Air Toxics under the Big Sky: A Real-World Investigation To Engage High School Science Students

This paper describes a problem-based chemistry education model in which students perform scientific research on a local environmentally relevant problem. The project is a collaboration among The University of Montana and local high schools centered around Missoula, Montana. Air Toxics under the Big Sky involves high school students in collecting air samples inside and outside their homes within and near Missoula. As part of this program, teachers, students, and university researchers investigate the relationship between air pollutants and their harmful respiratory effects. Students experience scientific research, use scientific equipment, gain an insight into the relationship between the environment and public health, and develop scientific hypotheses. UM benefits by having a pipeline of high school students, several of whom participated in the program while in high school and now attend UM. The local community benefits from the work students and university researchers have done producing high-quality data that are being used in a tracking database for respiratory disease in western Montana. Student research efforts have culminated in three annual symposia that allowed students to present their results at a public forum

Vegetation and ecological characteristics of mixed-conifer and Red Fir forests at the Teakettle Experimental Forest

Detailed analysis of mixed-conifer and red fir forests were made from extensive, large vegetation sampling, systematically conducted throughout the Teakettle Experimental Forest. Mixed conifer is characterized by distinct patch conditions of closed-canopy tree clusters, persistent gaps and shrub thickets. This heterogeneous spatial structure provides contrasting microclimate, habitat and resource conditions probably associated with the high diversity of understory plants, fungi, and invertebrates found in ongoing studies in the Teakettle Experiment. In contrast, red fir forests are more homogeneous with continuous high canopy cover, cooler, more consistent microclimate conditions and fewer plant species. In both forests, annual fluctuations in available soil moisture resulting from El Niño influences on snow pack depth may have a significant influence on tree establishment and understory diversity. In depth descriptions of Teakettle’s mixed conifer may provide a target of historic old-growth conditions for forest management

Vegetation and ecological characteristics of mixed-conifer and Red Fir forests at the Teakettle Experimental Forest

Detailed analysis of mixed-conifer and red fir forests were made from extensive, large vegetation sampling, systematically conducted throughout the Teakettle Experimental Forest. Mixed conifer is characterized by distinct patch conditions of closed-canopy tree clusters, persistent gaps and shrub thickets. This heterogeneous spatial structure provides contrasting microclimate, habitat and resource conditions probably associated with the high diversity of understory plants, fungi, and invertebrates found in ongoing studies in the Teakettle Experiment. In contrast, red fir forests are more homogeneous with continuous high canopy cover, cooler, more consistent microclimate conditions and fewer plant species. In both forests, annual fluctuations in available soil moisture resulting from El Niño influences on snow pack depth may have a significant influence on tree establishment and understory diversity. In depth descriptions of Teakettle’s mixed conifer may provide a target of historic old-growth conditions for forest management.Retrieval Terms: ectomycorrhizae, fire history, flying squirrels (Glaucomys sabrinus), hydrology, hypogeous fungi, incense cedar (Calocedrus decurrens), invertebrates, Jeffrey pine (Pinus Jeffreyi), old growth, pathogens, plant association, red fir (Abies magnifica), Sierra Nevada, soil nutrients, songbirds, sugar pine (Pinus lambertiana), truffles, vegetation classification, white fir (Abies concolor)

Vegetation and ecological characteristics of mixed-conifer and red fir forests at the Teakettle Experimental Forest

Detailed analysis of mixed-conifer and red fir forests were made from extensive, large vegetation sampling, systematically conducted throughout the Teakettle Experimental Forest. Mixed conifer is characterized by distinct patch conditions of closed-canopy tree clusters, persistent gaps and shrub thickets. This heterogeneous spatial structure provides contrasting microclimate, habitat and resource conditions probably associated with the high diversity of understory plants, fungi, and invertebrates found in ongoing studies in the Teakettle Experiment. In contrast, red fir forests are more homogeneous with continuous high canopy cover, cooler, more consistent microclimate conditions and fewer plant species. In both forests, annual fluctuations in available soil moisture resulting from El Niño influences on snow pack depth may have a significant influence on tree establishment and understory diversity. In depth descriptions of Teakettle’s mixed conifer may provide a target of historic old-growth conditions for forest management

Contributions of Muscles and External Forces to Medial Knee Load Reduction Due to Osteoarthritis Braces

Background Braces for medial knee osteoarthritis can reduce medial joint loads through a combination of three mechanisms: application of an external brace abduction moment, alteration of gait dynamics, and reduced activation of antagonistic muscles. Although the effect of knee bracing has been reported independently for each of these parameters, no previous study has quantified their relative contributions to reducing medial knee loads. Methods In this study, we used a detailed musculoskeletal model to investigate immediate changes in medial and lateral loads caused by two different knee braces: OA Assist and OA Adjuster 3 (DJO Global). Seventeen osteoarthritis subjects and eighteen healthy controls performed overground gait trials in unbraced and braced conditions. Results Across all subjects, bracing reduced medial loads by 0.1 to 0.3 times bodyweight (BW), or roughly 10%, and increased lateral loads by 0.03 to 0.2 BW. Changes in gait kinematics due to bracing were subtle, and had little effect on medial and lateral joint loads. The knee adduction moment was unaltered unless the brace moment was included in its computation. Only one muscle, biceps femoris, showed a significant change in EMG with bracing, but this did not contribute to altered peak medial contact loads. Conclusions Knee braces reduced medial tibiofemoral loads primarily by applying a direct, and substantial, abduction moment to each subject's knee. To further enhance brace effectiveness, future brace designs should seek to enhance the magnitude of this unloader moment, and possibly exploit additional kinematic or neuromuscular gait modifications

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead