6 research outputs found
Methods of Liver Stem Cell Therapy in Rodents as Models of Human Liver Regeneration in Hepatic Failure
Cell
therapy is a promising intervention for treating liver diseases and liver
failure. Different animal models of human liver cell therapy have been
developed in recent years. Rats and mice are the most commonly used liver
failure models. In fact, rodent models of hepatic failure have shown
significant improvement in liver function after cell infusion. With the advent
of stem-cell technologies, it is now possible to re-programme adult somatic
cells such as skin or hair-follicle cells from individual patients to stem-like
cells and differentiate them into liver cells. Such regenerative stem cells are
highly promising in the personalization of cell therapy. The present review
article will summarize current approaches to liver stem cell therapy with
rodent models. In addition, we discuss common cell tracking techniques and how
tracking data help to direct liver cell therapy research in animal models of
hepatic failure