mm
- Moe Tt
- Mogan Yp
- Moghazy Me
- Mohamed A
- Mohamed A
- Mohamed Am
- Mohamed Ar
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed Ma
- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
- Mohammed A
- Mohammed Ae
- Mohammed Ar
- Mohammed H
- Mohammed Mm
- Mohammed Mmh
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok Yt
- Mokhtar A
- Molina G
- Mollo Mc
- Monaghan E
- Monaghan E
- Monrad-Hansen Pw
- Montejo Msg
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
- Moore R
- Mora Jjv
- Morais Pab
- Morales C
- Moran Aer
- Morandi E
- Moreira G
- Moreno Sc
- Morgan C
- Morgan C
- Morshedy Em
- Morsi A
- Morsi M
- Morton D
- Morton D
- Morton R
- Mosad A
- Mosalum O
- Mostafa Ha
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe Am
- Mshelbwala P
- Msiska N
- Msosa V
- Msosa V
- Muddebihal U
- Mukin Adf
- Muktar U
- Mukuzunga C
- Muller C
- Muller C
- Munera A
- Munhoz Mm
- Munipalle Pc
- Muntean L
- Muntean Li
- Muralha N
- Murphy J
- Murray A
- Murutoglu B
- Musa Aek
- Musleh A
- Musowoya J
- Mussad A
- Mustafa M
- Mustafa M
- Mustafa Ma
- Musyoka Ck
- Mutabazi Az
- Mutabazi Az
- Mutlu D
- Mutlu V
- Muzio E
- Myers J
- Mykoniatis I
- Næ
- Nabawi A
- Nada F
- Nadeem N
- Nadkarni S
- Nagy Gs
- Nahar Sn
- Nair H
- Nanthakumaran S
- Napolitano L
- Napolitano L
- Naqvi Sa
- Naqvi T
- Naranjo Aristizã
- Narayanan R
- Narayanan R
- Narvestad Jk
- Nashaat A
- Nashat M
- Nasher O
- Nashidengo P
- Nasir A
- Nasir Aa
- Nasr A
- Nasr M
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- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
The evolution of lung cancer and impact of subclonal selection in TRACERx
- Author
- Abbosh Christopher
- AbdulJabbar Khalid
- Aerts Hugo J. W. L.
- Ahmad Tanya
- Ahmed Asia
- Al Bakir Maise
- Al-Sawaf Othman
- Alzetani Aiman
- Ambrose Lyn
- Ang Keng
- Angelova Mihaela
- Ashford Paul
- Asif Mo
- Athanasopoulou Foteini
- Austin Silvia
- Bailey Chris
- Bajaj Amrita
- Bandula Steve
- Barbè Vittorio
- Beck Stephan
- Begum Sofina
- Benafif Sarah
- Bentham Robert
- Bhakhri Kunal
- Bhayani Harshil
- Bilancia Rocco
- Birkbak Nicolai J.
- Bishop Paul
- Biswas Dhruva
- Black James R. M.
- Blackhall Fiona H.
- Blyth Kevin G.
- Boeing Stefan
- Bola Supreet Kaur
- Boleti Ekaterini
- Booth Sarah
- Borg Elaine
- Boyles Rebecca
- Brown Kate
- Buderi Silviu I.
- Bunkum Abigail
- Campbell Brittany B.
- Carter Mathew
- Castignani Carla
- Cave Judith
- Chain Benny
- Chan Kitty
- Chaturvedi Anshuman
- Chavan Hema
- Chee Serena
- Chen Kezhong
- Chervova Olga
- Cheyne Heather
- Choudhary Junaid
- Chowdhry Mohammed Fiyaz
- Chuter David
- Clark Tristan
- Clipson Alexandra
- Collins-Fekete Charles-Antoine
- Colliver Emma
- Cook Daniel E.
- Crosbie Philip
- Cruickshank Tracey
- Danson Sarah
- De Sousa Paulo
- Demeulemeester Jonas
- Denner Tamara
- Devaraj Anand
- Dhanda Harjot Kaur
- Dick Craig
- Dietzen Michelle
- Dijkstra Krijn
- Diossy Miklos
- Dive Caroline
- Djearaman Madava
- Doran Helen
- Dulloo Sean
- Enfield Katey S. S.
- Ensell Leah
- Escudero Mickael
- Falzon Mary
- Fennell Dean A.
- Fernandes Nadia
- Fontaine Eustace
- Forster Martin D.
- Fraioli Francesco
- Frankell Alexander M.
- Gamble Samuel
- Gilbert Kayleigh
- Gimeno-Valiente Francisco
- Goldman Jacki
- Gomes Fabio
- Gorman Pat
- Gower Nicole
- Granato Felice
- Grapa Anca
- Grigoriadis Kristiana
- Grönroos Eva
- Gálvez-Cancino Felip
- Hackshaw Allan
- Hartley John A.
- Hayward Martin
- Herrero Javier
- Hessey Sonya
- Hewish Madeleine
- Hiley Crispin T.
- Hill Mark S.
- Hill William
- Hobson Philip
- Hodgkinson Jack Davies
- Holding James W.
- Hoxha Elena
- Huebner Ariana
- Hynds Robert E.
- Ingram Papawadee
- Jamal-Hanjani Mariam
- Janes Sam M.
- Jordan Simon
- Joseph Leena
- Joshi Vijay
- Kadiri Salma
- Kaniu Daniel
- Kanu Nnennaya
- Karagianni Despoina
- Karamani Angeliki
- Karasaki Takahiro
- Kassiotis George
- Kaufmann Tom L.
- Kerr Alastair
- Kerr Keith M.
- Khalil Mohammed
- Khiroya Reena
- Kilgour Elaine
- Kirk Alan
- Kisistok Judit
- Kostoulas Nikos
- Krebs Matthew G.
- Lacson Christer
- Lam Jie Min
- Langman Gerald
- Larose Cadieux Elizabeth
- Lawrence David
- Le Quesne John
- Le Quesne John
- Lee Claudia
- Lee Siow Ming
- Leek Angela
- Leslie Rachel
- Lester Jason F.
- Leung Michelle
- Levi Dina
- Lim Emilia L.
- Lim Eric
- Lindsay Colin R.
- Litchfield Kevin
- Litovchenko Maria
- Liu Wing Kin
- Lowe Helen L.
- Lu Wei-Ting
- Lucas Olivia
- López Saioa
- MacKenzie Mairead
- Magness Alastair
- Malima Mpho
- Marafioti Teresa
- Marrone Domenic
- Martinoni Hoogenboom Emilie
- Martínez-Ruiz Carlos
- Mastrokalos Gerasimos
- Matharu Gurdeep
- Matos Ignacio
- McGranahan Nicholas
- Middleton Gary
- Miedema Daniël M.
- Monk Fleur
- Montero Angeles
- Moore David A.
- Moss Stuart
- Mourikis Thanos P.
- Naceur-Lombardelli Cristina
- Naidu Babu
- Nair Arjun
- Naito Yutaka
- Nakas Apostolos
- Navani Neal
- Ng Kevin W.
- Nicholson Andrew G.
- Nicod Jerome
- Novasio Juliette
- Nye Emma
- Oliveira Pedro
- Osman Aya
- Pan Xiaoxi
- Panagiotopoulos Nikolaos
- Papadatos-Pastos Dionysis
- Patel Akshay J.
- Patrini Davide
- Pawlik Piotr
- Pearce David R.
- Peggs Karl S.
- Pich Oriol
- Pilotti Camilla
- Price Gillian
- Priest Lynsey
- Primrose Lindsay
- Procter Alexander James
- Proli Chiara
- Prymas Paulina
- Puttick Clare
- Quezada Sergio A.
- Rammohan Kendadai
- Ramsden Zoe
- Rane Jayant K.
- Rathinam Sridhar
- Raubenheimer Hilgardt
- Reading James L.
- Rice Alexandra
- Richard Corentin
- Richards Jennifer
- Richardson Shirley
- Riley Joan
- Robinson Lily
- Rosenthal Rachel
- Rothwell Dominic G.
- Rowan Andrew
- Royle Gary
- Russell Peter
- Saghafinia Sadegh
- Salgado Roberto
- Scarci Marco
- Scarlett Lydia
- Schwarz Roland F.
- Scotland Molly
- Selvaraju Kayalvizhi
- Shackcloth Michael J.
- Shackleford Helen
- Shah Mansi
- Shah Pratibha
- Shah Rajesh
- Sharp Abigail
- Shaw Jacqui A.
- Sivakumar Monica
- Smith Elaine
- Smith Jon
- Smith Sean
- Sodha-Ramdeen Azmina
- Sokac Mateo
- Spanswick Victoria
- Stavrou Georgia
- Stephens Robert CM.
- Stewart Aengus
- Stone Richard Kevin
- Summers Yvonne
- Swanton Charles
- Szallasi Zoltan
- Tanić Miljana
- Taylor Magali N.
- Thakkar Krupa
- Thakrar Ricky M.
- Thol Kerstin
- Thomas Mathew
- Toncheva Antonia
- Totten Nicola
- Tufail Mohamad
- Tugwood Jonathan
- Ung Seng Kuong Anakin
- Van Loo Peter
- Van Loo Peter
- Vanloo Sharon
- Vasquez Marcos
- Veeriah Selvaraju
- Veiga Catarina
- Vendramin Roberto
- Ward Sophia
- Watkins Thomas B. K.
- Weeden Clare E.
- Werner Sunderland Mariana
- Wilson Claire
- Wilson Gareth A.
- Wilson James
- Wong Yien Ning Sophia
- Wu Yin
- Xing Wei
- Yuan Yinyin
- Zaccaria Simone
- Zhai Haoran
- Zhang Hanyun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 20/04/2023
- Field of study
Lung cancer is the leading cause of cancer-associated mortality worldwide. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx study. This project aims to decipher lung cancer evolution and address the primary study endpoint: determining the relationship between intratumour heterogeneity and clinical outcome. In lung adenocarcinoma, mutations in 22 out of 40 common cancer genes were under significant subclonal selection, including classical tumour initiators such as TP53 and KRAS. We defined evolutionary dependencies between drivers, mutational processes and whole genome doubling (WGD) events. Despite patients having a history of smoking, 8% of lung adenocarcinomas lacked evidence of tobacco-induced mutagenesis. These tumours also had similar detection rates for EGFR mutations and for RET, ROS1, ALK and MET oncogenic isoforms compared with tumours in never-smokers, which suggests that they have a similar aetiology and pathogenesis. Large subclonal expansions were associated with positive subclonal selection. Patients with tumours harbouring recent subclonal expansions, on the terminus of a phylogenetic branch, had significantly shorter disease-free survival. Subclonal WGD was detected in 19% of tumours, and 10% of tumours harboured multiple subclonal WGDs in parallel. Subclonal, but not truncal, WGD was associated with shorter disease-free survival. Copy number heterogeneity was associated with extrathoracic relapse within 1 year after surgery. These data demonstrate the importance of clonal expansion, WGD and copy number instability in determining the timing and patterns of relapse in non-small cell lung cancer and provide a comprehensive clinical cancer evolutionary data resource
The evolution of non-small cell lung cancer metastases in TRACERx
- Author
- Abbosh Christopher
- AbdulJabbar Khalid
- Aerts Hugo J. W. L.
- Ahmad Tanya
- Ahmed Asia
- Akther Mita
- Al Bakir Maise
- Al-Sawaf Othman
- Alzetani Aiman
- Ambrose Lyn
- Ang Keng
- Angelova Mihaela
- Ashford Paul
- Asif Mo
- Athanasopoulou Foteini
- Austin Silvia
- Bailey Chris
- Bajaj Amrita
- Bandula Steve
- Barbè Vittorio
- Beck Stephan
- Begum Sofina
- Benafif Sarah
- Bentham Robert
- Bhakhri Kunal
- Bhayani Harshil
- Bilancia Rocco
- Birkbak Nicolai J.
- Bishop Paul
- Biswas Dhruva
- Black James R. M.
- Blackhall Fiona H.
- Blyth Kevin G.
- Boeing Stefan
- Bola Supreet Kaur
- Boleti Ekaterini
- Booth Sarah
- Borg Elaine
- Boyles Rebecca
- Brown Kate
- Buderi Silviu I.
- Bunkum Abigail
- Campbell Brittany B.
- Carter Mathew
- Castignani Carla
- Cave Judith
- Chain Benny
- Chan Kitty
- Chaturvedi Anshuman
- Chavan Hema
- Chee Serena
- Chen Kezhong
- Chervova Olga
- Cheyne Heather
- Choudhary Junaid
- Chowdhry Mohammed Fiyaz
- Chuter David
- Clark Tristan
- Clipson Alexandra
- Collins-Fekete Charles-Antoine
- Colliver Emma
- Cook Daniel E.
- Crosbie Philip
- Cruickshank Tracey
- Danson Sarah
- De Sousa Paulo
- Demeulemeester Jonas
- Denner Tamara
- Devaraj Anand
- Dhanda Harjot Kaur
- Dick Craig
- Dietzen Michelle
- Dijkstra Krijn
- Diossy Miklos
- Dive Caroline
- Djearaman Madava
- Doran Helen
- Dulloo Sean
- Enfield Katey S. S.
- Ensell Leah
- Escudero Mickael
- Falzon Mary
- Fennell Dean A.
- Fernandes Nadia
- Fontaine Eustace
- Forster Martin D.
- Fraioli Francesco
- Frankell Alexander M.
- Gamble Samuel
- Gilbert Kayleigh
- Gimeno-Valiente Francisco
- Goldman Jacki
- Gomes Fabio
- Gorman Pat
- Gower Nicole
- Granato Felice
- Grapa Anca
- Grigoriadis Kristiana
- Grönroos Eva
- Gálvez-Cancino Felip
- Hackshaw Allan
- Hartley John A.
- Hayward Martin
- Herrero Javier
- Hessey Sonya
- Hewish Madeleine
- Hiley Crispin T.
- Hill Mark S.
- Hill William
- Hobson Philip
- Hodgkinson Jack Davies
- Holding James W.
- Hoxha Elena
- Huebner Ariana
- Hynds Robert E.
- Ingram Papawadee
- Jamal-Hanjani Mariam
- Janes Sam M.
- Johnson Diana
- Jordan Simon
- Joseph Leena
- Joshi Vijay
- Kadiri Salma
- Kaniu Daniel
- Kanu Nnennaya
- Karagianni Despoina
- Karamani Angeliki
- Karasaki Takahiro
- Kassiotis George
- Kaufmann Tom L.
- Kerr Alastair
- Kerr Keith M.
- Khalil Mohammed
- Khiroya Reena
- Kilgour Elaine
- Kirk Alan
- Kisistok Judit
- Kostoulas Nikos
- Krebs Matthew G.
- Lacson Christer
- Lam Jie Min
- Langman Gerald
- Larose Cadieux Elizabeth
- Lawrence David
- Laycock Joanne
- Le Quesne John
- Lee Claudia
- Lee Siow Ming
- Leek Angela
- Leslie Rachel
- Lester Jason F.
- Leung Michelle
- Levi Dina
- Lim Emilia L.
- Lim Eric
- Lindsay Colin R.
- Litchfield Kevin
- Litovchenko Maria
- Liu Wing Kin
- Lowe Helen L.
- Lu Wei-Ting
- Lucas Olivia
- López Saioa
- MacKenzie Mairead
- Magness Alastair
- Malima Mpho
- Marafioti Teresa
- Marrone Domenic
- Martinoni Hoogenboom Emilie
- Martínez-Ruiz Carlos
- Mastrokalos Gerasimos
- Matharu Gurdeep
- Matos Ignacio
- McGranahan Nicholas
- Middleton Gary
- Monk Fleur
- Montero Angeles
- Moore David A.
- Moss Stuart
- Mourikis Thanos P.
- Naceur-Lombardelli Cristina
- Naidu Babu
- Nair Arjun
- Naito Yutaka
- Nakas Apostolos
- Navani Neal
- Ng Kevin W.
- Nicholson Andrew G.
- Nicod Jerome
- Novasio Juliette
- Nye Emma
- Oliveira Pedro
- Osman Aya
- Pan Xiaoxi
- Panagiotopoulos Nikolaos
- Papadatos-Pastos Dionysis
- Patel Akshay J.
- Patrini Davide
- Pawlik Piotr
- Pearce David R.
- Peggs Karl S.
- Pich Oriol
- Pilotti Camilla
- Price Gillian
- Priest Lynsey
- Primrose Lindsay
- Procter Alexander James
- Proli Chiara
- Prymas Paulina
- Puttick Clare
- Quezada Sergio A.
- Rammohan Kendadai
- Ramsden Zoe
- Rane Jayant K.
- Rathinam Sridhar
- Raubenheimer Hilgardt
- Razaq Maryam
- Reading James L.
- Rice Alexandra
- Richard Corentin
- Richards Jennifer
- Richardson Shirley
- Riley Joan
- Robinson Lily
- Rosenthal Rachel
- Rothwell Dominic G.
- Rowan Andrew
- Royle Gary
- Russell Peter
- Saghafinia Sadegh
- Salgado Roberto
- Scarci Marco
- Scarlett Lydia
- Schwarz Roland F.
- Scotland Molly
- Selvaraju Kayalvizhi
- Shackcloth Michael J.
- Shackleford Helen
- Shah Mansi
- Shah Pratibha
- Shah Rajesh
- Sharp Abigail
- Shaw Jacqui A.
- Sivakumar Monica
- Smith Elaine
- Smith Sean
- Sodha-Ramdeen Azmina
- Sokac Mateo
- Spanswick Victoria
- Stavrou Georgia
- Stephens Robert C. M.
- Stewart Aengus
- Stone Richard Kevin
- Summers Yvonne
- Swanton Charles
- Szallasi Zoltan
- Tanić Miljana
- Taylor Magali N.
- Thakkar Krupa
- Thakrar Ricky M.
- Thol Kerstin
- Thomas Mathew
- Toncheva Antonia
- Totten Nicola
- Tufail Mohamad
- Tugwood Jonathan
- Ung Seng Kuong Anakin
- Van Loo Peter
- Vanloo Sharon
- Vasquez Marcos
- Veeriah Selvaraju
- Veiga Catarina
- Vendramin Roberto
- Ward Sophia
- Watkins Thomas B. K.
- Weeden Clare E.
- Werner Sunderland Mariana
- Wilson Claire
- Wilson Gareth A.
- Wilson James
- Wong Yien Ning Sophia
- Wu Yin
- Yuan Yinyin
- Zaccaria Simone
- Zhai Haoran
- Zhang Hanyun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 20/04/2023
- Field of study
Metastatic disease is responsible for the majority of cancer-related deaths. We report the longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited patients in TRACERx who developed metastatic disease, compared with a control cohort of 144 non-metastatic tumours. In 25% of cases, metastases diverged early, before the last clonal sweep in the primary tumour, and early divergence was enriched for patients who were smokers at the time of initial diagnosis. Simulations suggested that early metastatic divergence more frequently occurred at smaller tumour diameters (less than 8 mm). Single-region primary tumour sampling resulted in 83% of late divergence cases being misclassified as early, highlighting the importance of extensive primary tumour sampling. Polyclonal dissemination, which was associated with extrathoracic disease recurrence, was found in 32% of cases. Primary lymph node disease contributed to metastatic relapse in less than 20% of cases, representing a hallmark of metastatic potential rather than a route to subsequent recurrences/disease progression. Metastasis-seeding subclones exhibited subclonal expansions within primary tumours, probably reflecting positive selection. Our findings highlight the importance of selection in metastatic clone evolution within untreated primary tumours, the distinction between monoclonal versus polyclonal seeding in dictating site of recurrence, the limitations of current radiological screening approaches for early diverging tumours and the need to develop strategies to target metastasis-seeding subclones before relapse
Genomic–transcriptomic evolution in lung cancer and metastasis
- Author
- Abbosh Christopher
- AbdulJabbar Khalid
- Aerts Hugo J. W. L.
- Ahmad Tanya
- Ahmed Asia
- Al Bakir Maise
- Al-Rashed Ali M.
- Al-Sawaf Othman
- Alzetani Aiman
- Ambrose Lyn
- Ang Keng
- Angelova Mihaela
- Ashford Paul
- Asif Mo
- Athanasopoulou Foteini
- Austin Silvia
- Bailey Chris
- Bajaj Amrita
- Bakir Maise Al
- Bandula Steve
- Barbè Vittorio
- Beck Stephan
- Begum Sofina
- Benafif Sarah
- Bentham Robert
- Bhakhri Kunal
- Bhayani Harshil
- Bilancia Rocco
- Birkbak Nicolai J.
- Birkbak Nicolai J.
- Bishop Paul
- Biswas Dhruva
- Black James R. M.
- Blackhall Fiona H.
- Blyth Kevin G.
- Boeing Stefan
- Bola Supreet Kaur
- Boleti Ekaterini
- Booth Sarah
- Borg Elaine
- Boyles Rebecca
- Brown Kate
- Buderi Silviu I.
- Bunkum Abigail
- Campbell Brittany B.
- Carter Mathew
- Castignani Carla
- Cave Judith
- Chain Benny
- Chan Kitty
- Chaturvedi Anshuman
- Chavan Hema
- Chee Serena
- Chen Kezhong
- Chervova Olga
- Cheyne Heather
- Choudhary Junaid
- Chowdhry Mohammed Fiyaz
- Chuter David
- Clark Tristan
- Clements James
- Clipson Alexandra
- Collins-Fekete Charles-Antoine
- Colliver Emma
- Cook Daniel E.
- Crosbie Philip
- Cruickshank Tracey
- Cubitt Laura
- Danson Sarah
- de Carné Trécesson Sophie
- De Sousa Paulo
- Demeulemeester Jonas
- Denner Tamara
- Devaraj Anand
- Dhanda Harjot Kaur
- Dick Craig
- Dietzen Michelle
- Dijkstra Krijn
- Diossy Miklos
- Dive Caroline
- Djearaman Madava
- Doran Helen
- Dulloo Sean
- Duran Marcos Vasquez
- East Philip
- Enfield Katey S. S.
- Ensell Leah
- Escudero Mickael
- Falzon Mary
- Fennell Dean A.
- Fernandes Nadia
- Fontaine Eustace
- Forster Martin D.
- Fraioli Francesco
- Frankell Alexander M.
- Frankell Alexander M.
- Gamble Samuel
- Gilbert Kayleigh
- Gimeno-Valiente Francisco
- Goldman Jacki
- Gomes Fabio
- Gorman Pat
- Gower Nicole
- Granato Felice
- Grapa Anca
- Grigoriadis Kristiana
- Grönroos Eva
- Gálvez-Cancino Felip
- Hackshaw Allan
- Hartley John A.
- Hayward Martin
- Herrero Javier
- Hessey Sonya
- Hewish Madeleine
- Hiley Crispin T.
- Hill Mark S.
- Hill William
- Hobson Philip
- Hodgkinson Jack Davies
- Holding James W.
- Hoogenboom Emilie Martinoni
- Hoxha Elena
- Huebner Ariana
- Hynds Robert E.
- Ingram Papawadee
- Jamal-Hanjani Mariam
- Janes Sam M.
- Jones Thomas P.
- Jordan Simon
- Joseph Leena
- Joshi Vijay
- Kadiri Salma
- Kaniu Daniel
- Kanu Nnennaya
- Karagianni Despoina
- Karamani Angeliki
- Karasaki Takahiro
- Kassiotis George
- Kaufmann Tom L.
- Kerr Alastair
- Kerr Keith M.
- Khalil Mohammed
- Khiroya Reena
- Kilgour Elaine
- Kirk Alan
- Kisistok Judit
- Kostoulas Nikos
- Krebs Matthew G.
- Lacson Christer
- Lam Jie Min
- Lang Danny
- Langman Gerald
- Larose Cadieux Elizabeth
- Lawrence David
- Le Quesne John
- Lee Claudia
- Lee Siow Ming
- Leek Angela
- Leslie Rachel
- Lester Jason F.
- Leung Michelle
- Levi Dina
- Lim Emilia L.
- Lim Emilia L.
- Lim Eric
- Lindsay Colin R.
- Litchfield Kevin
- Litchfield Kevin
- Litovchenko Maria
- Liu Wing Kin
- Lowe Helen L.
- Lu Wei-Ting
- Lucas Olivia
- López Saioa
- MacKenzie Mairead
- Magness Alastair
- Malima Mpho
- Marafioti Teresa
- Marrone Domenic
- Martínez-Ruiz Carlos
- Mastrokalos Gerasimos
- Matharu Gurdeep
- Matos Ignacio Garcia
- McGranahan Nicholas
- McGranahan Nicholas
- Middleton Gary
- Monk Fleur
- Montero Angeles
- Moore David A.
- Moss Stuart
- Mourikis Thanos P.
- Naceur-Lombardelli Cristina
- Naidu Babu
- Nair Arjun
- Naito Yutaka
- Nakas Apostolos
- Navani Neal
- Ng Kevin W.
- Nicholson Andrew G.
- Nicod Jerome
- Novasio Juliette
- Nye Emma
- Oliveira Pedro
- Osman Aya
- Pan Xiaoxi
- Panagiotopoulos Nikolaos
- Papadatos-Pastos Dionysis
- Patel Akshay J.
- Patrini Davide
- Pawlik Piotr
- Pearce David R.
- Peggs Karl S.
- Pich Oriol
- Pilotti Camilla
- Price Gillian
- Priest Lynsey
- Primrose Lindsay
- Procter Alexander James
- Proli Chiara
- Prymas Paulina
- Puttick Clare
- Quezada Sergio A.
- Rammohan Kendadai
- Ramsden Zoe
- Rane Jayant K.
- Rathinam Sridhar
- Raubenheimer Hilgardt
- Reading James L.
- Rice Alexandra
- Richard Corentin
- Richards Jennifer
- Richardson Shirley
- Riley Joan
- Robinson Lily
- Rosenthal Rachel
- Rothwell Dominic G.
- Rowan Andrew
- Royle Gary
- Russell Peter
- Saghafinia Sadegh
- Salgado Roberto
- Scarci Marco
- Scarlett Lydia
- Schwarz Roland F.
- Scotland Molly
- Selvaraju Kayalvizhi
- Shackcloth Michael J.
- Shackleford Helen
- Shah Mansi
- Shah Pratibha
- Shah Rajesh
- Sharp Abigail
- Shaw Jacqui A.
- Sivakumar Monica
- Smith Elaine
- Smith Sean
- Sodha-Ramdeen Azmina
- Sokac Mateo
- Spanswick Victoria
- Stavrou Georgia
- Stephens Robert C. M.
- Stewart Aengus
- Stone Richard Kevin
- Summers Yvonne
- Sunderland Mariana Werner
- Swanton Charles
- Swanton Charles
- Szallasi Zoltan
- Tanić Miljana
- Taylor Magali N.
- Thakkar Krupa
- Thakrar Ricky M.
- Thol Kerstin
- Thomas Mathew
- Toncheva Antonia
- Totten Nicola
- Tufail Mohamad
- Tugwood Jonathan
- Ung Seng Kuong Anakin
- Van Loo Peter
- Van Loo Peter
- Vanloo Sharon
- Veeriah Selvaraju
- Veiga Catarina
- Vendramin Roberto
- Ward Sophia
- Watkins Thomas B. K.
- Weeden Clare E.
- Wilson Claire
- Wilson Gareth A.
- Wilson James
- Wong Yien Ning Sophia
- Wu Yin
- Yuan Yinyin
- Zaccaria Simone
- Zhai Haoran
- Zhang Hanyun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 20/04/2023
- Field of study
Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion and resistance to therapy. Here, using paired whole-exome and RNA sequencing data, we investigate intratumour transcriptomic diversity in 354 non-small cell lung cancer tumours from 347 out of the first 421 patients prospectively recruited into the TRACERx study. Analyses of 947 tumour regions, representing both primary and metastatic disease, alongside 96 tumour-adjacent normal tissue samples implicate the transcriptome as a major source of phenotypic variation. Gene expression levels and ITH relate to patterns of positive and negative selection during tumour evolution. We observe frequent copy number-independent allele-specific expression that is linked to epigenomic dysfunction. Allele-specific expression can also result in genomic–transcriptomic parallel evolution, which converges on cancer gene disruption. We extract signatures of RNA single-base substitutions and link their aetiology to the activity of the RNA-editing enzymes ADAR and APOBEC3A, thereby revealing otherwise undetected ongoing APOBEC activity in tumours. Characterizing the transcriptomes of primary–metastatic tumour pairs, we combine multiple machine-learning approaches that leverage genomic and transcriptomic variables to link metastasis-seeding potential to the evolutionary context of mutations and increased proliferation within primary tumour regions. These results highlight the interplay between the genome and transcriptome in influencing ITH, lung cancer evolution and metastasis
Antibodies against endogenous retroviruses promote lung cancer immunotherapy
- Author
- Abbosh Christopher
- AbdulJabbar Khalid
- Aerts Hugo J. W. L.
- Ahmad Tanya
- Ahmed Asia
- Al Bakir Maise
- Al-Sawaf Othman
- Almagro Jorge
- Alzetani Aiman
- Ambrose Lyn
- Anastasiou Panayiotis
- Ang Keng
- Angelova Mihaela
- Ashford Paul
- Asif Mo
- Athanasopoulou Foteini
- Attig Jan
- Au Lewis
- Austin Silvia
- Bailey Chris
- Bajaj Amrita
- Bandula Steve
- Banerjee Susana
- Barbè Vittorio
- Beck Stephan
- Begum Sofina
- Behrens Axel
- Benafif Sarah
- Bentham Robert
- Bhakhri Kunal
- Bhayani Harshil
- Bilancia Rocco
- Birkbak Nicolai J.
- Bishop Paul
- Biswas Dhruva
- Black James R. M.
- Blackhall Fiona H.
- Blyth Kevin G.
- Boeing Stefan
- Bola Supreet Kaur
- Boleti Ekaterini
- Boos Laura Amanda
- Booth Sarah
- Borg Elaine
- Boumelha Jesse
- Boyles Rebecca
- Brown Kate
- Buderi Silviu I.
- Bunkum Abigail
- Byrne Fiona
- Campbell Brittany B.
- Carter Mathew
- Castignani Carla
- Cave Judith
- Cha Hongui
- Chain Benny
- Chan Kitty
- Chaturvedi Anshuman
- Chau Ian
- Chavan Hema
- Chee Serena
- Chen Kezhong
- Chervova Olga
- Cheyne Heather
- Choudhary Junaid
- Chowdhry Mohammed Fiyaz
- Chuter David
- Clark Tristan
- Clipson Alexandra
- Collins-Fekete Charles-Antoine
- Colliver Emma
- Cook Daniel E.
- Crosbie Philip
- Cruickshank Tracey
- Cunningham David
- Danson Sarah
- de Carné Trécesson Sophie
- De Sousa Paulo
- Demeulemeester Jonas
- Denner Tamara
- Devaraj Anand
- Dhanda Harjot Kaur
- Dick Craig
- Dietzen Michelle
- Dijkstra Krijn
- Diossy Miklos
- Dive Caroline
- Djearaman Madava
- Doran Helen
- Downward Julian
- Droney Joanne
- Dulloo Sean
- Enfield Katey S. S.
- Ensell Leah
- Escudero Mickael
- Falzon Mary
- Faulkner Nikhil
- Fendler Annika
- Fennell Dean A.
- Fernandes Nadia
- Fontaine Eustace
- Forster Martin D.
- Fraioli Francesco
- Frankell Alexander M.
- Furness Andrew J. S.
- Gamble Samuel
- Gerard Camille L.
- Gilbert Kayleigh
- Gimeno-Valiente Francisco
- Goldman Jacki
- Gomes Fabio
- Gorman Pat
- Gower Nicole
- Granato Felice
- Grapa Anca
- Grigoriadis Kristiana
- Grönroos Eva
- Gálvez-Cancino Felip
- Hackshaw Allan
- Harrington Kevin
- Hartley John A.
- Hayward Martin
- Herrero Javier
- Hessey Sonya
- Hewish Madeleine
- Hiley Crispin T.
- Hill Mark S.
- Hill William
- Hobson Philip
- Hodgkinson Jack Davies
- Holding James W.
- Hoxha Elena
- Huebner Ariana
- Hynds Robert E.
- Ingram Papawadee
- Jamal-Hanjani Mariam
- Janes Sam M.
- Jhanji Shaman
- Jones Robin L.
- Jordan Simon
- Joseph Leena
- Joshi Vijay
- Kadiri Salma
- Kaniu Daniel
- Kanu Nnennaya
- Karagianni Despoina
- Karamani Angeliki
- Karasaki Takahiro
- Kassiotis George
- Kaufmann Tom L.
- Kerr Alastair
- Kerr Keith M.
- Khalil Mohammed
- Khiroya Reena
- Kilgour Elaine
- Kim Hyemin
- Kirk Alan
- Kisistok Judit
- Kostoulas Nikos
- Krebs Matthew G.
- Kumar Sacheen
- Lacson Christer
- Lam Jie Min
- Langman Gerald
- Larkin James
- Larose Cadieux Elizabeth
- Lawrence David
- Le Quesne John
- Lee Claudia
- Lee Se-Hoon
- Lee Siow Ming
- Leek Angela
- Leslie Rachel
- Lester Jason F.
- Leung Michelle
- Levi Dina
- Lim Emilia L.
- Lim Eric
- Lindsay Colin R.
- Litchfield Kevin
- Litovchenko Maria
- Liu Wing Kin
- Lowe Helen L.
- Lu Wei-Ting
- Lucas Olivia
- López Saioa
- MacKenzie Mairead
- Magness Alastair
- Magno Neil
- Malima Mpho
- Marafioti Teresa
- Marrone Domenic
- Martinoni Hoogenboom Emilie
- Martínez-Ruiz Carlos
- Mastrokalos Gerasimos
- Matharu Gurdeep
- Matos Ignacio
- McGranahan Nicholas
- Messiou Christina
- Middleton Gary
- Molina-Arcas Miriam
- Monk Fleur
- Montero Angeles
- Moore David A.
- Moss Stuart
- Mourikis Thanos P.
- Naceur-Lombardelli Cristina
- Naidu Babu
- Nair Arjun
- Naito Yutaka
- Nakas Apostolos
- Navani Neal
- Ng Kevin W.
- Nicholson Andrew G.
- Nicholson Emma
- Nicod Jerome
- Novasio Juliette
- Nye Emma
- Okines Alicia
- Oliveira Pedro
- Osman Aya
- Pan Xiaoxi
- Panagiotopoulos Nikolaos
- Papadatos-Pastos Dionysis
- Patel Akshay J.
- Patrini Davide
- Pawlik Piotr
- Pearce David R.
- Peggs Karl S.
- Pich Oriol
- Pickering Lisa
- Pilotti Camilla
- Popat Sanjay
- Price Gillian
- Priest Lynsey
- Primrose Lindsay
- Procter Alexander James
- Proli Chiara
- Prymas Paulina
- Puttick Clare
- Quezada Sergio A.
- Rammohan Kendadai
- Ramsden Zoe
- Rane Jayant K.
- Rathinam Sridhar
- Raubenheimer Hilgardt
- Reading James L.
- Reid Alison
- Rice Alexandra
- Richard Corentin
- Richards Jennifer
- Richardson Shirley
- Riley Joan
- Robinson Lily
- Rosenthal Rachel
- Rothwell Dominic G.
- Rowan Andrew
- Royle Gary
- Russell Peter
- Saghafinia Sadegh
- Salgado Roberto
- Scarci Marco
- Scarlett Lydia
- Schmitt Andreas M.
- Schwarz Roland F.
- Scotland Molly
- Selvaraju Kayalvizhi
- Shackcloth Michael J.
- Shackleford Helen
- Shah Mansi
- Shah Pratibha
- Shah Rajesh
- Sharp Abigail
- Shaw Jacqui A.
- Shepherd Scott T. C.
- Shim Seohee
- Shum Benjamin
- Sivakumar Monica
- Smith Elaine
- Smith Sean
- Sodha-Ramdeen Azmina
- Sokac Mateo
- Spanswick Victoria
- Starling Naureen
- Stavrou Georgia
- Stephens Robert C. M.
- Stewart Aengus
- Stone Richard Kevin
- Summers Yvonne
- Swanton Charles
- Swerdlow Anthony
- Szallasi Zoltan
- Tanić Miljana
- Tatham Kate C.
- Taylor Magali N.
- Thakkar Krupa
- Thakrar Ricky M.
- Thol Kerstin
- Thomas Mathew
- Toncheva Antonia
- Totten Nicola
- Tufail Mohamad
- Tugwood Jonathan
- Turajlic Samra
- Turner Nicholas
- Ung Seng Kuong Anakin
- Van Loo Peter
- Vanloo Sharon
- Vasquez Marcos
- Veeriah Selvaraju
- Veiga Catarina
- Vendramin Roberto
- Ward Sophia
- Watkins Thomas B. K.
- Weeden Clare E.
- Welsh Liam
- Werner Sunderland Mariana
- Wilkinson Katalin A.
- Wilkinson Robert J.
- Wilson Claire
- Wilson Gareth A.
- Wilson James
- Wong Yien Ning Sophia
- Wu Yin
- Young George
- Young Kate
- Yousaf Nadia
- Yuan Yinyin
- Zaccaria Simone
- Zhai Haoran
- Zhang Hanyun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 20/04/2023
- Field of study
B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS). Although TLS have been found to correlate with improved patient survival and response to immune checkpoint blockade (ICB), the underlying mechanisms of this association remain elusive. Here we investigate lung-resident B cell responses in patients from the TRACERx 421 (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy) and other lung cancer cohorts, and in a recently established immunogenic mouse model for lung adenocarcinoma. We find that both human and mouse lung adenocarcinomas elicit local germinal centre responses and tumour-binding antibodies, and further identify endogenous retrovirus (ERV) envelope glycoproteins as a dominant anti-tumour antibody target. ERV-targeting B cell responses are amplified by ICB in both humans and mice, and by targeted inhibition of KRAS(G12C) in the mouse model. ERV-reactive antibodies exert anti-tumour activity that extends survival in the mouse model, and ERV expression predicts the outcome of ICB in human lung adenocarcinoma. Finally, we find that effective immunotherapy in the mouse model requires CXCL13-dependent TLS formation. Conversely, therapeutic CXCL13 treatment potentiates anti-tumour immunity and synergizes with ICB. Our findings provide a possible mechanistic basis for the association of TLS with immunotherapy response