Time Prediction on Multi-perspective Declarative Business Processes

Process-aware information systems (PAISs) are increasingly used to provide flexible support for business processes. The support given through a PAIS is greatly enhanced when it is able to provide accurate time predictions which is typically a very challenging task. Predictions should be (1) multi-dimensional and (2) not based on a single process instance. Furthermore, the prediction system should be able to (3) adapt to changing circumstances and (4) deal with multi-perspective declarative languages (e.g., models which consider time, resource, data and control flow perspectives). In this work, a novel approach for generating time predictions considering the aforementioned characteristics is proposed. For this, first, a multi-perspective constraint-based language is used to model the scenario. Thereafter, an optimized enactment plan (representing a potential execution alternative) is generated from such a model considering the current execution state of the process instances. Finally, pre-dictions are performed by evaluating a desired function over this enactment plan. To evaluate the applicability of our approach in practical settings we apply it to a real process scenario. Despite the high complexity of the considered problems, results indicate that our approach produces a satisfactory number of good predictions in a reasonable time.Ministerio de Economía y Competitividad TIN2016-76956-C3-2-RMinisterio de Economía y Competitividad TIN2015-71618-

Predicciones en Procesos de Negocio Declarativos

La generación de predicciones sobre instancias de procesos de negocio permite anticipar problemas, evitar el incumplimiento de restricciones de una manera proactiva, y tomar decisiones sobre prioridades y restricciones al enfrentarse a eventos inesperados, e.g., retrasos. Sin embargo, elaborar una predicción es una tarea compleja en la mayoría de los casos ya que se deben tener en cuenta múltiples instancias y recursos, es necesario adaptar dichas predicciones a circunstancias cambiantes, y hay que tener en cuenta distintas dimensiones, no sólo el tiempo. En este contexto, el presente trabajo propone una propuesta novedosa para generar predicciones sobre un conjunto de instancias en ejecución relacionadas con un modelo declarativo de un proceso de negocio. Dicha propuesta consiste en generar un plan de ejecución optimizado a partir del modelo declarativo y del estado de las instancias en ejecución. Tras ello, la predicción se genera evaluando la función que se desea predecir sobre el plan de ejecución generado. La presente propuesta ha sido evaluada utilizando un modelo de proceso de un escenario real que incluye restricciones temporales, de datos, de recursos y de control-flow que lo dotan de una alta complejidad. Los prometedores resultados obtenidos alientan a continuar los trabajos en escenarios con características diferentes que permitan extender la validez de la propuesta.Ministerio de Economía y Competitividad TIN2016-76956-C3-2-RMinisterio de Economía y Competitividad TIN2015-71938-RED

Enfermedad injerto versus huésped tipo esclerodermiforme : a propósito de un caso

La enfermedad injerto versus huésped (EICH) es un trastorno multiorgánico causado por transferencia de células madre hematopoyéticas de un donante a un receptor huésped. Puede ser agudo o crónico según el tiempo de evolución. En la forma crónica, se puede observar en la presentación clínica e histológica patrón liquenoide o patrón esclerodermiforme. El diagnóstico se basa fundamentalmente en los antecedentes del paciente, la clínica y la histología. No se encuentra un tratamiento estandarizado para esta patología, sin embargo, se han descripto como opciones terapéuticas la corticoterapia, la fototerapia, y en algunos casos puede considerarse el uso de anticuerpos monoclonales.Graft versus host disease (GVHD) is a multiorgan disorder caused by the transfer of hematopoietic stem cells from a donor to a recipient host. It can be acute or chronic depending on the time of evolution. In both cases, 80% present cutaneous manifestations. Regarding chronic evolution, it can be observed in the clinical and histological presentation lichenoid pattern or sclerodermiform pattern. The diagnosis is based mainly on the patient's history, the clinic and histology. There is no standardized treatment for this pathology, however corticosteroid therapy and phototherapy have been described as therapeutic options, and in some cases the use of monoclonal antibody may be preferred.Fil: Marin, María del Valle. Hospital El Carmen (Mendoza, Argentina). Servicio de DermatologíaFil: Venturini, María Clara. Hospital El Carmen (Mendoza, Argentina). Servicio de DermatologíaFil: Camardella, Ileana Rosalía. Hospital El Carmen (Mendoza, Argentina). Servicio de DermatologíaFil: Ojeda, María Victoria. Hospital El Carmen (Mendoza, Argentina). Servicio de DermatologíaFil: Rodríguez Saa, Sonia. Hospital El Carmen (Mendoza, Argentina). Servicio de DermatologíaFil: Olivares, Marisa. Hospital El Carmen (Mendoza, Argentina). Servicio de Anatomía Patológic

Características fisicoquímicas y reológicas de leches fortificadas con sales de calcio

El objetivo de este trabajo fue analizar los cambios en las características fisicoquímicas y reológicas de leches fortificadas con diferentes sales de calcio. Se formularon muestras de leche utilizando leche en polvo descremada con diferentes concentraciones de cloruro y lactato de calcio (0,5 y 30 mmol kg-1). Se utilizaron diferentes técnicas fisicoquímicas y reométricas para analizar el efecto de la fortificación con calcio sobre la leche. Los resultados obtenidos indican que, para ambas sales de calcio, parte del calcio añadido migra al interior de la micela de caseína formando fosfato de calcio coloidal y que el calcio añadido como lactato de calcio ingresa en mayor proporción. Una fracción de proteínas del suero también se integraría a la estructura micelar. En tal sentido, sería factible una adición de 5 mmol kg-1 de cloruro o lactato de calcio como modificación tecnológica, debido a que el equilibrio mineral y la estabilidad térmica no se ven afectadossignificativamente a dicha concentración. Se concluyó que los resultados obtenidos a partir de las técnicas fisicoquímicas comúnmente utilizadas en la literatura, están en concordancia con los obtenidos por reometría, demostrando que esta técnica sencilla y rápida permite inferir sobre cambios en el equilibrio mineral y los efectos sobre la estabilidad térmica cuando se utilizan diferentes sales en la fortificación de leches.Fil: Acosta, Nadia Belén. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación de la Cadena Láctea. - Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea; ArgentinaFil: Sihufe, Guillermo Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Meza, Barbara Erica del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Marino, Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Costabel, Luciana Maria. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación de la Cadena Láctea. - Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea; ArgentinaFil: Zorrilla, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Olivares, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentin

Surgical treatment for colorectal cancer: Analysis of the influence of an enhanced recovery programme on long-term oncological outcomes-a study protocol for a prospective, multicentre, observational cohort study

Introduction The evidence currently available from enhanced recovery after surgery (ERAS) programmes concerns their benefits in the immediate postoperative period, but there is still very little evidence as to whether their correct implementation benefits patients in the long term. The working hypothesis here is that, due to the lower response to surgical aggression and lower rates of postoperative complications, ERAS protocols can reduce colorectal cancer-related mortality. The main objective of this study is to analyse the impact of an ERAS programme for colorectal cancer on 5-year survival. As secondary objectives, we propose to analyse the weight of each of the predefined items in the oncological results as well as the quality of life. Methods and analysis A multicentre prospective cohort study was conducted in patients older than 18 years of age who are scheduled to undergo surgery for colorectal cancer. The study involved 12 hospitals with an implemented enhanced recovery protocol according to the guidelines published by the Spanish National Health Service. The intervention group includes patients with a minimum implementation level of 70%, and the control group includes those who fail to reach this level. Compliance will be studied using 18 key performance indicators, and the results will be analysed using cancer survival indicators, including overall survival, cancer-specific survival and relapse-free survival. The time to recurrence, perioperative morbidity and mortality, hospital stay and quality of life will also be studied, the latter using the validated EuroQol Five questionnaire. The propensity index method will be used to create comparable treatment and control groups, and a multivariate regression will be used to study each variable. The Kaplan-Meier estimator will be used to estimate survival and the log-rank test to make comparisons. A p value of less than 0.05 (two-tailed) will be considered to be significant. Ethics and dissemination Ethical approval for this study was obtained from the Aragon Ethical Committee (C.P.-C.I. PI20/086) on 4 March 2020. The findings of this study will be submitted to peer-reviewed journals (BMJ Open, JAMA Surgery, Annals of Surgery, British Journal of Surgery). Abstracts will be submitted to relevant national and international meetings. Trial registration number NCT04305314

Surgical treatment for colorectal cancer: Analysis of the influence of an enhanced recovery programme on long-term oncological outcomes-a study protocol for a prospective, multicentre, observational cohort study

Introduction The evidence currently available from enhanced recovery after surgery (ERAS) programmes concerns their benefits in the immediate postoperative period, but there is still very little evidence as to whether their correct implementation benefits patients in the long term. The working hypothesis here is that, due to the lower response to surgical aggression and lower rates of postoperative complications, ERAS protocols can reduce colorectal cancer-related mortality. The main objective of this study is to analyse the impact of an ERAS programme for colorectal cancer on 5-year survival. As secondary objectives, we propose to analyse the weight of each of the predefined items in the oncological results as well as the quality of life. Methods and analysis A multicentre prospective cohort study was conducted in patients older than 18 years of age who are scheduled to undergo surgery for colorectal cancer. The study involved 12 hospitals with an implemented enhanced recovery protocol according to the guidelines published by the Spanish National Health Service. The intervention group includes patients with a minimum implementation level of 70%, and the control group includes those who fail to reach this level. Compliance will be studied using 18 key performance indicators, and the results will be analysed using cancer survival indicators, including overall survival, cancer-specific survival and relapse-free survival. The time to recurrence, perioperative morbidity and mortality, hospital stay and quality of life will also be studied, the latter using the validated EuroQol Five questionnaire. The propensity index method will be used to create comparable treatment and control groups, and a multivariate regression will be used to study each variable. The Kaplan-Meier estimator will be used to estimate survival and the log-rank test to make comparisons. A p value of less than 0.05 (two-tailed) will be considered to be significant. Ethics and dissemination Ethical approval for this study was obtained from the Aragon Ethical Committee (C.P.-C.I. PI20/086) on 4 March 2020. The findings of this study will be submitted to peer-reviewed journals (BMJ Open, JAMA Surgery, Annals of Surgery, British Journal of Surgery). Abstracts will be submitted to relevant national and international meetings.The present research study was awarded a Ministerio de Ciencia e Innovación health research project grant (PI19/00291) from the Carlos III Institute of the Spanish National Health Service as part of the 2019 call for Strategic Action in Health

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results