Radical Love Unlimited: A Biomythography

This is an experimental text of creative nonfiction. Radical love is defined, and its trivariate dimensions are illustrated—(re)memory, ritual, and (re)imagination— through the lived and imagined experiences of the author. She engages in the genre of biomythography through the speculative mediums of letter writing, memoir, and journaling. She attempts to expand the category of Blackgirlhood and Blackgirls’ subsequent sacred pursuits of healing. This work may be used as an intervention in a wide variety of capacities, but it stands, first and foremost, as a mirror for Blackgirls to bear witness to themselves being centered, as well as another opportunity for them to also see other Blackgirls who love them. This writing is constructed for their utility

Altimetry for the future: Building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the ‘‘Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion

Altimetry for the future: building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the “Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion

The Space Love Maps: A Blackgirl Legend in Three Plots

This is a love story from one Blackgirl (Boylorn, 2016) from St. Louis to Blackgirls in Philadelphia. It radically traces love across plots of race, gender, time, space, and affect. This text will provide non-conventional maps for how Blackgirls, young and old, have been memory keepers, cultural workers, love pillars, freedom mappers, and actors since before the inception of American slavery (Brown, 2013; Hartman, 2019; Hooks, 1993; Nash, 2013; Walker, 2004). Specifically, it will argue that we have problematized the settler-colonial project of mapping (McKittrick, 2006) and moved away from viewing space as an entrenchment of empire. Further, we have spatially conceived of natural and built environments as a strategy towards fostering sacred safety and deep social connections (Okafor, 2018). Blackgirls\u27 creative, conceptual, and material placemaking (Hunter et al, 2016) illustrates liminality that allows us to (re)member, ritualize, and (re)imagine. While we are not typically viewed as curators, we have a rich history of magically (re)claiming some of the most historically violent spaces, including farmland, homes, and even our very own kitchens, and converting them into sites within which we locate healing. Blackgirls practice love evangelism (This is Signified, 2012) through ecowomanism, sacred archiving, and spatial alchemy. The major argument for this dissertation is that radical love is a regular praxis through which Blackgirls create spaces that center themselves and their community. My dissertation seeks to serve as a remedy for recognition, a written corrective, and a meaningful, radical addendum

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control

Advanced human cancers are invariably aneuploid, in that they harbour cells with abnormal chromosome numbers(1,2). However, the molecular defects underlying this trait, and whether they are a cause or a consequence of the malignant phenotype, are not clear. Mutations that disable the retinoblastoma (Rb) pathway are also common in human cancers(1). These mutations promote tumour development by deregulating the E2F family of transcription factors leading to uncontrolled cell cycle progression(3). We show that the mitotic checkpoint protein Mad2 is a direct E2F target and, as a consequence, is aberrantly expressed in cells with Rb pathway defects. Concordantly, Mad2 is overexpressed in several tumour types, where it correlates with high E2F activity and poor patient prognosis. Generation of Rb pathway lesions in normal and transformed cells produces aberrant Mad2 expression and mitotic defects leading to aneuploidy, such that elevated Mad2 contributes directly to these defects. These results demonstrate how chromosome instability can arise as a by-product of defects in cell cycle control that compromise the accuracy of mitosis, and suggest a new model to explain the frequent appearance of aneuploidy in human cancer