The Gaze Fixation Assessed by Microperimetry : A Useful Tool for the Monitoring of the Cognitive Function in Patients with Type 2 Diabetes

Current guidelines recommend annual screening for cognitive impairment in patients > 65 years with type 2 diabetes (T2D). The most used tool is the mini-mental state evaluation (MMSE). Retinal microperimetry is useful for detecting cognitive impairment in these patients, but there is no information regarding its usefulness as a monitoring tool. We aimed to explore the role of retinal microperimetry in the annual follow-up of the cognitive function of patients with T2D older than 65 years. Materials and Methods: Prospective observational study, comprising patients > 65 years with T2D, attended at our center between March-October 2019. A complete neuropsychological evaluation assessed the baseline cognitive status (mild cognitive impairment, MCI, or normal, NC). Retinal microperimetry (sensitivity, gaze fixation) and MMSE were performed at baseline and after 12 months. Results: Fifty-nine patients with MCI and 22 NC were identified. A significant decline in the MMSE score was observed after 12 months in the MCI group (25.74 ± 0.9 vs. 24.71 ± 1.4; p = 0.001). While no significant changes in retinal sensitivity were seen, all gaze-fixation parameters worsened at 12 months and significantly correlated with a decrease in the MMSE scores. Conclusion: Retinal microperimetry is useful for the monitoring of cognitive decline in patients > 65 years with T2D. Gaze fixation seems a more sensitive parameter for follow-up after 12 months than retinal sensitivity

The Gaze Fixation Assessed by Microperimetry: A Useful Tool for the Monitoring of the Cognitive Function in Patients with Type 2 Diabetes

Cognitive impairment; Retinal microperimetry; Type 2 diabetesDeterioro cognitivo; Microperimetría retiniana; Diabetes tipo 2Deteriorament cognitiu; Microperimetria retiniana; Diabetis tipus 2Current guidelines recommend annual screening for cognitive impairment in patients > 65 years with type 2 diabetes (T2D). The most used tool is the mini-mental state evaluation (MMSE). Retinal microperimetry is useful for detecting cognitive impairment in these patients, but there is no information regarding its usefulness as a monitoring tool. We aimed to explore the role of retinal microperimetry in the annual follow-up of the cognitive function of patients with T2D older than 65 years. Materials and Methods: Prospective observational study, comprising patients > 65 years with T2D, attended at our center between March–October 2019. A complete neuropsychological evaluation assessed the baseline cognitive status (mild cognitive impairment, MCI, or normal, NC). Retinal microperimetry (sensitivity, gaze fixation) and MMSE were performed at baseline and after 12 months. Results: Fifty-nine patients with MCI and 22 NC were identified. A significant decline in the MMSE score was observed after 12 months in the MCI group (25.74 ± 0.9 vs. 24.71 ± 1.4; p = 0.001). While no significant changes in retinal sensitivity were seen, all gaze-fixation parameters worsened at 12 months and significantly correlated with a decrease in the MMSE scores. Conclusion: Retinal microperimetry is useful for the monitoring of cognitive decline in patients > 65 years with T2D. Gaze fixation seems a more sensitive parameter for follow-up after 12 months than retinal sensitivity.This study was supported by grants from the Instituto de Salud Carlos III (Fondo de Investigación Sanitaria, PI20/01703). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

EPOCHS VII: Discovery of high redshift (6.5<z<126.5 < z < 12) AGN candidates in JWST ERO and PEARLS data

We present an analysis of a sample of robust high redshift galaxies selected photometrically from the `blank' fields of the Prime Extragalactic Areas for Reionization Science (PEARLS) survey and Early Release Observations (ERO) data of the James Webb Space Telescope (JWST) with the aim of selecting candidate high redshift active galactic nuclei (AGN). Sources were identified from the parent sample using a threefold selection procedure, which includes spectral energy distribution (SED) fitting to identify sources that are best fitted by AGN SED templates, a further selection based on the relative performance of AGN and non-AGN models, and finally morphological fitting to identify compact sources of emission, resulting in a purity-oriented procedure. Using this procedure, we identify a sample of nine AGN candidates at $6.5 < z < 12$, from which we constrain their physical properties as well as measure a lower bound on the AGN fraction in this redshift range of $5 \pm 1$\%. As this is an extreme lower limit due to our focus on purity and our SEDs being calibrated for unobscured Type 1 AGN, this demonstrates that AGN are perhaps quite common at this early epoch. The rest-frame UV colors of our candidate objects suggest that these systems are potentially candidate obese black hole galaxies (OBG), or AGN with very little galaxy component. We also investigate emission from our sample sources from fields overlapping with Chandra and VLA surveys, allowing us to place X-ray and 3 GHz radio detection limits on our candidates. Of note is a $z = 11.9$ candidate source exhibiting an abrupt morphological shift in the reddest band as compared to the bluer bands, indicating a potential merger or an unusually strong outflow.Comment: Submitted to MNRAS, 12 pages, 11 figures, typos correcte

Magellanic System Stars Identified in the SMACS J0723.3-7327 JWST ERO Images

We identify 68 distant stars in JWST/NIRCam ERO images of the field of galaxy cluster SMACS J0723.3-7327 (SMACS 0723). Given the relatively small ($\sim$$10^{\circ}$) angular separation between SMACS 0723 and the Large Magellanic Cloud, it is likely that these stars are associated with the LMC outskirts or Leading Arm. This is further bolstered by a spectral energy distribution analysis, which suggests an excess of stars at a physical distance of $40-100$ kpc, consistent with being associated with or located behind the Magellanic system. In particular, we find that the overall surface density of stars brighter than 27.0 mag in the field of SMACS 0723 is $\sim$2.3 times that of stars in a blank field with similar galactic latitude (the North Ecliptic Pole Time Domain Field), and that the density of stars in the SMACS 0723 field with SED-derived distances consistent with the Magellanic system is $\sim$7.3 times larger than that of the blank field. The candidate stars at these distances are consistent with a stellar population at the same distance modulus with [Fe/H] $= -1.0$ and an age of $\sim$$5.0$ Gyr. On the assumption that all of the 68 stars are associated with the LMC, then the stellar density of the LMC at the location of the SMACS 0723 field is $\sim$$710$ stars kpc$^{-3}$, which helps trace the density of stars in the LMC outskirts.Comment: Submitted to ApJ, comments welcom

PEARLS: A Potentially Isolated Quiescent Dwarf Galaxy with a TRGB Distance of 31 Mpc

A wealth of observations have long suggested that the vast majority of isolated classical dwarf galaxies ($M_*=10^7$-$10^9$ M$_\odot$) are currently star-forming. However, recent observations of the large abundance of "Ultra-Diffuse Galaxies" beyond the reach of previous large spectroscopic surveys suggest that our understanding of the dwarf galaxy population may be incomplete. Here we report the serendipitous discovery of an isolated quiescent dwarf galaxy in the nearby Universe, which was imaged as part of the PEARLS GTO program. Remarkably, individual red-giant branch stars are visible in this near-IR imaging, suggesting a distance of $31$ Mpc, and a wealth of archival photometry point to an sSFR of $2\times10^{-12}$ yr$^{-1}$. Spectra obtained with the Lowell Discovery Telescope find a recessional velocity consistent with the Hubble Flow and ${>}1500$ km/s separated from the nearest massive galaxy in SDSS, suggesting that this galaxy was either quenched from internal mechanisms or had a very high-velocity interaction with a nearby massive galaxy in the past. This analysis highlights the possibility that many nearby quiescent dwarf galaxies are waiting to be discovered and that JWST has the potential to identify them.Comment: Submitted to ApJ Letters. Comments welcome

The JWST Discovery of the Triply-imaged Type Ia "Supernova H0pe" and Observations of the Galaxy Cluster PLCK G165.7+67.0

A Type Ia supernova (SN) at $z=1.78$ was discovered in James Webb Space Telescope Near Infrared Camera imaging of the galaxy cluster PLCK G165.7+67.0 (G165; $z = 0.35$). The SN is situated 1.5-2kpc from its host galaxy Arc 2 and appears in three different locations as a result of gravitational lensing by G165. These data can yield a value for Hubble's constant using time delays from this multiply-imaged SN Ia that we call "SN H0pe." Over the entire field we identified 21 image multiplicities, confirmed five of them using Near-Infrared Spectrograph (NIRspec), and constructed a new lens model that gives a total mass within 600kpc of ($2.6 \pm 0.3) \times 10^{14}$ M$_{\odot}$. The photometry uncovered a galaxy overdensity at Arc 2's redshift. NIRSpec confirmed six member galaxies, four of which surround Arc 2 with relative velocity $\lesssim$900 km s$^{-1}$ and projected physical extent $\lesssim$33 kpc. Arc 2 dominates the stellar mass ($(5.0 \pm 0.1) \times 10^{11}$ M$_{\odot}$), which is a factor of ten higher than other members of this compact galaxy group. These other group members have specific star formation rates (sSFR) of 2-260Gyr$^{-1}$ derived from the H$\alpha$-line flux corrected for stellar absorption, dust extinction, and slit losses. Another group centered on the dusty star forming galaxy Arc 1 is at $z=2.24$. The total SFR for the Arc 1 group ($gtrsim$ M$_{\odot}$ yr$^{-1}$) translates to a supernova rate of $\sim$1 SNe yr$^{-1}$, suggesting that regular monitoring of this cluster may yield additional SNe.Comment: 27 pages, submitted to Ap

Magellanic system stars identified in SMACS J0723.3-7327 James Webb Space Telescope early release observations images

We identify 71 distant stars in James Webb Space Telescope/NIRCam early release observations (ERO) images of the field of galaxy cluster SMACS J0723.3-7327 (SMACS 0723). Given the relatively small (∼10°) angular separation between SMACS 0723 and the Large Magellanic Cloud (LMC), it is likely that these stars are associated with the LMC outskirts or the Leading Arm. This is further bolstered by a spectral energy distribution (SED) analysis, which suggests an excess of stars at a physical distance of 40–100 kpc, consistent with being associated with or located behind the Magellanic system. In particular, we find that the overall surface density of stars brighter than 27.0 mag in the field of SMACS 0723 is ∼2.3 times that of stars in a blank field with similar Galactic latitude (the North Ecliptic Pole Time Domain Field), and that the density of stars in the SMACS 0723 field with SED-derived distances consistent with the Magellanic system is ∼6.1 times larger than that of the blank field. The candidate stars at these distances are consistent with a stellar population at the same distance modulus with [Fe/H] = −1.0 and an age of ∼5.0 Gyr. On the assumption that all of the 71 stars are associated with the LMC, then the stellar density of the LMC at the location of the SMACS 0723 field is ∼740 stars kpc−3, which helps trace the density of stars in the LMC outskirts.J.S. acknowledges support from an undergraduate Arizona NASA Space Grant, Cooperative Agreement 80NSSC20M0041. R.A.W., S.H.C., and R.A.J. acknowledge support from NASA JWST Interdisciplinary Scientist grants NAG5-12460, NNX14AN10G and 80NSSC18K0200 from GSFC. C.J.C. and N.J.A. acknowledge support from the European Research Council (ERC) Advanced Investigator Grant EPOCHS (788113). M.A.M. acknowledges the support of a National Research Council of Canada Plaskett Fellowship, and the Australian Research Council Centre of Excellence for All Sky Astrophysics in 3 Dimensions (ASTRO 3D), through project number CE17010001. C.N.A.W. acknowledges funding from the JWST/NIRCam contract NASS-0215 to the University of Arizona. This work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski Archive for Space Telescopes (MAST) at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with JWST programs 1176, 2736, and 2738. All of the JWST data used in this paper can be found on doi:10.17909/b7hf-he53. This work is based on observations taken by the RELICS Treasury Program (Coe 2016, GO 14096) with the NASA/ESA HST, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555. This work has made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium). Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. We also acknowledge the JWST ERO team responsible for providing these products.Peer reviewe

PEARLS: A potentially isolated quiescent dwarf galaxy with a tip of the red giant branch distance of 30 Mpc

A wealth of observations have long suggested that the vast majority of isolated classical dwarf galaxies (M* = 107–109M⊙) are currently star forming. However, recent observations of the large abundance of "ultra-diffuse galaxies" beyond the reach of previous large spectroscopic surveys suggest that our understanding of the dwarf galaxy population may be incomplete. Here we report the serendipitous discovery of an isolated quiescent dwarf galaxy in the nearby Universe, which was imaged as part of the JWST PEARLS Guaranteed Time Observation program. Remarkably, individual red-giant branch stars are visible in this near-IR imaging, suggesting a distance of 30 ± 4 Mpc, and a wealth of archival photometry point to an sSFR of 2 × 10−11 yr−1 and star formation rate of 4 × 10−4M⊙ yr−1. Spectra obtained with the Lowell Discovery Telescope find a recessional velocity consistent with the Hubble Flow and >1500 km s−1 separated from the nearest massive galaxy in Sloan Digital Sky Survey suggesting that this galaxy was either quenched from internal mechanisms or had a very high-velocity (≳1000 km s−1) interaction with a nearby massive galaxy in the past. This analysis highlights the possibility that many nearby quiescent dwarf galaxies are waiting to be discovered and that JWST has the potential to resolve them.T.M.C. is grateful for support from the Beus Center for Cosmic Foundations. R.A.W., S.H.C., and R.A.J. acknowledge support from NASA JWST Interdisciplinary Scientist grants NAG5-12460, NNX14AN10G and 80NSSC18K0200 from GSFC. J.M.D. acknowledges the support of project PGC2018-101814-B-100 (MCIU/AEI/MINECO/FEDER, UE) Ministerio de Ciencia, Investigación y Universidades. This project was funded by the Agencia Estatal de Investigación, Unidad de Excelencia María de Maeztu, ref. MDM-2017-0765. C.C. is supported by the National Natural Science Foundation of China, Nos. 11803044, 11933003, 12173045. This work is sponsored (in part) by the Chinese Academy of Sciences (CAS), through a grant to the CAS South America Center for Astronomy (CASSACA). We acknowledge the science research grants from the China Manned Space Project with No. CMS-CSST-2021-A05. R.A.B. gratefully acknowledges support from the European Space Agency (ESA) Research Fellowship. C.J.C. acknowledges support from the European Research Council (ERC) Advanced Investigator Grant EPOCHS (788113). C.N.A.W. acknowledges funding from the JWST/NIRCam contract NASS-0215 to the University of Arizona. M.A.M. acknowledges the support of a National Research Council of Canada Plaskett Fellowship, and the Australian Research Council Centre of Excellence for All Sky Astrophysics in 3 Dimensions (ASTRO 3D), through project number CE17010001.Peer reviewe

Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database

Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF fully explained by cardiac failure were excluded. Important clinical characteristics were included in a stepwise selection approach (forward and backward selection combined with a significance level of 0.05) to identify a set of independent variables associated with having ARDS at any time, developing ARDS (defined as ARDS occurring after day 2 from meeting AHRF criteria) and with hospital mortality. Furthermore, propensity score analysis was undertaken to account for the differences in baseline characteristics between patients with and without diabetes mellitus, and the association between diabetes mellitus and outcomes of interest was assessed on matched samples. Results: Of the 4107 patients with AHRF included in this study, 3022 (73.6%) patients fulfilled ARDS criteria at admission or developed ARDS during their ICU stay. Diabetes mellitus was a pre-existing co-morbidity in 913 patients (22.2% of patients with AHRF). In multivariable analysis, there was no association between diabetes mellitus and having ARDS (OR 0.93 (0.78-1.11); p = 0.39), developing ARDS late (OR 0.79 (0.54-1.15); p = 0.22), or hospital mortality in patients with ARDS (1.15 (0.93-1.42); p = 0.19). In a matched sample of patients, there was no association between diabetes mellitus and outcomes of interest. Conclusions: In a large, global observational study of patients with AHRF, no association was found between diabetes mellitus and having ARDS, developing ARDS, or outcomes from ARDS. Trial registration: NCT02010073. Registered on 12 December 2013