OPUS: an Alternate Reality Game to learn SQL at university

The project aims to test the effectiveness of applying the principles of experiential learning within a university course. In particular, the objective of the paper is to investigate the educational effectiveness of the Alternate Reality Games (ARGs) and of their characterizing elements: the immersive storytelling, which blends reality and fiction, and the collaborative approach, which activates collective intelligence dynamics. The project combines the concepts of a Database course with the transmedial interaction techniques of a Transmedia course. The idea was to stimulate the interest of Databases course’s students in this subject and help them learn and consolidate SQL. The result was the creation of a playful experience that is classified as Alternate Reality Game, a realistic and highly immersive interactive storytelling, set in a likely fictional universe where the basic rule is “This is not a game”. The ARG was designed to complement the laboratory practice in the context of a Databases university course. In this way, students can practice, review and consolidate the skills acquired during the course. Furthermore, the playful component is accompanied by on-demand educational content, which players have the opportunity to request when they experience difficulties in solving puzzles that require querying the database

Mechanical, thermomechanical and reprocessing behavior of green composites from biodegradable polymer and wood flour

The rising concerns in terms of environmental protection and the search for more versatile polymer-based materials have led to an increasing interest in the use of polymer composites filled with natural organic fillers (biodegradable and/or coming from renewable resources) as a replacement for traditional mineral inorganic fillers. At the same time, the recycling of polymers is still of fundamental importance in order to optimize the utilization of available resources, reducing the environmental impact related to the life cycle of polymer-based items. Green composites from biopolymer matrix and wood flour were prepared and the investigation focused on several issues, such as the effect of reprocessing on the matrix properties, wood flour loading effects on virgin and reprocessed biopolymer, and wood flour effects on material reprocessability. Tensile, Dynamic-mechanical thermal (DMTA), differential scanning calorimetry (DSC) and creep tests were performed, pointing out that wood flour leads to an improvement of rigidity and creep resistance in comparison to the pristine polymer, without compromising other properties such as the tensile strength. The biopolymer also showed a good resistance to multiple reprocessing; the latter even allowed for improving some properties of the obtained green composites

Beyond a Fluorescent Probe: Inhibition of Cell Division Protein FtsZ by mant-GTP Elucidated by NMR and Biochemical Approaches

© 2015 American Chemical Society. FtsZ is the organizer of cell division in most bacteria and a target in the quest for new antibiotics. FtsZ is a tubulin-like GTPase, in which the active site is completed at the interface with the next subunit in an assembled FtsZ filament. Fluorescent mant-GTP has been extensively used for competitive binding studies of nucleotide analogs and synthetic GTP-replacing inhibitors possessing antibacterial activity. However, its mode of binding and whether the mant tag interferes with FtsZ assembly function were unknown. Mant-GTP exists in equilibrium as a mixture of C2′- and C3′-substituted isomers. We have unraveled the molecular recognition process of mant-GTP by FtsZ monomers. Both isomers bind in the anti glycosidic bond conformation: 2′-mant-GTP in two ribose puckering conformations and 3′-mant-GTP in the preferred C2′ endo conformation. In each case, the mant tag strongly interacts with FtsZ at an extension of the GTP binding site, which is also supported by molecular dynamics simulations. Importantly, mant-GTP binding induces archaeal FtsZ polymerization into inactive curved filaments that cannot hydrolyze the nucleotide, rather than straight GTP-hydrolyzing assemblies, and also inhibits normal assembly of FtsZ from the Gram-negative bacterium Escherichia coli but is hydrolyzed by FtsZ from Gram-positive Bacillus subtilis. Thus, the specific interactions provided by the fluorescent mant tag indicate a new way to search for synthetic FtsZ inhibitors that selectively suppress the cell division of bacterial pathogens.BFU2011-23416 and BFU2014-51823-R (J.M.A), CTQ2012-32065 (J.J.B.), CM 2010/BMD-2353 (J.J.B. and J.M.A.), FCT SFRH/BPD/65462/2009 and UID/Multi/04378/2013 (F.M.) and a FPI fellowship (L.B.R.A).Peer Reviewe

La importancia de los intereses académicos en la política científica y tecnológica catalana

Publicado en: 'Papers: Revista de Sociología', 70: 11-40, 2003Este artículo describe la emergencia y orientación de las políticas de I+D e innovación en Cataluña. Se analizan cuáles son los factores más influyentes en la orientación de estas políticas y, en definitiva, en las opciones políticas que se toman. La política de ciencia y tecnología desarrollada por el gobierno regional catalán desde principios de los años ochenta ha sido una política en la que, a pesar de las preferencias manifestadas en el discurso político, ha predominado un modelo de política académico sobre el de orientación empresarial. Asimismo, en términos organizativos e institucionales, en la Administración autonómica, la política científica ha estado separada y diferenciada de la política tecnológica a pesar del diseño inicial de instituciones interdepartamentales. La principal razón de que la política de I+D catalana no siguiera un modelo más industrial, ligado al mundo empresarial, fue la presión que ejercieron las universidades catalanas para que, tanto el diseño institucional como el contenido de la política se adaptara a sus necesidades. La trayectoria académica previa de los gestores también contribuyó a la reorientación de las preferencias políticas. A pesar de la importancia de las empresas catalanas en la I+D, éstas no se movilizaron ni presionaron a los gobiernos suficientemente. Analíticamente, este caso ilustra cómo la sola creación política de instituciones no garantiza la realización de las preferencias políticas. También pone de manifiesto cómo el horizonte temporal de la toma de decisiones gubernamental tiene un efecto en las expectativas de los actores, que desarrollan procesos de aprendizaje a partir de las experiencias en arenas políticas similares a otros niveles. Por último, destaca la importancia del poder en las instituciones de gestión en este tipo de política distributiva.Peer reviewe

La importancia de los intereses académicos en la política científica y tecnológica catalana

Publicado en: 'Papers: Revista de Sociología', 70: 11-40, 2003Este artículo describe la emergencia y orientación de las políticas de I+D e innovación en Cataluña. Se analizan cuáles son los factores más influyentes en la orientación de estas políticas y, en definitiva, en las opciones políticas que se toman. La política de ciencia y tecnología desarrollada por el gobierno regional catalán desde principios de los años ochenta ha sido una política en la que, a pesar de las preferencias manifestadas en el discurso político, ha predominado un modelo de política académico sobre el de orientación empresarial. Asimismo, en términos organizativos e institucionales, en la Administración autonómica, la política científica ha estado separada y diferenciada de la política tecnológica a pesar del diseño inicial de instituciones interdepartamentales. La principal razón de que la política de I+D catalana no siguiera un modelo más industrial, ligado al mundo empresarial, fue la presión que ejercieron las universidades catalanas para que, tanto el diseño institucional como el contenido de la política se adaptara a sus necesidades. La trayectoria académica previa de los gestores también contribuyó a la reorientación de las preferencias políticas. A pesar de la importancia de las empresas catalanas en la I+D, éstas no se movilizaron ni presionaron a los gobiernos suficientemente. Analíticamente, este caso ilustra cómo la sola creación política de instituciones no garantiza la realización de las preferencias políticas. También pone de manifiesto cómo el horizonte temporal de la toma de decisiones gubernamental tiene un efecto en las expectativas de los actores, que desarrollan procesos de aprendizaje a partir de las experiencias en arenas políticas similares a otros niveles. Por último, destaca la importancia del poder en las instituciones de gestión en este tipo de política distributiva.Este trabajo se ha realizado gracias a la financiación del Programa Marco de I+D, del PRICIT de la Comunidad de Madrid y del III Plan Nacional de I+D de la CICYT (SEC 1999-0829-C02-01).Peer reviewe

WldS protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice

The slow Wallerian degeneration (WldS) protein protects injured axons from degeneration. This unusual chimeric protein fuses a 70–amino acid N-terminal sequence from the Ube4b multiubiquitination factor with the nicotinamide adenine dinucleotide–synthesizing enzyme nicotinamide mononucleotide adenylyl transferase 1. The requirement for these components and the mechanism of WldS-mediated neuroprotection remain highly controversial. The Ube4b domain is necessary for the protective phenotype in mice, but precisely which sequence is essential and why are unclear. Binding to the AAA adenosine triphosphatase valosin-containing protein (VCP)/p97 is the only known biochemical property of the Ube4b domain. Using an in vivo approach, we show that removing the VCP-binding sequence abolishes axon protection. Replacing the WldS VCP-binding domain with an alternative ataxin-3–derived VCP-binding sequence restores its protective function. Enzyme-dead WldS is unable to delay Wallerian degeneration in mice. Thus, neither domain is effective without the function of the other. WldS requires both of its components to protect axons from degeneration

Transcribing "Le Pèlerinage de Damoiselle Sapience": Scholarly Editing Covid19-Style

This article describes a methodological experiment conducted during the 13th Annual (Virtual) Schoenberg Symposium on Manuscript Studies in the Digital Age, hosted by the University of Pennsylvania, November 18–20, 2020. The experiment consisted of a “relay style” event in which three teams transcribed, revised, and prepared for submission to this journal a full edition of the “Le Pèlerinage de Damoiselle Sapience” and other texts from UPenn Ms Codex 660, ff. 86r–95v within the three-day timespan of the conference. The project used methods typical of crowdsourcing and drew participants from all over the world and from all different stages of their careers. After one group completed its work, the results were passed into the hands of the next. The final result—in the form of a finished manuscript edition, ready for submission to Digital Medievalist—was presented on the last day of the conference. The main purpose of this experiment was to demonstrate how the work of the transcriber and editor might be structured as a short-term digital event that relied wholly on virtual interactions with both the source materials and among collaborators. This method also reveals the positive aspects of the many challenges posed by working simultaneously, remotely, and globally

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe

Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe