Providing Event Notifications

An event notification system can be used to provide notifications to a user related to an event. The system can provide these notifications before, during, and after the event. The event notification system analyzes an upcoming event from a user’s calendar to determine a context information associated with the event. As an example, this context information can include location of the place where the event is scheduled, people attending the event, duration of the event, agenda associated with the event etc. Based on the determined context associated with the event, the system determines specific tasks associated with the event. For example, these tasks can include providing the user with a map with the coordinates of the location of the event, names of people who have not yet RSVP\u27d to the event etc. Subsequently, the system provides notifications to the user for the specific tasks associated with the event

Dynamic and steady: shear rheological properties of xanthan and guar gums dispersed in yellow passion fruit pulp (Passiflora edulis f. flavicarpa)

Yellow passion fruit pulp is unstable, presenting phase separation that can be avoided by the addition of hydrocolloids. For this purpose, xanthan and guar gum [0.3, 0.7 and 1.0% (w/w)] were added to yellow passion fruit pulp and the changes in the dynamic and steady - shear rheological behavior evaluated. Xanthan dispersions showed a more pronounced pseudoplasticity and the presence of yield stress, which was not observed in the guar gum dispersions. Cross model fitting to flow curves showed that the xanthan suspensions also had higher zero shear viscosity than the guar suspensions, and, for both gums, an increase in temperature led to lower values for this parameter. The gums showed different behavior as a function of temperature in the range of 5 - 35ºC. The activation energy of the apparent viscosity was dependent on the shear rate and gum concentration for guar, whereas for xanthan these values only varied with the concentration. The mechanical spectra were well described by the generalized Maxwell model and the xanthan dispersions showed a more elastic character than the guar dispersions, with higher values for the relaxation time. Xanthan was characterized as a weak gel, while guar presented a concentrated solution behavior. The simultaneous evaluation of temperature and concentration showed a stronger influence of the polysaccharide concentration on the apparent viscosity and the G' and G" moduli than the variation in temperature

Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase

We report herein the discovery of a fatty acid amide hydrolase (FAAH) positron emission tomography (PET) tracer. Starting from a pyrazole lead, medicinal chemistry efforts directed toward reducing lipophilicity led to the synthesis of a series of imidazole analogues. Compound <b>6</b> was chosen for further profiling due to its appropriate physical chemical properties and excellent FAAH inhibition potency across species. [¹¹C]-<b>6</b> (MK-3168) exhibited good brain uptake and FAAH-specific signal in rhesus monkeys and is a suitable PET tracer for imaging FAAH in the brain