Impact of Cosmic Variance on the Galaxy-Halo Connection for Lyman-α\alpha Emitters

In this paper we study the impact of cosmic variance and observational uncertainties in constraining the mass and occupation fraction, $f_{\rm occ}$, of dark matter halos hosting Ly-$\alpha$ Emitting Galaxies (LAEs) at high redshift. To this end, we construct mock catalogs from an N-body simulation to match the typical size of observed fields at $z=3.1$ ($\sim 1 {\rm deg^2}$). In our model a dark matter halo with mass in the range $M_{\rm min}<M_{\mathrm h}<M_{\rm max}$ can only host one detectable LAE at most. We proceed to explore the parameter space determined by $M_{\rm min}$,$M_{\rm max}$ and $f_{\rm occ}$ with a Markov Chain Monte-Carlo algorithm using the angular correlation function (ACF) and the LAEs number density as observational constraints. We find that the preferred minimum and maximum masses in our model span a wide range $10^{10.0}h^{-1}{\rm{M_{\odot}}}\leq M_{\rm min} \leq 10^{11.1}h^{-1}{\rm{M_{\odot}}}$ , $10^{11.0}h^{-1}{\rm{M_{\odot}}}\leq M_{\rm max} \leq 10^{13.0}h^{-1}{\rm{M_{\odot}}}$; followed by a wide range in the occupation fraction $0.02\leq f_{\rm occ} \leq 0.30$. As a consequence the median mass, $M_{50}$, of all the consistent models has a large uncertainty $M_{50} = 3.16^{+9.34}_{-2.37}\times 10^{10}$$h^{-1}{\rm{M_{\odot}}}$. However, we find that the same individual models have a relatively tight $1\sigma$ scatter around the median mass $\Delta M_{1\sigma} = 0.55^{+0.11}_{-0.31}$ dex. We are also able to show that \focc\ is uniquely determined by $M_{\rm min}$, regardless of $M_{\rm max}$. We argue that upcoming large surveys covering at least $25$ deg$^{2}$ should be able to put tighter constraints on $M_{\rm min}$ and $f_{\rm occ}$ through the LAE number density distribution width constructed over several fields of $\sim 1$ deg$^{2}$.Comment: 7 Pages, 5 figures. Accepted for publication in Ap

Probing the Structure and Evolution of BASS AGN through Eddington Ratios

We constrain the intrinsic Eddington ratio (\lamEdd ) distribution function for local AGN in bins of low and high obscuration (log NH <= 22 and 22 < log NH < 25), using the Swift-BAT 70-month/BASS DR2 survey. We interpret the fraction of obscured AGN in terms of circum-nuclear geometry and temporal evolution. Specifically, at low Eddington ratios (log lamEdd < -2), obscured AGN outnumber unobscured ones by a factor of ~4, reflecting the covering factor of the circum-nuclear material (0.8, or a torus opening angle of ~ 34 degrees). At high Eddington ratios (\log lamEdd > -1), the trend is reversed, with < 30% of AGN having log NH > 22, which we suggest is mainly due to the small fraction of time spent in a highly obscured state. Considering the Eddington ratio distribution function of narrow-line and broad-line AGN from our prior work, we see a qualitatively similar picture. To disentangle temporal and geometric effects at high lamEdd, we explore plausible clearing scenarios such that the time-weighted covering factors agree with the observed population ratio. We find that the low fraction of obscured AGN at high lamEdd is primarily due to the fact that the covering factor drops very rapidly, with more than half the time is spent with < 10% covering factor. We also find that nearly all obscured AGN at high-lamEdd exhibit some broad-lines. We suggest that this is because the height of the depleted torus falls below the height of the broad-line region, making the latter visible from all lines of sight.Comment: Accepted by ApJ

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

BAT AGN spectroscopic survey - XV: the high frequency radio cores of ultra-hard X-ray selected AGN

We have conducted 22 GHz radio imaging at 1 arcsec resolution of 100 low-redshift AGN selected at 14-195 keV by the Swift-BAT. We find a radio core detection fraction of 96 per cent, much higher than lower frequency radio surveys. Of the 96 radio-detected AGN, 55 have compact morphologies, 30 have morphologies consistent with nuclear star formation, and 11 have sub-kpc to kpc-scale jets. We find that the total radio power does not distinguish between nuclear star formation and jets as the origin of the radio emission. For 87 objects, we use optical spectroscopy to test whether AGN physical parameters are distinct between radio morphological types. We find that X-ray luminosities tend to be higher if the 22 GHz morphology is jet-like, but find no significant difference in other physical parameters. We find that the relationship between the X-ray and core radio luminosities is consistent with the L-R/L-X similar to 10(-5) of coronally active stars. We further find that the canonical fundamental planes of black hole activity systematically overpredict our radio luminosities, particularly for objects with star formation morphologies

BASS. XXIX. The Near-infrared View of the Broad-line Region (BLR): The Effects of Obscuration in BLR Characterization*

Virial black hole (BH) mass (M (BH)) determination directly involves knowing the broad-line region (BLR) clouds' velocity distribution, their distance from the central supermassive BH (R (BLR)), and the virial factor (f). Understanding whether biases arise in M (BH) estimation with increasing obscuration is possible only by studying a large (N > 100) statistical sample of obscuration-unbiased (hard) X-ray-selected active galactic nuclei (AGNs) in the rest-frame near-infrared (0.8-2.5 mu m) since it penetrates deeper into the BLR than the optical. We present a detailed analysis of 65 local Burst Alert Telescope (BAT) selected Seyfert galaxies observed with Magellan/FIRE. Adding these to the near-infrared BAT AGN spectroscopic survey database, we study a total of 314 unique near-infrared spectra. While the FWHMs of H alpha and near-infrared broad lines (He i, Pa beta, Pa alpha) remain unbiased to either BLR extinction or X-ray obscuration, the H alpha broad-line luminosity is suppressed when N (H) greater than or similar to 10(21) cm(-2), systematically underestimating M (BH) by 0.23-0.46 dex. Near-infrared line luminosities should be preferred to H alpha until N (H) < 10(22) cm(-2), while at higher obscuration a less-biased R (BLR) proxy should be adopted. We estimate f for Seyfert 1 and 2 using two obscuration-unbiased M (BH) measurements, i.e., the stellar velocity dispersion and a BH mass prescription based on near-infrared and X-ray, and find that the virial factors do not depend on the redshift or obscuration, but some broad lines show a mild anticorrelation with M (BH). Our results show the critical impact obscuration can have on BLR characterization and the importance of the near-infrared and X-rays for a less-biased view of the BLR.ISSN:1538-4365ISSN:0067-004

BASS. XXVI. DR2 Host Galaxy Stellar Velocity Dispersions

We present new central stellar velocity dispersions for 484 Sy 1.9 and Sy 2 from the second data release of the Swift/BAT AGN Spectroscopic Survey (BASS DR2). This constitutes the largest study of velocity dispersion measurements in X-ray-selected obscured active galactic nuclei (AGN) with 956 independent measurements of the Ca ii H and K lambda 3969, 3934 and Mg I lambda 5175 region (3880-5550 angstrom) and the calcium triplet region (8350-8730 angstrom) from 642 spectra mainly from VLT/X-Shooter or Palomar/DoubleSpec. Our sample spans velocity dispersions of 40-360 km s(1), corresponding to 4-5 orders of magnitude in black hole mass (M (BH) = 10(5.5-9.6) M (circle dot)), bolometric luminosity (L (bol) similar to 10(42-46) erg s(-1)), and Eddington ratio (L/L (Edd) similar to 10(-5) to 2). For 281 AGN, our data and analysis provide the first published central velocity dispersions, including six AGN with low-mass black holes (M (BH) = 10(5.5-6.5) M (circle dot)), discovered thanks to high spectral resolution observations (sigma (inst) similar to 25 km s(-1)). The survey represents a significant advance with a nearly complete census of velocity dispersions of hard X-ray-selected obscured AGN with measurements for 99% of nearby AGN (z 10 degrees). The BASS AGN have much higher velocity dispersions than the more numerous optically selected narrow-line AGN (i.e., similar to 150 versus similar to 100 km s(-1)) but are not biased toward the highest velocity dispersions of massive ellipticals (i.e., >250 km s(-1)). Despite sufficient spectral resolution to resolve the velocity dispersions associated with the bulges of small black holes (similar to 10(4-5) M (circle dot)), we do not find a significant population of super-Eddington AGN. Using estimates of the black hole sphere of influence from velocity dispersion, direct stellar and gas black hole mass measurements could be obtained with existing facilities for more than similar to 100 BASS AGN.ISSN:1538-4365ISSN:0067-004

BASS. XXVIII. Near-infrared Data Release 2: High-ionization and Broad Lines in Active Galactic Nuclei

We present the BAT AGN Spectroscopic Survey (BASS) Near-infrared Data Release 2 (DR2), a study of 168 nearby ((z) over bar = 0.04, z 100 eV). Comparing the emission of the [Si VI] lambda 1.9640 CL with the X-ray emission for the DR2 AGN, we find a significantly tighter correlation, with a lower scatter (0.37 dex) than that for the optical [O III] lambda 5007 line (0.71 dex). We do not find any correlation between CL emission and the X-ray photon index Gamma. We find a clear trend of line blueshifts with increasing ionization potential in several CLs, such as [Si VI] lambda 1.9640, [Si X] lambda 1.4300, [S VIII] lambda 0.9915, and [S IX] lambda 1.2520, indicating the radial structure of the CL region. Finally, we find a strong underestimation bias in black hole mass measurements of Sy 1.9 using broad H alpha due to the presence of significant dust obscuration. In contrast, the broad Pa alpha and Pa beta emission lines are in agreement with the M-sigma relation. Based on the combined DR1 and DR2 X-shooter sample, the NIR BASS sample now comprises 266 AGN with rest-frame NIR spectroscopic observations, the largest set assembled to date.ISSN:1538-4365ISSN:0067-004

BASS. XXII. The BASS DR2 AGN Catalog and Data

We present the active galactic nucleus (AGN) catalog and optical spectroscopy for the second data release of the Swift BAT AGN Spectroscopic Survey (BASS DR2). With this DR2 release we provide 1449 optical spectra, of which 1182 are released for the first time, for the 858 hard-X-ray-selected AGNs in the Swift BAT 70-month sample. The majority of the spectra (801/1449, 55%) are newly obtained from Very Large Telescope (VLT)/X-shooter or Palomar/Doublespec. Many of the spectra have both higher resolution (R > 2500, N similar to 450) and/or very wide wavelength coverage (3200-10000 angstrom, N similar to 600) that are important for a variety of AGN and host galaxy studies. We include newly revised AGN counterparts for the full sample and review important issues for population studies, with 47 AGN redshifts determined for the first time and 790 black hole mass and accretion rate estimates. This release is spectroscopically complete for all AGNs (100%, 858/858), with 99.8% having redshift measurements (857/858) and 96% completion in black hole mass estimates of unbeamed AGNs (722/752). This AGN sample represents a unique census of the brightest hard-X-ray-selected AGNs in the sky, spanning many orders of magnitude in Eddington ratio (L/L (Edd) = 10(-5)-100), black hole mass (M (BH) = 10(5)-10(10) M (circle dot)), and AGN bolometric luminosity (L (bol) = 10(40)-10(47) erg s(-1) ).ISSN:1538-4365ISSN:0067-004

BASS. XXI. The Data Release 2 Overview

The BAT AGN Spectroscopic Survey (BASS) is designed to provide a highly complete census of the key physical parameters of the supermassive black holes (SMBHs) that power local active galactic nuclei (AGNs) (z less than or similar to 0.3), including their bolometric luminosity (L (bol)), black hole (BH) mass (M (BH)), accretion rates (L (bol)/L (Edd)), line-of-sight gas obscuration (N (H)), and the distinctive properties of their host galaxies (e.g., star formation rates, masses, and gas fractions). We present an overview of the second data release of BASS (DR2), an unprecedented spectroscopic AGN survey in spectral range, resolution, and sensitivity, including 1449 optical (similar to 3200 angstrom-1 mu m) and 233 near-IR (1-2.5 mu m) spectra for the brightest 858 ultrahard X-ray (14-195 keV) selected AGNs across the entire sky and essentially all levels of obscuration. This release provides a highly complete set of key measurements (emission-line measurements and central velocity dispersions), with 99.9% measured redshifts and 98% BH masses estimated (for unbeamed AGNs outside the Galactic plane). The BASS DR2 AGN sample represents a unique census of nearby powerful AGNs, spanning over 5 orders of magnitude in AGN bolometric luminosity (L (bol) similar to 10(40)-10(47) erg s(-1)), BH mass (M (BH) similar to 10(5)-10(10) M (circle dot)), Eddington ratio (L (bol)/L (Edd) greater than or similar to 10(-5)), and obscuration (N (H) similar to 10(20)-10(25) cm(-2)). The public BASS DR2 sample and measurements can thus be used to answer fundamental questions about SMBH growth and its links to host galaxy evolution and feedback in the local universe, as well as open questions concerning SMBH physics. Here we provide a brief overview of the survey strategy, the key BASS DR2 measurements, data sets and catalogs, and scientific highlights from a series of DR2-based works pursued by the BASS team.ISSN:1538-4365ISSN:0067-004