Predictors of cardiac involvement in idiopathic inflammatory myopathies

Copyright © 2023 Bandeira, Dourado, Melo, Martins, Fraga, Ferraro, Saraiva, Sousa, Parente, Soares, Correia, Almeida, Dinis, Pinto, Oliveira Pinheiro, Rato, Beirão, Samões, Santos, Mazeda, Chícharo, Faria, Neto, Lourenço, Brites, Rodrigues, Silva-Dinis, Dias, Araújo, Martins, Couto, Valido, Santos, Barreira, Fonseca and Campanilho-Marques. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Objectives: Idiopathic inflammatory myopathies (IIM) are a group of rare disorders that can affect the heart. This work aimed to find predictors of cardiac involvement in IIM. Methods: Multicenter, open cohort study, including patients registered in the IIM module of the Rheumatic Diseases Portuguese Register (Reuma.pt/Myositis) until January 2022. Patients without cardiac involvement information were excluded. Myo(peri)carditis, dilated cardiomyopathy, conduction abnormalities, and/or premature coronary artery disease were considered. Results: 230 patients were included, 163 (70.9%) of whom were females. Thirteen patients (5.7%) had cardiac involvement. Compared with IIM patients without cardiac involvement, these patients had a lower bilateral manual muscle testing score (MMT) at the peak of muscle weakness [108.0 ± 55.0 vs 147.5 ± 22.0, p=0.008] and more frequently had oesophageal [6/12 (50.0%) vs 33/207 (15.9%), p=0.009] and lung [10/13 (76.9%) vs 68/216 (31.5%), p=0.001] involvements. Anti-SRP antibodies were more commonly identified in patients with cardiac involvement [3/11 (27.3%) vs 9/174 (5.2%), p=0.026]. In the multivariate analysis, positivity for anti-SRP antibodies (OR 104.3, 95% CI: 2.5-4277.8, p=0.014) was a predictor of cardiac involvement, regardless of sex, ethnicity, age at diagnosis, and lung involvement. Sensitivity analysis confirmed these results. Conclusion: Anti-SRP antibodies were predictors of cardiac involvement in our cohort of IIM patients, irrespective of demographical characteristics and lung involvement. We suggest considering frequent screening for heart involvement in anti-SRP-positive IIM patients.info:eu-repo/semantics/publishedVersio

Perversão e infância e adolescência

By going through the works of Freud and Lacan, the authors research perversion in childhood, going through the perverse polymorphism of the infant sexuality, increased with the view of the anatomic difference of the sexes, that leads the child to created sexual theories and fantasies. The phallic mother and the fetish are imaginary solutions with a straight relation of the Oedipal and castration complexes. Perversion is a particular position in face of the Oedipus, with a flaw in the symbolization of the law, the denial. Sexuality needs a second logic time, separated by the latency period, to confirm in act a fixed position of jouissance (enjoyment) that adolescence enhances. The distinction between a perverse trace and a perverse structure is established, taking in account that, in case of child analysis, the analyst is supposed to free the child from the family fantasy and help him/her to build his/her own fantasy.Através de percurso em Freud e Lacan o grupo interroga a perversão na infância, passando pelo polimorfirmo perverso na sexualidade infantil, acirrada com a visão da diferença anatômica entre os sexos, que faz a criança criar teorias sexuais e fantasias. A mãe fálica e o fetiche são soluções imaginárias concernentes aos complexos de Édipo e de castração. A perversão é uma posição particular diante do Édipo, com uma falha na simbolização da lei: o desmentido. A sexualidade precisa de um segundo tempo lógico separado pelo período de latência, para confirmar em ato uma posição de gozo fixada que a adolescência franqueia. Distingue-se o traço perverso e a estrutura perversa levando-se em conta que, no caso da Psicanálise com criança, se deve descolá-la do fantasma familiar e ajudá-la na construção do seu próprio fantasma

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved