Mobiiliterveyspeliin liittyvät tarpeet, toiveet ja ideat

Terveyssuuntautuneisuus on vahvistumassa, mikä edellyttää uudenlaisia keinoja terveyden edistämiseksi. Väestön koulutustason nousu mahdollistaa tiedon paremman hyväksikäytön sekä uudenlaisen tiedonvälityksen ja terveysneuvonnan. Opinnäytetyö liittyy InnoHealth- projektiin, jonka tarkoituksena on valmentaa terveys- ja hyvinvointiteknologian toimijoita monipuoliseen yhteistyöhön opetuksen ja työelämäkäytäntöjen kehittämiseksi. Yhteistyöyrityksenä on Dato Systems Ay, jonka tavoitteena on kehittää sovellus, joka vastaa asiakkaiden tarpeita terveyden edistämisen näkökulmasta. Nyt kehitteillä olevassa sovelluksessa keskitytään ravitsemukseen ja liikuntaan. Opinnäytetyön tarkoitus on ottaa selvää mitä tarpeita, toiveita ja ideoita 18–50 –vuotiailla älypuhelimen käyttäjillä on mobiiliterveyspelistä. Opinnäytetyön tavoitteena on tuottaa tietoa, joka auttaa yhteistyöyritystä kehittämään mobiiliterveyspeliä asiakaslähtöisesti. Opinnäytetyö on laadullinen tutkimus, jonka aineistonkeruumenetelmänä käytettiin teemahaastattelua. Teemahaastattelu toteutettiin haastattelemalla opinnäytetyön tekijöiden lähipiirin henkilöitä (n = 12), jotka olivat älypuhelimen käyttäjiä. Haastattelemalla saatu aineisto analysoitiin aineistolähtöistä sisällönanalyysiä käyttäen. Opinnäytetyön tulokset osoittivat, että kaikki haastateltavat kaipasivat tietoa ravitsemuksesta ja liikunnasta. Motivoitumiskeinoista tärkeimpinä pidettiin tulosten seurantaa, tavoitteita sekä niiden saavuttamista. Haastatteluista selvisi motivoitumisen olevan lähtöisin omista tarpeista ja taistelusta itseään vastaan. Sovelluksen helppokäyttöisyys, yksilöllisyys ja saatavuus olivat toiveita, joita haastateltavat korostivat vastauksissaan. Lisälaitteiksi toivottiin ainakin GPS-mahdollisuutta, sykemittaria, kalorilaskuria ja askelmittaria. Mobiililaite koettiin nopea- ja helppokäyttöiseksi. Selkeä hyötyä koettiin myös siitä, että mobiililaite kulkee aina mukana. Haastatteluvastauksissa korostui sovellukseen liittyvänä ideana se, että sovelluksen tulisi olla helppo ja yksinkertainen käyttää, mutta käyttöominaisuuksiltaan monipuolinen, jotta se vastaisi mahdollisimman laajan kohderyhmän tarpeisiin. Haastateltavat kokivat erityisesti kokonaisvaltaisen liikunnan ja ravitsemuksen yhdistävän sovelluksen tarpeelliseksi. Yhteistyöyritys on ollut tyytyväinen opinnäytetyön tuloksiin ja he ovat ottaneet ne huomioon tuotekehityksessään.Finnish people are becoming more health oriented and that requires new tools to promote health. The educational level is rising and it gives an opportunity to exploit more information in new ways. This thesis is based on InnoHealth project which aims to train healthcare and welfare technology operators in diverse collaboration to develop education and working life practices. Co-operation company is Dato Systems Ay. The company’s goal is to create a mobile phone application that is responding to clients’ needs in health promotion point of view. In this application the focus will be on nutrition and physical activity. The aim of the thesis is to provide information that helps co-operation company to develop customer-oriented mobile phone game for health. The goal is to find out what kind of needs, hopes and ideas 18 – 50 year old smartphone users have related to mobile phone game for health. In this thesis qualitative research was used and the data was collected by theme interviews. The interviews were accomplishing by interviewing smartphone users (n = 12) who belong to researcher’s inner circle. The collected data was analyzed by data-oriented content analysis. The results of the thesis pointed out that all interviewees need information concerning nutrition and physical activity. The most important motivating ways were setting goals, monitoring and accomplishing results. Most participants mentioned that they are motivated the best by their own needs and by competing against themselves. User friendliness, individuality and availability were hopes that the interviewees highlighted in their answers concerning the application. Additional devices like heart rate monitor, GPS, caloric counter and pedometer would be valuable qualities according the participants. Mobile phone was experienced as quick and easy to use. The mobile phone has the advantage of time and location independent training. The results pointed out that the application should be easy and simple to use but have versatile performance so that it would have potential to respond as many customer-oriented needs as possible. The interviewees experienced a comprehensive application that combines nutrition and physical activity especially necessary. The co-operation company has been satisfied with results and they have already used them in their product development

Evaluating bicyclists’ risk perception using video clips: Comparison of frequent and infrequent city cyclists

Abstract Hazard and risk perception has been studied extensively among car drivers, and their link to crash involvement is established. Bicyclists, in particular, are vulnerable road users. Better understanding of their risk and hazard perception could help to improve their traffic safety. In this study, we investigated the risk perception of bicyclists in a city environment. Two groups of bicyclists were compared: 19 frequent and 19 infrequent bicyclists. Participants were shown video clips taken with a camera attached to the handlebar of a bicycle, and they were asked to continuously indicate with a slider how much caution the situation needed. The frequent cyclists had more frequent rises in the caution estimate, which suggest that they anticipated or detected more hazards than infrequent cyclists. This is in line with the classical hazard perception results, which link the car driving experience to faster and more accurate hazard perception. The overall level or caution was not directly related to the rise event rate or bicycling frequency. Those cyclists who reported typically cycling faster than others showed elevated overall level of caution on sidewalks compared with others, but there was no difference on bike paths.Hazard and risk perception has been studied extensively among car drivers, and their link to crash involvement is established. Bicyclists, in particular, are vulnerable road users. Better understanding of their risk and hazard perception could help to improve their traffic safety. In this study, we investigated the risk perception of bicyclists in a city environment. Two groups of bicyclists were compared: 19 frequent and 19 infrequent bicyclists. Participants were shown video clips taken with a camera attached to the handlebar of a bicycle, and they were asked to continuously indicate with a slider how much caution the situation needed. The frequent cyclists had more frequent rises in the caution estimate, which suggest that they anticipated or detected more hazards than infrequent cyclists. This is in line with the classical hazard perception results, which link the car driving experience to faster and more accurate hazard perception. The overall level or caution was not directly related to the rise event rate or bicycling frequency. Those cyclists who reported typically cycling faster than others showed elevated overall level of caution on sidewalks compared with others, but there was no difference on bike paths. (C) 2015 Elsevier Ltd. All rights reserved.Peer reviewe

Electrophysiological Indicators of the Age-Related Deterioration in the Sensitivity to Auditory Duration Deviance

The present study investigates age-related changes in duration discrimination in millisecond time domain. We tested young (N = 20, mean age = 24.5, SD = 2.97) and elderly (N = 20, mean age = 65.2, SD = 2.94) subjects using the mismatch negativity (MMN) paradigm. White-noise bursts of two different durations (50 and 10 ms) were presented in two oddball blocks. In one block (Increment Condition), the repetitive sequence of 10 ms standards was interspersed by occasional 50 ms deviants. In the Decrement Condition, the roles of the two stimuli were reversed. We analyzed the P1-N1 complex, MMN and P3a and found the effect of age for all these components. Moreover, the impact of stimulus presentation condition (increment/decrement) was observed for MMN and P3a. Our results confirmed the previous evidence for deteriorated duration discrimination in elderly people. Additionally, we found that this effect may be influenced by procedural factors.Peer reviewe

The Multilingual Picture Database

Publisher Copyright: © 2022, The Author(s).The growing interdisciplinary research field of psycholinguistics is in constant need of new and up-to-date tools which will allow researchers to answer complex questions, but also expand on languages other than English, which dominates the field. One type of such tools are picture datasets which provide naming norms for everyday objects. However, existing databases tend to be small in terms of the number of items they include, and have also been normed in a limited number of languages, despite the recent boom in multilingualism research. In this paper we present the Multilingual Picture (Multipic) database, containing naming norms and familiarity scores for 500 coloured pictures, in thirty-two languages or language varieties from around the world. The data was validated with standard methods that have been used for existing picture datasets. This is the first dataset to provide naming norms, and translation equivalents, for such a variety of languages; as such, it will be of particular value to psycholinguists and other interested researchers. The dataset has been made freely available.Peer reviewe

Assessing the genetic architecture of epithelial ovarian cancer histological subtypes.

Epithelial ovarian cancer (EOC) is one of the deadliest common cancers. The five most common types of disease are high-grade and low-grade serous, endometrioid, mucinous and clear cell carcinoma. Each of these subtypes present distinct molecular pathogeneses and sensitivities to treatments. Recent studies show that certain genetic variants confer susceptibility to all subtypes while other variants are subtype-specific. Here, we perform an extensive analysis of the genetic architecture of EOC subtypes. To this end, we used data of 10,014 invasive EOC patients and 21,233 controls from the Ovarian Cancer Association Consortium genotyped in the iCOGS array (211,155 SNPs). We estimate the array heritability (attributable to variants tagged on arrays) of each subtype and their genetic correlations. We also look for genetic overlaps with factors such as obesity, smoking behaviors, diabetes, age at menarche and height. We estimated the array heritabilities of high-grade serous disease ([Formula: see text] = 8.8 ± 1.1 %), endometrioid ([Formula: see text] = 3.2 ± 1.6 %), clear cell ([Formula: see text] = 6.7 ± 3.3 %) and all EOC ([Formula: see text] = 5.6 ± 0.6 %). Known associated loci contributed approximately 40 % of the total array heritability for each subtype. The contribution of each chromosome to the total heritability was not proportional to chromosome size. Through bivariate and cross-trait LD score regression, we found evidence of shared genetic backgrounds between the three high-grade subtypes: serous, endometrioid and undifferentiated. Finally, we found significant genetic correlations of all EOC with diabetes and obesity using a polygenic prediction approach.The Ovarian Cancer Association Consortium is supported by a grant from the Ovarian Cancer Research Fund thanks to donations by the family and friends of Kathryn Sladek Smith (PPD/RPCI.07). The Nurses’ Health Studies would like to thank the participants and staff of the Nurses' Health Study and Nurses' Health Study II for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, WY. The authors assume full responsibility for analyses and interpretation of these data. Funding of the constituent studies was provided by the California Cancer Research Program (00-01389V-20170, N01-CN25403, 2II0200); the Canadian Institutes of Health Research (MOP-86727); Cancer Australia; Cancer Council Victoria; Cancer Council Queensland; Cancer Council New South Wales; Cancer Council South Australia; Cancer Council Tasmania; Cancer Foundation of Western Australia; the Cancer Institute of New Jersey; Cancer Research UK (C490/A6187, C490/A10119, C490/A10124); the Danish Cancer Society (94-222-52); the ELAN Program of the University of Erlangen-Nuremberg; the Eve Appeal; the Helsinki University Central Hospital Research Fund; Helse Vest; the Norwegian Cancer Society; the Norwegian Research Council; the Ovarian Cancer Research Fund; Nationaal Kankerplan of Belgium; the L & S Milken Foundation; the Polish Ministry of Science and Higher Education (4 PO5C 028 14, 2 PO5A 068 27); the Roswell Park Cancer Institute Alliance Foundation; the US National Cancer Institute (K07-CA095666, K07-CA80668, K07-CA143047, K22-CA138563, N01-CN55424, N01-PC67001, N01-PC067010, N01-PC035137, P01-CA017054, P01-CA087696, P30-CA072720, P30-CA15083, P30-CA008748, P50-CA159981, P50-CA105009, P50-CA136393, R01-CA149429, R01-CA014089, R01-CA016056, R01-CA017054, R01-CA049449, R01-CA050385, R01-CA054419, R01-CA058598, R01-CA058860, R01-CA061107, R01-CA061132, R01-CA063678, R01-CA063682, R01-CA067262, R01-CA071766, R01-CA074850, R01-CA080978, R01-CA083918, R01-CA087538, R01-CA092044, R01-CA095023, R01-CA122443, R01-CA112523, R01-CA114343, R01-CA126841, R01-CA136924, R03-CA113148, R03-CA115195, U01-CA069417, U01-CA071966, UM1-CA186107, UM1-CA176726 and Intramural research funds); the NIH/National Center for Research Resources/General Clinical Research Center (MO1-RR000056); the US Army Medical Research and Material Command (DAMD17-01-1-0729, DAMD17-02-1-0666, DAMD17-02-1-0669, W81XWH-07-0449, W81XWH-10-1-02802); the US Public Health Service (PSA-042205); the National Health and Medical Research Council of Australia (199600 and 400281); the German Federal Ministry of Education and Research of Germany Programme of Clinical Biomedical Research (01GB 9401); the State of Baden-Wurttemberg through Medical Faculty of the University of Ulm (P.685); the German Cancer Research Center; the Minnesota Ovarian Cancer Alliance; the Mayo Foundation; the Fred C. and Katherine B. Andersen Foundation; the Lon V. Smith Foundation (LVS-39420); the Oak Foundation; Eve Appeal; the OHSU Foundation; the Mermaid I project; the Rudolf-Bartling Foundation; the UK National Institute for Health Research Biomedical Research Centres at the University of Cambridge, Imperial College London, University College Hospital ‘Womens Health Theme’ and the Royal Marsden Hospital; and WorkSafeBC 14. Investigator-specific funding: G.C.P receives scholarship support from the University of Queensland and QIMR Berghofer. Y.L. was supported by the NHMRC Early Career Fellowship. G.C.T. is supported by the National Health and Medical Research Council. S.M. was supported by an ARC Future Fellowship

Shared genetics underlying epidemiological association between endometriosis and ovarian cancer

Epidemiological studies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer, including clear cell, low-grade serous and endometrioid carcinomas. We aimed to determine whether the observed associations might be due to shared genetic aetiology. To address this, we used two endometriosis datasets genotyped on common arrays with full-genome coverage (3194 cases and 7060 controls) and a large ovarian cancer dataset genotyped on the customized Illumina Infinium iSelect (iCOGS) arrays (10 065 cases and 21 663 controls). Previous work has suggested that a large number of genetic variants contribute to endometriosis and ovarian cancer (all histotypes combined) susceptibility. Here, using the iCOGS data, we confirmed polygenic architecture for most histotypes of ovarian cancer. This led us to evaluate if the polygenic effects are shared across diseases. We found evidence for shared genetic risks between endometriosis and all histotypes of ovarian cancer, except for the intestinal mucinous type. Clear cell carcinoma showed the strongest genetic correlation with endometriosis (0.51, 95% CI = 0.18-0.84). Endometrioid and low-grade serous carcinomas had similar correlation coefficients (0.48, 95% CI = 0.07-0.89 and 0.40, 95% CI = 0.05-0.75, respectively). High-grade serous carcinoma, which often arises from the fallopian tubes, showed a weaker genetic correlation with endometriosis (0.25, 95% CI = 0.11-0.39), despite the absence of a known epidemiological association. These results suggest that the epidemiological association between endometriosis and ovarian adenocarcinoma may be attributable to shared genetic susceptibility loci.Other Research Uni

Common variants at theCHEK2gene locus and risk of epithelial ovarian cancer

Genome-wide association studies have identified 20 genomic regions associated with risk of epithelial ovarian cancer (EOC), but many additional risk variants may exist. Here, we evaluated associations between common genetic variants [single nucleotide polymorphisms (SNPs) and indels] in DNA repair genes and EOC risk. We genotyped 2896 common variants at 143 gene loci in DNA samples from 15 397 patients with invasive EOC and controls. We found evidence of associations with EOC risk for variants at FANCA, EXO1, E2F4, E2F2, CREB5 and CHEK2 genes (P ≤ 0.001). The strongest risk association was for CHEK2 SNP rs17507066 with serous EOC (P = 4.74 x 10(-7)). Additional genotyping and imputation of genotypes from the 1000 genomes project identified a slightly more significant association for CHEK2 SNP rs6005807 (r (2) with rs17507066 = 0.84, odds ratio (OR) 1.17, 95% CI 1.11-1.24, P = 1.1×10(-7)). We identified 293 variants in the region with likelihood ratios of less than 1:100 for representing the causal variant. Functional annotation identified 25 candidate SNPs that alter transcription factor binding sites within regulatory elements active in EOC precursor tissues. In The Cancer Genome Atlas dataset, CHEK2 gene expression was significantly higher in primary EOCs compared to normal fallopian tube tissues (P = 3.72×10(-8)). We also identified an association between genotypes of the candidate causal SNP rs12166475 (r (2) = 0.99 with rs6005807) and CHEK2 expression (P = 2.70×10(-8)). These data suggest that common variants at 22q12.1 are associated with risk of serous EOC and CHEK2 as a plausible target susceptibility gene.Other Research Uni

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.

BACKGROUND: Regulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer. METHODS: In a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian cancer patients. RESULTS: The most significant global associations for all genes in the pathway were seen in endometrioid ( p = 0.082) and clear cell ( p = 0.083), with the most significant gene level association seen with TGFBR2 ( p = 0.001) and clear cell EOC. Gene associations with histotypes at p < 0.05 included: IL12 ( p = 0.005 and p = 0.008, serous and high-grade serous, respectively), IL8RA ( p = 0.035, endometrioid and mucinous), LGALS1 ( p = 0.03, mucinous), STAT5B ( p = 0.022, clear cell), TGFBR1 ( p = 0.021 endometrioid) and TGFBR2 ( p = 0.017 and p = 0.025, endometrioid and mucinous, respectively). CONCLUSIONS: Common inherited gene variation in Treg cell pathways shows some evidence of germline genetic contribution to odds of EOC that varies by histologic subtype and may be associated with mRNA expression of immune-complex receptor in EOC patients

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC