Storm-Time Equatorial Thermospheric Dynamics and Electrodynamics

We present the first complete study of the dynamics of the equatorial upper atmosphere (180-350 km) during periods of strong magnetic activity driven by the Sun, which are generally referred as geomagnetic storms. These storms have the potential to considerably affect satellite-based communications and navigation systems among other severe technological challenges. We used large databases of two of the most important parameters at these altitudes, which are the velocities of the neutral and ionized gas (plasma) referred to as neutral winds and plasma drifts. These measurements were acquired in the Peruvian equatorial region by the Jicamarca radar and by a network of optical instruments nearby. In the first part, we derived average patterns of the neutral winds under weak geomagnetic activity conditions, or quiet times, for different seasons and compared them with predictions from current upper-atmospheric models. Then, we present, for the first time, the seasonal patterns of the night-time perturbations in the neutral winds at equatorial latitudes, and their variations for different solar-driven geomagnetic storms. These wind perturbations are strongest in the east-west direction and around midnight. They are strongest and longer lasting during and after extended periods of geomagnetic activity. We present a simple empirical model that significantly improves the prediction of the perturbations in the neutral winds compared with current models. In the second part, we derive the velocity perturbations in the plasma drifts along the vertical direction following 3 to 9 hours of geomagnetic activity. We show in detail that these vertical velocity perturbations are small and down-ward during the day and upward and stronger at night, and vary throughout the year and for different solar conditions. They are strongest near sunrise and sunset and during the equinoxes. In the last part of the thesis, we show the close relationship of the neutral wind and plasma drift velocities along the east-west direction during both geomagnetic quiet and disturbed conditions. Finally, we summarize our main results and make suggestions to improve the understanding of this important topic

Storm-Time Thermospheric Winds Over Peru

We used Fabry-Perot Interferometer (FPI) observations at Jicamarca, Nasca and Arequipa, Peru from 2011 to 2017 to study the nighttime zonal and meridional disturbance winds over the Peruvian equatorial region. We derived initially the seasonal-dependent average thermospheric winds corresponding to 12 hours of continuous geomagnetically quiet conditions. These quiet-time climatological winds, which are in general agreement with results from the Horizontal Wind Model (HWM14), were then used as baselines for the calculation of the disturbance winds. Our results indicate that the nighttime zonal disturbance winds are westward with peak values near midnight and with magnitudes much larger than predicted by the Disturbance Wind Model (DWM07). The premidnight equinoctial and June solstice westward disturbance winds have comparable values and increase with local time. The postmidnight westward disturbance winds decrease towards dawn and are largest during equinox and smallest during June solstice. The meridional average disturbance winds have small values throughout the night. They are northward in the premidnight sector, and southward with larger (smaller) values during December solstice (equinox) in the postmidnight sector. We also present observations showing that during the main and recovery phases of the April 2012 and May 2016 geomagnetic storms the zonal disturbance winds have much larger magnitudes and lifetimes (up to about 48 hours) than suggested by the HWM14. These observations highlight the importance of longer-term disturbance wind effects. The large and short-lived (about 2 hours) observed meridional wind disturbances are not reproduced by current climatological empirical models

Equatorial Disturbance Dynamo Vertical Plasma Drifts Over Jicamarca: Bi‐Monthly and Solar Cycle Dependence

We use extensive incoherent scatter radar observations from the Jicamarca Radio Observatory to study the local time and bi‐monthly dependence of the equatorial disturbance dynamo vertical plasma drifts on solar flux and geomagnetic activity. We show that the daytime disturbance drifts have generally small magnitudes with largest values before noon and an apparent annual variation. Near dusk, they are downward throughout the year with largest values during the equinoxes and smallest during June solstice. These downward drifts increase strongly with solar flux, and shift to later local times. They also increase with increasing geomagnetically active conditions with no apparent local time shift. The equinoctial evening downward disturbance drifts are larger during the autumnal equinox than during the vernal equinox. The nighttime disturbance drifts are upward and have small seasonal and solar cycle dependence but increase strongly with geomagnetic activity, particularly in the late night sector. Our results are in general agreement with those from previous theoretical and experimental studies, except near dusk where our results show much stronger seasonal and solar cycle dependence

Conductance control for electromagnetic-compatible induction heating appliances

The design requirements of induction hobs are strongly restricted by efficiency, heating performance, cost, the generation of acoustic noise, and electromagnetic compatibility (EMC). These two latter topics, cost and EMC, motivated the research presented in this article. The different levels at which the equivalent load of the induction hob is excited generate a variation of the equivalent impedance throughout the grid period even if all the other parameters are kept constant. This can cause a nonsinusoidal consumption of the grid current which goes against the compliance with EMC standards. This article proposes an online controller which controls the conductance seen by the inverter by only modifying the switching frequency throughout the bus period. This greatly reduces the harmonic distortion of the grid current, no matter what is the type of the vessel used. Moreover, it requires neither power-factor correction rectifiers nor any additional circuitry and it has a faster dynamic response with respect to the traditional solutions used in induction hobs due to its higher bandwidth

Hypothesized role of pregnancy hormones on HER2+breast tumor development

Breast cancer incidence rates have declined among older but not younger women; the latter are more likely to be diagnosed with breast cancers carrying a poor prognosis. Epidemiological evidence supports an increase in breast cancer incidence following pregnancy with risk elevated as much as 10 years post-partum. We investigated the association between years since last full-term pregnancy at the time of diagnosis (10 years) and breast tumor subtype in a case series of premenopausal Hispanic women (n = 627). Participants were recruited in the United States, Mexico, and Spain. Cases with known estrogen receptor (ER), progesterone receptor (PR), and HER2 status, with one or more full-term pregnancies >/=1 year prior to diagnosis were eligible for this analysis. Cases were classified into three tumor subtypes according to hormone receptor (HR+ = ER+ and/or PR+; HR- = ER- and PR-) expression and HER2 status: HR+/HER2-, HER2+ (regardless of HR), and triple negative breast cancer. Case-only odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated for HER2+ tumors in reference to HR+/HER2- tumors. Participants were pooled in a mixed-effects logistic regression model with years since pregnancy as a fixed effect and study site as a random effect. When compared to HR+/HER2- cases, women with HER2+ tumors were more likely be diagnosed in the post-partum period of 45 years) did not materially alter our results (OR = 1.78; 95 % CI, 1.08-2.93). These findings support the novel hypothesis that factors associated with the post-partum breast, possibly hormonal, are involved in the development of HER2+ tumors

Measurement of the Lifetime Difference Between B_s Mass Eigenstates

We present measurements of the lifetimes and polarization amplitudes for B_s --> J/psi phi and B_d --> J/psi K*0 decays. Lifetimes of the heavy (H) and light (L) mass eigenstates in the B_s system are separately measured for the first time by determining the relative contributions of amplitudes with definite CP as a function of the decay time. Using 203 +/- 15 B_s decays, we obtain tau_L = (1.05 +{0.16}/-{0.13} +/- 0.02) ps and tau_H = (2.07 +{0.58}/-{0.46} +/- 0.03) ps. Expressed in terms of the difference DeltaGamma_s and average Gamma_s, of the decay rates of the two eigenstates, the results are DeltaGamma_s/Gamma_s = (65 +{25}/-{33} +/- 1)%, and DeltaGamma_s = (0.47 +{0.19}/-{0.24} +/- 0.01) inverse ps.Comment: 8 pages, 3 figures, 2 tables; as published in Physical Review Letters on 16 March 2005; revisions are for length and typesetting only, no changes in results or conclusion

Altered Hematopoiesis in Mice Lacking DNA Polymerase μ Is Due to Inefficient Double-Strand Break Repair

Polymerase mu (Polμ) is an error-prone, DNA-directed DNA polymerase that participates in non-homologous end-joining (NHEJ) repair. In vivo, Polμ deficiency results in impaired Vκ-Jκ recombination and altered somatic hypermutation and centroblast development. In Polμ−/− mice, hematopoietic development was defective in several peripheral and bone marrow (BM) cell populations, with about a 40% decrease in BM cell number that affected several hematopoietic lineages. Hematopoietic progenitors were reduced both in number and in expansion potential. The observed phenotype correlates with a reduced efficiency in DNA double-strand break (DSB) repair in hematopoietic tissue. Whole-body γ-irradiation revealed that Polμ also plays a role in DSB repair in non-hematopoietic tissues. Our results show that Polμ function is required for physiological hematopoietic development with an important role in maintaining early progenitor cell homeostasis and genetic stability in hematopoietic and non-hematopoietic tissues

Attaching and effacing (A/E) lesion formation by enteropathogenic E. coli on human intestinal mucosa is dependent on non-LEE effectors

Enteropathogenic E. coli (EPEC) is a human pathogen that causes acute and chronic pediatric diarrhea. The hallmark of EPEC infection is the formation of attaching and effacing (A/E) lesions in the intestinal epithelium. Formation of A/E lesions is mediated by genes located on the pathogenicity island locus of enterocyte effacement (LEE), which encode the adhesin intimin, a type III secretion system (T3SS) and six effectors, including the essential translocated intimin receptor (Tir). Seventeen additional effectors are encoded by genes located outside the LEE, in insertion elements and prophages. Here, using a stepwise approach, we generated an EPEC mutant lacking the entire effector genes (EPEC0) and intermediate mutants. We show that EPEC0 contains a functional T3SS. An EPEC mutant expressing intimin but lacking all the LEE effectors but Tir (EPEC1) was able to trigger robust actin polymerization in HeLa cells and mucin-producing intestinal LS174T cells. However, EPEC1 was unable to form A/E lesions on human intestinal in vitro organ cultures (IVOC). Screening the intermediate mutants for genes involved in A/E lesion formation on IVOC revealed that strains lacking non-LEE effector/s have a marginal ability to form A/E lesions. Furthermore, we found that Efa1/LifA proteins are important for A/E lesion formation efficiency in EPEC strains lacking multiple effectors. Taken together, these results demonstrate the intricate relationships between T3SS effectors and the essential role non-LEE effectors play in A/E lesion formation on mucosal surfaces

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe