18 research outputs found
Dynamics of neural systems with discrete and distributed time delays
In real-world systems, interactions between elements do not happen instantaneously, due to the time
required for a signal to propagate, reaction times of individual elements, and so forth. Moreover,
time delays are normally nonconstant and may vary with time. This means that it is vital to introduce
time delays in any realistic model of neural networks. In order to analyze the fundamental
properties of neural networks with time-delayed connections, we consider a system of two coupled
two-dimensional nonlinear delay differential equations. This model represents a neural network,
where one subsystem receives a delayed input from another subsystem. An exciting feature of the
model under consideration is the combination of both discrete and distributed delays, where distributed
time delays represent the neural feedback between the two subsystems, and the discrete
delays describe the neural interaction within each of the two subsystems. Stability properties are
investigated for different commonly used distribution kernels, and the results are compared to the
corresponding results on stability for networks with no distributed delays. It is shown how approximations
of the boundary of the stability region of a trivial equilibrium can be obtained analytically
for the cases of delta, uniform, and weak gamma delay distributions. Numerical techniques are used
to investigate stability properties of the fully nonlinear system, and they fully confirm all analytical
findings
Time-delayed model of RNA interference
RNA interference (RNAi) is a fundamental cellular process that inhibits gene expression through cleavage and destruction of target mRNA. It is responsible for a number of important intracellular functions, from being the first line of immune defence against pathogens to regulating development and morphogenesis. In this paper we consider a mathematical model of RNAi with particular emphasis on time delays associated with two aspects of primed amplification: binding of siRNA to aberrant RNA, and binding of siRNA to mRNA, both of which result in the expanded production of dsRNA responsible for RNA silencing. Analytical and numerical stability analyses are performed to identify regions of stability of different steady states and to determine conditions on parameters that lead to instability. Our results suggest that while the original model without time delays exhibits a bi-stability due to the presence of a hysteresis loop, under the influence of time delays, one of the two steady states with the high (default) or small (silenced) concentration of mRNA can actually lose its stability via a Hopf bifurcation. This leads to the co-existence of a stable steady state and a stable periodic orbit, which has a profound effect on the dynamics of the system
Heterogeneous Delays in Neural Networks
We investigate heterogeneous coupling delays in complex networks of excitable
elements described by the FitzHugh-Nagumo model. The effects of discrete as
well as of uni- and bimodal continuous distributions are studied with a focus
on different topologies, i.e., regular, small-world, and random networks. In
the case of two discrete delay times resonance effects play a major role:
Depending on the ratio of the delay times, various characteristic spiking
scenarios, such as coherent or asynchronous spiking, arise. For continuous
delay distributions different dynamical patterns emerge depending on the width
of the distribution. For small distribution widths, we find highly synchronized
spiking, while for intermediate widths only spiking with low degree of
synchrony persists, which is associated with traveling disruptions, partial
amplitude death, or subnetwork synchronization, depending sensitively on the
network topology. If the inhomogeneity of the coupling delays becomes too
large, global amplitude death is induced
Time-delayed SIS epidemic model with population awareness
This paper analyses the dynamics of infectious disease with a concurrent spread of disease awareness. The model includes local awareness due to contacts with aware individuals, as well as global awareness due to reported cases of infection and awareness campaigns. We investigate the effects of time delay in response of unaware individuals to available information on the epidemic dynamics by establishing conditions for the Hopf bifurcation of the endemic steady state of the model. Analytical results are supported by numerical bifurcation analysis and simulations
Time-delayed model of immune response in plants
In the studies of plant infections, the plant immune response is known to play an essential role. In this paper we derive and analyse a new mathematical model of plant immune response with particular account for post-transcriptional gene silencing (PTGS). Besides biologically accurate representation of the PTGS dynamics, the model explicitly includes two time delays to represent the maturation time of the growing plant tissue and the non-instantaneous nature of the PTGS. Through analytical and numerical analysis of stability of the steady states of the model we identify parameter regions associated with recovery
and resistant phenotypes, as well as possible chronic infections. Dynamics of the system in these regimes is illustrated by numerical simulations of the model
Mathematical model of plant-virus interactions mediated by RNA interference
Cross-protection, which refers to a process whereby artificially inoculating a plant with a mild strain provides protection against a more aggressive isolate of the virus, is known to be an effective tool of disease control in plants. In this paper we derive and analyse a new mathematical model of the interactions between two competing viruses with particular account for RNA interference. Our results show that co-infection of the host can either increase or decrease the potency of individual infections depending on the levels of cross-protection or cross-enhancement between different viruses. Analytical and numerical bifurcation analyses are employed to investigate the stability of all steady states of the model in order to identify parameter regions where the system exhibits synergistic or antagonistic behaviour between viral strains, as well as different types of host recovery. We show that not only viral attributes but also the propagating component of RNA-interference in plants can play an important role in determining the dynamics
Stability switches in a neutral delay differential equation with application to real-time dynamic substructuring
In this paper delay differential equations approach is used to model a real-time dynamic substructuring experiment. Real-time dynamic substructuring involves dividing the structure under testing into two or more parts. One part is physically constructed in the lab- oratory and the remaining parts are being replaced by their numerical models. The numerical and physical parts are connected via an actuator. One of the main difficulties of this testing technique is the presence of delay in a closed loop system. We apply real-time dynamic sub- structuring to a nonlinear system consisting of a pendulum attached to a mass-spring-damper. We will show how a delay can have (de)stabilising effect on the behaviour of the whole system. Theoretical results agree very well with experimental data
Stability Switches in a Neutral Delay Differential Equation with Application to Real-Time Dynamic Substructuring
Global Stability Analysis on the Dynamics of an SIQ Model with Nonlinear Incidence Rate
An SIQ epidemic model with isolation and nonlinear incidence rate is studied. We have obtained a threshold value R and shown that there is only a
disease free equilibrium point when R 1. With the help of Liapunov function, we have
shown that disease free- and endemic equilibrium point is globally stable