Enzyme-responsive nanomaterials for controlled drug delivery

Enzymes underpin physiological function and exhibit dysregulation in many disease-associated microenvironments and aberrant cell processes. Exploiting altered enzyme activity and expression for diagnostics, drug targeting, and drug release is tremendously promising. When combined with booming research in nanobiotechnology, enzyme-responsive nanomaterials for controlled drug release have achieved significant development and been studied as an important class of drug delivery devices in nanomedicine. In this review, we describe enzymes such as proteases, phospholipase and oxidoreductases that serve as delivery triggers. Subsequently, we explore recently developed enzyme-responsive nanomaterials with versatile applications for extracellular and intracellular drug delivery. We conclude by discussing future opportunities and challenges in this area

Environmental-energy analysis and the importance of design and remanufacturing recycled materials

This paper proposes a framework that interrelates the life cycle of the product, remanufacturing and recycling for plastics. The paper analyses the different chemical processes of recycling polymer wastes. We introduce a thermodynamic calculation of the energy consumed and CO2 emissions for all types of waste(municipal, electronic, vehicle). The remanufacturing process could reduce the amount of CO2 emissions through feedback to the product design stage with robust platforms that extend the product life cycle. In order to meet the requirements of remanufacturing we combine mechanical and chemical recycling solutions. These recycling processes must undergo a thermodynamic analysis to optimize energy and decrease the minimum CO2 emissions, i.e. recycling processes in line with the ultimate objective, which isthe reduction of CO2 emissions and slowing a part of the problem global warming