35 research outputs found
A novel formulation of inhaled sodium cromoglicate (PA101) in idiopathic pulmonary fibrosis and chronic cough: a randomised, double-blind, proof-of-concept, phase 2 trial
- Author
- Abel K.
- Adamali H.
- Adeloye D.
- Adeyemi F.
- Adeyemi O.
- Ahmad S.
- Ahmed R.
- Ainsworth M.
- Al-Sheklly B.
- Alamoudi A.
- Aljaroof M.
- Allan L.
- Allen R.
- Alli A.
- Altmann D.
- Anderson D.
- Andrews M.
- Angyal A.
- Antoniades C.
- Arbane G.
- Armour C.
- Armstrong L.
- Armstrong N.
- Arnold D.
- Arnold H.
- Ashworth A.
- Ashworth M.
- Assefa-Kebede H.
- Atkin P.
- Atkins A.
- Atkins H.
- Aul R.
- Avram C.
- Baggott R.
- Baguley D.
- Baillie J. Kenneth
- Baillie J.K.
- Bain S.
- Bakali M.
- Bakau M.
- Baldry E.
- Baldwin D.
- Ballard C.
- Bambrough J.
- Barker R.E.
- Barratt S.
- Barrett F.
- Basu N.
- Batterham R.
- Baxendale H.
- Bayes H.
- Bayley M.
- Beadsworth M
- Beirne P.
- Bell D.
- Bell R.
- Berry C.
- Betts S.
- Bhui K.
- Bishop L.
- Blaikely J.
- Bloomfield C.
- Bloss A.
- Bolger A.
- Bolton C.E.
- Bonnington J.
- Botkai A.
- Bourne C.
- Bourne M.
- Bradley E.
- Bramham K.
- Brear L.
- Breen G.
- Breeze J.
- Briggs A.
- Bright E.
- Brightling C.E.
- Brightling Christopher E.
- Brill S.
- Brindle K.
- Broad L.
- Broome M.
- Brown A
- Brown A
- Brown J.
- Brown J.
- Brown J.S.
- Brown Jeremy S.
- Brown M
- Brown M.
- Brown R.
- Brown V.
- Brugha T
- Brunskill N
- Buch M
- Bularga A
- Bullmore E
- Burn D
- Burns G
- Busby J
- Buttress A
- Byrne S
- Cairns P
- Calder P.C.
- Calvelo E
- Card B
- Carr L
- Carson G
- Carter P
- Cavanagh J
- Chalder T
- Chalder Trudie
- Chalmers J.D.
- Chalmers James D.
- Chambers R.C.
- Channon K
- Chapman K
- Charalambou A
- Chaudhuri N
- Checkley A
- Chen J
- Chetham L
- Chilvers E.R.
- Chinoy H
- Chong-James K
- Choudhury G
- Choudhury N
- Chowdhury P
- Chowienczyk P
- Christie C
- Clark C
- Clark D
- Clarke J
- Clift P
- Clohisey S
- Coburn Z
- Cole J
- Coleman C
- Connell D
- Connolly B
- Connor L
- Cook A
- Cooper B
- Coupland C
- Craig T
- Crisp P
- Cristiano D
- Crooks M.G.
- Cross A
- Cruz I
- Cullinan P
- Daines L
- Daines Luke
- Dalton M
- Dark P
- Dasgin J
- David A
- David C
- Davies F
- Davies G
- Davies G.A.
- Davies K
- Davies M
- Daynes E
- De Silva T
- De Soyza A
- De Soyza Anthony
- Deakin B
- Deans A
- Defres S
- Dell A
- Dempsey K
- Dennis J
- Dewar A
- Dharmagunawardena R
- Diar Bakerly N
- Diar Bakerly Nawar
- Dipper A
- Diver S
- Diwanji S.N.
- Dixon M
- Djukanovic R
- Dobson C
- Dobson H
- Dobson S.L.
- Docherty A.B.
- Docherty Annemarie B.
- Donaldson A
- Dong T
- Dormand N
- Dougherty A
- Dowling R
- Drain S
- Dulawan P
- Dunn S
- Dunn S
- Easom N
- Easom Nicholas
- Echevarria C
- Edwards S
- Edwardson C
- Elliott A
- Elliott B
- Ellis Y
- Elmer A
- Elneima O
- Elneima Omer
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- Evans H
- Evans J
- Evans R
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- Evans R.I.
- Evans Rachael A.
- Evans T
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- Fairman A
- Fallon K
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- Felton T
- Finch J
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- Gorsuch T
- Gourlay E
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- Greening N.J.
- Greening Neil J.
- Greenwood J
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- Gregory R
- Grieve D
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- Guthrie E
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- Lee D
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- Lomas D
- Lone N.I.
- Lone Nazir I.
- Loosley R
- Lord J.M.
- Lord Janet M.
- Lota H
- Lucey A
- MacGowan G
- Macharia I
- Mackay C
- Macliver L
- Madathil S
- Madzamba G
- Magee N
- Mairs N
- Majeed N
- Major E
- Malim M
- Mallison G
- Man W
- Mandal S
- Mangion K
- Mansoori P
- Marciniak S
- Mariveles M
- Marks M
- Marks Michael
- Marshall B
- Martineau A
- Maskell N
- Matila D
- Matthews L
- Mayet J
- McAdoo S
- McAllister-Williams H
- McArdle A
- McArdle P
- McAulay D
- McAuley D.F.
- McAuley H
- McAuley Hamish
- McCafferty K
- McCann G.P.
- McCann Gerry P.
- McCauley H
- McCourt P
- Mcgarvey L
- McGinness J
- McGovern A
- McGuinness H
- McInnes I.B.
- McIvor E
- McIvor K
- McMahon A
- McMahon M.J.
- McMorrow L
- Mcnally T
- McNarry M
- McQueen A
- McShane H
- Megson S
- Meiring J
- Menzies D
- Michael A
- Milligan L
- Mills N
- Mitchell J
- Mohamed A
- Molyneaux P.L.
- Monteiro W
- Morley A
- Morrison L
- Morriss R
- Morrow A
- Moss A
- Moss A.J.
- Moss P
- Mukaetova-Ladinska E
- Munawar U
- Murali E
- Murira J
- Nassa H
- Neill P
- Neubauer S
- Neubauer Stefan
- Newby D
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- Newton Cox A
- Nicholson T
- Nicoll D
- Nolan C.M.
- Noonan M.J.
- Novotny P
- Nunag J
- Nyaboko J
- O'Brien L
- Odell N
- Ogg G
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- Oliver C
- Omar Z
- Openshaw P.J.M.
- Openshaw Peter J. M.
- Osbourne R
- Ostermann M
- Overton C
- Oxton J
- Pacpaco E
- Paddick S
- Papineni P
- Paradowski K
- Pareek M
- Parekh D
- Parekh Dhruv
- Parfrey H
- Pariante C
- Parker S
- Parkes M
- Parmar J
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- Patale S
- Patel B
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- Pathmanathan B
- Pavlides M
- Pearl J.E.
- Peckham D
- Pendlebury J
- Peng Y
- Pennington C
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- Peto T
- Petousi N
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- Pfeffer Paul
- Phipps J
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- Plekhanova T
- Poinasamy K
- Poinasamy Krisnah
- Polgar O
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- Price A
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- Prickett A
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- Rahman M
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- Ralser M
- Raman B
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- Rees T
- Regan K
- Richards A
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- Richardson Matthew
- Rivera-Ortega P
- Robertson E
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- Rowland M.J.
- Rowland Matthew
- Rowland-Jones S.L.
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- Rudan I
- Russell E
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- Sabit R
- Sage E.K.
- Samani N
- Samuel R
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- Saralaya D
- Saratzis A
- Sargeant J
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- Sattar N
- Saunders K
- Saunders R
- Saxon W
- Sayer A
- Schwaeble W
- Scott Janet
- Scott K
- Selby N
- Semple M.G.
- Semple Malcolm G.
- Sereno M
- Sereno Marco
- Shah A
- Shah Ajay M.
- Shah K
- Shah P
- Sharma M
- Sharpe C
- Sharpe M
- Shaw V
- Sheikh A
- Sheikh Aziz
- Shevket K
- Shikotra A
- Shikotra Aarti
- Short J
- Siddiqui S
- Sigfrid L
- Simons G
- Simpson J
- Singapuri A
- Singapuri Amisha
- Singh C
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- Singh S.J.
- Singh Sally J.
- Skeemer J
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- Smith I
- Smith J
- Smith L
- Soares M
- Southern D
- Spears M
- Spencer L.G.
- Speranza F
- Stadon L
- Stanel S
- Steiner M
- Stensel D
- Stern M
- Stewart I
- Stockley J
- Stone R
- Storrie A
- Storton K
- Stringer E
- Subbe C
- Sudlow C
- Suleiman Z
- Summers C
- Summersgill C
- Sutherland D
- Sykes D.L.
- Sykes R
- Talbot N
- Tan A.L.
- Taylor A
- Taylor C
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- Tedd H
- Tee C.J.
- Tench H
- Terry S
- Thackray-Nocera S
- Thaivalappil F
- Thickett D
- Thomas A.K.
- Thomas D
- Thomas D.C.
- Thomas David
- Thompson A.A.R.
- Thompson T
- Thornton T
- Thwaites R.S.
- Tobin M
- Toingson G.F.
- Tong C
- Toshner M
- Toshner Mark
- Touyz R
- Tripp K.A.
- Tunnicliffe E
- Turner E
- Turtle L
- Turton H
- Ugwuoke R
- Upthegrove R
- Valabhji J
- Vellore K
- Wade E
- Wain L.V.
- Wain Louise V.
- Wajero L.O.
- Walder S
- Walker S
- Wall E
- Wallis T
- Walmsley S
- Walsh J.A.
- Walsh S
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- Watson J
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- West S
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- Williams-Howard S.A.
- Willicombe M
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- Witham M
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- Woodhead F
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- Wootton D
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- Xie C
- Yasmin S
- Yates T
- Yip K.P.
- Young A
- Young B
- Young S
- Yousuf A
- Yousuf A.J.
- Zawia A
- Zhao B
- Zongo O
- Publication venue
- Elsevier
- Publication date
- 01/03/2013
- Field of study
Background Cough can be a debilitating symptom of idiopathic pulmonary fibrosis (IPF) and is difficult to treat. PA101 is a novel formulation of sodium cromoglicate delivered via a high-efficiency eFlow nebuliser that achieves significantly higher drug deposition in the lung compared with the existing formulations. We aimed to test the efficacy and safety of inhaled PA101 in patients with IPF and chronic cough and, to explore the antitussive mechanism of PA101, patients with chronic idiopathic cough (CIC) were also studied. Methods This pilot, proof-of-concept study consisted of a randomised, double-blind, placebo-controlled trial in patients with IPF and chronic cough and a parallel study of similar design in patients with CIC. Participants with IPF and chronic cough recruited from seven centres in the UK and the Netherlands were randomly assigned (1:1, using a computer-generated randomisation schedule) by site staff to receive PA101 (40 mg) or matching placebo three times a day via oral inhalation for 2 weeks, followed by a 2 week washout, and then crossed over to the other arm. Study participants, investigators, study staff, and the sponsor were masked to group assignment until all participants had completed the study. The primary efficacy endpoint was change from baseline in objective daytime cough frequency (from 24 h acoustic recording, Leicester Cough Monitor). The primary efficacy analysis included all participants who received at least one dose of study drug and had at least one post-baseline efficacy measurement. Safety analysis included all those who took at least one dose of study drug. In the second cohort, participants with CIC were randomly assigned in a study across four centres with similar design and endpoints. The study was registered with ClinicalTrials.gov (NCT02412020) and the EU Clinical Trials Register (EudraCT Number 2014-004025-40) and both cohorts are closed to new participants. Findings Between Feb 13, 2015, and Feb 2, 2016, 24 participants with IPF were randomly assigned to treatment groups. 28 participants with CIC were enrolled during the same period and 27 received study treatment. In patients with IPF, PA101 reduced daytime cough frequency by 31·1% at day 14 compared with placebo; daytime cough frequency decreased from a mean 55 (SD 55) coughs per h at baseline to 39 (29) coughs per h at day 14 following treatment with PA101, versus 51 (37) coughs per h at baseline to 52 (40) cough per h following placebo treatment (ratio of least-squares [LS] means 0·67, 95% CI 0·48–0·94, p=0·0241). By contrast, no treatment benefit for PA101 was observed in the CIC cohort; mean reduction of daytime cough frequency at day 14 for PA101 adjusted for placebo was 6·2% (ratio of LS means 1·27, 0·78–2·06, p=0·31). PA101 was well tolerated in both cohorts. The incidence of adverse events was similar between PA101 and placebo treatments, most adverse events were mild in severity, and no severe adverse events or serious adverse events were reported. Interpretation This study suggests that the mechanism of cough in IPF might be disease specific. Inhaled PA101 could be a treatment option for chronic cough in patients with IPF and warrants further investigation
Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study
- Author
- Abel K
- Adamali H
- Adeloye D
- Adeyemi O
- Adrego R
- Ahmad S
- Ahmed R
- Ahwireng N
- Ainsworth M
- Al-Sheklly B
- Alamoudi A
- Ali M
- Aljaroof M
- All AM
- Allan L
- Allen RJ
- Allerton L
- Allsop L
- Almeida P
- Altmann D
- Amoils S
- Anderson D
- Anifowose S
- Antoniades C
- Arbane G
- Arias A
- Armour C
- Armour C
- Armstrong L
- Armstrong N
- Armstrong N
- Arnold D
- Arnold H
- Ashish A
- Ashworth A
- Ashworth M
- Aslani S
- Assefa-Kebede H
- Atkin C
- Atkin P
- Atkins H
- Aul R
- Aul R
- Aul R
- Aung H
- Austin L
- Avram C
- Ayoub A
- Babores M
- Baggott R
- Bagshaw J
- Baguley D
- Bailey L
- Baillie JK
- Baillie JK
- Baillie JK
- Baillie JK
- Baillie JK
- Baillie JK
- Bain S
- Bakali M
- Bakau M
- Bakerly ND
- Bakerly ND
- Baldry E
- Baldwin D
- Baldwin M
- Baldwin M
- Ballard C
- Banerjee A
- Bang B
- Barker RE
- Barman L
- Barratt S
- Barrett F
- Barrett S
- Basire D
- Basu N
- Basu N
- Bates A
- Bates M
- Batterham R
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- Baxendale H
- Baxendale H
- Baxter G
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- Beadsworth M
- Beadsworth M
- Beckett P
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- Bramham K
- Brear L
- Breen G
- Breen G
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- Briggs A
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- Bright E
- Brightling CE
- Brightling CE
- Brightling CE
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- Brightling CE
- Brightling CE
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- Brill S
- Brindle K
- Broad L
- Broadley A
- Brookes C
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- McArdle A
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- McAuley DF
- McAuley HJC
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- McAuley HJC
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- McCann GP
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- McMahon MJ
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- Parkes M
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- Pearl JE
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- Peckham D
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- Pfeffer P
- Pfeffer P
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- Piechnik S
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- Plein S
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- Poinasamy K
- Poinasamy K
- Poinasamy K
- Poinasamy K
- Polgar O
- Poll L
- Porter J
- Porter J
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- Porter JC
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- Price C
- Price C
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- Propescu I
- Propescu J
- Prosper S
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- Quint JK
- Quint JK
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- Qureshi IN
- Radhakrishnan K
- Rahman N
- Rahman NM
- Rahman NM
- Ralser M
- Raman B
- Raman B
- Raman B
- Raman B
- Raman B
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- Ramos H
- Rangeley J
- Rangelov B
- Rangelov B
- Ratcliffe L
- Ravencroft P
- Reddington A
- Reddy A
- Reddy R
- Redfearn H
- Redwood D
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- Rees T
- Regan K
- Reynolds W
- Ribeiro C
- Richards A
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- Richardson M
- Richardson M
- Rivera-Ortega P
- Roberts K
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- Rossdale J
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- Rostron A
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- Rowland MJ
- Rowland MJ
- Rowland-Jones SL
- Rowland-Jones SL
- Rowland-Jones SL
- Roy K
- Roy M
- Rudan I
- Russell E
- Russell RJ
- Saalmink G
- Sabit R
- Sage EK
- Samakomva T
- Samani N
- Samat AA
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- Sanderson A
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- Sapey E
- Sapey E
- Saralaya D
- Sargent J
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- Sass T
- Sattar AN
- Sattar N
- Sattar N
- Sattar N
- Saunders K
- Saunders K
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- Saunders LC
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- Saunders RM
- Saunders RM
- Saunders RM
- Saunders RM
- Savill H
- Saxon W
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- Sayer A
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- Semple MG
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- Semple MG
- Sereno M
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- Sewell TA
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- Sharma M
- Sharpe C
- Sharpe M
- Sharpe M
- Shashaa S
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- Sidebottom J
- Sigfrid L
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- Singapuri A
- Singapuri A
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- Sissons D
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- Solano TS
- Solly R
- Solstice AR
- Soulsby T
- Southern D
- Sowter D
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- Spencer LG
- Speranza F
- Stadon L
- Stanel S
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- Steele N
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- Stensel D
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- Stephenson L
- Stern M
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- Stimpson R
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- Stockley J
- Stoker W
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- Storrar W
- Storrie A
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- Stringer E
- Strong-Sheldrake S
- Stroud N
- Subbe C
- Sudlow C
- Sudlow CL
- Suleiman Z
- Summers C
- Summersgill C
- Sutherland D
- Sykes DL
- Sykes R
- Talbot N
- Tan AL
- Tan AL
- Tarusan L
- Tavoukjian V
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- Taylor JP
- Te A
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- Teixeira J
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- Thaivalappil F
- Thamu B
- Thickett D
- Thomas AK
- Thomas C
- Thomas D
- Thomas D
- Thomas DC
- Thomas DC
- Thomas S
- Thomas-Woods T
- Thompson AAR
- Thompson AAR
- Thompson AAR
- Thompson AAR
- Thompson AR
- Thompson T
- Thornton T
- Thorpe M
- Thorpe M
- Thwaites R
- Thwaites RS
- Tilley J
- Tinker N
- Tiongson GF
- Tobin M
- Tomlinson J
- Tong C
- Toshner M
- Toshner M
- Toshner M
- Toshner M
- Toshner M
- Touyz R
- Treibel T
- Tripp KA
- Tunnicliffe E
- Tunnicliffe EM
- Turnbull A
- Turner E
- Turner K
- Turner S
- Turner V
- Turney S
- Turtle L
- Turtle L
- Turton H
- Ugoji J
- Ugwuoke R
- Upthegrove R
- Valabhji J
- Venson B
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- Vere J
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- Vinson B
- Vogiatzis I
- Wade E
- Wade P
- Wain LV
- Wain LV
- Wain LV
- Wain LV
- Wain LV
- Wain LV
- Wain LV
- Wain LV
- Wain LV
- Wainwright T
- Wajero LO
- Walder S
- Walker S
- Walker S
- Walker S
- Walker S
- Wall E
- Wallis T
- Walmsley S
- Walsh JA
- Walsh S
- Warburton L
- Ward TJC
- Warwick K
- Wassall H
- Waterson S
- Watson E
- Watson J
- Watson L
- Webster M
- Welch C
- Welch H
- Welsh B
- Wessely S
- West S
- Weston H
- Wheeler H
- White S
- Whitehead V
- Whitney J
- Whittaker S
- Whittam B
- Whitworth V
- Wight A
- Wild JM
- Wild JM
- Wild JM
- Wild JM
- Wilkins M
- Wilkinson D
- Wilkinson D
- Williams B
- Williams J
- Williams N
- Williams N
- Williams N
- Williams-Howard SA
- Willicombe M
- Willis G
- Willoughby J
- Wilson A
- Wilson D
- Wilson D
- Wilson I
- Window N
- Witham M
- Witham M
- Wolf-Roberts R
- Wood C
- Woodhead F
- Woods J
- Wootton DG
- Wootton DG
- Wootton DG
- Wootton DG
- Wormleighton J
- Worsley J
- Wraith D
- Wright C
- Wright L
- Wright S
- Wyles J
- Wynn E
- Wynter I
- Xie C
- Xu M
- Xu M
- Yasmin N
- Yasmin S
- Yates T
- Yates T
- Yip KP
- Young A
- Young B
- Young S
- Yousuf A
- Zawia A
- Zeidan L
- Zhao B
- Zheng B
- Zongo O
- Publication venue
- Oxford University Press (OUP)
- Publication date
- 18/12/2023
- Field of study
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
- Author
- A. Abraheem
- A. Agasou
- A. Ahmed
- A. Ali
- A. Allan
- A. Altabaibeh
- A. Alvaro
- A. Aspinwall
- A. Ayers
- A. Bamford
- A. Barron
- A. Bashyal
- A. Bellini
- A. Bociek
- A. Botello
- A. Bowes
- A. Brady
- A. Brayne
- A. Brown
- A. Brown
- A. Butler
- A. Carter
- A. Collins
- A. Cowley
- A. Cowton
- A. Cowton
- A. Cox
- A. Crew
- A. Dance
- A. Daniel
- A. Daniels
- A. Dela Rosa
- A. Drummond
- A. Durie
- A. E. Heron
- A. Easthope
- A. Easthorpe
- A. Evans.
- A. Fofano
- A. Gales
- A. Ganesan
- A. Gardner
- A. Garg
- A. Gherman
- A. Gordon
- A. Gratrix
- A. Gulati
- A. Gupta
- A. Haigh
- A. Haldeos
- A. Harrison
- A. Harvey
- A. Hayes
- A. Higham
- A. Higham
- A. Hilldrith
- A. Holden
- A. Hormis
- A. Hutcheon
- A. Javaid
- A. Joseph
- A. Kaliappan
- A. Katary
- A. Kay
- A. Kayani
- A. Kent
- A. Kirkby
- A. Knight
- A. Kubisz-Pudelko
- A. Kuravi
- A. Lewis
- A. Loveridge
- A. Lyle
- A. Mayer
- A. McAlpine
- A. McCarthy
- A. McGregor
- A. McGregor
- A. Meikle
- A. Mitchell
- A. Mitra
- A. Morris
- A. Morrison
- A. Naranjo
- A. Nicholson
- A. Nicholson
- A. Noakes
- A. Patel
- A. Pickard
- A. Price
- A. Puxty
- A. Quinn
- A. Quinn
- A. Raithatha
- A. Rattray
- A. Reddy
- A. Reed
- A. Reyes
- A. Rose
- A. Rose
- A. Rostron
- A. Roy
- A. Roynon-Reed
- A. S. Raj
- A. Salberg
- A. Sanderson
- A. Serrano-Ruiz
- A. Solesbury
- A. Sukha
- A. Swain
- A. Tariq
- A. Thomas
- A. Thomas
- A. Todd
- A. Tomas
- A. Tridente
- A. Tucci
- A. Turnbull
- A. Uriel
- A. Ustianowski
- A. Vochin
- A. Vuylsteke
- A. Waite
- A. Walden
- A. Whileman
- A. Wilkinson
- A. Williams
- A. Williams
- A. Wilson
- A. Zak
- A. Zaki
- Achille Iolascon
- Adam Brown
- Adam Krętowski
- Adriana Roży
- Agnese Verzuri
- Agnieszka Adamek
- Agnieszka Bielska
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Albert Tenesa
- Aleksandra Berkan-Kawinska
- Aleksandra Jezela-Stanek
- Aleksandra Starosz
- Alessandra Guarnaccia
- Alessandra Renieri &
- Alessandra Stella
- Alessandra Vergori
- Alessandro Pancrazzi
- Alessia Giorli
- Alice Donati
- Alison Meynert
- Alistair Nichol
- Anders Larsson
- Andrea Antinori
- Andrea Cossarizza
- Andrea Gabbuti
- Andrea Tommasi
- Andrew D. Bretherick
- Andrew Law
- Andrew Stenhouse
- Andrzej Eljaszewicz
- Andrzej Horban
- Andy Law
- Angelica Pagliazzi
- Angie Fawkes
- Anke Hinney
- Anna Canaccini
- Anna Kruk
- Anna Maria Pinto
- Anna Moniuszko-Malinowska
- Anna Parfieniuk-Kowerda
- Anna Piekarska
- Anna Szałkowska
- Annarita Giliberti
- Anne Richmond
- Antonella D. ’Arminio Monforte
- Antonella Vincenti
- Antonia Ho
- Antonio Di Biagio
- Antonio Perrella
- Arianna Emiliozzi
- Arianna Gabrieli
- Arsalin Azzadin
- Asma Al Thani &
- Athanasios Kousathanas
- Audrey Coutts
- Axel Schmidt
- Axel Schmidt
- B. Anwar
- B. Attwood
- B. Baines
- B. Blackledge
- B. Borislavova
- B. Chandler
- B. Charles
- B. Creagh-Brown
- B. David
- B. Deacon
- B. Deacon
- B. Digby
- B. Faulkner
- B. Fuller
- B. Gumbrill
- B. Gurung
- B. Hadebe
- B. Hairsine
- B. Hopkins
- B. Johnson
- B. Lenagh
- B. Masunda
- B. Ogg
- B. Patel
- B. Player
- B. Purewal
- B. Scholefield
- B. Shelley
- B. Sloan
- B. Thomas
- B. Wadams
- B. Welsh
- B. Wilkinson
- B. Winter-Goodwin
- B. Yates
- Barbara Rossetti
- Barbara Shih
- Barbara Sobala-Szczygiel
- Beata Puzanowska
- Benedetta Romanin
- Björn Jensen
- Bo Wang
- Brent Richards
- Bruno Frediani
- C. Adams
- C. Ahmed
- C. Almaden-Boyle
- C. Ashbrook-Raby
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- S. Cutler
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- S. Donlon
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- S. Hussain
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- S. Kumar
- S. Latham
- S. Leaver
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- S. Leggett
- S. MacFadyen
- S. Manna
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- S. Masuko
- S. McIvor
- S. McKechnie
- S. Mellor
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- S. Metherell
- S. Mitchard
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- S. Monnery
- S. Moore
- S. Morrison
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- S. Munt
- S. Murdoch
- S. O’Sullivan
- S. Packham
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- S. Preston
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- S. Quaid
- S. Ray
- S. Roche
- S. Rose
- S. Rundell
- S. Salmi
- S. Sathe
- S. Selvanayagam
- S. Shelton
- S. Shepardson
- S. Siddiqui
- S. Sousa Arias
- S. Spencer
- S. Srikaran
- S. Stone
- S. Swann
- S. Tilbey
- S. Turki
- S. Turney
- S. Twiss
- S. Wadd
- S. Whiteley
- S. Williams
- S. Wood
- S. Yussuf
- Sabino Scolletta
- Sabrina Ravaglia
- Said I. Ismail
- Salam Massadeh
- Sandra Uszok
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
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- Sara Clohisey
- Sara Clohisey
- Sara Clohisey Peter Horby
- Sara Modica
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- Sarah Iacopini
- Sarah Law
- Sarah McCafferty
- Sauro Luchi
- Saverio Giuseppe Parisi
- Selina Rolker
- Serafina Valente
- Serena Ludovisi
- Serghei Mangul
- Sergio Daga
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- Simona Dei
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- Simona Sarzi-Braga
- Simone Furini
- Slawomir Czaban
- SMelling
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Busani
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- Stefano Rusconi
- Sten Rubertsson
- Stephan Ossowski
- Susan Walker
- Susanna Croci
- Susanna Guerrini
- Sławomir Pancewicz
- T. Anderson
- T. Arden
- T. Baird
- T. Behan
- T. Bemand
- T. Cosier
- T. Coventry
- T. Duncan
- T. Felton
- T. Geary
- T. Hazleton
- T. Joefield
- T. Kannan
- T. Marsden
- T. Martin
- T. McHugh
- T. Newman
- T. Nortcliffe
- T. O. Jones
- T. Pogreban
- T. Rees
- T. Samakomva
- T. Smith
- T. Smith
- T. Szakmany
- T. Varghes
- T. Williams
- T. Wood
- Tammy Gilchrist
- Thorsten Brenner
- Tim Walsh
- Tiziana Bachetti
- Tomas Luther
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- Tony Wackett
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- Trevor Paterson
- Tullio Trotta
- U. Poultney
- Ulrike Protzer
- Umberto Zuccon
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- Urszula Lechowicz
- Urszula Polowianiuk
- V. Amin
- V. Anumakonda
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- V. Crickmore
- V. Gopal
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- V. Lake
- V. Linnett
- V. Martinson
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- V. Page
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- V. Parris
- V. Pristopan
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- V. Rivers’
- V. Sarathy
- V. Thomas
- V. Thwaites
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- V. Turner
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- V. Waugh
- Valentina Anemoli
- Valentina Borgo
- Valentina Perticaroli
- Verena Keitel
- Veronique Vitart
- W. Harrison
- W. Khaliq
- W. Khaliq
- W. McCormick
- W. Woodyatt
- Wadha Al-Muftah
- WES/WGS Working Group Within the HGI
- Wiktoria Izdebska
- Wilna Oosthuyzen
- X. Qiu
- Xia Shen
- Y. Baird
- Y. Choudhury
- Y. Hussain
- Y. Jackson
- Y. Thirlwall
- Yanara Marincevic-Zuniga
- Yang Wu
- Yaser Al-Sarraj
- Z. Alldis
- Z. Belagodu
- Z. Bradshaw
- Z. Coton
- Z. Daly
- Z. Farzad
- Z. Fernandez
- Z. Garland
- Z. Maqsood
- Z. Omar
- Z. Prime
- Z. Scott
- Zhijian Yang
- Publication venue
- Publication date
- 01/01/2022
- Field of study
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. © 2021, The Author(s)
Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial
- Author
- Abdel-Rahman Emaad
- Abhayaratna Walter
- Abramof Ness Rosane
- Acosta Idalia
- Adams Atoya
- Adawi Faiad
- Adler Sharon
- Ahmed Fayzal
- Aizenberg Diego
- Ajani Dilawar
- Al-Karadsheh Amer
- Albota Adrian
- Alferi Dino
- Alicic Radica
- Alla Sreedhara
- Allison D
- Almeida Edgar
- Alpizar Salazar Melchor
- Amer Joseph
- Amod Aslam
- Andrawis Nabil
- Antonio Bossi Carlo
- Antsiferov Mikhail
- Antunes Daniela
- Araki Hideo
- Arango Clara
- Arcos Edgar
- Arif Ahmed
- Arif Imrozia
- Arkhipov Mikhail
- Armaly Zaher
- Aroca Gustavo
- Asprusten Emil
- Atar Shaul
- Avila Pardo Sandro
- Awad Ahmed
- Axthelm Christoph
- Azizad Masoud
- Azizah Aziz Nor
- B Brouwer C
- Babikova Jana
- Babkin Andrey
- Badak Ozer
- Bahrami Michael
- Bajcsi Dora
- Baker John
- Bala Cornelia
- Ballesteros Rosa
- Bansal Shweta
- Barag Steven
- Barakzoy Ahmad
- Baranov Vitaliy
- Barbarash Olga
- Barbonta Hortensia
- Barney Mark
- Barre Paul
- Barrera Sandra
- Barreto Carlos
- Barreto Germ\ue1n
- Bartolacci In\ue9s
- Bashir Khalid
- Bashkin Amir
- Bastidas Adrian Miriam
- Bautista Albert
- Bautista Jose
- Bech Jesper
- Beddhu Srinivasan
- Beltr\ue1n L\uf3pez Nelly
- Ben Chetrit Sydney
- Benitez Diego
- Benjamin Sabrina
- Berar Yanay Noa
- Berenji Ramin
- Bertram Pitt
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- Besada Diego
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- Bu Ruifang
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- Burgner Anna
- Busch Klaus
- Busch Robert
- Butrymowicz Patrycja
- C Bakker R
- C\ue1rdenas Tatiana
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- Cai Hanqing
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- Canadas Rafael
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- Cardona Jose
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- Christina Nowack
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- L Penne E
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- Wei Jiali
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- Weissman Peter
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- Wierusz-Wysocka Bogna
- Wilderman Igor
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- Wittert Gary
- Wnetrzak-Michalska Renata
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- Wu Chaoqing
- Wu Mai-Szu
- Wu Ming-Ju
- Wu Tianfeng
- Wudi Krisztina
- Wuerzner Gregoire
- Wynne Katie-Jane
- Xing Changying
- Xiong Fei
- Xu Ning
- Xu Xudong
- Yagil Yoram
- Yajima Ken
- Yakhontov Davyd
- Yale Jean-Francois
- Yamada Daishiro
- Yamada Masayo
- Yamagata Kazuo
- Yamakawa Fumiko
- Yamakawa Ken
- Yamasaki Yoshimitsu
- Yambe Yuko
- Yanai Hidekatsu
- Yang Jinkui
- Yasuda Tetsuyuki
- Yenicerioglu Yavuz
- Yeung Vincent
- Yilmaz Huseyin
- Yin Aiping
- Yoncheva-Mihaylova Mariana
- Young Park Cheol
- Yuan Lee Li
- Yupanqui Hern\ue1n
- Yuryev Michael
- Zakharova Elena
- Zalevskaya Alsu
- Zanozina Olga
- Zaoui Philippe
- Zeig Steven
- Zeng Longyi
- Zhang Hao
- Zhang Yanlin
- Zhang Ying
- Zhao Zhiquan
- Zhdanova Elena
- Zheng Hongguang
- Zhong Ling
- Zhong Liyong
- Zhu Dalong
- Zhukova Larisa
- Zilahi Zsolt
- Zsom Marianna
- Zukermann Robert
- Zykova Tatyana
- Publication venue
- 'S. Karger AG'
- Publication date
- 01/01/2019
- Field of study
Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials.
Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure.
Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049
Long COVID and cardiovascular disease: a prospective cohort study
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- Publication venue
- BMJ
- Publication date
- 27/05/2024
- Field of study
Background
Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known.
Objectives
To determine whether the rate of patient-perceived recovery following hospitalisation with COVID-19 was affected by the presence of CVD or cardiovascular risk factors.
Methods
In a multicentre prospective cohort study, patients were recruited following discharge from the hospital with COVID-19 undertaking two comprehensive assessments at 5 months and 12 months. Patients were stratified by the presence of either CVD or cardiovascular risk factors prior to hospitalisation with COVID-19 and compared with controls with neither. Full recovery was determined by the response to a patient-perceived evaluation of full recovery from COVID-19 in the context of physical, physiological and cognitive determinants of health.
Results
From a total population of 2545 patients (38.8% women), 472 (18.5%) and 1355 (53.2%) had CVD or cardiovascular risk factors, respectively. Compared with controls (n=718), patients with CVD and cardiovascular risk factors were older and more likely to have had severe COVID-19. Full recovery was significantly lower at 12 months in patients with CVD (adjusted OR (aOR) 0.62, 95% CI 0.43 to 0.89) and cardiovascular risk factors (aOR 0.66, 95% CI 0.50 to 0.86).
Conclusion
Patients with CVD or cardiovascular risk factors had a delayed recovery at 12 months following hospitalisation with COVID-19. Targeted interventions to reduce the impact of COVID-19 in patients with cardiovascular disease remain an unmet need
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 01/04/2024
- Field of study
One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1. Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID. IL-1R2, MATN2 and COLEC12 were associated with cardiorespiratory symptoms, fatigue and anxiety/depression; MATN2, CSF3 and C1QA were elevated in gastrointestinal symptoms and C1QA was elevated in cognitive impairment. Additional markers of alterations in nerve tissue repair (SPON-1 and NFASC) were elevated in those with cognitive impairment and SCG3, suggestive of brain–gut axis disturbance, was elevated in gastrointestinal symptoms. Severe acute respiratory syndrome coronavirus 2-specific immunoglobulin G (IgG) was persistently elevated in some individuals with long COVID, but virus was not detected in sputum. Analysis of inflammatory markers in nasal fluids showed no association with symptoms. Our study aimed to understand inflammatory processes that underlie long COVID and was not designed for biomarker discovery. Our findings suggest that specific inflammatory pathways related to tissue damage are implicated in subtypes of long COVID, which might be targeted in future therapeutic trials
Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury
- Author
- Abel K.
- Adeloye D.
- Adeyemi O.
- Adrego R.
- Aguilar Jimenez L.A.
- Ahmad S.
- Ahmed R.
- Ahwireng N.
- Ainsworth M.
- Al-Sheklly B.
- Alamoudi A.
- Ali M.
- Aljaroof M.
- All A.M.
- Allan L.
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- Publication venue
- Oxford University Press
- Publication date
- 27/12/2023
- Field of study
A proportion of patients infected with severe acute respiratory syndrome coronavirus 2 experience a range of neuropsychiatric symptoms months after infection, including cognitive deficits, depression and anxiety. The mechanisms underpinning such symptoms remain elusive. Recent research has demonstrated that nervous system injury can occur during COVID-19. Whether ongoing neural injury in the months after COVID-19 accounts for the ongoing or emergent neuropsychiatric symptoms is unclear. Within a large prospective cohort study of adult survivors who were hospitalized for severe acute respiratory syndrome coronavirus 2 infection, we analysed plasma markers of nervous system injury and astrocytic activation, measured 6 months post-infection: neurofilament light, glial fibrillary acidic protein and total tau protein. We assessed whether these markers were associated with the severity of the acute COVID-19 illness and with post-acute neuropsychiatric symptoms (as measured by the Patient Health Questionnaire for depression, the General Anxiety Disorder assessment for anxiety, the Montreal Cognitive Assessment for objective cognitive deficit and the cognitive items of the Patient Symptom Questionnaire for subjective cognitive deficit) at 6 months and 1 year post-hospital discharge from COVID-19. No robust associations were found between markers of nervous system injury and severity of acute COVID-19 (except for an association of small effect size between duration of admission and neurofilament light) nor with post-acute neuropsychiatric symptoms. These results suggest that ongoing neuropsychiatric symptoms are not due to ongoing neural injury
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
- Author
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- 'Elsevier BV'
- Publication date
- 01/01/2023
- Field of study
BACKGROUND: Most studies of immunity to SARS-CoV-2 focus on circulating antibody, giving limited insights into mucosal defences that prevent viral replication and onward transmission. We studied nasal and plasma antibody responses one year after hospitalisation for COVID-19, including a period when SARS-CoV-2 vaccination was introduced. METHODS: In this follow up study, plasma and nasosorption samples were prospectively collected from 446 adults hospitalised for COVID-19 between February 2020 and March 2021 via the ISARIC4C and PHOSP-COVID consortia. IgA and IgG responses to NP and S of ancestral SARS-CoV-2, Delta and Omicron (BA.1) variants were measured by electrochemiluminescence and compared with plasma neutralisation data. FINDINGS: Strong and consistent nasal anti-NP and anti-S IgA responses were demonstrated, which remained elevated for nine months (p < 0.0001). Nasal and plasma anti-S IgG remained elevated for at least 12 months (p < 0.0001) with plasma neutralising titres that were raised against all variants compared to controls (p < 0.0001). Of 323 with complete data, 307 were vaccinated between 6 and 12 months; coinciding with rises in nasal and plasma IgA and IgG anti-S titres for all SARS-CoV-2 variants, although the change in nasal IgA was minimal (1.46-fold change after 10 months, p = 0.011) and the median remained below the positive threshold determined by pre-pandemic controls. Samples 12 months after admission showed no association between nasal IgA and plasma IgG anti-S responses (R = 0.05, p = 0.18), indicating that nasal IgA responses are distinct from those in plasma and minimally boosted by vaccination. INTERPRETATION: The decline in nasal IgA responses 9 months after infection and minimal impact of subsequent vaccination may explain the lack of long-lasting nasal defence against reinfection and the limited effects of vaccination on transmission. These findings highlight the need to develop vaccines that enhance nasal immunity. FUNDING: This study has been supported by ISARIC4C and PHOSP-COVID consortia. ISARIC4C is supported by grants from the National Institute for Health and Care Research and the Medical Research Council. Liverpool Experimental Cancer Medicine Centre provided infrastructure support for this research. The PHOSP-COVD study is jointly funded by UK Research and Innovation and National Institute of Health and Care Research. The funders were not involved in the study design, interpretation of data or the writing of this manuscript
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome