Toward a New Theory of Gender Transcendence: Insights from a Qualitative Study of Gendered Self-Concept and Self-Expression in a Sample of Individuals Assigned Female at Birth

Sex and gender are two concepts that are often conflated in popular culture. However, those who experience dissonance between their assigned sex and gender identity intimately understand the difference between sex, a biologicallybased distinction, and gender, a confluence of social and behavioral factors that contribute to understanding who one is as well as how one is seen by others. The gendered self-understanding and self-expression of 170 North Americans who selfidentified as gender nonconforming and who were assigned female at birth were explored using a transpersonal lens and thematic analysis. Data suggested a range and variety of gendered self-concepts that aligned across two broad themes: binary (female/woman; male/man) and non-binary (gender nonbinary; trans masculine) gender core identities. Themes of gendered self-concept, expression in behavior, dress style and appearance, and surgical body modification are discussed. These data support the application of transpersonal theory to transgender identity development, and they underscore the need for more research to test the validity of a new theoretical model of gender transcendence discussed herein

Toward a New Theory of Gender Transcendence: Insights from a Qualitative Study of Gendered Self-Concept and Self-Expression in a Sample of Individuals Assigned Female at Birth

Sex and gender are two concepts that are often conflated in popular culture. However, those who experience dissonance between their assigned sex and gender identity intimately understand the difference between sex, a biologicallybased distinction, and gender, a confluence of social and behavioral factors that contribute to understanding who one is as well as how one is seen by others. The gendered self-understanding and self-expression of 170 North Americans who selfidentified as gender nonconforming and who were assigned female at birth were explored using a transpersonal lens and thematic analysis. Data suggested a range and variety of gendered self-concepts that aligned across two broad themes: binary (female/woman; male/man) and non-binary (gender nonbinary; trans masculine) gender core identities. Themes of gendered self-concept, expression in behavior, dress style and appearance, and surgical body modification are discussed. These data support the application of transpersonal theory to transgender identity development, and they underscore the need for more research to test the validity of a new theoretical model of gender transcendence discussed herein

The Religious and Philosophical Characteristics in a Consensually Nonmonogamous Sample

Consensual nonmonogamy refers to the variety of ways people partner romantically and/or sexually with multiple others. This study examined the spiritual identities of people who self-identify as consensually and openly partnered with more than one person, as well as if and how these identities changed since childhood. Moreover, to deepen previous transpersonal research that investigated how nonmonogamous paradigms of loving contribute to spiritual development, the study also examined between group differences of whether nonmonogamous sexual behavior and spirituality are emotionally linked. Data were gathered from 484 participants; they were mostly college-educated, Caucasian, bisexual women in their 30s, who were raised in moderately conservative, Judeo-Christian households. The majority self-identified as polyamorous. Between-group differences tests revealed that participants reported lower degrees of religiosity and greater degrees of liberalism since childhood, and a change from more traditional to nonreligious but spiritual values in adulthood. Data also suggested that pagan spiritualities may provide more supportive philosophical and spiritual frameworks that normalize and validate nonmonogamous behavior, nonheterosexual interests, sexual desire, and the sacredness of sexuality. Clinical implications of these findings are discussed

Altered Connectivity Pattern of Hubs in Default-Mode Network with Alzheimer's Disease: An Granger Causality Modeling Approach

Background: Evidences from normal subjects suggest that the default-mode network (DMN) has posterior cingulate cortex (PCC), medial prefrontal cortex (MPFC) and inferior parietal cortex (IPC) as its hubs; meanwhile, these DMN nodes are often found to be abnormally recruited in Alzheimer’s disease (AD) patients. The issues on how these hubs interact to each other, with the rest nodes of the DMN and the altered pattern of hubs with respect to AD, are still on going discussion for eventual final clarification. Principal Findings: To address these issues, we investigated the causal influences between any pair of nodes within the DMN using Granger causality analysis and graph-theoretic methods on resting-state fMRI data of 12 young subjects, 16 old normal controls and 15 AD patients respectively. We found that: (1) PCC/MPFC/IPC, especially the PCC, showed the widest and distinctive causal effects on the DMN dynamics in young group; (2) the pattern of DMN hubs was abnormal in AD patients compared to old control: MPFC and IPC had obvious causal interaction disruption with other nodes; the PCC showed outstanding performance for it was the only region having causal relation with all other nodes significantly; (3) the altered relation between hubs and other DMN nodes held potential as a noninvasive biomarker of AD. Conclusions: Our study, to the best of our knowledge, is the first to support the hub configuration of the DMN from the perspective of causal relationship, and reveal abnormal pattern of the DMN hubs in AD. Findings from young subject

Targeting Huntington’s disease through histone deacetylases

Huntington’s disease (HD) is a debilitating neurodegenerative condition with significant burdens on both patient and healthcare costs. Despite extensive research, treatment options for patients with this condition remain limited. Aberrant post-translational modification (PTM) of proteins is emerging as an important element in the pathogenesis of HD. These PTMs include acetylation, phosphorylation, methylation, sumoylation and ubiquitination. Several families of proteins are involved with the regulation of these PTMs. In this review, I discuss the current evidence linking aberrant PTMs and/or aberrant regulation of the cellular machinery regulating these PTMs to HD pathogenesis. Finally, I discuss the evidence suggesting that pharmacologically targeting one of these protein families the histone deacetylases may be of potential therapeutic benefit in the treatment of HD

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio