Persistence of G10P[11] neonatal rotavirus infections in southern India

BACKGROUND: Neonatal rotavirus infections are predominantly caused by distinct genotypes restricted to this age-group and are mostly asymptomatic. METHOD: Stool samples from neonates admitted for >48 h in neonatal intensive care units (NICUs) in Vellore (2014–2015) and Chennai (2015–2016) in southern India, and from neonates born at hospitals in Vellore but not admitted to NICUs (2015–2016) were tested for rotavirus by ELISA and genotyped by hemi-nested RT-PCR. RESULTS: Of 791 neonates, 150 and 336 were recruited from Vellore and Chennai NICUs, and 305 were born in five hospitals in Vellore. Positivity rates in the three settings were 49.3% (74/150), 29.5% (99/336) and 54% (164/305), respectively. G10P[11] was the commonly identified genotype in 87.8% (65/74), 94.9% (94/99) and 98.2% (161/164) of the neonates in Vellore and Chennai NICUs, and those born at Vellore hospitals, respectively. Neonates delivered by lower segment cesarian section (LSCS) at Vellore hospitals, not admitted to NICUs, had a significantly higher odds of acquiring rotavirus infection compared to those delivered vaginally [p = 0.002, OR = 2.4 (1.4–4.3)]. CONCLUSIONS: This report demonstrates the persistence of G10P[11] strain in Vellore and Chennai, indicating widespread neonatal G10P[11] strain in southern India and their persistence over two decades, leading to interesting questions about strain stability

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Combating Acid Violence in Bangladesh, India and Cambodia

This Report is the first comprehensive, comparative study of acid violence that examines the underlying causes, its consequences, and the multiple barriers to justice for its victims. Acid attacks, like other forms of violence against women, are not random or natural phenomena. Rather, they are social phenomena deeply embedded in a gender order that has historically privileged patriarchal control over women and justified the use of violence to “keep women in their places.” Through an in-depth study of three countries, the authors of the Report argue that the due diligence standard can be a powerful tool for state and non-state actors to prevent and adequately respond to acid violence with the aim of combating it. In this respect, they identify key ways in which acid violence can be addressed by governments and corporations

Authentication methods in cloud computing: a survey

The study focuses on presenting a review on the various biometric authentication mechanisms in the cloud computing environment. Cloud Computing is used to deliver computing Services over the internet and is used to store data in cloud servers. Due to the sharing of services, privacy and data security have become a major area of concern in cloud computing. The cloud service providers store and maintain client data across data centers which provides threats of data leaks. It is found that several mechanisms have emphasized on data security and in the ensuing process have ignored privacy. Authentication helps to ensure and confirms a user's identity. The existing traditional password authentication does not provide enough security for the data residing in cloud and there have been instances when the password based authentication has been manipulated to gain access into the cloud data. Multifactor authentication is a methodology that uses two or more authentication techniques along with the password but it still does not provide fool-proof data security. Since the conventional methods such as passwords do not serve the purpose of data security, research works focused on biometric traits were as a means of user authentication in cloud services. The biometric authentication is broadly classified into physical based biometric authentication and behavioral based biometric authentication. This paper presents an overview of those methods and analyzes their merits and demerits. The study has been structured to analyze the prevailing biometric authentication mechanisms to gain insights in developing a new authentication model that is more efficient than the existing methods

Activity based costing and activity data collection : a case study in the higher education sector

This paper presents a non-traditional method of collecting staff activity data at an Australian university for the purposes of more accurately and completely identifying costs for use in an Activity Based Costing (ABC) model. A discussion of the use of ABC in the nonprofit sector, with particular emphasis on higher education, is followed by a description of the research site and the previous data collection method. Four alternative methods are compared and analysed in the light of various selection criteria, with the Revolving Door Workshop (RDW) being the preferred alternative. The paper reports on the implementation of the RDW and concludes that it is an effective method in the critical process of staff activity data collection as part of broader activity-based management in universities

A mild and highly selective method for the regeneration of carbonyl compounds from oximes and (2,4-dinitrophenyl)hydrazones

This article does not have an abstract

Comparative study of composite scarf and strap joints for equivalent repair signature under uniaxial tension

Scarf joints are preferred in aerospace composite repairs that offer better strength, flushed surface and nearly uniform shear and peel stress distribution along the bond length. However, a shallow scarf angle repair of 2° to 3° as practiced requires significant parent material removal thus increasing the repair signature and cost. Scarfing the single side accessible, multi-layered composite structures is difficult. Herein, different repair designs based on 8.6° scarf, thin CFRP strap (0.5 mm and 1.1 mm), 0.5 mm thin Ti-6Al-4V straps (with and without pins) are used in bonding CFRP composites, their repair strength is measured through tensile testing. Results show that the failure load of the scarf and Ti-6Al-4V strap joints are similar implicating that the higher scarf angle designs can be replaced with Ti-6Al-4V straps for better repair efficacy. Failure analysis depicts that delamination due to the inner edge peel stresses is a critical failure mode of the strap repaired joints.This work was conducted within the Rolls-Royce@NTU Corporate Lab under the project “ARMS 1.3 Repair of Composite Aero-engine Structures” with support from the Industry Alignment Fund (IAF) Singapore under the Corp Lab@University Scheme

The key role of water in the heterogeneous permanganate oxidation of &#969;-hydroxy alkenes

Potassium permanganate–copper sulphate in dichloromethane in the presence of a catalytic amount of water effects a smooth oxidative cyclization of ω-hydroxy alkenes to ω-lactones in good yields with the net loss of one or more carbon atoms in the process

Heterogeneous permanganate oxidation of 1,5-dienes: a novel synthesis of 5-substituted butanolides

In the presence of a catalytic amount of water, 1,5-dienes undergo novel and unusual oxidation with potassium permanganate–copper sulfate in dichloromethane to give substituted butanolides in good yields under very mild conditions