Alien Registration- Bylund, Tycko (Westmanland, Aroostook County)

https://digitalmaine.com/alien_docs/32556/thumbnail.jp

Structural characterization of the D290V mutation site in hnRNPA2 low-complexity-domain polymers.

Human genetic studies have given evidence of familial, disease-causing mutations in the analogous amino acid residue shared by three related RNA binding proteins causative of three neurological diseases. Alteration of aspartic acid residue 290 of hnRNPA2 to valine is believed to predispose patients to multisystem proteinopathy. Mutation of aspartic acid 262 of hnRNPA1 to either valine or asparagine has been linked to either amyotrophic lateral sclerosis or multisystem proteinopathy. Mutation of aspartic acid 378 of hnRNPDL to either asparagine or histidine has been associated with limb girdle muscular dystrophy. All three of these aspartic acid residues map to evolutionarily conserved regions of low-complexity (LC) sequence that may function in states of either intrinsic disorder or labile self-association. Here, we present a combination of solid-state NMR spectroscopy with segmental isotope labeling and electron microscopy on the LC domain of the hnRNPA2 protein. We show that, for both the wild-type protein and the aspartic acid 290-to-valine mutant, labile polymers are formed in which the LC domain associates into an in-register cross-β conformation. Aspartic acid 290 is shown to be charged at physiological pH and immobilized within the polymer core. Polymers of the aspartic acid 290-to-valine mutant are thermodynamically more stable than wild-type polymers. These observations give evidence that removal of destabilizing electrostatic interactions may be responsible for the increased propensity of the mutated LC domains to self-associate in disease-causing conformations

Statistics of skyrmions in Quantum Hall systems

We analyze statistical interactions of skyrmions in the quantum Hall system near a critical filling fraction in the framework of the Ginzburg-Landau model. The phase picked up by the wave-function during an exchange of two skyrmions close to $\nu=1/(2n+1)$ is $\pi[S+1/2(2n+1)]$, where $S$ is the skyrmion's spin. In the same setting an exchange of two fully polarized vortices gives rise to the phase $\pi/(2n+1)$. Skyrmions with odd and even numbers of reversed spins have different quantum statistics. Condensation of skyrmions with an even number of reversed spins leads to filling fractions with odd denominators, while condensation of those with an odd number of reversed spins gives rise to filling fractions with even denominators.Comment: 6 pages in Latex. addendum - skyrmions with odd or even number of reversed spins have different quantum statistics. They condense to form respectively even or odd denominator filling fraction state

Arbitrary precision composite pulses for NMR quantum computing

We discuss the implementation of arbitrary precision composite pulses developed using the methods of Brown et al. [Phys. Rev. A 70 (2004) 052318]. We give explicit results for pulse sequences designed to tackle both the simple case of pulse length errors and for the more complex case of off-resonance errors. The results are developed in the context of NMR quantum computation, but could be applied more widely.Comment: 16 pages elsart, no figures. In press at Journal of Magnetic resonanc

Spin Transition in Strongly Correlated Bilayer Two Dimensional Electron Systems

Using a combination of heat pulse and nuclear magnetic resonance techniques we demonstrate that the phase boundary separating the interlayer phase coherent quantum Hall effect at $\nu_T = 1$ in bilayer electron gases from the weakly coupled compressible phase depends upon the spin polarization of the nuclei in the host semiconductor crystal. Our results strongly suggest that, contrary to the usual assumption, the transition is attended by a change in the electronic spin polarization.Comment: 4 pages, 3 postscript figur

Tackling Systematic Errors in Quantum Logic Gates with Composite Rotations

We describe the use of composite rotations to combat systematic errors in single qubit quantum logic gates and discuss three families of composite rotations which can be used to correct off-resonance and pulse length errors. Although developed and described within the context of NMR quantum computing these sequences should be applicable to any implementation of quantum computation.Comment: 6 pages RevTex4 including 4 figures. Will submit to Phys. Rev.

Structural differences in amyloid-β fibrils from brains of non-demented elderly individuals and Alzheimer's disease patients

Although amyloid plaques composed of fibrillar amyloid-β (Aβ) assemblies are a diagnostic hallmark of Alzheimer's disease (AD), quantities of amyloid similar to those in AD patients are observed in brain tissue of some nondemented elderly individuals. The relationship between amyloid deposition and neurodegeneration in AD has, therefore, been unclear. Here, we use solid-state NMR to investigate whether molecular structures of Aβ fibrils from brain tissue of nondemented elderly individuals with high amyloid loads differ from structures of Aβ fibrils from AD tissue. Two-dimensional solid-state NMR spectra of isotopically labeled Aβ fibrils, prepared by seeded growth from frontal lobe tissue extracts, are similar in the two cases but with statistically significant differences in intensity distributions of cross-peak signals. Differences in solid-state NMR data are greater for 42-residue amyloid-β (Aβ42) fibrils than for 40-residue amyloid-β (Aβ40) fibrils. These data suggest that similar sets of fibril polymorphs develop in nondemented elderly individuals and AD patients but with different relative populations on average

Galilean non-invariance of geometric phase

It is shown that geometric phase in non-relativistic quantum mechanics is not Galilean invariant.Comment: LaTeX, 6 pages, no figure

Critical Behavior of Nuclear-Spin Diffusion in GaAs/AlGaAs Heterostructures near Landau Level Filling \nu=1

Thermal measurements on a GaAs/AlGaAs heterostructure reveal that the state of the confined two-dimensional electrons dramatically affects the nuclear-spin diffusion near Landau level filling factor \nu=1. The experiments provide quantitative evidence that the sharp peak in the temperature dependence of heat capacity near \nu=1 is due to an enhanced nuclear-spin diffusion from the GaAs quantum wells into the AlGaAs barriers. We discuss the physical origin of this enhancement in terms the possible Skyrme solid-liquid phase transition.Comment: 1 LateX file, 3 figures, submitte

The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface

BACKGROUND: The Tnfrh1 gene (gene symbol Tnfrsf23) is located near one end of a megabase-scale imprinted region on mouse distal chromosome 7, about 350 kb distant from the nearest known imprinting control element. Within 20 kb of Tnfrh1 is a related gene called Tnfrh2 (Tnfrsf22) These duplicated genes encode putative decoy receptors in the tumor necrosis factor (TNF) receptor family. Although other genes in this chromosomal region show conserved synteny with genes on human Chr11p15.5, there are no obvious human orthologues of Tnfrh1 or Tnfrh2. RESULTS: We analyzed Tnfrh1 for evidence of parental imprinting, and characterized its tissue-specific expression. Tnfrh1 mRNA is detectable in multiple adult and fetal tissues, with highest expression in placenta, where in situ hybridization reveals a distinctive population of Tnfrh1-positive cells in maternal decidua, directly beneath the trophoblast giant cells. In offspring of interspecific mouse crosses, Tnfrh1 shows a consistent parent-of-origin-dependent allelic expression bias, with relative repression, but not silencing, of the paternal allele in several organs including fetal liver and adult spleen. CONCLUSIONS: Genes preferentially expressed in the placenta are predicted to evolve rapidly, and Tnfrh1 appears to be an example of this phenomenon. In view of its strong expression in cells at the fetal-maternal boundary, Tnfrh1 warrants further study as a gene that might modulate immune or trophic interactions between the invasive placental trophoblast and the maternal decidua. The preferential expression of Tnfrh1 from the maternal allele indicates weak functional imprinting of this locus in some tissues