Возможности использования адеметионинав терапии больных псориазом с патологией органовгепатобилиарной системы

The endogenous intoxication syndrome manifested in the form of excessive accumulation of low and mean molar mass substances in plasma and urine as well as increased blood plasma concentrations of malonic dialdehyde against the background of reduced alpha-tocopherol was revealed in psoriatic patients with the concomitant hepatobiliary system pathology. Application of Ademetionine in the dose of 800 mg per day for 15 days as a part of the complex therapy for such patients as opposed to the patients receiving standard therapy resulted in reliable reduction in the severity of clinical manifestations of the disease and PASI value as well as decrease in the concentration of low and mean molecular mass substances in plasma and erythrocytes, reduction in the blood plasma malonic dialdehyde concentration and increase in alpha-tocopherol.У больных псориазом с сопутствующей патологией гепатобилиарной системы обнаружено наличие синдрома эндогенной интоксикации, проявляющегося избыточным накоплением в плазме крови и моче веществ низкой и средней молеку лярной массы, повышенного содержания в плазме крови малонового диальдегида и сниженного уровня α-токоферола. Применение в комплексной терапии данной категории больных адеметионина в дозе 800 мг в сутки в течение 15 дней в отличие от пациентов, получавших стандартную терапию, приводило к достоверному снижению выраженности клинических проявлений заболевания (величины индекса PASI), уменьшению в плазме крови и эритроцитах концентрации веществ низкой и средней молекулярной массы, снижению в плазме крови уровня малонового диальдегида и увеличению содержания α-токоферола

Analysis of structural transformations in natural quartzites under the influence of gamma irradiation

Using the methods of IR spectroscopy, crystal-optical and XRD analysis the evolution of the structure of Ovruch deposit natural quartzites under the influence of γ-irradiation in the range of absorbed doses (Dabs = 10⁶…3.5⋅10⁷ Gy) has been researched. The elemental composition of natural quartzites was determined by the gamma activation method on a linear electron accelerator. It was found that as a result of irradiation the crystal structure of quartz, which forms the basis of quartzite, is improved due to radiation annealing of the defects in the initial structure. At the same time crystallization of amorphous silica, which fringes large grains of quartz, occurs with its transformation into fine-crystalline quartz. These processes do not lead to cracking in the quartzite rock. Obtained data indicates a high radiation resistance of the Ovruch deposit quartzites and confirms the prospects of using this geological formation as a natural barrier for the construction of radioactive waste long-term storage.За допомогою методів ІЧ-спектроскопії, кристалооптичного та рентгеноструктурного аналізів вивчена еволюція структури природних кварцитів Овруцького родовища під впливом γ-опромінення в інтервалі поглинених доз Dпогл = 10⁶…3,5⋅10⁷Гр. Визначений елементний склад природних кварцитів методом гаммаактивації на лінійному прискорювачі електронів. Встановлено, що в результаті опромінення кристалічна структура кварцу, що становить основу кварциту, вдосконалюється внаслідок радіаційного відпалу дефектів вихідної структури. Одночасно відбувається кристалізація аморфного кремнезему, що окаймляє великі зерна кварцу, з перетворенням його в дрібнокристалічний кварц. Ці процеси не призводять до утворення тріщин у кварцитовій породі. Отримані дані свідчать про високу радіаційну стійкість кварцитів Овруцького родовища і підтверджують перспективність використання даної геологічної формації як природного бар'єру для спорудження довготривалого сховища радіоактивних відходів.С помощью методов ИК-спектроскопии, кристаллооптического и рентгеноструктурного анализов изучена эволюция структуры природных кварцитов Овручского месторождения под влиянием облучения γ-квантами в интервале поглощенных доз Dпогл = 10⁶…3,5⋅10⁷Гр. Определен элементный состав природных кварцитов методом гамма-активации на линейном ускорителе электронов. Установлено, что в результате облучения кристаллическая структура кварца, составляющего основу кварцита, совершенствуется вследствие радиационного отжига дефектов исходной структуры. Одновременно происходит кристаллизация аморфного кремнезема, окаймляющего крупные зерна кварца, с превращением его в мелкокристаллический кварц. Эти процессы не приводят к трещинообразованию в кварцитовой породе. Полученные данные свидетельствуют о высокой радиационной стойкости кварцитов Овручского месторождения и подтверждают перспективность использования данной геологической формации в качестве природного барьера для сооружения долговременного хранилища радиоактивных отходов

A self-interaction corrected pseudopotential scheme for magnetic and strongly-correlated systems

Local-spin-density functional calculations may be affected by severe errors when applied to the study of magnetic and strongly-correlated materials. Some of these faults can be traced back to the presence of the spurious self-interaction in the density functional. Since the application of a fully self-consistent self-interaction correction is highly demanding even for moderately large systems, we pursue a strategy of approximating the self-interaction corrected potential with a non-local, pseudopotential-like projector, first generated within the isolated atom and then updated during the self-consistent cycle in the crystal. This scheme, whose implementation is totally uncomplicated and particularly suited for the pseudopotental formalism, dramatically improves the LSDA results for a variety of compounds with a minimal increase of computing cost.Comment: 18 pages, 14 figure

H∞ filtering for non-linear systems with stochastic sensor saturations and Markov time delays: The asymptotic stability in probability

This study is concerned with the filtering problem for a class of non-linear systems with stochastic sensor saturations and Markovian measurement transmission delays, where the asymptotic stability in probability is considered. The sensors are subject to random saturations characterised by a Bernoulli distributed sequence. The transmission time delays are governed by a discrete-time Markov chain with finite states. In the presence of the non-linearities, stochastic sensor saturations and Markovian time delays, sufficient conditions are established to guarantee that the filtering process is asymptotically stable in probability without disturbances and also satisfies the H∞ criterion with respect to non-zero exogenous disturbances under the zero-initial condition. Moreover, it is illustrated that the results can be specialised to linear filters. Two simulation examples are presented to show the effectiveness of the proposed algorithms.This work was supported by National Natural Science Foundation of China under Grants 61490701, 61290324, 61273156, 61473163, and 61210012, and Research Fund for the Taishan Scholar Project of Shandong Province of China, and Jiangsu Provincial Key Laboratory of E-business at Nanjing University of Finance and Economics of China under Grant JSEB201301, and Tsinghua University Initiative Scientific Research Program

Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV

Results are presented from a search for a W' boson using a dataset corresponding to 5.0 inverse femtobarns of integrated luminosity collected during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV. The W' boson is modeled as a heavy W boson, but different scenarios for the couplings to fermions are considered, involving both left-handed and right-handed chiral projections of the fermions, as well as an arbitrary mixture of the two. The search is performed in the decay channel W' to t b, leading to a final state signature with a single lepton (e, mu), missing transverse energy, and jets, at least one of which is tagged as a b-jet. A W' boson that couples to fermions with the same coupling constant as the W, but to the right-handed rather than left-handed chiral projections, is excluded for masses below 1.85 TeV at the 95% confidence level. For the first time using LHC data, constraints on the W' gauge coupling for a set of left- and right-handed coupling combinations have been placed. These results represent a significant improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe

Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV

A search for a Higgs boson decaying into two photons is described. The analysis is performed using a dataset recorded by the CMS experiment at the LHC from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross section of the standard model Higgs boson decaying to two photons. The expected exclusion limit at 95% confidence level is between 1.4 and 2.4 times the standard model cross section in the mass range between 110 and 150 GeV. The analysis of the data excludes, at 95% confidence level, the standard model Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The largest excess of events above the expected standard model background is observed for a Higgs boson mass hypothesis of 124 GeV with a local significance of 3.1 sigma. The global significance of observing an excess with a local significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is estimated to be 1.8 sigma. More data are required to ascertain the origin of this excess.Comment: Submitted to Physics Letters

Search for new physics in events with opposite-sign leptons, jets, and missing transverse energy in pp collisions at sqrt(s) = 7 TeV

A search is presented for physics beyond the standard model (BSM) in final states with a pair of opposite-sign isolated leptons accompanied by jets and missing transverse energy. The search uses LHC data recorded at a center-of-mass energy sqrt(s) = 7 TeV with the CMS detector, corresponding to an integrated luminosity of approximately 5 inverse femtobarns. Two complementary search strategies are employed. The first probes models with a specific dilepton production mechanism that leads to a characteristic kinematic edge in the dilepton mass distribution. The second strategy probes models of dilepton production with heavy, colored objects that decay to final states including invisible particles, leading to very large hadronic activity and missing transverse energy. No evidence for an event yield in excess of the standard model expectations is found. Upper limits on the BSM contributions to the signal regions are deduced from the results, which are used to exclude a region of the parameter space of the constrained minimal supersymmetric extension of the standard model. Additional information related to detector efficiencies and response is provided to allow testing specific models of BSM physics not considered in this paper.Comment: Replaced with published version. Added journal reference and DO

Measurement of the Lambda(b) cross section and the anti-Lambda(b) to Lambda(b) ratio with Lambda(b) to J/Psi Lambda decays in pp collisions at sqrt(s) = 7 TeV

The Lambda(b) differential production cross section and the cross section ratio anti-Lambda(b)/Lambda(b) are measured as functions of transverse momentum pt(Lambda(b)) and rapidity abs(y(Lambda(b))) in pp collisions at sqrt(s) = 7 TeV using data collected by the CMS experiment at the LHC. The measurements are based on Lambda(b) decays reconstructed in the exclusive final state J/Psi Lambda, with the subsequent decays J/Psi to an opposite-sign muon pair and Lambda to proton pion, using a data sample corresponding to an integrated luminosity of 1.9 inverse femtobarns. The product of the cross section times the branching ratio for Lambda(b) to J/Psi Lambda versus pt(Lambda(b)) falls faster than that of b mesons. The measured value of the cross section times the branching ratio for pt(Lambda(b)) > 10 GeV and abs(y(Lambda(b))) < 2.0 is 1.06 +/- 0.06 +/- 0.12 nb, and the integrated cross section ratio for anti-Lambda(b)/Lambda(b) is 1.02 +/- 0.07 +/- 0.09, where the uncertainties are statistical and systematic, respectively.Comment: Submitted to Physics Letters

Measurement of isolated photon production in pp and PbPb collisions at sqrt(sNN) = 2.76 TeV

Isolated photon production is measured in proton-proton and lead-lead collisions at nucleon-nucleon centre-of-mass energies of 2.76 TeV in the pseudorapidity range |eta|<1.44 and transverse energies ET between 20 and 80 GeV with the CMS detector at the LHC. The measured ET spectra are found to be in good agreement with next-to-leading-order perturbative QCD predictions. The ratio of PbPb to pp isolated photon ET-differential yields, scaled by the number of incoherent nucleon-nucleon collisions, is consistent with unity for all PbPb reaction centralities.Comment: Submitted to Physics Letters