A simulation based supply partner selection decision support tool for service provision in Dell.

Partner selection is an important aspect of all outsourcing processes. Traditional partner selection, typically involves steps to determine the criteria for outsourcing, followed by a qualification of potential suppliers and concluding with a final selection of partner(s). Reverse auctions (RAs) have widely been used for partner selection in recent times. However, RAs, although proven successful in initial price reduction strategies for product and service provision, can suffer from reduced effectiveness as the number of executions increases. This paper illustrates Dell’s experience of such diminishing returns for its outsourced after sales product repair service and presents the development, of a new partner selection methodology which incorporates a new process improvement stage to be executed in combination with the final selection phase. This new methodology is underpinned by the development of a computer based simulation supply partner selection decision support tool for service provision. The paper highlights the significant additional cost saving benefits achievable and improvement in service through the use of advanced simulation based decision supports

Can we learn from aviation : safety enhancements in transport by achieving human orientated resilient shipping environment

It is well reported in the literature that more than 80% of shipping accidents are attributed to Human/organisational Error. Maritime community has realised that despite all the increased safety standards and technological developments, accidents are still occurring and the systems are not resilient to errors at various levels. The FP7 SEAHORSE project focuses on safety in marine transport by addressing human and organisational factors through transfer of well proven practices and methodologies from air transport to marine transport in an effective, collaborative and innovative manner. This will be primarily achieved by introducing the principles of resilience engineering in an integrated framework which will result in multi-level resilience that linking individuals, team, multi-party teams and organisations in ship operation that ultimately enhancing shipping safety. This paper presents similarities and gaps between two transport sectors while establishing the principles of transfer of skills, technology from aviation to maritime, which includes but not limited to rules, standard operating procedures, safety culture, just culture and mandatory safety reporting methodologies. The paper further present the feasible areas for transfer, experience gained during the transfer of technology/skills from air to marine while outlining the resilience framework adapted to maritime transport

SafePASS - Transforming marine accident response

The evacuation of a ship is the last line of defence against human loses in case of emergencies in extreme fire and flooding casualties. Since the establishment of the International Maritime Organisation (IMO), Maritime Safety is its cornerstone with the Safety of Life at Sea Convention (SOLAS) spearheading its relentless efforts to reduce risks to human life at sea. However, the times are changing. On one hand, we have the new opportunities created with the vast technological advances of today. On the other, we are facing new challenges, with the ever-increasing size of the passenger ships and the societal pressure for a continuous improvement of maritime safety. In this respect, the EU-funded Horizon 2020 Research and Innovation Programme project SafePASS, presented herein, aims to radically redefine the evacuation processes, the involved systems and equipment and challenge the international regulations for large passenger ships, in all environments, hazards and weather conditions, independently of the demographic factors. The project consortium, which brings together 15 European partners from industry, academia and classification societies. The SafePASS vision and plan for a safer, faster and smarter ship evacuation involves: i) a holistic and seamless approach to evacuation, addressing all states from alarm to rescue, including the design of the next generation of life-saving appliances and; ii) the integration of ‘smart’ technology and Augmented Reality (AR) applications to provide individual guidance to passengers, regardless of their demographic characteristics or hazard (flooding or fire), towards the optimal route of escape

Human and Organisational Factors as a Risk Management Strategy in an Aviation Maintenance Company

Aviation has for many years been one of the leading industries in addressing human and organisational factors (HOF) within its different sectors – flight operations, air traffic control, ground operations, maintenance, etc. In particular aviation has led the way in mandating a range of measures that address HOF issues – reporting systems, shift-handover procedures, etc (e.g. UK CAA, 2003). A key element of the regulation has been the mandating of initial and continuation training in HOF for virtually all personnel working in aviation maintenance. By contrast the development of practice and regulation of risk and safety management in aviation has lagged behind process (Gambetti et al., 2012) and power (Leva et al., 2012). industries ICAO published its requirements for Safety Management in 2009 (ICAO, 2009) and these are still being translated into regulations by local aviation authorities. For example the EASA regulations require implementation of Safety Management Systems (SMS) in airlines by 2013. As a consequence of this historical sequence – the development of HOF regulations prior to safety management regulations – organisations are facing the challenge of integrating two programmes with related objectives developed to meet the requirements of different regulations. HOF training in aviation maintenance, in the European context, normally comprises of a two day initial training classroom based workshop supplemented by a one-day continuation training workshop every 2 years. The continuation training typically comprises a refresher of key HOF concepts and information about company specific challenges. E-learning and blended learning are sometimes used for continuation training, but their acceptance by the local aviation authorities is variable. This paper reports an initiative to integrate HOF continuation training within a risk management context in an aviation maintenance company

Release of miR-29 Target Laminin C2 Improves Skin Repair

miRNAs are small noncoding RNAs that regulate mRNA targets in a cell-specific manner. miR-29 is expressed in murine and human skin, where it may regulate functions in skin repair. Cutaneous wound healing model in miR-29a/b1 gene knockout mice was used to identify miR-29 targets in the wound matrix, where angiogenesis and maturation of provisional granulation tissue was enhanced in response to genetic deletion of miR-29. Consistently, antisense-mediated inhibition of miR-29 promoted angiogenesis in vitro by autocrine and paracrine mechanisms. These processes are likely mediated by miR-29 target mRNAs released upon removal of miR-29 to improve cell–matrix adhesion. One of these, laminin (Lam)-c2 (also known as laminin γ2), was strongly up-regulated during skin repair in the wound matrix of knockout mice. Unexpectedly, Lamc2 was deposited in the basal membrane of endothelial cells in blood vessels forming in the granulation tissue of knockout mice. New blood vessels showed punctate interactions between Lamc2 and integrin α6 (Itga6) along the length of the proto-vessels, suggesting that greater levels of Lamc2 may contribute to the adhesion of endothelial cells, thus assisting angiogenesis within the wound. These findings may be of translational relevance, as LAMC2 was deposited at the leading edge in human wounds, where it formed a basal membrane for endothelial cells and assisted neovascularization. These results suggest a link between LAMC2, improved angiogenesis, and re-epithelialization

Scythes, sickles and other blades: Defining the diversity of pectoral fin morphotypes in Pachycormiformes

The traditional terminology of 'scythe' or 'sickle' shaped is observed to be flawed as an effective descriptor for pectoral fin shape in pachycormids. The diversity of pachycormid pectoral fin shapes is assessed across the 14 recognised genera that preserve complete pectoral fins, and improved terms are defined to more effectively describe their form, supported by anatomical observation and aspect ratio analysis of individual fins, and corroborated by landmark analysis. Three clear and distinct pectoral fin structural morphotypes emerge (falceform, gladiform, falcataform), reflecting a diversity of pachycormid lifestyles throughout the Mesozoic, from agile pursuit predator to slow-cruising suspension feeder

The impact of negative selection on thymocyte migration in the medulla

Developing thymocytes are screened for self-reactivity before they exit the thymus, but how thymocytes scan the medulla for self antigens is unclear. Using two-photon microscopy, we observed that medullary thymocytes migrated rapidly and made frequent, transient contacts with dendritic cells. In the presence of a negative selecting ligand, thymocytes slowed, became confined to areas of approximately 30 mum in diameter and had increased contact with dendritic cells surrounding confinement zones. One third of polyclonal medullary thymocytes also showed confined, slower migration and may correspond to autoreactive thymocytes. Our data suggest that many autoreactive thymocytes do not undergo immediate arrest and death after encountering a negative selecting ligand but instead adopt an altered migration program while remaining in the medullary microenvironment

Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity.

Epigenetic and transcriptional variability contribute to the vast diversity of cellular and organismal phenotypes and are key in human health and disease. In this review, we describe different types, sources, and determinants of epigenetic and transcriptional variability, enabling cells and organisms to adapt and evolve to a changing environment. We highlight the latest research and hypotheses on how chromatin structure and the epigenome influence gene expression variability. Further, we provide an overview of challenges in the analysis of biological variability. An improved understanding of the molecular mechanisms underlying epigenetic and transcriptional variability, at both the intra- and inter-individual level, provides great opportunity for disease prevention, better therapeutic approaches, and personalized medicine

The mucosal immune system and its regulation by autophagy

The gastrointestinal tract presents a unique challenge to the mucosal immune system, which has to constantly monitor the vast surface for the presence of pathogens, while at the same time maintaining tolerance to beneficial or innocuous antigens. In the intestinal mucosa, specialized innate and adaptive immune components participate in directing appropriate immune responses toward these diverse challenges. Recent studies provide compelling evidence that the process of autophagy influences several aspects of mucosal immune responses. Initially described as a “self-eating” survival pathway that enables nutrient recycling during starvation, autophagy has now been connected to multiple cellular responses, including several aspects of immunity. Initial links between autophagy and host immunity came from the observations that autophagy can target intracellular bacteria for degradation. However, subsequent studies indicated that autophagy plays a much broader role in immune responses, as it can impact antigen processing, thymic selection, lymphocyte homeostasis, and the regulation of immunoglobulin and cytokine secretion. In this review, we provide a comprehensive overview of mucosal immune cells and discuss how autophagy influences many aspects of their physiology and function. We focus on cell type-specific roles of autophagy in the gut, with a particular emphasis on the effects of autophagy on the intestinal T cell compartment. We also provide a perspective on how manipulation of autophagy may potentially be used to treat mucosal inflammatory disorders