Boris Angelo Cu-(Ag) deposit, Coastal Cordillera, Central Chile. Preliminary data

Este trabajo ha sido publicado en la revista Macla y es accesible en:http://www.ehu.eus/sem/macla_pdf/macla13/Macla13_083.pdfSe hace una descripción, con énfasis en la mineralogía del depósito de Cobre de Boris-Ángelo, situado en la Cordillera de la Costa.Departamento de Mineralogía y Petrología (Universidad de Granada)Departamento de Didáctica de las Ciencias Experimentales (Universidad de Granada

Geology and preliminary REE and trace elements geochemistry of Boris Ángelo Cu-(Ag) deposit, Central Chile

El capítulo de libro ha sido publicado en los “Proceedings of the eleventh biennial SGA meeting”Boris Ángelo Cu-(Ag) deposit, located inCentral Chilean CoastalCordillera, is included within JurassictoCretaceouscopper Chilean Manto type (CMT) deposits belt. Itis hosted by LowerCretaceousvolcanoclastic sequences of the Las Chilcas Formationand by Upper Cretaceous Paleocene small sub-volcanicbodies.Based in this geologicalcontext weconsider the Boris Ángelo deposit as one oftheyoungestdeposits fromCMT deposits belt. In thispaper wedescribe thebehaviour of REE and trace elements fromBoris Ángelo Cu-(Ag) depositand compare thisfeaturewith fresh host rockand with other copperdeposit-types.The Boris Ángelo geochemical signatures aresimilar to LasChilcas ( fresh hostrocks) samples, butwith a general depletionin all REE and trace elements.They also show great similarityin REE and trace element patterns withothers CMT depositsDepartamento de Mineralogía y Petrología (Universidad de Granada). Departamento de Didáctica de las Ciencias Experimentales (Universidad de Granada). Instituto Andaluz de Ciencias de la Tierra (Universidad de Granada- Centro Superior de Investigaciones Científicas) Grupo de Investigación de la Junta de Andalucía RNM-0131. Grupo de Investigación de la Junta de Andalucía HUM 613. Minera Las Ceniza

Las Mineralizaciones de Cu de Cabildo, Cordillera de la Costa, Chile central

Este artículo ha sido publicado en la Revista Macla de la Sociedad Española de Mineralogía disponible en: http://www.ehu.eus/sem/macla_pdf/macla9/macla9_165.pdfSe presenta una caracterización de las Mineralizaciones de Cu de Cabildo, Cordillera de la Costa, Chile central, con la presencia de dos tipos de yacimientos: depósitos de Cu de tipo manto chileno (detpósitos de tipo CMT) y skarn.Departamento de Mineralogía y Petrología (Universidad de Granada)Departamento de Didáctica de las Ciencias Experimentales (Universidad de Granada)Este trabajo ha sido realizado en el marco del proyecto CGL2006-02594 (Ministerio de Educación y Ciencia y FEDER). Verónica Moreno agradece al MEC la financiación recibida a través de una beca FPU

Origen de los metales en depósitos tipo “manto” y skarn. Isótopos de Pb y Cu (Cabildo, Chile Central)

Este artículo ha sido publicado por la revista Macla y está accesible en: http://www.ehu.eus/sem/macla_pdf/macla13/Macla13_161.pdfEl distrito minero de Cabildo, situado en la Cordillera de la Costa de Chile Central, constituye un área minera de especial interés, dado que en la misma confluyen dos tipos de depósitos minerales: mineralizaciones de Cu-(Ag) de tipo “manto” chileno y depósitos de tipo skarn. Los depósitos de tipo skarn son bien conocidos a nivel mundial, pero poco frecuentes en la Cordillera de la Costa, siendo el skarn de Cu de Cabildo el único en producción para el Cu en la región. Los depósitos tipo “manto”, presentan aún bastantes incógnitas respecto a su génesis a pesar de su importancia económica y abundancia en la zona (Maksaev y Zentilli, 2002). En este estudio se aportan datos isotópicos de Pb y Cu de las mineralizaciones principales del distrito minero de Cabildo. Los resultados presentados ofrecen la oportunidad de discutir el origen y el comportamiento de los metales en estos depósitos.Departamento de Mineralogía y Petrología (Universidad de Granada)Departamento de Didáctica de las Ciencias Experimentales (Universidad de Granada)Este trabajo ha sido realizado en el marco del proyecto CGL2006-02594 (Ministerio de Educación y Ciencia y FEDER). Verónica Moreno agradece al MEC la financiación recibida a través de una beca FPU

Characteristics of emergency medicine residency programs in Colombia

Q2Q1Artículo original1120-1127Introduction: Emergency medicine (EM) is in different stages of development around the world. Colombia has made significant strides in EM development in the last two decades and recognized it as a medical specialty in 2005. The country now has seven EM residency programs: three in the capital city of Bogotá, two in Medellin, one in Manizales, and one in Cali. The seven residency programs are in different stages of maturity, with the oldest founded 20 years ago and two founded in the last two years. The objective of this study was to characterize these seven residency programs. Methods: We conducted semi-structured interviews with faculty and residents from all the existing programs in 2013-2016. Topics included program characteristics and curricula. Results: Colombian EM residencies are three-year programs, with the exception of one four-year program. Programs accept 3-10 applicants yearly. Only one program has free tuition and the rest charge tuition. The number of EM faculty ranges from 2-15. EM rotation requirements range from 11-33% of total clinical time. One program does not have a pediatric rotation. The other programs require 1-2 months of pediatrics or pediatric EM. Critical care requirements range from 4-7 months. Other common rotations include anesthesia, general surgery, internal medicine, obstetrics, gynecology, orthopedics, ophthalmology, radiology, toxicology, psychiatry, neurology, cardiology, pulmonology, and trauma. All programs offer 4-6 hours of protected didactic time each week. Some programs require Advanced Cardiac Life Support, Pediatric Advanced Life Support and Advanced Trauma Life Support, with some programs providing these trainings in-house or subsidizing the cost. Most programs require one research project for graduation. Resident evaluations consist of written tests and oral exams several times per year. Point-of-care ultrasound training is provided in four of the seven programs. Conclusion: As emergency medicine continues to develop in Colombia, more residency programs are expected to emerge. Faculty development and sustainability of academic pursuits will be critically important. In the long term, the specialty will need to move toward certifying board exams and professional development through a national EM organization to promote standardization across programs

Characteristics of Emergency Medicine Residency Programs in Colombia

Introduction: Emergency medicine (EM) is in different stages of development around the world. Colombia has made significant strides in EM development in the last two decades and recognized it as a medical specialty in 2005. The country now has seven EM residency programs: three in the capital city of Bogotá, two in Medellin, one in Manizales, and one in Cali. The seven residency programs are in different stages of maturity, with the oldest founded 20 years ago and two founded in the last two years. The objective of this study was to characterize these seven residency programs. Methods: We conducted semi-structured interviews with faculty and residents from all the existing programs in 2013–2016. Topics included program characteristics and curricula. Results: Colombian EM residencies are three-year programs, with the exception of one four-year program. Programs accept 3–10 applicants yearly. Only one program has free tuition and the rest charge tuition. The number of EM faculty ranges from 2–15. EM rotation requirements range from 11–33% of total clinical time. One program does not have a pediatric rotation. The other programs require 1–2 months of pediatrics or pediatric EM. Critical care requirements range from 4–7 months. Other common rotations include anesthesia, general surgery, internal medicine, obstetrics, gynecology, orthopedics, ophthalmology, radiology, toxicology, psychiatry, neurology, cardiology, pulmonology, and trauma. All programs offer 4–6 hours of protected didactic time each week. Some programs require Advanced Cardiac Life Support, Pediatric Advanced Life Support and Advanced Trauma Life Support, with some programs providing these trainings in-house or subsidizing the cost. Most programs require one research project for graduation. Resident evaluations consist of written tests and oral exams several times per year. Point-of-care ultrasound training is provided in four of the seven programs. Conclusion: As emergency medicine continues to develop in Colombia, more residency programs are expected to emerge. Faculty development and sustainability of academic pursuits will be critically important. In the long term, the specialty will need to move toward certifying board exams and professional development through a national EM organization to promote standardization across programs

HCV-coinfection is related to an increased HIV-1 reservoir size in cART-treated HIV patients: a cross-sectional study

In HIV-1/HCV-coinfected patients, chronic HCV infection leads to an increased T-lymphocyte immune activation compared to HIV-monoinfected patients, thereby likely contributing to increase HIV-1 reservoir that is the major barrier for its eradication. Our objective was to evaluate the influence of HCV coinfection in HIV-1 viral reservoir size in resting (r) CD4+ T-cells (CD25-CD69-HLADR-). Multicenter cross-sectional study of 97 cART-treated HIV-1 patients, including 36 patients with HIV and HCV-chronic co-infection without anti-HCV treatment, 32 HIV patients with HCV spontaneous clearance and 29 HIV-monoinfected patients. rCD4+ T-cells were isolated and total DNA was extracted. HIV viral reservoir was measured by Alu-LTR qPCR. Differences between groups were calculated with a generalized linear model. Overall, 63.9% were men, median age of 41 years and Caucasian. Median CD4+ and CD8+ T-lymphocytes were 725 and 858 cells/mm 3 , respectively. CD4+ T nadir cells was 305 cells/mm 3 . Proviral HIV-1 DNA size was significantly increased in chronic HIV/HCV-coinfected compared to HIV-monoinfected patients (206.21 ± 47.38 vs. 87.34 ± 22.46, respectively; P = 0.009), as well as in spontaneously clarified HCV co-infected patients when compared to HIV-monoinfected individuals (136.20 ± 33.20; P = 0.009). HIV-1/HCV co-infected patients showed a larger HIV-1 reservoir size in comparison to HIV-monoinfected individuals. This increase could lead to a greater complexity in the elimination of HIV-1 reservoir in HIV-1/HCV-coinfected individuals, which should be considered in the current strategies for the elimination of HIV-1 reservoir.Financial support was provided by the Instituto de Salud Carlos III to VB (PI15CIII/00031), by the Spanish Ministry of Economy and Competitiveness to MC (SAF2016–78480-R) and The SPANISH AIDS Research Network RD16CIII/0002/0001, RD16CIII/0002/0002 and RD16/0025/0013 - ISCIII – FEDER. MRLP is supported by ISCIII - Subdirección General de Evaluacion and European Funding for Regional Development (FEDER) (PIE 13/00040 and RD12/0017/0017 RETIC de SIDA). C.P. is supported by the Portuguese Fundação para a Ciência e Tecnologia (FCT) (grant number SFRH/ BPD/77448/2011 is part of the EDCTP2 programme supported by the European Union). V.B., A.F.R. and N.R. are supported by the Miguel Servet programme from Fondo de Investigación Sanitaria (ISCIII) (grant number CP13/00098, CP14/CIII/00010 and CP14/00198, respectively)

Combined Forward-Backward Asymmetry Measurements in Top-Antitop Quark Production at the Tevatron

The CDF and D0 experiments at the Fermilab Tevatron have measured the asymmetry between yields of forward- and backward-produced top and antitop quarks based on their rapidity difference and the asymmetry between their decay leptons. These measurements use the full data sets collected in proton-antiproton collisions at a center-of-mass energy of $\sqrt s =1.96$ TeV. We report the results of combinations of the inclusive asymmetries and their differential dependencies on relevant kinematic quantities. The combined inclusive asymmetry is $A_{\mathrm{FB}}^{t\bar{t}} = 0.128 \pm 0.025$. The combined inclusive and differential asymmetries are consistent with recent standard model predictions

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio