485 research outputs found
Debate sobre o artigo de Narvai et al.
English title: Debate on the paper by Narvai et al.Margareth Crisóstomo Portela & Mauricio Teixeira Leite de Vasconcello
Cardiovascular abnormalities in patients with oral cleft: a clinical-electrocardiographic-echocardiographic study
OBJECTIVES: The present study aims to describe the clinical, electrocardiographic, and echocardiographic cardiological findings in a group of patients with oral clefts. METHODS: This is a prospective cross-sectional study on 70 children (age range from 13 days to 19 years) with oral clefts who attended the multidisciplinary program of a university hospital from March 2013 to September 2014. The patients were evaluated by a pediatric cardiologist and underwent detailed anamnesis, physical examination, electrocardiogram, and echocardiogram. RESULTS: Sixty percent of the patients were male; 55.7% presented with cleft lip and palate, and 40.0% presented with health complaints. Comorbidities were found in 44.3%. Relevant pregnancy, neonatal, family and personal antecedents were present in 55.7%, 27.1%, 67.2%, and 24.3% of the patients, respectively. Regarding the antecedents, 15.2% of the patients presented with a cardiac murmur, 49.0% with a familial risk of developing plurimetabolic syndrome, and 6% with family antecedents of rheumatic fever. Electrocardiographic evaluation showed one case of atrioventricular block. Echocardiograms were abnormal in 35.7% of the exams, including 5 cases of mitral valve prolapse — one of which was diagnosed with rheumatic heart disease. CONCLUSION: The finding of a family risk of developing plurimetabolic syndrome and a diagnosis of rheumatic heart disease indicates that patients with oral clefts may be more prone to developing acquired heart disease. Thus, our findings highlight the importance of anamnesis and methodological triangulation (clinical-electrocardiographic-echocardiographic) in the investigation of patients with oral clefts and emphasize that cardiological follow-up to evaluate acquired and/or rhythm heart diseases is necessary. This strategy permits comorbidity prevention and individualized planned treatment
Stability of the monoclinic phase in the ferroelectric perovskite PbZr(1-x)TixO3
Recent structural studies of ferroelectric PbZr(1-x)TixO3 (PZT) with x= 0.48,
have revealed a new monoclinic phase in the vicinity of the morphotropic phase
boundary (MPB), previously regarded as the the boundary separating the
rhombohedral and tetragonal regions of the PZT phase diagram. In the present
paper, the stability region of all three phases has been established from high
resolution synchrotron x-ray powder diffraction measurements on a series of
highly homogeneous samples with 0.42 <=x<= 0.52. At 20K the monoclinic phase is
stable in the range 0.46 <=x<= 0.51, and this range narrows as the temperature
is increased. A first-order phase transition from tetragonal to rhombohedral
symmetry is observed only for x= 0.45. The MPB, therefore, corresponds not to
the tetragonal-rhombohedral phase boundary, but instead to the boundary between
the tetragonal and monoclinic phases for 0.46 <=x<= 0.51. This result provides
important insight into the close relationship between the monoclinic phase and
the striking piezoelectric properties of PZT; in particular, investigations of
poled samples have shown that the monoclinic distortion is the origin of the
unusually high piezoelectric response of PZT.Comment: REVTeX file, 7 figures embedde
Towards a nanospecific approach for risk assessment.
In the current paper, a new strategy for risk assessment of nanomaterials is described, which builds upon
previous project outcomes and is developed within the FP7 NANoREG project. NANoREG has the aim to
develop, for the long term, new testing strategies adapted to a high number of nanomaterials where
many factors can affect their environmental and health impact. In the proposed risk assessment strategy,
approaches for (Quantitative) Structure Activity Relationships ((Q)SARs), grouping and read-across are
integrated and expanded to guide the user how to prioritise those nanomaterial applications that may
lead to high risks for human health. Furthermore, those aspects of exposure, kinetics and hazard
assessment that are most likely to be influenced by the nanospecific properties of the material under
assessment are identified. These aspects are summarised in six elements, which play a key role in the
strategy: exposure potential, dissolution, nanomaterial transformation, accumulation, genotoxicity and
immunotoxicity.
With the current approach it is possible to identify those situations where the use of nanospecific
grouping, read-across and (Q)SAR tools is likely to become feasible in the future, and to point towards the
generation of the type of data that is needed for scientific justification, which may lead to regulatory
acceptance of nanospecific applications of these tools.The research leading to these results has been partially funded
by the European Union Seventh Framework Programme (FP7/
2007e2013) under the project NANoREG (A common European
approach to the regulatory testing of nanomaterials), grant agreement
310584.info:eu-repo/semantics/publishedVersio
Hyperendemicity, heterogeneity and spatial overlap of leprosy and cutaneous leishmaniasis in the southern Amazon region of Brazil
Neglected tropical diseases characterized by skin lesions are highly endemic in the state of Mato Grosso, Brazil. We analyzed the spatial distribution of leprosy and Cutaneous Leishmaniasis (CL) and identified the degree of overlap in their distribution. All new cases of leprosy and CL reported between 2008 and 2017 through the national reporting system were included in the study. Scan statistics together with univariate Global and Local Moran's I were employed to identify clusters and spatial autocorrelation for each disease, with the spatial correlation between leprosy and CL measured by bivariate Global and Local Moran's I. Finally, we evaluated the demographic characteristics of the patients. The number of leprosy (N = 28,204) and CL (N = 24,771) cases in Mato Grosso and the highly smoothed detection coefficients indicated hyperendemicity and spatial distribution heterogeneity. Scan statistics demonstrated overlap of high-risk clusters for leprosy (RR = 2.0; P <0.001) and CL (RR = 4.0; P <0.001) in the North and Northeast mesoregions. Global Moran's I revealed a spatial autocorrelation for leprosy (0.228; P = 0.001) and CL (0.311; P = 0.001) and a correlation between them (0.164; P = 0.001). Both diseases were found to be concentrated in urban areas among men aged 31-60 years, of brown-skinned ethnicity and with a low educational level. Our findings indicate a need for developing integrated and spatially as well as socio-demographically targeted public health policies
Equine infectious anemia : prevalence in working equids of livestock herds, in Minas Gerais, Brazil
Estimaram-se, no estado de Minas Gerais, a prevalência e a distribuição espacial da anemia infecciosa eqüina (AIE) em propriedades com eqüídeos de serviço. As amostras de sangue, de 6540 eqüídeos de 1940 rebanhos foram coletadas no período de setembro de 2003 a março de 2004, nos 853 municípios do estado. Utilizaram-se dois testes de laboratório em seqüência: ELISA, usando-se antígeno recombinante gp90, e imunodifusão em gel de ágar (IDGA). As prevalências foram de 5,3% [IC=4,3 a 6,3%] para rebanhos e de 3,1% [IC=2,2 a 3,9%] para animais. O estado de Minas Gerais foi considerado área endêmica para AIE. As mais altas prevalências para rebanhos e para animais foram encontradas na região Norte/Noroeste, seguida pela região Vale do Mucuri/Jequitinhonha. ___________________________________________________________________________________________________________ ABSTRACTThe prevalence and spatial distribution of equine infectious anemia (EIA) were estimated in livestock herds where equids were used as draft power and for transportation in the State of Minas Gerais, Brazil. Serum samples were collected from September/2003 to March/2004 in 853 municipalities of the state. The sample comprised 6,540 equids from 1,940 herds. Two laboratorial tests were performed in sequence: ELISA using a recombinant gp90 protein, following by the AGID. The prevalence in the herds was estimated in 5.3% [CI = 4.3 to 6.3%], and 3.1% [CI = 2.2 to 3.9%] of the animals tested were positive. Minas Gerais was considered an endemic region for EIA. The highest prevalence for herds and animals was found in North/Northwest region (strata) followed by Vale do Mucuri/Jequitinhonha region
System Size and Energy Dependence of Jet-Induced Hadron Pair Correlation Shapes in Cu+Cu and Au+Au Collisions at sqrt(s_NN) = 200 and 62.4 GeV
We present azimuthal angle correlations of intermediate transverse momentum
(1-4 GeV/c) hadrons from {dijets} in Cu+Cu and Au+Au collisions at sqrt(s_NN) =
62.4 and 200 GeV. The away-side dijet induced azimuthal correlation is
broadened, non-Gaussian, and peaked away from \Delta\phi=\pi in central and
semi-central collisions in all the systems. The broadening and peak location
are found to depend upon the number of participants in the collision, but not
on the collision energy or beam nuclei. These results are consistent with sound
or shock wave models, but pose challenges to Cherenkov gluon radiation models.Comment: 464 authors from 60 institutions, 6 pages, 3 figures, 2 tables.
Submitted to Physical Review Letters. Plain text data tables for the points
plotted in figures for this and previous PHENIX publications are (or will be)
publicly available at http://www.phenix.bnl.gov/papers.htm
Improved Measurement of Double Helicity Asymmetry in Inclusive Midrapidity pi^0 Production for Polarized p+p Collisions at sqrt(s)=200 GeV
We present an improved measurement of the double helicity asymmetry for pi^0
production in polarized proton-proton scattering at sqrt(s) = 200 GeV employing
the PHENIX detector at the Relativistic Heavy Ion Collider (RHIC). The
improvements to our previous measurement come from two main factors: Inclusion
of a new data set from the 2004 RHIC run with higher beam polarizations than
the earlier run and a recalibration of the beam polarization measurements,
which resulted in reduced uncertainties and increased beam polarizations. The
results are compared to a Next to Leading Order (NLO) perturbative Quantum
Chromodynamics (pQCD) calculation with a range of polarized gluon
distributions.Comment: 389 authors, 4 pages, 2 tables, 1 figure. Submitted to Phys. Rev. D,
Rapid Communications. Plain text data tables for the points plotted in
figures for this and previous PHENIX publications are (or will be) publicly
available at http://www.phenix.bnl.gov/papers.htm
Formation of dense partonic matter in relativistic nucleus-nucleus collisions at RHIC: Experimental evaluation by the PHENIX collaboration
Extensive experimental data from high-energy nucleus-nucleus collisions were
recorded using the PHENIX detector at the Relativistic Heavy Ion Collider
(RHIC). The comprehensive set of measurements from the first three years of
RHIC operation includes charged particle multiplicities, transverse energy,
yield ratios and spectra of identified hadrons in a wide range of transverse
momenta (p_T), elliptic flow, two-particle correlations, non-statistical
fluctuations, and suppression of particle production at high p_T. The results
are examined with an emphasis on implications for the formation of a new state
of dense matter. We find that the state of matter created at RHIC cannot be
described in terms of ordinary color neutral hadrons.Comment: 510 authors, 127 pages text, 56 figures, 1 tables, LaTeX. Submitted
to Nuclear Physics A as a regular article; v3 has minor changes in response
to referee comments. Plain text data tables for the points plotted in figures
for this and previous PHENIX publications are (or will be) publicly available
at http://www.phenix.bnl.gov/papers.htm
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