STUDIES ON THE LOUSINESS IN SILK

ArticleJournal of the Faculty of Textiles and Sericulture, Shinshu University. Ser. B, Textile engineering 1-2: 1-61(1952)departmental bulletin pape

STUDIES ON THE LOUSINESS IN SILK

ArticleJournal of the Shinshu University. 2: 131-184(1952)departmental bulletin pape

Comparison of Physical Fitness between Sport and Non-Sport Groups among Elementary School Children

We compared physical fitness factors between sport and non-sport groups of elementary school children in all grades. The subjects of this study were 1,079 1st- to 6th-grade male elementary school children. Their parents completed a questionnaire examining whether the child attended sports lessons as a regular after-school activity. Physical fitness was evaluated by a new physical fitness test recommended by the Japanese Ministry of Education, Culture, Sports, Science, and Technology (4). The test consists of the following items: 1) Grip strength (kg); 2) Sit-ups (number completed in 30 sec); 4) Sitting front stretches (cm); 5) Side steps (number completed in 20 sec); 6) 20-m shuttle run (number of repetitions); 7) 50-m run (sec); 8) Standing long jump (m); 9) Softball throw (m); 10) Height (m); and 11) weight (kg). Point of application ＃1: In regards to the sit-ups, 20-m shuttle run, and softball throw, children who attend sports lessons after school showed a better performance compared to children who do not attend sport lessons, especially after the 3rd grade. Point of application ＃2: Performance in physical fitness that requires complex movements, such as the side steps and 50-m run, were susceptible to sports lessons. Point of application ＃3: Flexibility and performance in physical fitness that require simple movement, such as the grip strength and standing long jump, were not affected significantly by sport lessons during elementary school ages

Activated prothrombin complex concentrate (APCC)-mediated activation of factor (F)VIII in mixtures of FVIII and APCC enhances hemostatic effectiveness.

BACKGROUND AND OBJECTIVES: Activated prothrombin complex concentrates (APCCs), utilized in bypassing therapy for hemophiliacs with inhibitor, contain factors (Fs) VII, FII, FIX and FX, and their active forms. A recent report has demonstrated that mixtures of APCC and FVIII potentiated thrombin generation, in vitro, in plasma from patients with severe hemophilia A, but the mechanism(s) involved remains unknown. RESULTS: APCC (0.05 U mL(-1) ) increased FVIII activity ~ 4-fold within 1 min in one-stage clotting assays, followed by a return to initial levels within 10 min. This reaction was dependent on the presence of tissue factor and phospholipid. Thrombin generation produced from APCC was ~ 3.5-fold greater in the presence of FVIII than that in its absence. SDS-PAGE analysis revealed that APCC sequentially proteolyzed the heavy chain of FVIII at Arg(372) and Arg(740) , followed by cleavage at Arg(336) . Proteolysis was prevented by FVIIa inhibitor, but not by hirudin, supporting the concept that APCC itself possessed the potential to activate FVIII in early coagulation phases, and that FVIIa in APCC contributed mainly to this reaction. APCC-mediated FVIII activation was unaffected by the addition of anti-FVIII inhibitor antibodies, irrespective of epitope specificity. Anti-C2 type 1 inhibitors, however, diminished the inactivation phase of the APCC reaction by inhibiting cleavage at Arg(336) . CONCLUSION: Small amounts of APCC, relative to the standard concentration used for clinical purposes, could activate FVIII directly, even in the presence of anti-FVIII antibodies. Combination therapy based on mixtures of APCC and FVIII could have significant beneficial implications for the treatment of hemophilia A patients with inhibitors.博士（医学）・甲第601号・平成25年7月22日発行元の猶予期間終了の後、本文を登録予定（2014.05