Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

HumanTop: a multi-object tracking tabletop

In this paper, a computer vision based interactive multi-touch tabletop system called HumanTop is introduced. HumanTop implements a stereo camera vision subsystem which allows not only an accurate fingertip tracking algorithm but also a precise touch-over-the-working surface detection method. Based on a pair of visible spectra cameras, a novel synchronization circuit makes the camera caption and the image projection independent from each other, providing the minimum basis for the development of computer vision analysis based on visible spectrum cameras without any interference coming from the projector. The assembly of both cameras and the synchronization circuit is not only capable of performing an ad-hoc version of a depth camera, but it also introduces the recognition and tracking of textured planar objects, even when contents are projected over them. On the other hand HumanTop supports the tracking of sheets of paper and ID-code markers. This set of features makes the HumanTop a comprehensive, intuitive and versatile augmented tabletop that provides multitouch interaction with projective augmented reality on any flat surface. As an example to exploit all the capabilities of HumanTop, an educational application has been developed using an augmented book as a launcher to different didactic contents. A pilot study in which 28 fifth graders participated is presented. Results about efficiency, usability/satisfaction and motivation are provided. These results suggest that HumanTop is an interesting platform for the development of educational contents. © 2012 Springer Science+Business Media, LLC.This study was funded by Ministerio de Educacion y Ciencia Spain, Project SALTET (TIN2010-21296-C02-01), Project Game Teen (TIN2010-20187) projects Consolider-C (SEJ2006-14301/PSIC), "CIBER of Physiopathology of Obesity and Nutrition, an initiative of ISCIII" and Excellence Research Program PROMETEO (Generalitat Valenciana. Conselleria de Educacio, 2008-157).Soto Candela, E.; Ortega Pérez, M.; Marín Romero, C.; Pérez López, DC.; Salvador Herranz, GM.; Contero, M.; Alcañiz Raya, ML. (2014). HumanTop: a multi-object tracking tabletop. Multimedia Tools and Applications. 70(3):1837-1868. https://doi.org/10.1007/s11042-012-1193-yS18371868703Agarwal A, Izadi S, Chandraker M, Blake A (2007) High precision multi-touch sensing on surfaces using overhead cameras. In: IEEE int. workshop horiz. interact. hum.-comput. interact., TABLETOP’07. IEEE, pp 197–200Alexa M, Bollensdorff B, Bressler I, Elstner S, Hahne U, Kettlitz N, Lindow N, Lubkoll R, Richter R, Stripf C et al (2008) Continuous reference images for ftir touch sensing. In: ACM SIGGRAPH poster. ACM, p 49Argyros A, Lourakis M (2006) Vision-based interpretation of hand gestures for remote control of a computer mouse. 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ACM, pp 267–274Dung L, Mizukawa M (2009) Fast hand feature extraction based on connected component labeling, distance transform and hough transform. J. Robot. Mechatronics 21(6):726–738Echtler F, Sielhorst T, Huber M, Klinker G (2009) A short guide to modulated light. In: Proc. 3rd int. conf. tang. embed. interact. ACM, pp 393–396Echtler F, Pototschnig T, Klinker G (2010) An led-based multitouch sensor for lcd screens. In: Proc. 4th int. conf. tang. embed. interact.. ACM, pp 227–230Han J (2005) Low-cost multi-touch sensing through frustrated total internal reflection. In: Proc. 18th ACM symp. user interface softw. technol. ACM, pp 115–118Holman D, Vertegaal R, Altosaar M, Troje N, Johns D (2005) Paper windows: interaction techniques for digital paper. In: Proc. SIGCHI conf. hum. factor comput. syst. ACM, pp 591–599Izadi S, Agarwal A, Criminisi A, Winn J, Blake A, Fitzgibbon A (2007) C-slate: a multi-touch and object recognition system for remote collaboration using horizontal surfaces. In: IEEE int. workshop horiz. interact. hum.-comput. interact., TABLETOP’07. IEEE, pp 3–10Jordà S, Geiger G, Alonso M, Kaltenbrunner M (2007) The reactable: exploring the synergy between live music performance and tabletop tangible interfaces. In: Proc. 1st int. conf. tangible embed. interact. ACM, pp 139–146Kaltenbrunner M (2009) Reactivision and tuio: a tangible tabletop toolkit. In: Proc. ACM int. conf. interact. tabletop. surf. ACM, pp 9–16Katz I, Gabayan K, Aghajan H (2007) A multi-touch surface using multiple cameras. In: Proc. 9th int. conf. adv. concept. intell. vis. syst.. Springer, pp 97–108Kim K, Lepetit V, Woo W (2010) Scalable real-time planar targets tracking for digilog books. 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In: Comput. vis. cent., pp 1–7Martín-Gutiérrez J, Luís Saorín J, Contero M, Alcañiz M, Pérez-López D, Ortega M (2010) Design and validation of an augmented book for spatial abilities development in engineering students. Comput Graph 34(1):77–91McNaughton J (2010) Utilising emerging multi-touch table designs. Durham UniversityMicrosoft (2011) Microsoft surface. URL http://www.microsoft.com/surface/Muja M, Lowe D (2009) Fast approximate nearest neighbors with automatic algorithm configuration. In: Int. conf. comput. vis. theory appl. VISSAPP, pp 331–340Nister D, Stewenius H (2006) Scalable recognition with a vocabulary tree. In: IEEE Comput. Soc. conf. comput. vis. pattern recognit., vol 2. IEEE, pp 2161–2168Oka K, Sato Y, Koike H (2002) Real-time fingertip tracking and gesture recognition. IEEE Comput Graph 22(6):64–71OpenSource (2011) Fast sift image features library. 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Investigación, reflexión y acción de la realidad socio-educativa a principios del siglo XXI : vol. II

Consciente de la importancia de la investigación educativa para promover las transformaciones que permitan ofrecer a la sociedad nacional e internacional una educación pertinente y relevante que al mismo tiempo, contribuya con el desarrollo humano, en febrero del 2011 y en el marco de la celebración del 30 aniversario de su fundación, el Instituto de Investigación en Educación (INIE) organiza el II Congreso Internacional de Investigación Educativa: Su Incidencia en la Realidad Social. Los aportes presentados durante este II Congreso Internacional de Investigación Educativa, se han recopilado en la publicación del libro digital: Investigación, reflexión y acción de la realidad socio-educativa a principios del siglo XXI. Estos trabajos tienen por objetivo ofrecer propuestas para repensar la educación y los procesos educativos que se desarrollan en las aulas, así como valorar la importancia de realizar las transformaciones que se requieren a partir de los resultados de las investigacione

Association between HLA DNA Variants and Long-Term Response to Anti-TNF Drugs in a Spanish Pediatric Inflammatory Bowel Disease Cohort

The genetic polymorphisms rs2395185 and rs2097432 in HLA genes have been associated with the response to anti-TNF treatment in inflammatory bowel disease (IBD). The aim was to analyze the association between these variants and the long-term response to anti-TNF drugs in pediatric IBD. We performed an observational, multicenter, ambispective study in which we selected 340 IBD patients under 18 years of age diagnosed with IBD and treated with anti-TNF drugs from a network of Spanish hospitals. Genotypes and failure of anti-TNF drugs were analyzed using Kaplan-Meier curves and Cox logistic regression. The homozygous G allele of rs2395185 and the C allele of rs2097432 were associated with impaired long-term response to anti-TNF drugs in children with IBD after 3 and 9 years of follow-up. Being a carrier of both polymorphisms increased the risk of anti-TNF failure. The SNP rs2395185 but not rs2097432 was associated with response to infliximab in adults with CD treated with infliximab but not in children after 3 or 9 years of follow-up. Conclusions: SNPs rs2395185 and rs2097432 were associated with a long-term response to anti-TNFs in IBD in Spanish children. Differences between adults and children were observed in patients diagnosed with CD and treated with infliximab

Esto va de Micro

Depto. de Genética, Fisiología y MicrobiologíaFac. de Ciencias BiológicasFac. de Bellas ArtesFALSEsubmitte

Biochemical and histological characterization of succulent plant Tacitus bellus response to Fusarium verticillioides infection in vitro

We present changes in Tacitus bellus antioxidative system that specifically correspond to subsequent phases of hemibiotroph Fusarium verticillioides infection revealed by histological analysis. T. bellus response to spore germination 6 h post inoculation (hpi), manifested as first oxidative burst, was characterized by transient decrease in malondialdehyde (MDA) content, transient increase in catalase (CAT), low level of superoxide dismutase (SOD) and peroxidase (POD) activity, as well as with transient decrease in total antioxidant capacity (TAC), total phenol content (TPC) and phenylalanine ammonium lyase activity (PAL), and no changes in polyphenol oxidase (PPO) activity, or phenolic profile. During the biotrophic phase of F. verticillioides infection, characterized by hyphae spread intercellularly in epidermal and mesophyll tissue, the host antioxidative system was suppressed. The transition to necrotrophic phase of F. verticillioides infection (inter- and intracellular colonization and sporulation), occurred 3-4 days post inoculation (dpi). During the necrotrophic phase, 5-7 dpi, slowed progression of colonization of T. bellus mesophyll cells occurred and it coincided with sharp increase in MDA content and CAT, SOD and POD activities, but the drop in TAC, TPC content, and PPO activity, as well as the production of phytotoxin fusaric acid. Presented results add to the knowledge of events and mechanisms related to the transition from biotrophy to necrotrophy in F. verticillioides