IDE ‑OTALEX C: A Primeira Infraestrutura de Dados Espaciais transfronteiriça entre Portugal e Espanha

Em 2007 criou ‑se a primeira Infraestrutura de Dados Espaciais transfronteiriça entre Portugal e Espanha (IDE ‑OTALEX – www.ideotalex.eu), que constituiu o Observatório Territorial e Ambiental Alentejo e Extremadura, ao qual se incorporou, em 2011, a região Centro de Portugal, que no total abrange uma superfície de 92.500 km2. Assim, surgiu o Observatório Territorial Alentejo ‑Extremadura ‑Centro (OTALEX C), possibilitando a integração da informação produzida pelas diversas instituições que desenvolvem as suas competências de planeamento e gestão territorial, nestas três regiões. Tendo como objetivo a monitorização e análise de alterações decorrentes de fenómenos naturais e da atividade humana sobre o território, bem como a disponibilização de dados e indicadores aos agentes que atuam neste território, foi desenvolvido um sistema de indicadores comuns, distribuídos por cinco vetores (territorial, ambiental, social, económico e de sustentabilidade). Os dados sofreram trabalhos de homogeneização e estandardização antes de serem integrados tendo em vista facilitar a visualização de mapas, consulta de topónimos e de catálogo, no âmbito da Diretiva INSPIRE. A IDE ‑OTALEX C é o resultado do esforço, do compromisso e da colaboração entre instituições da fronteira, com implicação aos três níveis administrativos: Nacional, Regional e Local. Concede uma visão sobre a situação real do território, ao mesmo tempo que faculta instrumentos adequados para as políticas de ação, que contribuem para apoiar o planeamento e ordenamento do território, a fim de alcançar um desenvolvimento sustentável.info:eu-repo/semantics/acceptedVersio

Immune synapse instructs epigenomic and transcriptomic functional reprogramming in dendritic cells.

Understanding the fate of dendritic cells (DCs) after productive immune synapses (postsynaptic DCs) with T cells during antigen presentation has been largely neglected in favor of deciphering the nuances of T cell activation and memory generation. Here, we describe that postsynaptic DCs switch their transcriptomic signature, correlating with epigenomic changes including DNA accessibility and histone methylation. We focus on the chemokine receptor Ccr7 as a proof-of-concept gene that is increased in postsynaptic DCs. Consistent with our epigenomic observations, postsynaptic DCs migrate more efficiently toward CCL19 in vitro and display enhanced homing to draining lymph nodes in vivo. This work describes a previously unknown DC population whose transcriptomics, epigenomics, and migratory capacity change in response to their cognate contact with T cells.This study was supported by grant SAF2017-82886-R from the Spanish Ministry of Economy and Competitiveness (MINECO), grant S2017/BMD-3671-INFLAMUNE-CM from the Comunidad de Madrid, a grant from the Ramon Areces Foundation “Ciencias de la Vida y la Salud” (XIX Concurso-2018), a grant from Ayudas Fundacion BBVA a Equipos de Investigacion Cientifica (BIOMEDICINA-2018), the Fundacio Marato TV3 (grant 122/C/2015), “la Caixa” Banking Foundation (HR17-00016), BIOIMID (PIE13/041) from Instituto de Salud Carlos III, CIBER Cardiovascular (CB16/11/00272), and Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III and co-funding by Fondo Europeo de Desarrollo Regional FEDER). D.C.-F. is supported by a Fellowship from “la Caixa” Foundation (LCF/BQ/DR19/11740010). I.F.-D. is supported by a Fellowship from the Spanish Ministry of Science, Innovation, and Universities (FPU15/02539). The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015- 0505). Funding agencies did not intervene in the design of the studies, with no copyright over the study.S

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Fundamentals for the design of energy management strategies for smart grids based on predictive control techniques. Methodology and case studies (EMS validation test)

This document compiles all the simulations performed to validate the EMS developed in the paper "Fundamentals for the design of energy management strategies for smart grids based on predictive control techniques. Methodology and case studies"This work was supported in part by grant PID2020-116616RB-C31 and grant PID2021-124908NB-I00 founded by MCIN/AEI/10.13039/501100011033 and by ‘‘ERDF A way of making Europe’’; by the Generalitat Valenciana regional government through project CIAICO/2021/064, by Andalusian Regional Program of R+D+i (P20- 00730), and by the project “The green hydrogen vector. Residential and mobility application”, approved in the call for research projects of the Cepsa Foundation Chair of the University of Huelva. Funding for open access charge: CRUE-Universitat Politècnica de València.Pajares Ferrando, A.; Vivas Fernandez, FJ.; Blasco Ferragud, FX.; Herrero Durá, JM.; Segura Manzano, F.; Andújar Márquez, JM. (2023). Fundamentals for the design of energy management strategies for smart grids based on predictive control techniques. Methodology and case studies (EMS validation test). http://hdl.handle.net/10251/19329

Physical Activity Reduces the Risk of Developing Diabetes and Diabetes Medication Use

Diabetes is a global public health challenge, exerting a large socioeconomic burden on healthcare systems. This study aimed to explore Diabetes prevalence and Diabetes medication use in diabetics regarding sex, age group, Physical Activity Level (PAL) and Body Mass Index (BMI) by studying possible differences and calculating the risks of developing Diabetes and Diabetes medication use in the population according to their PAL. A cross-sectional study was conducted using data extracted from the Spanish National Health Survey (ENSE2017). The sample was finally composed of 17,710 participants. A descriptive analysis was performed to characterise Diabetes prevalence and Diabetes medication use (Chi-square test and a z-test for independent proportions). Odds Ratios (OR) and 95% Confidence Intervals (CI) were calculated for Diabetes prevalence and Diabetes medication use according to the participants’ PAL. Both the Diabetes and Diabetes medication use was higher in men than in women, increasing with age and BMI, and decreasing with increasing PAL (p p < 0.001). Inactive people had a higher risk of Diabetes and use of Diabetes medication risk compared to the very active and active groups. Prevalence decreased the higher the PAL both in men and women

A 12-Month Follow-Up of PROCARE+, a Transdiagnostic, Selective, Preventive Intervention for Adolescents At-Risk for Emotional Disorders

Few studies have reported long-term follow-up data on selective preventive interventions for adolescents. No follow-up selective preventive transdiagnostic studies for adolescents at-risk for emotional disorders, such as anxiety and depression, have been reported. To fill this gap, this study aims to provide the first follow-up assessment of a randomized controlled trial (RCT) studying selective transdiagnostic prevention in at-risk adolescents. A 12-month follow-up assessment was conducted with subjects who originally received either PROCARE (Preventive transdiagnostic intervention for Adolescents at Risk for Emotional disorders), PROCARE+, which includes the PROCARE protocol along with personalized add-on modules or an active control condition (ACC) based on emotional psychoeducation, and their respective booster session for each experimental condition. 80 subjects (47.5% girls) aged between 12 and 18 years (M = 14.62; SD 1.43) who completed these treatment conditions were available for the 12-month follow-up. The results demonstrate the superior long-term efficacy of the PROCARE+ intervention in mitigating emotional symptoms and obsessive-compulsive symptomatology compared to the PROCARE and ACC conditions, with effect sizes notably exceeding those commonly observed in preventive programs. While the three treatments demonstrated beneficial impacts, the pronounced results associated with PROCARE+ at the 12-month follow-up emphasized the importance of personalized treatment modules and the sustained benefits of booster sessions in the realm of preventive psychological interventions. The findings also highlight the potential role of add-on modules in enhancing the effects of the PROCARE+ condition

Associations between Psychological Distress, Perceived Social Support and Physical Activity Level in Spanish Adults with Depression

Perceived social support (PSS) and physical activity (PA) could help to reduce psychological distress in people with depression. This study aims to analyse the associations between (a) mental health and its dimensions through the Goldberg General Health Questionnaire (GHQ-12), (b) the PA level (PAL), and c) the PSS in the Spanish adult population with psychological distress. This cross-sectional study is based on Spanish National Health Survey 2017 data, including 1670 adults with depression. A descriptive analysis was performed. Differences in medians between sexes were analysed using the Mann–Whitney U test. The Chi-square test was used to assess the independence between sex and PAL. The Kruskal–Wallis’ test was performed to analyse possible baseline differences between PAL and continuous variables derived from the GHQ-12. Finally, a correlation study was conducted between the generated variables and the GHQ-12 items, together with the PAL and the Duke-UNC-11, using Spearman’s rho correlation coefficients. Weak inverse correlations were found between the GHQ-12 and PAL (rho: −0.214); and PSS (r: −0.286). PAL and PSS showed weak inverse correlations with successful coping (rho: −0.216 and r: −0.265), self-esteem (rho: −0.209 and r: −0.283), and stress (rho: −0.130 and r: −0.232). Thus, higher PAL and SSP is associated with lower psychological distress

Intrasession Reliability Analysis for Oscillometric Blood Pressure Method Using a Digital Blood Pressure Monitor in Peruvian Population

Blood Pressure (BP) is one of the most used measured clinical parameters in health promotion and intervention. BP measures can vary due to different parameters, so we aim to study the intrasession test&ndash;retest reliability for an oscillometric method using a digital tensiometer in the Peruvian population aged over 15 with and without a diagnosis of hypertension (HT). Data were taken from the Demographic and Family Health Survey conducted in Peru in 2019. Technicians had to follow a standardized protocol on the conditions to carry out a valid and reliable measurement. Relative reliability was excellent in most cases (intraclass correlation coefficient &gt; 0.9); absolute reliability was excellent (standard error of measurement &lt; 5%) and smallest real difference &lt; 10% in most cases. The Bland&ndash;Altman plot showed a systematic error of 2.36 for systolic BP in men and 2.16 in women, and 0.823 for diastolic BP in men and 0.71 for diastolic BP in women. Results suggest that the oscillometric method with a digital blood pressure monitor was reliable in absolute and relative terms in this population, so it could be used as a reliable control test to measure changes after an intervention

Effectiveness of a transdiagnostic indicated preventive intervention for adolescents at high risk for anxiety and depressive disorders

Abstract Despite ample evidence for transdiagnostic interventions in clinical populations and in universal prevention approaches, there are only a few controlled trials examining their role for indicated prevention. This study is the first randomized controlled trial to assess the effectiveness of a brief, 8-session group version of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents (UP-A), called PROCARE-I (Preventive Transdiagnostic Intervention for Adolescents at Risk for Emotional Disorders-Indicated), delivered online, and including a booster session, in reducing symptoms of anxiety and depression in adolescents compared to an active control condition. Sixty-four adolescents (53% identifying as female) with elevated levels of anxiety and/or depression were randomly assigned to either the 8-week PROCARE-I or the active control condition. Self-report, parent, and clinician measures were collected before and after the interventions, at the 6-month follow-up, and 1 month after the booster session. After the intervention, participants in the PROCARE-I group showed improved scores on 9 of the 13 primary and secondary outcome measures, including reduction of anxiety and mood symptomatology, level of risk of developing emotional disorders, resilience, as well as increase of psychological flexibility, and emotional regulation. In contrast, those in the control group showed improvements in only 2 of the 13 outcome measures. After the booster session, significant differences were found between the PROCARE-I and control condition on measures of overall anxiety and depression symptoms, emotional risk, resilience, and quality of life. Low dropout rates and limited incidence of emotional disorders were observed at follow-ups. The interventions were well-accepted, with high satisfaction rates

Randomized controlled trial for selective preventive transdiagnostic intervention for adolescents at risk for emotional disorders

Highlights 1. Selective transdiagnostic preventive intervention with personalized add-on modules was effective. 2. Selective transdiagnostic prevention intervention reduced the risk of developing emotional problems. 3. A 6-month follow-up booster session contributed to maintain treatment effects