480 research outputs found
Gold Nanorods in Photodynamic Therapy, as Hyperthermia Agents, and in Near-Infrared Optical Imaging
Effect of tip mass on modal flexural sensitivity of rectangular AFM cantilevers to surface stiffness variations
Extrinsic CPT Violation in Neutrino Oscillations in Matter
We investigate matter-induced (or extrinsic) CPT violation effects in
neutrino oscillations in matter. Especially, we present approximate analytical
formulas for the CPT-violating probability differences for three flavor
neutrino oscillations in matter with an arbitrary matter density profile. Note
that we assume that the CPT invariance theorem holds, which means that the CPT
violation effects arise entirely because of the presence of matter. As special
cases of matter density profiles, we consider constant and step-function matter
density profiles, which are relevant for neutrino oscillation physics in
accelerator and reactor long baseline experiments as well as neutrino
factories. Finally, the implications of extrinsic CPT violation on neutrino
oscillations in matter for several past, present, and future long baseline
experiments are estimated.Comment: 47 pages, 7 figures, RevTeX4. Final version to be published in Phys.
Rev.
Lorentz and CPT Violation in Neutrinos
A general formalism is presented for violations of Lorentz and CPT symmetry
in the neutrino sector. The effective hamiltonian for neutrino propagation in
the presence of Lorentz and CPT violation is derived, and its properties are
studied. Possible definitive signals in existing and future
neutrino-oscillation experiments are discussed. Among the predictions are
direction-dependent effects, including neutrino-antineutrino mixing, sidereal
and annual variations, and compass asymmetries. Other consequences of Lorentz
and CPT violation involve unconventional energy dependences in oscillation
lengths and mixing angles. A variety of simple models both with and without
neutrino masses are developed to illustrate key physical effects. The
attainable sensitivities to coefficients for Lorentz violation in the
Standard-Model Extension are estimated for various types of experiments. Many
experiments have potential sensitivity to Planck-suppressed effects, comparable
to the best tests in other sectors. The lack of existing experimental
constraints, the wide range of available coefficient space, and the variety of
novel effects imply that some or perhaps even all of the existing data on
neutrino oscillations might be due to Lorentz and CPT violation.Comment: 25 pages REVTe
Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV
A search for a Higgs boson decaying into two photons is described. The
analysis is performed using a dataset recorded by the CMS experiment at the LHC
from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an
integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross
section of the standard model Higgs boson decaying to two photons. The expected
exclusion limit at 95% confidence level is between 1.4 and 2.4 times the
standard model cross section in the mass range between 110 and 150 GeV. The
analysis of the data excludes, at 95% confidence level, the standard model
Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The
largest excess of events above the expected standard model background is
observed for a Higgs boson mass hypothesis of 124 GeV with a local significance
of 3.1 sigma. The global significance of observing an excess with a local
significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is
estimated to be 1.8 sigma. More data are required to ascertain the origin of
this excess.Comment: Submitted to Physics Letters
Measurement of isolated photon production in pp and PbPb collisions at sqrt(sNN) = 2.76 TeV
Isolated photon production is measured in proton-proton and lead-lead
collisions at nucleon-nucleon centre-of-mass energies of 2.76 TeV in the
pseudorapidity range |eta|<1.44 and transverse energies ET between 20 and 80
GeV with the CMS detector at the LHC. The measured ET spectra are found to be
in good agreement with next-to-leading-order perturbative QCD predictions. The
ratio of PbPb to pp isolated photon ET-differential yields, scaled by the
number of incoherent nucleon-nucleon collisions, is consistent with unity for
all PbPb reaction centralities.Comment: Submitted to Physics Letters
Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue pathology. Cell membrane bound angiotensin-converting enzyme 2 (ACE2) and associated proteases, transmembrane protease serine 2 (TMPRSS2) and Cathepsin L (CTSL), were previously identified as mediators of SARS-CoV2 cellular entry. Here, we assess the cell type-specific RNA expression of ACE2, TMPRSS2, and CTSL through an integrated analysis of 107 single-cell and single-nucleus RNA-Seq studies, including 22 lung and airways datasets (16 unpublished), and 85 datasets from other diverse organs. Joint expression of ACE2 and the accessory proteases identifies specific subsets of respiratory epithelial cells as putative targets of viral infection in the nasal passages, airways, and alveoli. Cells that co-express ACE2 and proteases are also identified in cells from other organs, some of which have been associated with COVID-19 transmission or pathology, including gut enterocytes, corneal epithelial cells, cardiomyocytes, heart pericytes, olfactory sustentacular cells, and renal epithelial cells. Performing the first meta-analyses of scRNA-seq studies, we analyzed 1,176,683 cells from 282 nasal, airway, and lung parenchyma samples from 164 donors spanning fetal, childhood, adult, and elderly age groups, associate increased levels of ACE2, TMPRSS2, and CTSL in specific cell types with increasing age, male gender, and smoking, all of which are epidemiologically linked to COVID-19 susceptibility and outcomes. Notably, there was a particularly low expression of ACE2 in the few young pediatric samples in the analysis. Further analysis reveals a gene expression program shared by ACE2(+)TMPRSS2(+) cells in nasal, lung and gut tissues, including genes that may mediate viral entry, subtend key immune functions, and mediate epithelial-macrophage cross-talk. Amongst these are IL6, its receptor and co-receptor, IL1R, TNF response pathways, and complement genes. Cell type specificity in the lung and airways and smoking effects were conserved in mice. Our analyses suggest that differences in the cell type-specific expression of mediators of SARS-CoV-2 viral entry may be responsible for aspects of COVID-19 epidemiology and clinical course, and point to putative molecular pathways involved in disease susceptibility and pathogenesis
Dynamic analysis of a simply supported beam resting on a nonlinear elastic foundation under compressive axial load using nonlinear normal modes techniques under three-to-one internal resonance condition
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