The z=0.0912 and z=0.2212 Damped Lyman Alpha Galaxies Along the Sight-Line Toward the Quasar OI 363

New optical and infrared observations along the sight-line toward the quasar OI 363 (0738+313) are presented and discussed. Excluding systems which lack confirming UV spectroscopic observations of the actual Lyman alpha line, this sight-line presently contains the two lowest-redshift classical damped Lyman alpha (DLA) quasar absorption line systems known (i.e. with N(HI) \ge 2 x 10^{20} atoms cm^{-2}), one at z(abs)=0.0912 and the other at z(abs)=0.2212. The z=0.09 DLA galaxy appears to be an extended low surface brightness galaxy which is easily visible only in infrared images and shows rich morphological structure. Subtraction of the quasar nuclear and host light yields L_K \approx 0.08L_K* at z=0.09. The impact parameter between the galaxy and quasar sight-line is very small, b<3.6 kpc (<2 arcsec), which makes measurements difficult. The z=0.22 DLA galaxy is an early-type dwarf with a K-band luminosity of L_K \approx 0.1L_K* at impact parameter b=20 kpc. In general, these results serve to support mounting evidence that DLA galaxies are drawn from a wide variety of gas-rich galaxy types. (Abridged)Comment: 27 pages, 6 figures, 2 in color. Submitted to Ap

DR1 doped sol-gel planar waveguides for nonlinear devices operating at telecommunications wavelengths

International audienceWe report on linear and nonlinear optical properties of Disperse Red 1-doped solgel waveguides. The refractive-index and optical-propagation losses of the guiding layer were measured between 0.756 mm and 1.64 mm. The spectral broadening of the chromophore charge-transfer transition in the visible is modeled with a Voigt-profile function. In the telecommunications window the attenuation is dominated by the overtones of the O--H bonds vibration bands. The nonlinear optical coefficients were measured at different poling strengths with the Maker-fringe method. The nonlinear coefficient d33 was found to be 4.5 pm V21 at 1.58 mm for a poling field of 60 Vmm21

Assessing the economic impact of diseases in Mediterranean grow-out farms culturing European sea bass

The aim of this work is to propose a novel and formal approach to evaluate the direct costs of diseases caused by different pathogens as well as their economic impact on typical Mediterranean grow-out farms culturing European sea bass under different scenarios of production related to the biomass produced (farm size) and the size of the fish produced (production strategy). We employ a deterministic static model to simulate the annual income statement of those facilities to evaluate the direct costs caused by different diseases as well as, through a partial budget and sensitivity analyses, the economic impact of them. An important conclusion of this work is that the profitability and economic viability of sea bass grow-out farms suffering recurrent outbreaks of diseases caused by different pathogens depend on the farm typology (farm size) as well as the decisions taken by owners/investors about the size of the fish produced and sold in the market. Our estimations show that as the larger is the farm and the size of the fish produced, the larger are the direct cost of a disease outbreak. However, the economic impact on the net operating profit is significantly worse as smaller is the farm and smaller the fish produced. The conclusions of this research stress the need for small producers to pay attention and devote resources to prevent and treat disease outbreaks.info:eu-repo/semantics/publishedVersio

Magnetization-induced second harmonic generation of light by exchange-coupled magnetic layers

International audienceA longitudinal magneto-optical Kerr effect and magnetization-induced second-harmonic generation (MSHG) of light (at 2v) have been measured in a SiO2/Fe96Si4/Dy30Fe58Co12/glass exchange-coupled magnetic bilayer system with competitive anisotropies. Theoretical MSHG predictions in this structure that give rise to an effect proportional to magnetization components and that are allowed by an electric dipole mechanism are reported and discussed. The magnitude of the MSHG effect depends on the electric field of the incoming radiation at each interface and on the corresponding incoming (at v) and outgoing (at 2v) Fresnel coefficients. It is demonstrated that transverse pp MSHG selectively probes the magnetization of the first SiO2/Fe96Si4 interface, while transverse sp and longitudinal ps MSHG is sensitive, but less selectively, to the Fe96Si4/Dy30Fe58Co12 interface that supports a planar magnetic domain wall. (p and s are the usual parallel and perpendicular polarizations to the plane of incidence.) The contribution to MSHG by gradient magnetization terms is negligibl

A new reciprocal translocation in a subfertile bull

Three bulls of the Montbéliarde breed that exhibited fertility rates lower than 30% following more than 400 artificial inseminations were examined. Semen quality (sperm motility and morphology) from these bulls was normal. Fertilizing ability estimated from in vitro embryo production results was studied for two of them. In vitro production rate was very low for one bull (A) and normal for the other (B). Cytogenetic analyses were carried out on the three bulls using chromosome banding techniques. These analyses revealed a reciprocal translocation (12;17)(q22;q14) in bull B. Based on family analyses, the hypothesis of a de novo origin of this rearrangement is proposed

Clinical management of molecular alterations identified by high throughput sequencing in patients with advanced solid tumors in treatment failure: Real-world data from a French hospital

BackgroundIn the context of personalized medicine, screening patients to identify targetable molecular alterations is essential for therapeutic decisions such as inclusion in clinical trials, early access to therapies, or compassionate treatment. The objective of this study was to determine the real-world impact of routine incorporation of FoundationOne analysis in cancers with a poor prognosis and limited treatment options, or in those progressing after at least one course of standard therapy.MethodsA FoundationOneCDx panel for solid tumor or liquid biopsy samples was offered to 204 eligible patients.ResultsSamples from 150 patients were processed for genomic testing, with a data acquisition success rate of 93%. The analysis identified 2419 gene alterations, with a median of 11 alterations per tumor (range, 0–86). The most common or likely pathogenic variants were on TP53, TERT, PI3KCA, CDKN2A/B, KRAS, CCDN1, FGF19, FGF3, and SMAD4. The median tumor mutation burden was three mutations/Mb (range, 0–117) in 143 patients with available data. Of 150 patients with known or likely pathogenic actionable alterations, 13 (8.6%) received matched targeted therapy. Sixty-nine patients underwent Molecular Tumor Board, which resulted in recommendations in 60 cases. Treatment with genotype-directed therapy had no impact on overall survival (13 months vs. 14 months; p = 0.95; hazard ratio = 1.04 (95% confidence interval, 0.48–2.26)].ConclusionsThis study highlights that an organized center with a Multidisciplinary Molecular Tumor Board and an NGS screening system can obtain satisfactory results comparable with those of large centers for including patients in clinical trials

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis