King’s Technology Evaluation Centre is funded by NICE to
act as an External Assessment Centre for the Medical Technologies
Evaluation Programme. The NHS has a financial interest in the
guidance issued by NICE as a result of this work and two authors are
NHS employees (Prof. Keevil and Dr. Lewis

Abdel Douiri

Anastasia Chalkidou

Anita Patel

C Cassinotto

Cornelius Lewis

Elizabeth Morris

G Crespo

H Kuroda

H Takahashi

I Sporea

J Nierhoff

Janet Peacock

Jennifer A. Summers

Joanne Higgins

L Rizzo

LT Le

M Friedrich-Rust

M Lupsor

M Noruegas

Muralikrishnan Radhakrishnan

National Institute for Health and Care Excellence

R Badea

R Dhillon

R Steadman

R Yamada

S Atzori

S Bota

S Hanquinet

Salma Ayis

SH Chen

Stephen Keevil

T Aoki

T Karlas

T Nishikawa

T Toshima

Tiago Rua

V Calvaruso

Viktoria McMillan

XP Ye

Y Liu

Yanzhong Wang

Applied Health Economics and Health Policy

PubMed

Springer - Publisher Connector

Virtual Touch™ Quantification to Diagnose and Monitor Liver Fibrosis in Hepatitis B and Hepatitis C: A NICE Medical Technology Guidance

Summers, JA

Radhakrishnan, M

Morris, E

Chalkidou, A

Rua, T

Patel, A

McMillan, V

Douiri, A

Wang, Y

Ayis, S

Higgins, J

Keevil, S

Lewis, C

Peacock, J

Queen Mary Research Online

Virtual Touch (TM) Quantification to Diagnose and Monitor Liver Fibrosis in Hepatitis B and Hepatitis C: A NICE Medical Technology Guidance

Virtual Touch™ Quantification (VTq) is a software application used with Siemens Acuson ultrasound scanners to assess the stiffness of liver tissue. The National Institute for Health and Care Excellence (NICE) Medical Technologies Advisory Committee (MTAC) selected VTq for evaluation and invited the company to submit clinical and economic evidence. King's Technology Evaluation Centre, an External Assessment Centre (EAC) commissioned by NICE, independently assessed the evidence submitted. The EAC conducted its own systematic review, meta-analysis and economic analysis to supplement the company's submitted evidence. The meta-analyses comparing VTq and transient elastography (TE) with liver biopsy (LB) provided pooled estimates of liver stiffness and stage of fibrosis for the study populations (hepatitis B, hepatitis C or combined populations). When comparing significant fibrosis (Metavir score F ≥ 2) for both hepatitis B and C, VTq had slightly higher values for both sensitivity and specificity (77 and 81 %) than TE (76 and 71 %). The overall prevalence of cirrhosis (F4, combined populations) was similar with VTq and TE (23 vs. 23 %), and significant fibrosis (F ≥ 2) was lower for VTq than for TE (55 vs. 62 %). The EAC revised the company's de novo cost model, which resulted in a cost saving of £53 (against TE) and £434 (against LB). Following public consultation, taking into account submitted comments, NICE Medical Technology Guidance MTG27 was published in September 2015. This recommended the adoption of the VTq software to diagnose and monitor liver fibrosis in patients with hepatitis B or hepatitis C.</p

Summers, Jennifer A.

Radhakrishnan, Muralikrishnan

Morris, Elizabeth

Chalkidou, Anastasia

Rua, Tiago

Patel, Anita

McMillan, Viktoria

Douiri, Abdel

Wang, Yanzhong

Ayis, Salma

Higgins, Joanne

Keevil, Stephen

Lewis, Cornelius

Peacock, Janet

King's Research Portal

English

Virtual Touch™ Quantification to Diagnose and Monitor Liver Fibrosis in Hepatitis B and Hepatitis C:A NICE Medical Technology Guidance

Crossref

https://kclpure.kcl.ac.uk/portal/files/56900460/summers_2016_a.pdf

Virtual Touch (TM) Quantification to Diagnose and Monitor Liver Fibrosis in Hepatitis B and Hepatitis C: A NICE Medical Technology Guidance

Abstract

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Springer - Publisher Connector

Springer - Publisher Connector

Queen Mary Research Online

King's Research Portal

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