Expanding the Boundary of Water-Tolerant Frustrated Lewis Pair Hydrogenation: Enhanced Back Strain in the Lewis Acid Enables the Reductive Amination of Carbonyls

The development of a boron/nitrogen-centered frustrated Lewis pair (FLP) with remarkably high water tolerance is presented. As systematic steric tuning of the boron-based Lewis acid (LA) component revealed, the enhanced back-strain makes water binding increasingly reversible in the presence of relatively strong base. This advance allows the limits of FLP's hydrogenation to be expanded, as demonstrated by the FLP reductive amination of carbonyls. This metal-free catalytic variant displays a notably broad chemo-selectivity and generality

Microwave-irridation and flow chemistry for a straightforward synthesis of piano-stool iron complexes

International audienceTwo series of piano-stool iron(II) complexes bearing bidentate phosphine or mixed phosphorus–nitrogen ligands have been prepared upon reaction with CpFe(CO)2I or [CpFe(naphthalene)][PF6] under microwave irradiation or using flow chemistry

Microwave irradiation and flow chemistry for a straightforward synthesis of piano-stool iron complexes

Two series of piano-stool iron(II) complexes bearing bidentate phosphine or mixed phosphoruse-nitrogen ligands have been prepared upon reaction with CpFe(CO)(2)I or [CpFe(naphthalene)][PF6] under microwave irradiation or using flow chemistry

Bifunctional (Cyclopentadienone) Iron-Tricarbonyl Complexes: Synthesis, Computational Studies and Application in Reductive Amination

Reductive amination under hydrogen pressure is a valuable process in organic chemistry to access amine derivatives from aldehydes or ketones. Knolker's complex has been shown to be an efficient iron catalyst in this reaction. To determine the influence of the substituents on the cyclopentadienone ancillary ligand, a series of modified Knolker's complexes was synthesised and fully characterised. These complexes were also transformed into their analogous acetonitrile iron-dicarbonyl complexes. Catalytic activities of these complexes were evaluated and compared in a model reaction. The scope of this reaction is also reported. For mechanistic insights, deuterium-labelling experiments and DFT calculations were undertaken and are also presented