24 research outputs found

    A qualitative study exploring the health-related quality of life and symptomatic experiences of adults and adolescents with ulcerative colitis

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    Background: Ulcerative colitis (UC) often first presents during adolescence and early adulthood. Primary symptoms of UC are well known, yet similarities and differences of disease experience in adults and adolescents are not well characterized. Methods: To understand the health-related quality of life (HRQoL) and symptomatic experience of UC, in-depth interviews were conducted in the US with 21 adults (20–70 years) and 14 adolescents (12–17 years). Eligibility and medical history were confirmed by clinician report. A previously conducted literature review and resultant conceptual model informed the discussion guide to explore symptoms and HRQoL. Age appropriate creative tasks (“animal” task and collage) were employed to facilitate discussion. Transcripts and collages were subjected to thematic analysis using ATLAS.ti software. Results: Clinician-reported UC severity included 24% mild, 38% moderate, 38% severe among adults; and 64% mild, 29% moderate, 7% severe among adolescents. Among adults, 52% were female, 67% were white. Among adolescents, 50% were female, 71% were white. During analysis it was noted that all participants reported stomach/abdominal pain. Other key symptoms identified were frequent bowel movements, diarrhea, blood in stools, sudden need for bowel movement, stomach cramping, bloating, and feeling gassy/passing gas (?75% of participants). Key impacts identified were embarrassment, dietary limitations, having to plan around UC, worry/fear, anger, low mood/depression, and relationship with others, (?75% of participants). In creative tasks, animals were chosen to represent their UC and content included in the collages reflected the most commonly discussed themes from the interviews. Only adults discussed feeling dehydrated, while only adolescents discussed the impact of UC on school life. Conclusions: Open-ended interviews highlighted the HRQoL and symptomatic experiences of UC from the patient’s perspective, which were similar between adult and adolescent UC patients

    Measurement of the t-channel single top quark production cross section in pp collisions at √s =7 TeV

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    Peer reviewe

    Search for microscopic black holes in pp collisions at √s̅ = 7 TeV

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    Peer reviewe

    Study of the production of charged pions, kaons, and protons in pPb collisions at √SNN=5.02 TeV

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    Peer reviewe

    Search for New Physics in the Multijet and Missing Transverse Momentum Final State in Proton-Proton Collisions at √s=7 TeV

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    A search for physics beyond the standard model is performed in events with at least three jets and large missing transverse momentum produced in proton-proton collisions at sqrt(s) = 7 TeV. No significant excess of events above the expected backgrounds is observed in 4.98 inverse femtobarns of data collected with the CMS detector at the Large Hadron Collider. The results are presented in the context of the constrained minimal supersymmetric extension of the standard model and more generically for simplified models. For the simplified models of gluino-gluino and squark-squark production, gluino masses below 1.0 TeV and squark masses below 0.76 TeV are excluded in case the lightest supersymmetric particle mass is below 200 GeV. These results significantly extend previous searches

    Ratios of dijet production cross sections as a function of the absolute difference in rapidity between jets in proton-proton collisions at √s = 7TeV

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    A study of dijet production in proton-proton collisions was performed at root s = 7 TeV for jets with p(T) > 35 GeV and vertical bar y vertical bar < 4.7 using data collected with the CMS detector at the LHC in 2010. Events with at least one pair of jets are denoted as "inclusive". Events with exactly one pair of jets are called "exclusive". The ratio of the cross section of all pairwise combinations of jets to the exclusive dijet cross section as a function of the rapidity difference between jets vertical bar Delta y vertical bar is measured for the first time up to vertical bar Delta y vertical bar = 9.2. The ratio of the cross section for the pair consisting of the most forward and the most backward jet from the inclusive sample to the exclusive dijet cross section is also presented. The predictions of the Monte Carlo event generators PYTHIA6 and PYTHIA8 agree with the measurements. In both ratios the HERWIG++ generator exhibits a more pronounced rise versus vertical bar Delta y vertical bar than observed in the data. The BFKL-motivated generators CASCADE and HEJ+ARIADNE predict for these ratios a significantly stronger rise than observed

    Patients' Perspectives on the Impact of Genital Psoriasis: A Qualitative Study

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    Contains fulltext : 181645.pdf (publisher's version ) (Open Access
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