Etrasimod intermediate

The present study aims to identify and characterize the polymorphic form of the Etrasimod intermediate disclosed in international publication WO2011/094008 A1, specifically the compound of Formula (I)

Quantum-resilient Democracy: Open-access Reference for an Energy-efficient Substrate-based Majority Judgment Voting System

This document, produced with the assistance of ChatGPT o3 and ChatGPT 5 Thinking, is released under the Apache 2.0 licence. It is a voluntary defensive publication (prior art) and therefore enters the prior art upon release under the applicable patent statutes: EPC Art. 54(2) (European Patent Convention), French IPC Art. L 611-11 (French Intellectual Property Code), 35 U.S.C. §102(a) (United States Patent Act), Chinese Patent Law Art. 22(5) (中华人民共和国专利法), and Japanese Patent Act Art. 29(1) (特許法). We disclose an enabling, open reference for a national-to-planetary Majority Judgment (JM) voting stack on an energy-frugal Substrate chain: on-chain JM tallying, PQ signatures (Dilithium), PQ KEM ballot secrecy (Kyber), threshold decryption, ZK/MPC verifiability, energy-aware networking, ESG metrology (≤ 0.2 Wh/tx), and field workflows (kiosks, identity, grievance). Each proposal includes IPC/CPC classifications and reproducible implementation facets; timestamp proofs (RFC 3161 / FreeTSA) ensure verifiable dating and integrity. Original publication on Zenodo : https://zenodo.org/records/1687821

Next-Generation ISRU Materials for Space Infrastructure: HIBE, ENZ–THz and Graphene–Regolith Aerogel

This document, produced with the assistance of ChatGPT o3 and GPT-5 Thinking, is released under the Apache 2.0 licence. It is a voluntary defensive publication (prior art) and therefore enters the prior art upon release under the applicable patent statutes: EPC Art. 54(2) (European Patent Convention), French IPC Art. L 611-11 (French Intellectual Property Code), 35 U.S.C. §102(a) (United States Patent Act), Chinese Patent Law Art. 22(5) (中华人民共和国专利法), and Japanese Patent Act Art. 29(1) (特許法). It discloses 103 enabling inventions spanning ISRU materials (HIBE, ENZ–THz, graphene–regolith aerogels), orbital manufacturing, rail-launch subsystems (vacuum/diaphragms, MHD shields, cryo-tribology), QA/standards, logistics and controls. Each entry provides an enabling contribution, novelty rationale, IPC/CPC classes and intended strategy. Every proposal is described with sufficient technical detail to be reproduced; time-stamped artefacts ensure verifiability (RFC 3161 / FreeTSA). This release aims to secure open access, pre-empt blocking patents, and accelerate collaborations across agencies and industry. Original publication on Zenodo : https://zenodo.org/records/16795546

Framework for Governed Orchestration and Adaptive Lifecycle Management of Hierarchical Artificial Intelligence Agents

This document describes a framework for governing and managing hierarchical artificial intelligence (AI) agent systems. The framework addresses various limitations of current approaches, such as static architectures, naive delegation, high operational costs, lack of auditability, security vulnerabilities, and poor conflict handling. The framework includes a primary orchestrator node (PON) for task decomposition, a delegation and provisioning engine (DAPE) for agent selection and provisioning, specialized execution agents (SEAs) for task execution in secure sandboxes, a shared context manifold (SCM) for collaboration, a synthesis and reconciliation module (SRM) for output assembly, a causal traceability ledger for auditability, and a performance-driven optimization loop for continuous improvement. The framework enables dynamic adaptation, intelligent agent selection, built-in governance, stateful collaboration, full auditability, and self-evolution

Correlating Cross-Service Behavioral Signals to Identify Coordinated Inauthentic Activity

Some systems for detecting fraudulent user-generated content (UGC) can be siloed and reactive, analyzing individual pieces of content or account metrics in isolation, which may leave them susceptible to coordinated campaigns spanning multiple services. A system and method are described that can construct a unified cross-service behavioral graph to address such challenges. This graph can ingest and correlate metadata from user activities across disparate services, for example, productivity, payment, and communication platforms, to identify precursor signals that may be indicative of fraudulent intent. By analyzing patterns such as co-reviewing, temporal pulsing, and suspicious cross-service coordination (e.g., template creation), the system can identify coordinated inauthentic behavior. This approach can facilitate a shift from reactive analysis toward pre-emptive detection, potentially improving the identification of large-scale UGC fraud, in some cases before malicious content is published

Process for the preparation of Orforglipron intermediates

The inventors have solved the technical problem of the compound through experimental research, and the reaction route is as follows

Cyber Resilience Through Software-Layer Digital Twin

A complex, resource-intensive system such as a hybrid of information technology (IT), operational technology (OT), cloud computing networks, etc. can potentially be analyzed for cybersecurity and resilience by creating its digital twin. However, traditional approaches to creating digital twins involve accurate modelling of both the hardware and software layers, which renders the rapid design, deployment, and scaling of digital twins infeasible. This disclosure describes techniques to efficiently create a digital twin of a complex, resource-intensive system by decoupling its software and the hardware layers, by creating a digital twin for the software layer, and by modeling the hardware layer by accurately capturing changes in hardware states caused under software control. By doing so, modelers effectively create twins of the software and of the hardware interactions with software, making the design of the digital twin substantially faster. The digital twin can be subjected to chaos engineering based offensive testing to discover gaps in control-to-subsystem/component interactions, potential exploits, threats that can perform malicious actions, etc., and can also be used to design mitigative or compensatory security controls. The digital twin can be used for proactive cyberstudies relating to security, resilience, etc

Framework for Multi-Resource Condition Evaluation

In many computing scenarios, ensuring a desired state or enforcing a policy for a cloud workload requires considering the relationships and dependencies between distinct entities, resources, or assets. Traditional approaches that focus on the properties and configurations of single resources or assets can prevent accurate assessment of requirements. This disclosure describes techniques to evaluate conditions and constraints that involve multiple, disparate types of resources or entities. The techniques include resource identification and relationship mapping; data retrieval; cross-resource constraint evaluation; result aggregation and reporting; etc. A generic framework and data model define and evaluate conditions that span the boundaries of individual resource metadata, enabling comprehensive and accurate assessments of complex requirements

Style-Consistent Video Augmentation that Maintains Visual Style and Subject Identity

A media platform can receive client data from a client device including an image of a user’s face. A model framework can generate input data from the client data and provide the input data to a model trained to generate animation frames as output. The model can provide the generated animation frames back to the model framework, which may perform one or more postprocessing operations on the generated animation frames to generate animation data. The animation data is provided back to the client device

WIND TURBINE CONSTRUCTION AND INSTALLATION

The present disclosure relates to construction and installation of wind turbine units, and particularly construction and installation of floating offshore wind turbine units