238 research outputs found
Is There Really a de Sitter/CFT Duality
In this paper a de Sitter Space version of Black Hole Complementarity is
formulated which states that an observer in de Sitter Space describes the
surrounding space as a sealed finite temperature cavity bounded by a horizon
which allows no loss of information. We then discuss the implications of this
for the existence of boundary correlators in the hypothesized dS/cft
correspondence. We find that dS complementarity precludes the existence of the
appropriate limits. We find that the limits exist only in approximations in
which the entropy of the de Sitter Space is infinite. The reason that the
correlators exist in quantum field theory in the de Sitter Space background is
traced to the fact that horizon entropy is infinite in QFT.Comment: 12 Figures, STIAS Workshop on Quantum Gravit
Do OB runaway stars have pulsar companions?
We have conducted a VLA search for radio pulsars at the positions of 44 nearby OB runaway stars. The observations involved both searching images for point sources of continuum emission and a time series analysis. Our mean flux sensitivity at 1.4 GHz to pulsars slower than 50 ms was 0.2 mJy. No new pulsars were found in the survey. The size of the survey, combined with the high sensitivity of the observations, sets a significant constraint on the probability, fp, of a runaway OB star having an observable pulsar companion. We find fpâ¤6.5% with 95% confidence, if the general pulsar luminosity function is applicable to OB star pulsar companions. If a pulsar beaming fraction of 1/3 is assumed, then we estimate that fewer than 20% of runaway OB stars have neutron star companions, unless pulsed radio emission is frequently obscured by the OB stellar wind. Our result is consistent with the dynamical (or cluster) ejection model for the formation of OB runaways. The supernova ejection model is not ruled out, but is constrained by these observations to allow only a small binary survival fraction, which may be accommodated if neutron stars acquire significant natal kicks. According to Leonard, Hills and Dewey (1994), a 20% survival fraction corresponds to a 3-d kick velocity of 420 km s-1. This limit supports recent revisions of the pulsar velocity distribution
Peripheral monitoring of direct and indirect alloantigen presentation pathways in clinical heart transplant recipients
It has been reported that the response to alloantigens presented by the direct and indirect pathway may be of differential relevance after human kidney transplantation. Accordingly, we monitored these routes in peripheral blood mononuclear cells (PBMC) of heart transplant patients from before transplantation and up to 2 years thereafter in an attempt to find a correlation with the clinical status of the patients. Both before and after transplantation, comparable proportions of PBMC samples reacted in mixed lymphocyte culture to nondepleted donor spleen cells (direct route), but never to donor cells depleted for antigen-presenting cells (indirect route). In contrast, the latter route could easily be activated by a nominal antigen and persisted after transplantation, although the proportion of PBMC samples responding was significantly suppressed, irrespective of the occurrence of rejection. Consequently, complete removal of antigen-presenting cells from the stimulator population in a mixed lymphocyte culture with PBMC as responder is not a suitable tool for measuring indirect presentation of alloantigens, and therefore not relevant for monitoring the immunological status of heart transplant recipients
Low-energy p-d Scattering: High Precision Data, Comparisons with Theory, and Phase-Shift Analyses
Angular distributions of sigma(theta), A_y, iT_11, T_20, T_21, and T_22 have
been measured for d-p scattering at E_c.m.=667 keV. This set of high-precision
data is compared to variational calculations with the nucleon-nucleon potential
alone and also to calculations including a three-nucleon (3N) potential.
Agreement with cross-section and tensor analyzing power data is excellent when
a 3N potential is used. However, a comparison between the vector analyzing
powers reveals differences of approximately 40% in the maxima of the angular
distributions which is larger than reported at higher energies for both p-d and
n-d scattering. Single-energy phase-shift analyses were performed on this data
set and a similar data set at E_c.m.=431.3 keV. The role of the different
phase-shift parameters in fitting these data is discussed.Comment: 18 pages, 6 figure
Observational Consequences of a Landscape
In this paper we consider the implications of the "landscape" paradigm for
the large scale properties of the universe. The most direct implication of a
rich landscape is that our local universe was born in a tunnelling event from a
neighboring vacuum. This would imply that we live in an open FRW universe with
negative spatial curvature. We argue that the "overshoot" problem, which in
other settings would make it difficult to achieve slow roll inflation, actually
favors such a cosmology.
We consider anthropic bounds on the value of the curvature and on the
parameters of inflation. When supplemented by statistical arguments these
bounds suggest that the number of inflationary efolds is not very much larger
than the observed lower bound. Although not statistically favored, the
likelihood that the number of efolds is close to the bound set by observations
is not negligible. The possible signatures of such a low number of efolds are
briefly described.Comment: 21 pages, 4 figures v2: references adde
Sterols sense swelling in lipid bilayers
In the mimetic membrane system of phosphatidylcholine bilayers, thickening
(pre-critical behavior, anomalous swelling) of the bilayers is observed, in the
vicinity of the main transition, which is non-linear with temperature. The
sterols cholesterol and androsten are used as sensors in a time-resolved
simultaneous small- and wide angle x-ray diffraction study to investigate the
cause of the thickening. We observe precritical behavior in the pure lipid
system, as well as with sterol concentrations less than 15%. To describe the
precritical behavior we introduce a theory of precritical phenomena.The good
temperature resolution of the data shows that a theory of the influence of
fluctuations needs modification. The main cause of the critical behavior
appears to be a changing hydration of the bilayer.Comment: 11 pages, 7 ps figures included, to appear in Phys.Rev.
A tethered ligand assay to probe SARS-CoV-2:ACE2 interactions
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are initiated by attachment of the receptor-binding domain (RBD) on the viral Spike protein to angiotensin-converting enzyme-2 (ACE2) on human host cells. This critical first step occurs in dynamic environments, where external forces act on the binding partners and avidity effects play an important role, creating an urgent need for assays that can quantitate SARS-CoV-2 interactions with ACE2 under mechanical load. Here, we introduce a tethered ligand assay that comprises the RBD and the ACE2 ectodomain joined by a flexible peptide linker. Using magnetic tweezers and atomic force spectroscopy as highly complementary single-molecule force spectroscopy techniques, we investigate the RBD:ACE2 interaction over the whole physiologically relevant force range. We combine the experimental results with steered molecular dynamics simulations and observe and assign fully consistent unbinding and unfolding events across the three techniques, enabling us to establish ACE2 unfolding as a molecular fingerprint. Measuring at forces of 2 to 5 pN, we quantify the force dependence and kinetics of the RBD:ACE2 bond in equilibrium. We show that the SARS-CoV-2 RBD:ACE2 interaction has higher mechanical stability, larger binding free energy, and a lower dissociation rate compared to SARS-CoV-1, which helps to rationalize the different infection patterns of the two viruses. By studying how free ACE2 outcompetes tethered ACE2, we show that our assay is sensitive to prevention of bond formation by external binders. We expect our results to provide a way to investigate the roles of viral mutations and blocking agents for targeted pharmaceutical intervention
Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV
Results are presented from a search for a W' boson using a dataset
corresponding to 5.0 inverse femtobarns of integrated luminosity collected
during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV.
The W' boson is modeled as a heavy W boson, but different scenarios for the
couplings to fermions are considered, involving both left-handed and
right-handed chiral projections of the fermions, as well as an arbitrary
mixture of the two. The search is performed in the decay channel W' to t b,
leading to a final state signature with a single lepton (e, mu), missing
transverse energy, and jets, at least one of which is tagged as a b-jet. A W'
boson that couples to fermions with the same coupling constant as the W, but to
the right-handed rather than left-handed chiral projections, is excluded for
masses below 1.85 TeV at the 95% confidence level. For the first time using LHC
data, constraints on the W' gauge coupling for a set of left- and right-handed
coupling combinations have been placed. These results represent a significant
improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe
Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV
A search for a Higgs boson decaying into two photons is described. The
analysis is performed using a dataset recorded by the CMS experiment at the LHC
from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an
integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross
section of the standard model Higgs boson decaying to two photons. The expected
exclusion limit at 95% confidence level is between 1.4 and 2.4 times the
standard model cross section in the mass range between 110 and 150 GeV. The
analysis of the data excludes, at 95% confidence level, the standard model
Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The
largest excess of events above the expected standard model background is
observed for a Higgs boson mass hypothesis of 124 GeV with a local significance
of 3.1 sigma. The global significance of observing an excess with a local
significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is
estimated to be 1.8 sigma. More data are required to ascertain the origin of
this excess.Comment: Submitted to Physics Letters
Measurement of the Lambda(b) cross section and the anti-Lambda(b) to Lambda(b) ratio with Lambda(b) to J/Psi Lambda decays in pp collisions at sqrt(s) = 7 TeV
The Lambda(b) differential production cross section and the cross section
ratio anti-Lambda(b)/Lambda(b) are measured as functions of transverse momentum
pt(Lambda(b)) and rapidity abs(y(Lambda(b))) in pp collisions at sqrt(s) = 7
TeV using data collected by the CMS experiment at the LHC. The measurements are
based on Lambda(b) decays reconstructed in the exclusive final state J/Psi
Lambda, with the subsequent decays J/Psi to an opposite-sign muon pair and
Lambda to proton pion, using a data sample corresponding to an integrated
luminosity of 1.9 inverse femtobarns. The product of the cross section times
the branching ratio for Lambda(b) to J/Psi Lambda versus pt(Lambda(b)) falls
faster than that of b mesons. The measured value of the cross section times the
branching ratio for pt(Lambda(b)) > 10 GeV and abs(y(Lambda(b))) < 2.0 is 1.06
+/- 0.06 +/- 0.12 nb, and the integrated cross section ratio for
anti-Lambda(b)/Lambda(b) is 1.02 +/- 0.07 +/- 0.09, where the uncertainties are
statistical and systematic, respectively.Comment: Submitted to Physics Letters
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