Estudio de la cinetica de la oxidación de la harmina por peroxidisulfato potásico

Se ha estudiado la cinética de la reacción de oxidación del alcaloide indólico harrnina por peroxodisulfato potásico en disoluciones acuosas alcalinas. La reacción sigue la ecuación de velocidad: v= k3 / Harmina / / S2O8 = / /OH- / La constante K3 es independiente de la fuerza iónica y su valor a 25oC es (4.8 ± 0.2) 10-2 M-2seg-1.A study has been made on the kinetics of the harrnine oxidation by potassium peroxodisulfate in aqueous alkaline solutions. The reaction follows the rate law: v= k3 / Harmine / / S2O8 = / /OH- / The rate constant k3 is independent on ionic strength and it is equal to (4.8 ± 0.2) 10-2M-2 seg-1 at 25oC

Deutsch-senegalesische Transferbeziehungen: Möglichkeiten einer interkulturellen Kommunikation anhand der deutschen Übersetzung von Mariama Bâs 'Une si longue lettre (Ein so langer Brief)'

Der Beitrag fokussiert auf die interkulturelle Kommunikation aus Sicht des deutsch-senegalesischen Kulturtransfers anhand von Literatur und Übersetzung. In dieser Hinsicht wird die Bedeutung der Übersetzer senegalesischer Literatur sowie deren Rezeption im deutschsprachigen Kontext herausgestellt. Der Dichterpräsident Léopold Sédar Senghor spielt dabei eine besondere Rolle sowohl hinsichtlich seiner Beschäftigung mit der deutschen Sprache, Kultur und Landeskunde als auch im Hinblick auf vorliegende deutsche Übersetzungen seines literarischen Schaffens. Hiervon ausgehend und gerade im Hinblick auf theoretische Ansätze zu interkulturellen Fragestellungen im Zusammenhang mit Übersetzung wird am Beispiel der deutschen Übersetzung von Mariama Bâs Roman 'Une si longue lettre' unter dem Titel 'Ein so langer Brief: ein afrikanisches Frauenschicksal' die Vermittlung kultureller Inhalte (im Hinblick auf Ort, Geschichte, Gesellschaft, Religion, Interaktion etc.) im deutsch-senegalesischen Kontext betrachtet.This contribution deals with intercultural communication in the frame of German-Senegalese cultural transfer through literature and translation. In this sense, I point out the importance of the translators of Senegalese literature as well as its reception in the German speaking area. The poet president Léopold Sédar Senghor played an important role in this context. He was much interested in German language, culture and civilization, and his literary works were translated into German as well. sing my analysis on theoretical approaches related to intercultural issues linked to translation, I examine the transmission of cultural information (in relation with place, history, society, religion, interaction etc.) in the translation of Mariama Bâ´s novel 'Une si longue lettre (Ein so langer Brief: ein afrikanisches Frauenschicksal) in the German-Senegalese context

Dengue virus genomic variation associated with mosquito adaptation defines the pattern of viral non-coding RNAs and fitness in human cells

The Flavivirus genus includes a large number of medically relevant pathogens that cycle between humans and arthropods. This host alternation imposes a selective pressure on the viral population. Here, we found that dengue virus, the most important viral human pathogen transmitted by insects, evolved a mechanism to differentially regulate the production of viral non-coding RNAs in mosquitos and humans, with a significant impact on viral fitness in each host. Flavivirus infections accumulate non-coding RNAs derived from the viral 3'UTRs (known as sfRNAs), relevant in viral pathogenesis and immune evasion. We found that dengue virus host adaptation leads to the accumulation of different species of sfRNAs in vertebrate and invertebrate cells. This process does not depend on differences in the host machinery; but it was found to be dependent on the selection of specific mutations in the viral 3'UTR. Dissecting the viral population and studying phenotypes of cloned variants, the molecular determinants for the switch in the sfRNA pattern during host change were mapped to a single RNA structure. Point mutations selected in mosquito cells were sufficient to change the pattern of sfRNAs, induce higher type I interferon responses and reduce viral fitness in human cells, explaining the rapid clearance of certain viral variants after host change. In addition, using epidemic and pre-epidemic Zika viruses, similar patterns of sfRNAs were observed in mosquito and human infected cells, but they were different from those observed during dengue virus infections, indicating that distinct selective pressures act on the 3'UTR of these closely related viruses. In summary, we present a novel mechanism by which dengue virus evolved an RNA structure that is under strong selective pressure in the two hosts, as regulator of non-coding RNA accumulation and viral fitness. This work provides new ideas about the impact of host adaptation on the variability and evolution of flavivirus 3'UTRs with possible implications in virulence and viral transmission.Fil: Filomatori, Claudia Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Carballeda, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Villordo, Sergio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Aguirre, Sebastian. Cedars Sinai Medical Center; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pallarés, Horacio Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Maestre, Ana M.. Cedars Sinai Medical Center; Estados UnidosFil: Sánchez Vargas, Irma. State University of Colorado - Fort Collins; Estados UnidosFil: Blair, Carol D.. State University of Colorado - Fort Collins; Estados UnidosFil: Fabri, Cintia. Instituto Nacional de Enfermedades Virales Humanas "Dr. Julio I. Maiztegui"; ArgentinaFil: Morales, Maria A.. Instituto Nacional de Enfermedades Virales Humanas "Dr. Julio I. Maiztegui"; ArgentinaFil: Fernandez Sesma, Ana. Cedars Sinai Medical Center; Estados UnidosFil: Gamarnik, Andrea Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentin

OTOVIRT: Un flujo de trabajo para el entrenamiento por simulación y el ensayo preoperatorio en cirugía virtual otológica

El desarrollo de intervenciones de cirugía otológica presenta el reto de trabajar con estructuras de muy compleja anatomía y gran variabilidad inter e intra-sujeto. El objetivo de este estudio es introducir un nuevo flujo de trabajo para la simulación virtual de cirugías del oído y la obtención sistemática de variables anatómicas y datos clínicos de los pacientes. El sistema propuesto está basado en el procesado de imágenes, el análisis de elementos finitos de los modelos y la simulación virtual; y ofrece un entorno en el que realizar el análisis pre y post-operatorio. Tras un registro inicial de imágenes de resonancia magnética (RM) y tomografía computerizada (TC), se segmentan una serie de estructuras de interés como el hueso temporal y la cóclea, entre otras, para generar los modelos tridimensionales de la anatomía del paciente. Se ha realizado para ello una armonización de herramientas basadas en software abierto que simplifican y optimizan la capacidad de apoyo al entrenamiento por parte del personal clínico. OTOVIRT ha sido validado en un entorno clínico con imágenes de seis pacientes candidatos a cirugía de implante coclear.Este trabajo ha sido financiado por el proyecto OTOVIRT (PIN-0097-2020): “Cirugía Virtual para el entrenamiento por simulación y el ensayo preoperatorio en cirugía otológica y cirugía endoscópica endonasal”

Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE

Search for anomalous t t-bar production in the highly-boosted all-hadronic final state

A search is presented for a massive particle, generically referred to as a Z', decaying into a t t-bar pair. The search focuses on Z' resonances that are sufficiently massive to produce highly Lorentz-boosted top quarks, which yield collimated decay products that are partially or fully merged into single jets. The analysis uses new methods to analyze jet substructure, providing suppression of the non-top multijet backgrounds. The analysis is based on a data sample of proton-proton collisions at a center-of-mass energy of 7 TeV, corresponding to an integrated luminosity of 5 inverse femtobarns. Upper limits in the range of 1 pb are set on the product of the production cross section and branching fraction for a topcolor Z' modeled for several widths, as well as for a Randall--Sundrum Kaluza--Klein gluon. In addition, the results constrain any enhancement in t t-bar production beyond expectations of the standard model for t t-bar invariant masses larger than 1 TeV.Comment: Submitted to the Journal of High Energy Physics; this version includes a minor typo correction that will be submitted as an erratu

Combined search for the quarks of a sequential fourth generation

Results are presented from a search for a fourth generation of quarks produced singly or in pairs in a data set corresponding to an integrated luminosity of 5 inverse femtobarns recorded by the CMS experiment at the LHC in 2011. A novel strategy has been developed for a combined search for quarks of the up and down type in decay channels with at least one isolated muon or electron. Limits on the mass of the fourth-generation quarks and the relevant Cabibbo-Kobayashi-Maskawa matrix elements are derived in the context of a simple extension of the standard model with a sequential fourth generation of fermions. The existence of mass-degenerate fourth-generation quarks with masses below 685 GeV is excluded at 95% confidence level for minimal off-diagonal mixing between the third- and the fourth-generation quarks. With a mass difference of 25 GeV between the quark masses, the obtained limit on the masses of the fourth-generation quarks shifts by about +/- 20 GeV. These results significantly reduce the allowed parameter space for a fourth generation of fermions.Comment: Replaced with published version. Added journal reference and DO

Measurement of the t t-bar production cross section in the dilepton channel in pp collisions at sqrt(s) = 7 TeV

The t t-bar production cross section (sigma[t t-bar]) is measured in proton-proton collisions at sqrt(s) = 7 TeV in data collected by the CMS experiment, corresponding to an integrated luminosity of 2.3 inverse femtobarns. The measurement is performed in events with two leptons (electrons or muons) in the final state, at least two jets identified as jets originating from b quarks, and the presence of an imbalance in transverse momentum. The measured value of sigma[t t-bar] for a top-quark mass of 172.5 GeV is 161.9 +/- 2.5 (stat.) +5.1/-5.0 (syst.) +/- 3.6(lumi.) pb, consistent with the prediction of the standard model.Comment: Replaced with published version. Included journal reference and DO