Gestão estratégica ambiental: barreiras à implementação da ferramenta produção mais limpa em indústria de cerâmica vermelha de Caetité – Bahia / Environmental strategic management: barriers to the implementation of the tool cleaner production in Caetité red ceramic industry - Bahia

A busca pela preservação ambiental e preocupação com as gerações futuras, trouxe às empresas uma nova forma de se relacionar com o meio ambiente. Dessa forma, as empesas passaram a aderir novas estratégias ambientais em seus processos, produtos e serviços.  Nesse enfoque, o presente trabalho tem o objetivo de identificar as principais barreiras quanto à implementação do Programa Produção mais Limpa (P+L) no setor industrial de cerâmicas vermelhas do município de Caetité. Quanto à metodologia, a pesquisa apresenta-se como exploratória e descritiva utilizando o método de estudo de caso. Conjuntamente, realizou-se uma pesquisa-ação em um dos loci da pesquisa para possibilitar um aprofundamento no tema investigado.

Gestão estratégica ambiental: barreiras à implementação da ferramenta produção mais limpa em indústria de cerâmica vermelha de Caetité – Bahia / Environmental strategic management: barriers to the implementation of the tool cleaner production in Caetité red ceramic industry - Bahia

A busca pela preservação ambiental e preocupação com as gerações futuras, trouxe às empresas uma nova forma de se relacionar com o meio ambiente. Dessa forma, as empesas passaram a aderir novas estratégias ambientais em seus processos, produtos e serviços.  Nesse enfoque, o presente trabalho tem o objetivo de identificar as principais barreiras quanto à implementação do Programa Produção mais Limpa (P+L) no setor industrial de cerâmicas vermelhas do município de Caetité. Quanto à metodologia, a pesquisa apresenta-se como exploratória e descritiva utilizando o método de estudo de caso. Conjuntamente, realizou-se uma pesquisa-ação em um dos loci da pesquisa para possibilitar um aprofundamento no tema investigado.

Integrated Itinerary for Birdwatching on the Bioceanic Route: Brazil, Paraguay, Argentina and Chile

Este trabalho tem como objetivo avaliar como a geografia territorial da Rota de Integração Latino-Americana contribui para a construção e a formatação de roteiro para o turismo de observação de aves, com enaltecimento de paisagens, de práticas culturais, de territorialidades e da sociobiodiversidade como um todo representadas na Rota. A área de estudo envolve municípios brasileiros, paraguaios, argentinos e chilenos atingidos diretamente por esse Corredor Rodoviário. O território abarcado pela Rota de Integração Latino-Americana é contemplado por vários ambientes propícios para a prática do turismo de observação de aves, em especial aqueles contemplados por Áreas Protegidas e arredores. O roteiro proposto percorre diferentes topografias, ecorregiões e ecossistemas singulares da América do Sul, tais como: Cerrado, Pantanal, Mata Atlântica, Chaco (seco e úmido), Yungas, Deserto de Montanhas, Campos de Altitude, Puna, Lagoas Altoandinas, Deserto e Vales desérticos, Costa do Pacífico e Tamarugales. Em cada localidade a biodiversidade compõe o espaço junto das práticas culturais e de territorialidades singulares. Tamanha riqueza e diversidade projeta esse percurso como um excelente roteiro para o turismo de observação de aves, pronto a ser percorrido, contemplado e apreciado em suas múltiplas possibilidades.The objective of this work is to evaluate how the territorial geography of the Latin American Integration Route contributes to the construction and formation of a route for birdwatching tourism, with the enhancement of landscapes, cultural practices, territorialities and socio-biodiversity as a whole represented in the Route. The study area involves Brazilian, Paraguayan, Argentine and Chilean municipalities directly affected by the Bioceanic Route Corridor. The territory covered by the Latin American Integration Route is covered by several sites suitable for the practice of birdwatching tourism, especially the protected areas in its direct and indirect influence area. The territory includes environments such as: Cerrado, Pantanal, Atlantic Forest, Dry and Humid Chaco, Yungas, Monte Desert, High Altitude Grasslands, Puna, High Andean Lagoons, Desert and Desert Valleys, Pacific Coast and Tamarugales. The great variety of landscape characteristics makes it an excellent route for ornithological tourism, ready to be explored and contemplated in its innumerable possibilities.Fil: Batista Mamede, Simone. Instituto Mamede de Pesquisa Ambiental e Ecoturismo; BrasilFil: Benites da Silva, Maristela. Universidade Federal Do Mato Grosso (ufmt);Fil: Mangini, Gabriela Giselle. Universidad Nacional de Tucumán. Instituto de Ecología Regional. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Ecología Regional; ArgentinaFil: Esquivel Mattos, Alberto. World Wildlife Fund; Paragua

Integrated Itinerary for Birdwatching on the Bioceanic Route: Brazil, Paraguay, Argentina and Chile

Este trabalho tem como objetivo avaliar como a geografia territorial da Rota de Integração Latino-Americana contribui para a construção e a formatação de roteiro para o turismo de observação de aves, com enaltecimento de paisagens, de práticas culturais, de territorialidades e da sociobiodiversidade como um todo representadas na Rota. A área de estudo envolve municípios brasileiros, paraguaios, argentinos e chilenos atingidos diretamente por esse Corredor Rodoviário. O território abarcado pela Rota de Integração Latino-Americana é contemplado por vários ambientes propícios para a prática do turismo de observação de aves, em especial aqueles contemplados por Áreas Protegidas e arredores. O roteiro proposto percorre diferentes topografias, ecorregiões e ecossistemas singulares da América do Sul, tais como: Cerrado, Pantanal, Mata Atlântica, Chaco (seco e úmido), Yungas, Deserto de Montanhas, Campos de Altitude, Puna, Lagoas Altoandinas, Deserto e Vales desérticos, Costa do Pacífico e Tamarugales. Em cada localidade a biodiversidade compõe o espaço junto das práticas culturais e de territorialidades singulares. Tamanha riqueza e diversidade projeta esse percurso como um excelente roteiro para o turismo de observação de aves, pronto a ser percorrido, contemplado e apreciado em suas múltiplas possibilidades.The objective of this work is to evaluate how the territorial geography of the Latin American Integration Route contributes to the construction and formation of a route for birdwatching tourism, with the enhancement of landscapes, cultural practices, territorialities and socio-biodiversity as a whole represented in the Route. The study area involves Brazilian, Paraguayan, Argentine and Chilean municipalities directly affected by the Bioceanic Route Corridor. The territory covered by the Latin American Integration Route is covered by several sites suitable for the practice of birdwatching tourism, especially the protected areas in its direct and indirect influence area. The territory includes environments such as: Cerrado, Pantanal, Atlantic Forest, Dry and Humid Chaco, Yungas, Monte Desert, High Altitude Grasslands, Puna, High Andean Lagoons, Desert and Desert Valleys, Pacific Coast and Tamarugales. The great variety of landscape characteristics makes it an excellent route for ornithological tourism, ready to be explored and contemplated in its innumerable possibilities.Fil: Batista Mamede, Simone. Instituto Mamede de Pesquisa Ambiental e Ecoturismo; BrasilFil: Benites da Silva, Maristela. Universidade Federal Do Mato Grosso (ufmt);Fil: Mangini, Gabriela Giselle. Universidad Nacional de Tucumán. Instituto de Ecología Regional. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Ecología Regional; ArgentinaFil: Esquivel Mattos, Alberto. World Wildlife Fund; Paragua

Birds of the Pantanal floodplains, Brazil: historical data, diversity, and conservation

The Pantanal floodplains of Brazil are a region of rich biodiversity. To date, the true richness of the Pantanal avifauna has not been explored satisfactorily caused by a lack of studies in the region and, especially, by the divergence of opinion among the works published by various authors on the many species found in the region. This is due to the lack of criteria in examining records, both with regard to the reliability of the identifications and in the precise geographical allocation. Therefore, in the study, we collage findings from various studies and records created by us in the last few decades from 199 distinct locations to produce a list of birds in the Pantanal floodplains. We grouped the results into three lists: primary, secondary, and tertiary. We found that the avifauna of the Pantanal floodplain is composed of a total of 617 species, of which 571 (92%) have supporting records of occurrence (primary list) and 46 still lack documentation (secondary list). The number of species listed here for the Pantanal floodplain represents 32% of all avifauna known to the Brazilian territory. This reflects the importance of the biome, as part of the national territory, for the maintenance of a meaningful avifaunistic richness. Migratory birds (n = 183), notably northern ones (n = 43), are among the main players involved in ecological processes of nutrient cycling and dispersion of important pathogens between the two continents. With regard to conservation, 25 species are included in some category of threat in the lists of threatened species with global extinction. We hope that our list will help future researchers a more definitive approach when researching the avian fauna in this bountiful region

Checklist of the birds of Mato Grosso do Sul state, Brazil: diversity and conservation

Several phytogeographic regions (Cerrado, Pantanal, Atlantic Forest, Gran Chaco, and Chiquitano Dry Forests) converge in the state of Mato Grosso do Sul, Brazil, and influence regional biodiversity. Despite a list of birds in the state of Mato Grosso do Sul being published by Nunes et al. (2017), it is necessary to update and critically review avifauna records. In this study, we gathered the results of several records obtained from species lists and online data platforms of the 336 sites in this state over the last decades and grouped them into Main (Primary and Secondary) and Tertiary Lists. The avifauna of Mato Grosso do Sul is composed of 678 species, of which 643 (95%) have records proving their occurrence (Primary List), whereas 34 still lack documentation (Secondary List). The number of related species for Mato Grosso do Sul represents 34% of the Brazilian avifauna. Some species stand out for their unique occurrence in Mato Grosso do Sul, such as Melanerpes cactorum, Celeus lugubris, Phaethornis subochraceus, and Cantorchilus guarayanus, reflecting the influence of different phytogeographic regions of the Chaco and Chiquitano Dry Forests. Migrants represent 20% of the bird community occurring in the state, of which 93 species correspond to migrants from various regions of South America (south and west) and 40 to boreal migrants. Thirty-three species perform nomadic movements across the Pantanal Plain and other regions of the state. Thirty-one species are included in some conservation-threatened categories of global and/or national endangered species lists. Other 30 species are included in the near-threatened category at the global level and 23 at the national level. In addition, species typical of dry forests (in Serra da Bodoquena and Maciço do Urucum) and those from the Atlantic Forest in the south of the state deserve attention due to their restricted distribution and the high anthropogenic pressure on their habitat

Checklist of the birds of Mato Grosso do Sul state, Brazil: diversity and conservation

Several phytogeographic regions (Cerrado, Pantanal, Atlantic Forest, Gran Chaco, and Chiquitano Dry Forests) converge in the state of Mato Grosso do Sul, Brazil, and influence regional biodiversity. Despite a list of birds in the state of Mato Grosso do Sul being published by Nunes et al. (2017), it is necessary to update and critically review avifauna records. In this study, we gathered the results of several records obtained from species lists and online data platforms of the 336 sites in this state over the last decades and grouped them into Main (Primary and Secondary) and Tertiary Lists. The avifauna of Mato Grosso do Sul is composed of 678 species, of which 643 (95%) have records proving their occurrence (Primary List), whereas 34 still lack documentation (Secondary List). The number of related species for Mato Grosso do Sul represents 34% of the Brazilian avifauna. Some species stand out for their unique occurrence in Mato Grosso do Sul, such as Melanerpes cactorum, Celeus lugubris, Phaethornis subochraceus, and Cantorchilus guarayanus, reflecting the influence of different phytogeographic regions of the Chaco and Chiquitano Dry Forests. Migrants represent 20% of the bird community occurring in the state, of which 93 species correspond to migrants from various regions of South America (south and west) and 40 to boreal migrants. Thirty-three species perform nomadic movements across the Pantanal Plain and other regions of the state. Thirty-one species are included in some conservation-threatened categories of global and/or national endangered species lists. Other 30 species are included in the near-threatened category at the global level and 23 at the national level. In addition, species typical of dry forests (in Serra da Bodoquena and Maciço do Urucum) and those from the Atlantic Forest in the south of the state deserve attention due to their restricted distribution and the high anthropogenic pressure on their habitat

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS.Peer reviewe

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

A cross-ancestry genome-wide association meta-analysis of amyotrophic lateral sclerosis (ALS) including 29,612 patients with ALS and 122,656 controls identifies 15 risk loci with distinct genetic architectures and neuron-specific biology. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 individuals with whole-genome sequencing (6,538 patients, 2,415 controls) and a large cortex-derived expression quantitative trait locus (eQTL) dataset (MetaBrain), analyses revealed locus-specific genetic architectures in which we prioritized genes either through rare variants, short tandem repeats or regulatory effects. ALS-associated risk loci were shared with multiple traits within the neurodegenerative spectrum but with distinct enrichment patterns across brain regions and cell types. Of the environmental and lifestyle risk factors obtained from the literature, Mendelian randomization analyses indicated a causal role for high cholesterol levels. The combination of all ALS-associated signals reveals a role for perturbations in vesicle-mediated transport and autophagy and provides evidence for cell-autonomous disease initiation in glutamatergic neurons

Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy

Because hyper-excitability has been shown to be a shared pathophysiological mechanism, we used the latest and largest genome-wide studies in amyotrophic lateral sclerosis (n = 36,052) and epilepsy (n = 38,349) to determine genetic overlap between these conditions. First, we showed no significant genetic correlation, also when binned on minor allele frequency. Second, we confirmed the absence of polygenic overlap using genomic risk score analysis. Finally, we did not identify pleiotropic variants in meta-analyses of the 2 diseases. Our findings indicate that amyotrophic lateral sclerosis and epilepsy do not share common genetic risk, showing that hyper-excitability in both disorders has distinct origins