7 research outputs found

    Net methylmercury production in 2 contrasting stream sediments and associated accumulation and toxicity to periphyton

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    Periphyton uptake of bioaccumulative methylmercury (MeHg) may be an important entryway into the food web of many stream ecosystems where periphyton can be dominant primary producers. The net production of MeHg in stream sediment, its bioaccumulation in periphyton, and the potential toxicity of divalent Hg (Hg[II]) and MeHg in sediment to periphyton were investigated with a 67‐d in situ incubation experiment using chemical exposure substrates containing either a fine‐grained, organic‐rich or a sandy, low‐organic sediment, each amended with varying concentrations of mercuric chloride. Methylmercury was produced in sediment, and concentrations increased with greater amounts of added Hg(II); however, the net production of MeHg was inhibited in the highest Hg(II) treatments of both sediments. The range of total Hg concentrations that inhibited MeHg production was between approximately 80 000 ng Hg and 350 000 ng Hg per gram of organic matter for both sediments. Periphyton colonizing substrates accumulated MeHg in proportion to the concentration in sediment, but periphyton exposed to the sandy sediment accumulated approximately 20‐fold more than those exposed to the organic‐rich sediment relative to sediment MeHg concentrations. Toxicity of either Hg(II) or MeHg to periphyton was not observed with either periphyton organic content, net primary production, or respiration as endpoints. These results suggest that in situ production and bioaccumulation of MeHg in stream ecosystems can vary as a function of sediment characteristics and Hg(II) loadings to the sediment. Environ Toxicol Chem 2016;35:1759–1765. © 2015 SETACPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134236/1/etc3324_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134236/2/etc3324.pd

    The Relationship Of Low Birth Weight To Blood Pressure, Cortisol Levels, And Reactivity In African American Adolescents: A Pilot Study

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    Epidemiological studies show a relationship between low birth weight (LBW) and adult cardiovascular disease. Blood pressure and cortisol hyper-responsiveness during physiologic stress may function as biological markers for hypertension. The purpose of this study was to explore the relationship of blood pressure and cortisol levels with induced physiologic stress to LBW. Forty-eight adolescents, 14 to 16 years old, were tested for blood pressure and cortisol levels at rest and in response to a physiological stressor. A history of LBW was obtained. Multivariate repeated measures analysis and chi-square analyses were used to determine the changes in blood pressure and cortisol. Forty-eight African American adolescents, mean age 14.98 years (SD = 0.33), completed the study. Thirteen adolescents (27%) reported LBW. Although not statistically significant, systolic and diastolic pressures were 6 mmHg and 2 mmHg, respectively, higher in the LBW group when compared with the normal birth weight (NBW) group (p = 0.33 and p = 0.21, and 6 (46%) had elevated blood pressures (p = 0.005)). Blood pressure changes, cardiovascular reactivity, elevated blood, or all of these were significantly higher in LBW African American adolescents (p = 0.006). Cardiovascular reactivity was not significant (p = 0.208)). The mean average cortisol levels were (18.8 nmol/dL (SD = 11.0) but comparable (p = 0.72)). The number of LBW adolescents with cortisol reactivity was significantly higher that in the NBW group (p = 0.041). This study adds support to the association of LBW to biological markers of hypertension in childhood. Copyright © Informa Healthcare

    Epigenetics and the embodiment of race: Developmental origins of US racial disparities in cardiovascular health

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    Community-based interventions for enhancing access to or consumption of fruit and vegetables among five to 18-year olds: a scoping review

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    <p>Abstract</p> <p>Background</p> <p>Low fruit and vegetable ( FV) consumption is a key risk factor for morbidity and mortality. Consumption of FV is limited by a lack of access to FV. Enhanced understanding of interventions and their impact on both access to and consumption of FV can provide guidance to public health decision-makers. The purpose of this scoping review is to identify and map literature that has evaluated effects of community-based interventions designed to increase FV access or consumption among five to 18-year olds.</p> <p>Methods</p> <p>The search included 21 electronic bibliographic databases, grey literature, targeted organization websites, and 15 key journals for relevant studies published up to May 2011. Retrieved citations were screened in duplicate for relevance. Data extracted from included studies covered: year, country, study design, target audience, intervention setting, intervention strategies, interventionists, and reported outcomes.</p> <p>Results</p> <p>The search located 19,607 unique citations. Full text relevance screening was conducted on 1,908 studies. The final 289 unique studies included 30 knowledge syntheses, 27 randomized controlled trials, 55 quasi-experimental studies, 113 cluster controlled studies, 60 before-after studies, one mixed method study, and three controlled time series studies. Of these studies, 46 included access outcomes and 278 included consumption outcomes. In terms of target population, 110 studies focused on five to seven year olds, 175 targeted eight to 10 year olds, 192 targeted 11 to 14 year olds, 73 targeted 15 to 18 year olds, 55 targeted parents, and 30 targeted teachers, other service providers, or the general public. The most common intervention locations included schools, communities or community centres, and homes. Most studies implemented multi-faceted intervention strategies to increase FV access or consumption.</p> <p>Conclusions</p> <p>While consumption measures were commonly reported, this review identified a small yet important subset of literature examining access to FV. This is a critically important issue since consumption is contingent upon access. Future research should examine the impact of interventions on direct outcome measures of FV access and a focused systematic review that examines these interventions is also needed. In addition, research on interventions in low- and middle-income countries is warranted based on a limited existing knowledge base.</p

    DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome

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