The Role of the Nuclear Factor-Kappa B (NF-κB) Pathway in SARS-CoV-2 Infection

COVID-19 is a global health threat caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is associated with a significant increase in morbidity and mortality. The present review discusses nuclear factor-kappa B (NF-κB) activation and its potential therapeutical role in treating COVID-19. COVID-19 pathogenesis, the major NF-κB pathways, and the involvement of NF-κB in SARS-CoV-2 have been detailed. Specifically, NF-κB activation and its impact on managing COVID-19 has been discussed. As a central player in the immune and inflammatory responses, modulating NF-κB activation could offer a strategic avenue for managing SARS-CoV-2 infection. Understanding the NF-κB pathway’s role could aid in developing treatments against SARS-CoV-2. Further investigations into the intricacies of NF-κB activation are required to reveal effective therapeutic strategies for managing and combating the SARS-CoV-2 infection and COVID-19

Recent advances in nanomaterials for neural applications: opportunities and challenges - supplementary tables

Nanomedicines are promising for delivering drugs to the central nervous system, though their precision is still being improved. Fortifying nanoparticles with vital molecules can interact with the blood–brain barrier, enabling access to brain tissue. This study summarizes recent advances in nanomedicine to treat neurological complications. The integration of nanotechnology into cell biology aids in the study of brain cells' interactions. Magnetic microhydrogels have exhibited superior neuron activation compared with superparamagnetic iron oxide nanoparticles and hold promise for neuropsychiatric disorders. Nanomaterials have shown notable results, such as tackling neurodegenerative diseases by hindering harmful protein buildup and regulating cellular processes. However, further studies of the safety and effectiveness of nanoparticles in managing neurological diseases and disorders are still required.</p

Recent advances in green synthesized nanoparticles for bactericidal and wound healing applications

Nanotechnology has become an exciting area of research in diverse fields, such as: healthcare, food, agriculture, cosmetics, paints, lubricants, fuel additives and other fields. This review is a novel effort to update the practioneers about the most current developments in the widespread use of green synthesized nanoparticles in medicine. Biosynthesis is widely preferred among different modes of nanoparticle synthesis since they do not require toxic chemical usage and they are environment-friendly. In the green bioprocess, plant, algal, fungal and cyanobacterial extract solutions have been utilized as nucleation/capping agents to develop effective nanomaterials for advanced medical applications. Several metal salts, such as silver, zinc, titanium and other inorganic salts, were utilized to fabricate innovative nanoparticles for healthcare applications. Irrespective of the type of wound, infection in the wound area is a widespread problem. Micro-organisms, the prime reason for wound complications, are gradually gaining resistance against the commonly used antimicrobial drugs. This necessitates the need to generate nanoparticles with efficient antimicrobial potential to keep the pathogenic microbes under control. These nanoparticles can be topically applied as an ointment and also be used by incorporating them into hydrogels, sponges or electrospun nanofibers. The main aim of this review is to highlight the recent advances in the Ag, ZnO and TiO2 nanoparticles with possible wound healing applications, coupled with the bactericidal ability of a green synthesis process