The correlation structure of dark matter halo properties

We investigate the correlation between nine different dark matter halo properties using a rank correlation analysis and a Principal Component Analysis for a sample of haloes spanning five orders of magnitude in mass. We consider mass and dimensionless measures of concentration, age, relaxedness, sphericity, triaxiality, substructure, spin, and environment, where the latter is defined in a way that makes it insensitive to mass. We find that concentration is the most fundamental property. Except for environment, all parameters are strongly correlated with concentration. Concentration, age, substructure, mass, sphericity and relaxedness can be considered a single family of parameters, albeit with substantial scatter. In contrast, spin, environment, and triaxiality are more independent, although spin does correlate strongly with substructure and both spin and triaxiality correlate substantially with concentration. Although mass sets the scale of a halo, all other properties are more sensitive to concentration.Comment: 5 pages, 2 figures. Accepted by MNRAS Letters. Minor change

Triplets of supermassive black holes: Astrophysics, Gravitational Waves and Detection

Supermassive black holes (SMBHs) found in the centers of many galaxies have been recognized to play a fundamental active role in the cosmological structure formation process. In hierarchical formation scenarios, SMBHs are expected to form binaries following the merger of their host galaxies. If these binaries do not coalesce before the merger with a third galaxy, the formation of a black hole triple system is possible. Numerical simulations of the dynamics of triples within galaxy cores exhibit phases of very high eccentricity (as high as $e \sim 0.99$). During these phases, intense bursts of gravitational radiation can be emitted at orbital periapsis. This produces a gravitational wave signal at frequencies substantially higher than the orbital frequency. The likelihood of detection of these bursts with pulsar timing and the Laser Interferometer Space Antenna ({\it LISA}) is estimated using several population models of SMBHs with masses $\gtrsim 10^7 {\rm M_\odot}$. Assuming a fraction of binaries $\ge 0.1$ in triple system, we find that few to few dozens of these bursts will produce residuals $>1$ ns, within the sensitivity range of forthcoming pulsar timing arrays (PTAs). However, most of such bursts will be washed out in the underlying confusion noise produced by all the other 'standard' SMBH binaries emitting in the same frequency window. A detailed data analysis study would be required to assess resolvability of such sources. Implementing a basic resolvability criterion, we find that the chance of catching a resolvable burst at a one nanosecond precision level is 2-50%, depending on the adopted SMBH evolution model. On the other hand, the probability of detecting bursts produced by massive binaries (masses \gtrsim 10^7\msun) with {\it LISA} is negligible.Comment: Accepted for publication by MNRAS, minor change

Self consistent model for the evolution of eccentric massive black hole binaries in stellar environments: implications for gravitational wave observations

We construct evolutionary tracks for massive black hole binaries (MBHBs) embedded in a surrounding distribution of stars. The dynamics of the binary is evolved by taking into account the erosion of the central stellar cusp bound to the massive black holes, the scattering of unbound stars feeding the binary loss cone, and the emission of gravitational waves (GWs). Stellar dynamics is treated in a hybrid fashion by coupling the results of numerical 3-body scattering experiments of bound and unbound stars to an analytical framework for the evolution of the stellar density distribution and for the efficiency of the binary loss cone refilling. Our main focus is on the behaviour of the binary eccentricity, in the attempt of addressing its importance in the merger process and its possible impact for GW detection with the planned Laser Interferometer Space Antenna ({\it LISA}), and ongoing and forthcoming pulsar timing array (PTA) campaigns. We produce a family of evolutionary tracks extensively sampling the relevant parameters of the system which are the binary mass, mass ratio and initial eccentricity, the slope of the stellar density distribution, its normalization and the efficiency of loss cone refilling. We find that, in general, stellar dynamics causes a dramatic increase of the MBHB eccentricity, especially for initially already mildly eccentric and/or unequal mass binaries. When applied to standard MBHB population models, our results predict eccentricities in the ranges $10^{-3}-0.2$ and $0.03-0.3$ for sources detectable by {\it LISA} and PTA respectively. Such figures may have a significant impact on the signal modelling, on source detection, and on the development of parameter estimation algorithms.Comment: 15 pages, 9 figures, accepted for publication in the Astrophysical Journa

Nano-ADEPT Aeroloads Wind Tunnel Test

A wind tunnel test of the Adaptable Deployable Entry and Placement Technology (ADEPT) was conducted in April 2015 at the US Army's 7 by10 Foot Wind Tunnel located at NASA Ames Research Center. Key geometric features of the fabric test article were a 0.7 meter deployed base diameter, a 70 degree half-angle forebody cone angle, eight ribs, and a nose-to-base radius ratio of 0.7. The primary objective of this wind tunnel test was to obtain static deflected shape and pressure distributions while varying pretension at dynamic pressures and angles of attack relevant to entry conditions at Earth, Mars, and Venus. Other objectives included obtaining aerodynamic force and moment data and determining the presence and magnitude of any dynamic aeroelastic behavior (buzz/flutter) in the fabric trailing edge. All instrumentation systems worked as planned and a rich data set was obtained. This paper describes the test articles, instrumentation systems, data products, and test results. Four notable conclusions are drawn. First, test data support adopting a pre-tension lower bound of 10 foot pounds per inch for Nano-ADEPT mission applications in order to minimize the impact of static deflection. Second, test results indicate that the fabric conditioning process needs to be reevaluated. Third, no flutter/buzz of the fabric was observed for any test condition and should also not occur at hypersonic speeds. Fourth, translating one of the gores caused ADEPT to generate lift without the need for a center of gravity offset. At hypersonic speeds, the lift generated by actuating ADEPT gores could be used for vehicle control

Massive black hole binary plane reorientation in rotating stellar systems

We study the evolution of the orientation of the orbital plane of massive black hole binaries (BHBs) in rotating stellar systems in which the total angular momentum of the stellar cusp is misaligned with respect to that of the binary. We compare results from direct summation N-body simulations with predictions from a simple theoretical model. We find that the same encounters between cusp stars and the BHB that are responsible for the hardening and eccentricity evolution of the binary, lead to a reorientation of the binary orbital plane. In particular, binaries whose angular momentum is initially misaligned with respect to that of the stellar cusp tend to realign their orbital planes with the angular momentum of the cusp on a timescale of a few hardening times. This is due to angular momentum exchange between stars and the BHB during close encounters, and may have important implications for the relative orientation of host galaxies and radio jets.Comment: 5 pages, 5 figures, accepted for publication in MNRA

Enabling Venus In-Situ Science - Deployable Entry System Technology, Adaptive Deployable Entry and Placement Technology (ADEPT): A Technology Development Project funded by Game Changing Development Program of the Space Technology Program

Venus is one of the important planetary destinations for scientific exploration, but: The combination of extreme entry environment coupled with extreme surface conditions have made mission planning and proposal efforts very challenging. We present an alternate, game-changing approach (ADEPT) where a novel entry system architecture enables more benign entry conditions and this allows for greater flexibility and lower risk in mission desig

Target genes and structure of the direct repeats in the DNA-binding sequences of the response regulator PhoP in Streptomyces coelicolor

Expression of genes belonging to the pho regulon in Streptomyces coelicolor is positively regulated (as shown by comparing the wild-type and a ΔphoP mutant) by binding of the response regulator PhoP to 11-nt direct repeats (DRus). These sequences have been found in over 100 genes of Streptomyces coelicolor; 20 of them were cloned and the binding of PhoPDBD to most of their promoters has been shown by electrophoretic mobility shift assays. Deletion experiments showed that at least two DRus are required for proper binding of PhoPDBD. Deletion of 1 nt leaving a 10-nt direct repeat reduced drastically binding of PhoPDBD. Three different types of operators have been identified. Complex operators (class III) contain up to six DRus, some of them with poor conservation of the 11-nt consensus sequence, which however were protected by PhoPDBD in footprinting analyses. A cooperative binding of PhoPDBD molecules initiated at conserved core DRus appears to be the mechanism involved in binding of several PhoPDBD monomers to those complex operators. The information theory-based model that incorporates the positive or negative contribution to the binding of PhoPDBD of adjacent sequences has been used to deduce the structure of PHO boxes and the relevance of each DRu

Arboviral Etiologies of Acute Febrile Illnesses in Western South America, 2000–2007

Over recent decades, the variety and quantity of diseases caused by viruses transmitted to humans by mosquitoes and other arthropods (also known as arboviruses) have increased around the world. One difficulty in studying these diseases is the fact that the symptoms are often non-descript, with patients reporting such symptoms as low-grade fever and headache. Our goal in this study was to use laboratory tests to determine the causes of such non-descript illnesses in sites in four countries in South America, focusing on arboviruses. We established a surveillance network in 13 locations in Ecuador, Peru, Bolivia, and Paraguay, where patient samples were collected and then sent to a central laboratory for testing. Between May 2000 and December 2007, blood serum samples were collected from more than 20,000 participants with fever, and recent arbovirus infection was detected for nearly one third of them. The most common viruses were dengue viruses (genera Flavivirus). We also detected infection by viruses from other genera, including Alphavirus and Orthobunyavirus. This data is important for understanding how such viruses might emerge as significant human pathogens

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder