Physics of Quantum Relativity through a Linear Realization

The idea of quantum relativity as a generalized, or rather deformed, version of Einstein (special) relativity has been taking shape in recent years. Following the perspective of deformations, while staying within the framework of Lie algebra, we implement explicitly a simple linear realization of the relativity symmetry, and explore systematically the resulting physical interpretations. Some suggestions we make may sound radical, but are arguably natural within the context of our formulation. Our work may provide a new perspective on the subject matter, complementary to the previous approach(es), and may lead to a better understanding of the physics.Comment: 27 pages in Revtex, no figure; proof-edited version to appear in Phys.Rev.

NC Wilson lines and the inverse Seiberg-Witten map for nondegenerate star products

Open Wilson lines are known to be the observables of noncommutative gauge theory with Moyal-Weyl star product. We generalize these objects to more general star products. As an application we derive a formula for the inverse Seiberg-Witten map for star products with invertible Poisson structures.Comment: 8 page

On the Design of a Secure Proxy Signature-based Handover Authentication Scheme for LTEWireless Networks

Designing a secure and efficient handover authentication scheme has always been a concern of cellular networks especially in 4G Long Term Evolution (LTE) wireless networks. What makes their handover so complex, is the presence of different types of base stations namely eNodeB (eNB) and Home eNodeB (HeNB). In addition, they cannot directly communicate with each other. Recently, an efficient proxy signature-based handover authentication scheme has been suggested by Qui et al. Despite its better performance and security advantages than previous schemes, it suffers serious vulnerabilities, namely being prone to DoS attack , eNB impersonation attack and lack of perfect forward secrecy. In this paper, we propose an improved handover authentication scheme in LTE wireless networks that resists against such attacks. Further, we validate the security of the proposed scheme using Real-Or- Random (ROR) model and ProVerif analysis tool. The results confirm our security claims of the proposed scheme. In addition, the performance analysis shows that compared to other schemes, our proposed scheme is more efficient

A Study of the Antioxidant Effect of Alpha Lipoic Acids on Sperm Quality

OBJECTIVE: Assisted reproductive techniques are useful in helping infertile couples achieve successful conception. Initial studies have shown that sperm cryopreservation, one step in assisted reproduction, causes a dramatic reduction in sperm quality. This has been attributed to, among other things, free radical activities. The aim of the present study was to minimize this oxidative attack by adding an antioxidant into the sperm microenvironment. Alpha lipoic acids were selected for this purpose for their efficient free radical scavenging properties and solubility in lipid and aqueous phases. METHODS: For this investigation, semen from six Boer bucks was pooled. Seminal analysis of the baseline prior to incubation of samples with different concentrations of Alpha lipoic acids (0.00625, 0.0125, 0.025, 0.05, 0.1 mmol/ml) was performed, and post-seminal analysis was conducted after a one-hour incubation. The comet assay was used to observe the effect of Alpha lipoic acids on sperm DNA integrity. Statistical analysis using an unpaired t-test with a significance level of p<0.05 was then performed. RESULTS: Our results indicate that the sperm motility rate was improved after incubation with Alpha lipoic acids at a concentration of 0.02 mmol/ml. This concentration was also capable of reducing DNA damage. CONCLUSION: In conclusion, Alpha lipoic acids renders cryoprotection to sperm, thereby improving sperm quality

Strings on Plane Waves, Super-Yang Mills in Four Dimensions, Quantum Groups at Roots of One

We show that the BMN operators in D=4 N=4 super Yang Mills theory proposed as duals of stringy oscillators in a plane wave background have a natural quantum group construction in terms of the quantum deformation of the SO(6) $R$ symmetry. We describe in detail how a q-deformed U(2) subalgebra generates BMN operators, with $q \sim e^{2 i \pi \over J}$. The standard quantum co-product as well as generalized traces which use $q$-cyclic operators acting on tensor products of Higgs fields are the ingredients in this construction. They generate the oscillators with the correct (undeformed) permutation symmetries of Fock space oscillators. The quantum group can be viewed as a spectrum generating algebra, and suggests that correlators of BMN operators should have a geometrical meaning in terms of spaces with quantum group symmetry.Comment: 34 pages (Harvmac); v2 : minor correction + refs adde

PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage

Amyotrophic lateral sclerosis (ALS) is associated with progressive degeneration of motor neurons. Several of the genes associated with this disease encode proteins involved in RNA processing, including fused-in-sarcoma/translocated-in-sarcoma (FUS/TLS). FUS is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family of proteins that bind thousands of pre-mRNAs and can regulate their splicing. Here, we have examined the possibility that FUS is also a component of the cellular response to DNA damage. We show that both GFP-tagged and endogenous FUS re-localize to sites of oxidative DNA damage induced by UVA laser, and that FUS recruitment is greatly reduced or ablated by an inhibitor of poly (ADP-ribose) polymerase activity. Consistent with this, we show that recombinant FUS binds directly to poly (ADP-ribose) in vitro, and that both GFP-tagged and endogenous FUS fail to accumulate at sites of UVA laser induced damage in cells lacking poly (ADP-ribose) polymerase-1. Finally, we show that GFP-FUS(R521G), harbouring a mutation that is associated with ALS, exhibits reduced ability to accumulate at sites of UVA laser-induced DNA damage. Together, these data suggest that FUS is a component of the cellular response to DNA damage, and that defects in this response may contribute to ALS

Rehabilitation of memory following brain injury (ReMemBrIn): study protocol for a randomised controlled trial

Background Impairments of memory are commonly reported by people with traumatic brain injuries (TBI). Such deficits are persistent, debilitating, and can severely impact quality of life. Currently, many do not routinely receive follow-up appointments for residual memory problems following discharge. Methods/Design This is a multi-centre, randomised controlled trial investigating the clinical and cost-effectiveness of a group-based memory rehabilitation programme. Three hundred and twelve people with a traumatic brain injury will be randomised from four centres. Participants will be eligible if they had a traumatic brain injury more than 3 months prior to recruitment, have memory problems, are 18 to 69 years of age, are able to travel to one of our centres and attend group sessions, and are able to give informed consent. Participants will be randomised in clusters of 4 to 6 to the group rehabilitation intervention or to usual care. Intervention groups will receive 10 weekly sessions of a manualised memory rehabilitation programme, which has been developed in previous pilot studies. The intervention will include restitution strategies to retrain impaired memory functions and compensation strategies to enable participants to cope with their memory problems. All participants will receive a follow-up postal questionnaire and an assessment by a research assistant at 6 and 12 months post-randomisation. The primary outcome is the Everyday Memory Questionnaire at 6 months. Secondary outcomes include the Rivermead Behavioural Memory Test-3, General Health Questionnaire-30, health related quality of life, cost-effectiveness analysis determined by the EQ-5D and a service use questionnaire, individual goal attainment, European Brain Injury Questionnaire (patient and relative versions), and the Everyday Memory Questionnaire-relative version. The primary analysis will be based on intention to treat. A mixed-model regression analysis of the Everyday Memory Questionnaire at 6 months will be used to estimate the effect of the group memory rehabilitation programme. Discussion The study will hopefully provide robust evidence regarding the clinical and cost-effectiveness of a group-based memory rehabilitation intervention for civilians and military personnel following TBI. We discuss our decision-making regarding choice of outcome measures and control group, and the unique challenges to recruiting people with memory problems to trials

Memory rehabilitation for people with multiple sclerosis

Background: This is an update of the Cochrane review ‘Memory rehabilitation for people with multiple sclerosis’ (first published in the Cochrane Library 14 March 2012, Issue 3). Impairments in cognitive function, particularly memory, are common in people with multiple sclerosis (MS) and can potentially affect their ability to complete functional activities. There is evidence from single-case or small group studies that memory rehabilitation can be beneficial for people with MS, but findings from randomised controlled trials (RCTs) and systematic reviews have been inconclusive. Objectives: To determine whether people with MS who received memory rehabilitation showed: 1. better outcomes in their memory functions compared to those given no treatment or receiving a placebo control; and 2. better functional abilities, in terms of activities of daily living, mood, and quality of life, than those who received no treatment or a placebo. Search methods: We searched the Trials Specialised Register of the Cochrane Multiple Sclerosis and Rare Diseases of the CNS Group (2 June 2015) and the following electronic databases: The NIHR Clinical Research Network Portfolio database (NIHR CRN) (from 2010 to June 2015), The Allied and Complementary Medicine Database (AMED) (2010 to June 2015), British Nursing Index (BNI) (2010 to June 2015), PsycINFO (2011 to June 2015), and CAB Abstracts (2010 to June 2015). Start dates for the electronic databases coincided with the last search for the previous review. We handsearched relevant journals and reference lists. Selection criteria: We selected RCTs or quasi-randomised trials ofmemory rehabilitation or cognitive rehabilitation for people with MS in which a memory rehabilitation treatment group was compared to a control group. Selection was conducted independently first and then confirmed through group discussion. We excluded studies that included participants whose memory deficits were the result of conditions other than MS unless we could identify a subgroup of participants with MS with separate results. Data collection and analysis: Three review authors were involved in this update in terms of study selection, quality assessment, and data extraction. We contacted investigators of primary studies for further information where required. We conducted data analysis and synthesis in accordance with the Cochrane Handbook for Systematic Reviews ofInterventions (Higgins 2011). We performed a ’best evidence’ synthesis based on the methodological quality of the primary studies included. Main results: We added seven studies during this update, bringing the total to 15 studies, involving 989 participants. The interventions involved various memory retraining techniques, such as computerised programmes and training on internal and external memory aids. Control groups varied in format from assessment-only groups, discussion and games, non-specific cognitive retraining, and attention or visuospatial training. The risk of bias of the included studies was generally low, but we found eight studies to have high risk of bias related to certain aspects of their methodology. We found significant effect of intervention on objective assessments of memory in both the immediate and long-term follow-ups: standardised mean difference (SMD) 0.23 (95% confidence interval (CI) 0.05 to 0.41) and SMD 0.26 (95% CI 0.03 to 0.49), respectively. We also found significant effect of intervention for quality of life in the immediate follow-up (SMD 0.23 (95% CI 0.05 to 0.41)). These findings showed that the intervention group performed significantly better than the control group. We also found a significant difference for activities of daily living (ADL) in the long-term follow-up (SMD -0.33 (95% CI -0.63 to -0.03)), showing that the control groups had significantly less difficulty completing ADLs than the intervention groups. We found no significant effects, either immediate or long-term, on subjective reports of memory problems (SMD 0.04 (95% CI -0.19 to 0.27) and SMD 0.04 (95% CI -0.19 to 0.27)); on mood (SMD 0.02 (95% CI -0.16 to 0.20) and SMD -0.01 (95% CI -0.21 to 0.20)); and on immediate follow-up for ADL (SMD -0.13 (95% CI -0.60 to 0.33)) and in the long term for quality of life (SMD 0.16 (95% CI -0.03 to 0.36)). We could not complete a sensitivity analysis of intention-to-treat in comparison with per-protocol analysis, due to insufficient information from the included papers. However, a sensitivity analysis of high- versus low-risk studies suggested that while quality of the trials did not affect most outcomes, differences were seen in the objective memory outcomes (both at immediate and long term) and quality of life (immediate) outcome, with studies with higher risk of bias inflating the overall effect size estimates for these outcomes, and the test of overall effect changing from being statistically significant to not significant when studies at high risk of bias were excluded. This suggests that lower-quality studies may have positively influenced the outcomes. Authors’ conclusions: There is some evidence to support the effectiveness of memory rehabilitation on memory function, as well as on quality of life. However, the evidence is limited and does not extend to subjective reports of memory functioning or mood. Furthermore, the objective measures used are not ecologically valid measures, and thus potentially limit generalisability of these findings into daily life. Further robust RCTs of high methodological quality and better quality of reporting, using ecologically valid outcome assessments, are still needed

Meta-heuristic algorithms for optimized network flow wavelet-based image coding

Optimal multipath selection to maximize the received multiple description coding (MDCs) in a lossy network model is proposed. Multiple description scalar quantization (MDSQ) has been applied to the wavelet coefficients of a color image to generate the MDCs which are combating transmission loss over lossy networks. In the networks, each received description raises the reconstruction quality of an MDC-coded signal (image, audio or video). In terms of maximizing the received descriptions, a greater number of optimal routings between source and destination must be obtained. The rainbow network flow (RNF) collaborated with effective meta-heuristic algorithms is a good approach to resolve it. Two meta-heuristic algorithms which are genetic algorithm (GA) and particle swarm optimization (PSO) have been utilized to solve the multi-objective optimization routing problem for finding optimal routings each of which is assigned as a distinct color by RNF to maximize the coded descriptions in a network model. By employing a local search based priority encoding method, each individual in GA and particle in PSO is represented as a potential solution. The proposed algorithms are compared with the multipath Dijkstra algorithm (MDA) for both finding optimal paths and providing reliable multimedia communication. The simulations run over various random network topologies and the results show that the PSO algorithm finds optimal routings effectively and maximizes the received MDCs with assistance of RNF, leading to reduce packet loss and increase throughput

Quantum Gravity, Field Theory and Signatures of Noncommutative Spacetime

A pedagogical introduction to some of the main ideas and results of field theories on quantized spacetimes is presented, with emphasis on what such field theories may teach us about the problem of quantizing gravity. We examine to what extent noncommutative gauge theories may be regarded as gauge theories of gravity. UV/IR mixing is explained in detail and we describe its relations to renormalization, to gravitational dynamics, and to deformed dispersion relations in models of quantum spacetime of interest in string theory and in doubly special relativity. We also discuss some potential experimental probes of spacetime noncommutativity.Comment: 26 pages, 4 figures; v2: comments and references added; v3: typos corrected, clarifying comments and references added; Based on Plenary Lecture delivered at the XXIX Encontro Nacional de Fisica de Particulas e Campos, Sao Lourenco, Brasil, September 22-26, 2008; Final version to be published in General Relativity and Gravitatio