Gestión financiera y su incidencia en los resultados económicos-financieros de una empresa de transporte

Objetivo: Determinar la incidencia de la gestión financiera en los resultados económicosfinancieros en una empresa de Transporte. Metodología: El diseño de la investigación es cualitativa, de diseño transversal; la técnica utilizada para la recolección de datos fue la guía de entrevistas, lista de cotejo y guía de análisis documental. Resultados: Se determino un nivel de incumplimiento del 70% de las actividades de la gestión financiera, siendo estos bajos en los resultados económicos debido al problema de la pandemia, disminuyendo la demanda de pasajeros o por ende de ingresos. Conclusión: Se evidencia la existencia de incidencia significativa entre la gestión financiera y los resultados económicos financieros. Asimismo, la organización ha tenido que realizar gastos imprevistos para poder cumplir con los protocolos de bioseguridad por causa de la pandemia

Caveolin 1 protein expression in renal cell carcinoma predicts survival

<p>Abstract</p> <p>Background</p> <p>Caveolae play a significant role in disease phenotypes such as cancer, diabetes, bladder dysfunction, and muscular dystrophy. The aim of this study was to elucidate the caveolin-1 <it>(</it>CAV1<it>) </it>protein expression in renal cell cancer (RCC) and to determine its potential prognostic relevance.</p> <p>Methods</p> <p>289 clear cell RCC tissue specimens were collected from patients undergoing surgery for renal tumors. Both cytoplasmic and membranous CAV1 expression were determined by immunohistochemistry and correlated with clinical variables. Survival analysis was carried out for 169 evaluable patients with a median follow up of 80.5 months (interquartile range (IQR), 24.5 - 131.7 months).</p> <p>Results</p> <p>A high CAV1 expression in the tumor cell cytoplasm was significantly associated with male sex (p = 0.04), a positive nodal status (p = 0.04), and poor tumor differentiation (p = 0.04). In contrast, a higher than average (i.e. > median) CAV1 expression in tumor cell membranes was only linked to male sex (p = 0.03). Kaplan-Meier analysis disclosed significant differences in 5-year overall (51.4 vs. 75.2%, p = 0.001) and tumor specific survival (55.3 vs. 80.1%, p = 0.001) for patients with higher and lower than average cytoplasmic CAV1 expression levels, respectively. Applying multivariable Cox regression analysis a high CAV1 protein expression level in the tumor cell cytoplasm could be identified as an independent poor prognostic marker of both overall (p = 0.02) and tumor specific survival (p = 0.03) in clear cell RCC patients.</p> <p>Conclusion</p> <p>Over expression of caveolin-1 in the tumour cell cytoplasm predicts a poor prognosis of patients with clear cell RCC. CAV1 is likely to be a useful prognostic marker and may play an important role in tumour progression. Therefore, our data encourage further investigations to enlighten the role of CAV1 and its function as diagnostic and prognostic marker in serum and/or urine of RCC patients.</p

Fichte and Hegel on recognition and slavery

In the first section of this essay I show how Hegel’s account of the struggle for recognition can be explained in terms of the role that Fichte accords to recognition in his deduction of the concept of right and, in particular, in terms of a problem to which this deduction gives rise. In the second section, I show how Hegel seeks to resolve this problem by means of his account of the struggle for recognition. Finally, in the third section, I show how Fichte’s and Hegel’s claims concerning the necessity of mutual recognition do not prevent them from regarding slavery as justified in certain circumstances, or at least as being as much the fault of the person enslaved as the person who has enslaved him or her, despite the fact that slavery represents one of the clearest possible examples of a situation in which mutual recognition is absent. One may therefore question the extent to which they regard mutual recognition as an absolutely fundamental norm of social relations. There is the difference, however, that Hegel’s position appears to be that mutual recognition becomes such a norm in the course of history, whereas Fichte implies that the absence of mutual recognition may be justified simply whenever an individual has failed to raise him-or herself to the level of a being whose attitude towards him-or herself as demonstrated through his or her actions is proof of a status that demands recognition from others

The silicon isotope composition of Ethmodiscus rexlaminated diatom mats from the tropical West Pacific: Implications for silicate cycling during the Last Glacial Maximum

The cause of massive blooms of Ethmodiscus rex laminated diatom mats (LDMs) in the eastern Philippine Sea (EPS) during the Last Glacial Maximum (LGM) remains uncertain. In order to better understand the mechanism of formation of E. rex LDMs from the perspective of dissolved silicon (DSi) utilization, we determined the silicon isotopic composition of single E. rex diatom frustules (δ30SiE. rex) from two sediment cores in the Parece Vela Basin of the EPS. In the study cores, δ30SiE. rex varies from −1.23‰ to −0.83‰ (average −1.04‰), a range that is atypical of marine diatom δ30Si and that corresponds to the lower limit of reported diatom δ30Si values of any age. A binary mixing model (upwelled silicon versus eolian silicon) accounting for silicon isotopic fractionation during DSi uptake by diatoms was constructed. The binary mixing model demonstrates that E. rex dominantly utilized DSi from eolian sources (i.e., Asian dust) with only minor contributions from upwelled seawater sources (i.e., advected from Subantarctic Mode Water, Antarctic Intermediate Water, or North Pacific Intermediate Water). E. rex utilized only ~24% of available DSi, indicating that surface waters of the EPS were eutrophic with respect to silicon during the LGM. Our results suggest that giant diatoms did not always use a buoyancy strategy to obtain nutrients from the deep nutrient pool, thus revising previously proposed models for the formation of E. rex LDMs

Structure of the Sec13–Sec16 edge element, a template for assembly of the COPII vesicle coat

The crystal structure of a Sec13–Sec16 complex reveals its functions in the early steps of COPII coat complex assembly

Diretrizes para avaliar os efeitos econômicos e as consequências não comerciais e ambientais da entrada de pragas

22 páginasEste documento fue desarrollado como resultado del componente orientado a incrementar la capacidad técnica de la región para la utilización del proceso de análisis de riesgo de plagas con énfasis en el estudio de las consecuencias económicas y las consecuencias no comerciales y ambientales. La evaluación contempla el análisis del impacto general; tomando en cuenta las altas y bajas con respecto a la incertidumbre y las áreas de peligro por las pérdidas económicas.This document was developed as a result of the component aimed at increasing the technical capacity of the region for the use of the pest risk analysis process with emphasis on the study of economic consequences and non-commercial and environmental consequences. The evaluation includes the analysis of the general impact; taking into account the ups and downs with respect to uncertainty and areas of danger from economic losses.Este documento foi desenvolvido como resultado do componente que visa aumentar a capacidade técnica da região para a utilização do processo de análise de risco de pragas com ênfase no estudo de consequências econômicas e não comerciais e ambientais. A avaliação inclui a análise do impacto geral; levando em consideração os altos e baixos com respeito à incerteza e áreas de perigo de perdas econômicas

Evaluating compulsory minimum volume standards in Germany: how many hospitals were compliant in 2004?

<p>Abstract</p> <p>Background</p> <p>Minimum hospital procedure volumes are discussed as an instrument for quality assurance. In 2004 Germany introduced such annual minimum volumes nationwide on five surgical procedures: kidney, liver, stem cell transplantation, complex oesophageal, and pancreatic interventions. The present investigation is the first part of a study evaluating the effects of these minimum volumes on health care provision. Research questions address how many hospitals and cases were affected by minimum volume regulations in 2004, how affected hospitals were distributed according to minimum volumes, and how many hospitals within the 16 German states complied with the standards set for 2004.</p> <p>Methods</p> <p>The evaluation is based on the mandatory hospital quality reports for 2004. In the reports, all hospitals are statutorily obliged to state the number of procedures performed for each minimum volume. The data were analyzed descriptively.</p> <p>Results</p> <p>In 2004, 485 out of 1710 German hospitals providing acute care and approximately 0.14% of all hospital cases were affected by minimum volume regulations. Liver, kidney, and stem cell transplantation affected from 23 to hospitals; complex oesophageal and pancreatic interventions affected from 297 to 455 hospitals. The inter-state comparison of the average hospital care area demonstrates large differences between city states and large area states and the eastern and western German states ranging from a minimum 51 km²up to a maximum 23.200 km², varying according to each procedure. A range of 9% – 16% of the transplantation hospitals did not comply with the standards affecting 1% – 2% of the patients whereas 29% and 18% of the hospitals treating complex oesophageal and pancreatic interventions failed the standards affecting 2% – 5% of the prevailing cases.</p> <p>Conclusion</p> <p>In 2004, the newly introduced minimum volume regulations affected only up to a quarter of German acute care hospitals and few cases. However, excluding the hospitals not meeting the minimum volume standards from providing the respective procedures deserves considering two aspects: the hospital health care provision concepts by the German states as being responsible and from a patient perspective the geographically equal access to hospital care.</p