Illustrative Discussion of MC-dropout Method in General Dataset: Uncertainty Estimation in Bitcoin.

The past few years have witnessed the resurgence of uncertainty estimation in deep neural networks (DNNs). Providing uncertainty besides the predictions is desirable to provide a degree of belief about the predicted output in neural networks (NNs). Recent researches have introduced probabilistic approaches which are computationally less expensive than Bayesian neural networks (BNNs). Out of the existing approaches, we focus on probabilistic approach based Bayesian approximations known as Monte-Carlo dropout (MC-dropout). In this paper, we aim to provide an overview of the misconception arisen about MC-dropout, wherein criticism occurs. We fulfill our opinion using a 2-D synthetic dataset to derive insights about the empirical study. On the other hand, previous researches have often applied MC-dropout on classification tasks using image dataset. While, we provide an illustrative discussion of MC-dropout using a general dataset derived from Bitcoin blockchain known as Elliptic data. Using Elliptic data, we highlight the performance of uncertainty estimation using different sets of features. We further discuss the effect of MC-dropout regarding the uncertainty metrics when dealing with imbalanced data. The overall model have provided adequate results in terms of uncertainty measurements yielded by MC-dropout

Investigation of Power Factor on Harmonic Effect due to Types of Voltage Source

This paper discussed about power factor on harmonic effect due to types of voltage source. Usually, the voltage source is sinusoidal. But in actual condition the load that has voltage sources through the elements where the output voltage of element as input to load is not pure sinusoidal, for example at Power of Common Coupling (PCC) between transformer and linear load and nonlinear load. The research has been done with Schhafner Power Quality Analyzer and was focused to power factor (p.f.), Total Harmonic Distortion (THD), and harmonic energy losses cost from measurement where load is Induction motor and Adjustable Speed Drive (ASD). As voltage source in this research are sine wave, square wave and combinations of 3rd, 5th and 7th harmonic order like harmonic 313, and harmonic 357

Zeros of Orthogonal Polynomials Generated by the Geronimus Perturbation of Measures

Proceedings of: 14th International Conference Computational Science and Its Applications (ICCSA 2014). Guimarães, Portugal, June 30 – July 3, 2014This paper deals with monic orthogonal polynomial sequences (MOPS in short) generated by a Geronimus canonical spectral transformation of a positive Borel measure μ, i.e., (x−c) −1dμ(x)+Nδ(x−c), for some free parameter N ∈ IR+ and shift c. We analyze the behavior of the corresponding MOPS. In particular, we obtain such a behavior when the mass N tends to infinity as well as we characterize the precise values of N such the smallest (respectively, the largest) zero of these MOPS is located outside the support of the original measure μ. When μ is semi-classical, we obtain the ladder operators and the second order linear differential equation satisfied by the Geronimus perturbed MOPS, and we also give an electrostatic interpretation of the zero distribution in terms of a logarithmic potential interaction under the action of an external field. We analyze such an equilibrium problem when the mass point of the perturbation c is located outside the support of μ

Effect of the Lacuna Distribution on Stress and Strain in Single Osteon

In order to understand bone behaviour and bone failure behaviour, this study aimed to investigate stress distribution and strain developed in a single osteon with a different number of lacunae when a compressive load was given. Finite element (FE) analysis of single osteon was developed, one osteon with no lacuna (Model A) and three osteon models with a different number of lacunae (10 lacunae = Model B, 8 lacunae = Model C, 6 lacunae = Model D). The single osteon is developed as a semi-circle due to symmetric structure, with the presence of Haversian canal at the centre in each model. Stress distribution in Model B, Model C and Model D were shown to yield the highest stress at the lacuna near the given load and Model A was shown to yield maximum stress near the Haversian canal. The maximum strain of Model B, Model C and Model D were measured at the ellipse lacuna near the load while the maximum strain of Model A was shown at lamella near Haversian canal. These investigated results for the stress distribution and strain in the osteon can be used in the study to determine the yield region in osteon in bone fracture study

STUDIES ON BACTERIAL POLLUTION IN LAKE MANZALA

Lake Manzala in Egypt have shown great changes in water properties including pH (7.4 to 8.4), total suspended solids (19 to 350 mg/l), total dissolved salts (1578 to 33480 mg/l), dissolved oxygen (2.25 to 8.45 mg/l), ammonia (0.00 to 44.8 mg/l) and nitrate (0.00 to 8.96 mg/l). In addition there has been quite high bacterial density in water and fish of the lake, including total viable bacterial counts and indicator organisms such as total coliforms, faecal coliforms and some other organisms such as Aeromonas spp., Vibrio spp. and Staphylococcus spp. However, the magnitude number of bacteria in water and fish was found to vary sometimes considerably and sometimes slightly depending on the site of sampling. Our results herein showed that LakeManzala is highly contaminated

Asymmetric dimethylation of ribosomal S6 kinase 2 regulates its cellular localisation and pro-survival function

Ribosomal S6 kinases (S6Ks) are critical regulators of cell growth, homeostasis, and survival, with dysregulation of these kinases found to be associated with various malignancies. While S6K1 has been extensively studied, S6K2 has been neglected despite its clear involvement in cancer progression. Protein arginine methylation is a widespread post-translational modification regulating many biological processes in mammalian cells. Here, we report that p54-S6K2 is asymmetrically dimethylated at Arg-475 and Arg-477, two residues conserved amongst mammalian S6K2s and several AT-hook-containing proteins. We demonstrate that this methylation event results from the association of S6K2 with the methyltransferases PRMT1, PRMT3, and PRMT6 in vitro and in vivo and leads to nuclear the localisation of S6K2 that is essential to the pro-survival effects of this kinase to starvation-induced cell death. Taken together, our findings highlight a novel post-translational modification regulating the function of p54-S6K2 that may be particularly relevant to cancer progression where general Arg-methylation is often elevated

The evaluation of the photocatalytic activity of magnetic and non-magnetic polymorphs of Fe2O3 in natural sunlight exposure: a comparison of photocatalytic activity

The non-magnetic and magnetic polymorphs of iron oxide (Fe2O3) namely: alpha-Fe2O3 (hematite) and gamma-Fe2O3 (maghemite) respectively, were synthesized by a facile surfactant aided hydrogel route. The synthesized polymorphs were characterized by diffuse reflectance, photoluminescence and raman spectroscopy for optical properties whereas the morphological, structural, chemical and electronic state evaluation were performed by FESEM, HRTEM, XRD, and XPS. The charge transport and the stability of the materials were examined electrochemically. The photocatalytic activity of the synthesized polymorphs was evaluated for the degradation of 2-chlorophenol and 2-nitrophenol in the exposure of the visible region and complete spectrum natural sunlight. Both the polymorphs exhibited a significantly high activity for the degradation of the phenolic substrate in the exposure of the complete spectrum of sunlight, however, the activity in the visible region of the sunlight was relatively lower. A substantial increase in the activity in the visible region was noticed when the polymorphs were exposed to complete spectrum sunlight prior to the photocatalytic experiments. The comparison of the exposed and unexposed samples revealed the induction of defects that served as traps for the excited electrons and increased activity of the polymorphs. (C) 2018 Elsevier B.V. All rights reserved

An Improved Method for Measuring Phthalates in Seawater With Blank Contamination Using GC-MS

Quantification of phthalates or phthalic acid esters (PAEs) might be problematic due to matrix overlap, auto-self absorbance and background scattering noise by the plastic lab materials although plastics have been reported in the release of PAEs. These materials (ambient air, reagents bottles, sampling devices, and various analytical instruments), are ubiquitous in the laboratory environment, thereby making it more difficult to reliably analyze of trace concentration of PAEs. Thus, in the current study, a straight forward and reliable protocol has been established for the analysis of PAEs including control of blank contamination, and the experimental conditions such as extraction time and temperature were optimized. The mass of PAEs in blank tests of selected materials ranged from 3±0.7 to 35±6 ng for liquid-liquid extraction (LLE) and from 5±1.8 to 63±15 ng for solid-phase extraction (SPE). For both extraction methods, higher blank values were measured for dibutyl phthalate (DBP) (35±6 ng, 12±3 ng), and DEHP (63±12 ng, 23±5 ng) in LLE and SPE, respectively. Average recoveries of PAEs in LLE were 90-97% and obtained with successive aliquots of 2 mL, 1 mL, and 1 mL dichloromethane (DCM). For SPE, recoveries up to 86-90% were achieved with successive aliquots of 5, 3, and 2 mL DCM at a sample flow rate of 5 mL min -1 . Under the optimized conditions, the method quantification limits (MQL) for PAEs was 10-20 ng L -1 for LLE and 10-35 ng L -1 for SPE. Moreover, the dissolved concentrations of PAEs from LDPE measured by the LLE method ranged < 1.5 to 5.83 ng cm -2, and those measured by SPE ranged from 1.0to256ngL -1 , in seawater samples of Sharm Obhur. The method has lower MQL values for LLE and SPE than average reported values of 10-100 ng L -1 and 30-100 ng L -1 , respectively

Tracking development assistance for health and for COVID-19 : a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990-2050

Background The rapid spread of COVID-19 renewed the focus on how health systems across the globe are financed, especially during public health emergencies. Development assistance is an important source of health financing in many low-income countries, yet little is known about how much of this funding was disbursed for COVID-19. We aimed to put development assistance for health for COVID-19 in the context of broader trends in global health financing, and to estimate total health spending from 1995 to 2050 and development assistance for COVID-19 in 2020. Methods We estimated domestic health spending and development assistance for health to generate total health-sector spending estimates for 204 countries and territories. We leveraged data from the WHO Global Health Expenditure Database to produce estimates of domestic health spending. To generate estimates for development assistance for health, we relied on project-level disbursement data from the major international development agencies' online databases and annual financial statements and reports for information on income sources. To adjust our estimates for 2020 to include disbursements related to COVID-19, we extracted project data on commitments and disbursements from a broader set of databases (because not all of the data sources used to estimate the historical series extend to 2020), including the UN Office of Humanitarian Assistance Financial Tracking Service and the International Aid Transparency Initiative. We reported all the historic and future spending estimates in inflation-adjusted 2020 US$, 2020 US$ per capita, purchasing-power parity-adjusted US$per capita, and as a proportion of gross domestic product. We used various models to generate future health spending to 2050. Findings In 2019, health spending globally reached$8. 8 trillion (95% uncertainty interval [UI] 8.7-8.8) or $1132 (1119-1143) per person. Spending on health varied within and across income groups and geographical regions. Of this total,$40.4 billion (0.5%, 95% UI 0.5-0.5) was development assistance for health provided to low-income and middle-income countries, which made up 24.6% (UI 24.0-25.1) of total spending in low-income countries. We estimate that $54.8 billion in development assistance for health was disbursed in 2020. Of this,$13.7 billion was targeted toward the COVID-19 health response. $12.3 billion was newly committed and$1.4 billion was repurposed from existing health projects. $3.1 billion (22.4$2.4 billion (17.9%) was for supply chain and logistics. Only $714.4 million (7.7$1519 (1448-1591) per person in 2050, although spending across countries is expected to remain varied. Interpretation Global health spending is expected to continue to grow, but remain unequally distributed between countries. We estimate that development organisations substantially increased the amount of development assistance for health provided in 2020. Continued efforts are needed to raise sufficient resources to mitigate the pandemic for the most vulnerable, and to help curtail the pandemic for all. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362